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| Opinion |  Top |
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| Editorials |
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Why buy biotech? p111
doi:10.1038/6072
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Signal transduction 2000 p111
doi:10.1038/6073
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| Commentary |
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Five stages of the Human Genome Project p112
Richard C. Strohman
doi:10.1038/6074
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(60K)
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The real curse of Frankenfood p113
Henry I. Miller
doi:10.1038/6075
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(54K)
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Core ethical values for European bioindustries pp114 - 115
Robin Fears
& Erik Tambuyzer
doi:10.1038/6076
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(64K)
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| In Brief | Top |
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| Business and Regulatory News |
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New plan from industry to preserve Bt crops p117
Jeff Fox
doi:10.1038/6077
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(282K)
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Another hiccup at British Biotech p117
Adam Michael
doi:10.1038/6079
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(282K)
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More merger of markets p117
Adam Michael
doi:10.1038/6080
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(282K)
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15 years ago—February 1984 p117
Emma Dorey
doi:10.1038/6081
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(282K)
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Initial public offerings, 4th quarter 1998 p118
doi:10.1038/6082
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(80K)
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Biopharmaceutical sector performance 4th quarter 1998 p118
doi:10.1038/6084
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(80K)
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UK news is good and bad p118
Adam Michael
doi:10.1038/6087
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(80K)
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Flu deal is nothing to sneeze at p118
Emma Dorey
doi:10.1038/6089
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(80K)
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Biotechnology fundraising, Q4 1998 v. Q3 1998 p118
doi:10.1038/6090
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(80K)
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A rotten year for funding p118
Adam Michael
doi:10.1038/6093
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(80K)
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Tapping into Mexican plants p119
Adam Michael
doi:10.1038/6095
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(49K)
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A knock for genomics p119
Vicki Brower
doi:10.1038/6096
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(49K)
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Human clone update p119
Asako Saegusa
doi:10.1038/6097
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(49K)
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Research collaborations p119
doi:10.1038/6098
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| Research News |
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Panning for Taxol−binding proteins p120
LeeAnn Leshko
doi:10.1038/6099
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A Crick in the elbow p120
Alan Dove
doi:10.1038/6101
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(70K)
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Gene therapy on demand p120
Alan Dove
doi:10.1038/6102
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(70K)
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Breathing easier with AAT deficiency p120
Margret Einarson
doi:10.1038/6103
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(70K)
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Predicting protein function p120
Alan Dove
doi:10.1038/6104
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(70K)
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| This Month in Biotechnology |
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Fab direction for AAV p121
Andrew Marshall
doi:10.1038/6105
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(102K)
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A new twist on protein folding p121
Andrew Marshall
doi:10.1038/6107
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(102K)
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Bladder in a dish p121
Andrew Marshall
doi:10.1038/6108
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(102K)
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PDZ domains to order p121
Andrew Marshall
doi:10.1038/6110
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Low−lactose transgenic milk p121
Andrew Marshall
doi:10.1038/6112
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(102K)
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Photopolymerizable bone substitute p121
Andrew Marshall
doi:10.1038/6113
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(102K)
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Optimizing Mab function p121
Andrew Marshall
doi:10.1038/6114
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(102K)
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Ironing out plant stress p121
Andrew Marshall
doi:10.1038/6293
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(102K)
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| Analysis | Top |
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| Business and Regulatory News |
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Delegates face many challenges negotiating Biosafety Protocol p123
Jeffrey L. Fox
doi:10.1038/6116
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(70K)
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Amgen's NESP victory cuts out Johnson & Johnson p124
Ingeborg Fürst
doi:10.1038/6117
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(84K)
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EST patent granted for human kinase homologs p125
Debra Robertson
doi:10.1038/6119
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(121K)
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Companies chase money in and out of the Eurozone pp125 - 126
Adam Michael
doi:10.1038/6120
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(127K)
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Japanese budget boosts biotech pp126 - 127
Asako Saegusa
doi:10.1038/6122
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(94K)
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deCODE looks forward as database law passes p127
John Hodgson
doi:10.1038/6124
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(85K)
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Will investors return to biotechnology? p128
Emma Dorey
doi:10.1038/6126
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(72K)
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Asthma targets: Research dilemma pp128 - 129
Alan Dove
doi:10.1038/6127
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(76K)
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| Research News and Views |
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RASSLing with receptors pp131 - 132
Tim Clackson
doi:10.1038/6128
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(151K)
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The PDZ domain as you like it pp132 - 133
Robert E. Hughes
& Stanley Fields
doi:10.1038/6130
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(237K)
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Reconstructing the urinary bladder pp133 - 134
Christian Lorenz
& Birgit Margareta Schaefer
doi:10.1038/6132
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(334K)
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Toward designer milk pp135 - 136
Bruce Whitelaw
doi:10.1038/6134
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(101K)
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Ironing out the protein folding problem? pp136 - 137
Paul M. Horowitz
doi:10.1038/6136
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(90K)
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Metabolic engineers in the Bavarian Alps pp137 - 138
Philip A. Lessard, Mary Callan
& Guy della−Cioppa
doi:10.1038/6138
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(160K)
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| Feature | Top |
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Human ES cells: Can you build a business around them? pp139 - 142
Vicki Brower
doi:10.1038/6140
Abstract | Full text | PDF
(159K)
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| Research Review | Top |
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Improving enzymes for cancer gene therapy pp143 - 147
Lance P. Encell, Daniel M. Landis
& Lawrence A. Loeb
doi:10.1038/6142
Abstract | Full text | PDF
(104K)
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| Research Articles | Top |
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De novo reconstitution of a functional mammalian urinary bladder by tissue
engineering pp149 - 155
Frank Oberpenning, Jun Meng, James J. Yoo
& Anthony Atala
doi:10.1038/6146
Abstract | Full text | PDF
(598K)
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Photopolymerizable degradable polyanhydrides with osteocompatibility pp156 - 159
Kristi S. Anseth, Venkatram R. Shastri
& Robert Langer
doi:10.1038/6152
Abstract | Full text | PDF
(261K)
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Production of low-lactose milk by ectopic expression of intestinal lactase in the mouse mammary gland pp160 - 164
Bernard Jost, Jean−Luc Vilotte, Isabelle Duluc, Jean−Luc Rodeau
& Jean−Noël Freund
doi:10.1038/6158
Abstract | Full text | PDF
(242K)
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Conditional expression and signaling of a specifically designed G
i-coupled receptor in transgenic mice pp165 - 169
Charles H. Redfern, Peter Coward, Michael Y. Degtyarev, Elena K. Lee, Andrew T. Kwa, Lothar Hennighausen, Hermann Bujard, Glenn I. Fishman
& Bruce R. Conklin
doi:10.1038/6165
Abstract | Full text | PDF
(243K)
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Mutagenesis and selection of PDZ domains that bind new protein targets
pp170 - 175
Stefan Schneider, Michael Buchert, Oleg Georgiev, Bruno Catimel, Michael Halford, Steven A. Stacker, Thomas Baechi, Karin Moelling
& Christopher M. Hovens
doi:10.1038/6172
Abstract | Full text | PDF
(618K)
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Engineered glycoforms of an antineuroblastoma IgG1 with optimized antibody-dependent
cellular cytotoxic activity pp176 - 180
Pablo Umaña, Joël Jean−Mairet, Radmila Moudry, Hanspeter Amstutz
& James E. Bailey
doi:10.1038/6179
Abstract | Full text | PDF
(136K)
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Targeted adeno-associated virus vector transduction of nonpermissive cells mediated by a bispecific F(ab' )2 antibody pp181 - 186
Jeffrey S. Bartlett, Jurgen Kleinschmidt, Richard C. Boucher
& R. Jude Samulski
doi:10.1038/6185
Abstract | Full text | PDF
(144K)
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Oxidative refolding chromatography: folding of the scorpion toxin Cn5 pp187 - 191
Myriam M. Altamirano, Consuelo García, Lourival D. Possani
& Alan R. Fersht
doi:10.1038/6192
Abstract | Full text | PDF
(161K)
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Plants ectopically expressing the ironbinding protein, ferritin, are
tolerant to oxidative damage and pathogens pp192 - 196
Mária Deák, Gábor V. Horváth, Sholpan Davletova, Katalin Török, László Sass, Imre Vass, Balázs Barna, Zoltán Király
& Dénes Dudits
doi:10.1038/6198
Abstract | Full text | PDF
(295K)
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| Resources | Top |
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| Patents |
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Intellectual property protection for plants pp197 - 198
Cheryl H. Agris
doi:10.1038/6205
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(113K)
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Recent patent applications in peptide nucleic acids p199
doi:10.1038/6207
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(39K)
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| In the Laboratory |
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Detection and sizing of telomeric repeat DNA in situ pp200 - 201
Nedime Serakinci
& Jørn Koch
doi:10.1038/6209
Abstract | Full text | PDF
(82K)
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| Internet |
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Clinical trials p202
Michael Francisco
doi:10.1038/6211
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(69K)
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| People |
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People p203
doi:10.1038/6213
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(67K)
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| New Products |
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Chromatography p204
doi:10.1038/6215
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(109K)
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| Industry Trends |
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Xenotransplantation pp205 - 206
Aris Persidis
doi:10.1038/6222
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(68K)
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