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| Opinion |  Top |
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| Editorial |
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Much more than elegant p1
doi:10.1038/5295
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| Commentary |
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Intellectual property and the parsing of protein space pp2 - 3
Harvey Bialy
doi:10.1038/5164
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(88K)
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| Correspondence |
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Resolving contradictory reports on cell aging p4
Harry Rubin
doi:10.1038/5165
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(123K)
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Mycoplasmas as gene therapy vectors? p4
David Blum, Jean Michel Vicat, François Berger, Alim-Louis Benabid
& Didier Wion
doi:10.1038/5166
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(123K)
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Errata p4
doi:10.1038/5167
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(123K)
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| In Brief | Top |
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| Business and Regulatory News |
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Drug merger A to Z p7
Emma Dorey
& Adam Michael
doi:10.1038/5168
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(180K)
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FDA-style agency for Japan p7
Asako Saegusa
doi:10.1038/5343
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(180K)
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German−Canadian deal p7
Ellen Peerenboom
doi:10.1038/5344
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(180K)
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15 years ago—January 1984 p7
doi:10.1038/5342
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Japan shells out for biotech p8
Asako Saegusa
doi:10.1038/5345
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(70K)
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Indian patents don't impress p8
K.S. Jayaraman
doi:10.1038/5346
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(70K)
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UK investors in merge talks p8
Adam Michael
doi:10.1038/5347
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(70K)
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Cancer gene therapy for dogs p8
Adam Michael
doi:10.1038/5348
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(70K)
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Research collaborations p8
doi:10.1038/5349
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(70K)
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| Research News |
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Signal transduction gets hairy p9
Alan Dove
doi:10.1038/5172
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(107K)
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Plant polyketides p9
Musa M. Mhlanga
doi:10.1038/5350
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(107K)
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RNA vaccine p9
Margret Einarson
doi:10.1038/5351
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(107K)
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Silencing gene silence p9
Alan Dove
doi:10.1038/5352
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(107K)
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Oocyte gene transfer p9
Alan Dove
doi:10.1038/5353
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(107K)
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| This Month in Biotechnology |
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Less shocking antitumor agents? p10
Andrew Marshall
doi:10.1038/5174
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(189K)
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Rapid histological analysis p10
Andrew Marshall
doi:10.1038/5358
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(189K)
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Antisense that delivers p10
Andrew Marshall
doi:10.1038/5359
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(189K)
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Ribozymes as diagnostics p10
Andrew Marshall
doi:10.1038/5355
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(189K)
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Photoreversible enzyme solubility p10
Andrew Marshall
doi:10.1038/5356
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(189K)
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Four goes into three p10
Andrew Marshall
doi:10.1038/5354
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(189K)
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A trick in the tail p10
Andrew Marshall
doi:10.1038/5360
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(189K)
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Mab-regulated enzyme sensors p10
Andrew Marshall
doi:10.1038/5357
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(189K)
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Streptococci come unstuck p10
Andrew Marshall
doi:10.1038/5361
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(189K)
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| Analysis | Top |
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| Business and Regulatory News |
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Stem cell hearing stirs bioethics debate p11
Jeffrey L. Fox
doi:10.1038/5179
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(74K)
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Battle lines redrawn in BTWC debate pp11 - 12
Alan Dove
doi:10.1038/5180
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(82K)
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Code alone can't stop misconduct pp12 - 13
Adam Michael
doi:10.1038/5181
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(80K)
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TBA's structure and focus confuse investors pp13 - 14
Joseph Alper
doi:10.1038/5182
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(76K)
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Fallout from the merger that might be pp15 - 16
John Hodgson
doi:10.1038/5183
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(83K)
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Should platform companies move toward products? pp16 - 17
Mark Ratner
doi:10.1038/5184
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(85K)
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Billion-dollar market blossoms as botanicals take root pp17 - 18
Vicki Glaser
doi:10.1038/5186
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(80K)
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The state of grace p18
Barbara Nasto
doi:10.1038/5187
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(69K)
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| Research News and Views |
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Infection, inflammation, and cancer p19
Richard Darveau
doi:10.1038/5188
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(81K)
See also: Research Article by Low et al. |
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Hope for the post-antibiotic era? p20
Randall T. Irvin
& Daisy L. Bautista
doi:10.1038/5189
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(127K)
See also: Research Article by Kelly et al. |
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Longer is better—random elongation mutagenesis p21
Robert K. Scopes
doi:10.1038/5190
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(76K)
See also: Research Article by Matsuura et al. |
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Tuning up crop photosynthesis pp22 - 23
Gerry Edwards
doi:10.1038/5192
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(265K)
See also: Research Article by Ku et al. |
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In search of the tabula rasa of human cells pp23 - 24
Janet Rossant
& Andras Nagy
doi:10.1038/5194
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(252K)
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Transgene vectors go retro pp25 - 26
Kevin Wells, Karen Moore
& Robert Wall
doi:10.1038/5196
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(113K)
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| Feature | Top |
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Making forest biotechnology a commercial reality pp27 - 30
Clare Robinson
doi:10.1038/5199
Abstract | Full text | PDF
(83K)
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| Research Review | Top |
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Strategies for bioengineering the development and metabolism of glandular
tissues in plants pp31 - 36
David McCaskill
& Rodney Croteau
doi:10.1038/5202
Abstract | Full text | PDF
(136K)
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| Research Articles | Top |
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Lipid A mutant Salmonella with suppressed virulence and TNF
induction retain tumor-targeting in vivo pp37 - 41
K. Brooks Low, Martina Ittensohn, Trung Le, James Platt, Stefano Sodi, Max Amoss, Olivia Ash, Ellen Carmichael, Ashok Chakraborty, Jessica Fischer, Stanley L. Lin, Xiang Luo, Samuel I. Miller, Li-mou Zheng, Ivan King, John M. Pawelek
& David Bermudes*
doi:10.1038/5205
Abstract | Full text | PDF
(175K)
See also: Analysis by Darveau |
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A synthetic peptide adhesion epitope as a novel antimicrobial agent pp42 - 47
Charles G. Kelly, Justine S. Younson, Ban Y. Hikmat, Stephen M. Todryk, Michael Czisch, Parvez I. Haris, Ian R. Flindall, Craig Newby, Anthony I. Mallet, Julian K-C. Ma
& Thomas Lehner
doi:10.1038/5213
Abstract | Full text | PDF
(157K)
See also: Analysis by Irvin & Bautista |
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Cellular penetration and antisense activity by a phenoxazine-substituted
heptanucleotide pp48 - 52
W. Michael Flanagan, Richard W. Wagner, Deborah Grant, Kuei-Ying Lin
& Mark D. Matteucci
doi:10.1038/5220
Abstract | Full text | PDF
(200K)
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High-throughput quantitative histological analysis of Alzheimer's disease
pathology using a confocal digital microscanner pp53 - 57
David K. Hanzel, John Q. Trojanowski, Richard F. Johnston
& Jeanne F. Loring
doi:10.1038/5225
Abstract | Full text | PDF
(285K)
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Evolutionary molecular engineering by random elongation mutagenesis pp58 - 61
Tomoaki Matsuura, Kouji Miyai, Savitr Trakulnaleamsai, Tetsuya Yomo, Yasufumi Shima, Shigeji Miki, Keizo Yamamoto
& Itaru Urabe
doi:10.1038/5232
Abstract | Full text | PDF
(113K)
See also: Analysis by Scopes |
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In vitro selection of an allosteric ribozyme that transduces analytes
to amplicons pp62 - 66
Michael P. Robertson
& Andrew Ellington
doi:10.1038/5236
Abstract | Full text | PDF
(507K)
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Engineering a regulatable enzyme for homogeneous immunoassays pp67 - 72
Daniel Legendre, Patrice Soumillion
& Jacques Fastrez
doi:10.1038/5243
Abstract | Full text | PDF
(545K)
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Enzyme modification by polymers with solublities that change in response
to photoirradiation in organic media pp73 - 75
Yoshihiro Ito, Norio Sugimura, Oh Hyeong Kwon
& Yukio Imanishi
doi:10.1038/5250
Abstract | Full text | PDF
(91K)
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High-level expression of maize phosphoenolpyruvate carboxylase
in transgenic rice plants pp76 - 80
Maurice S.B. Ku, Sakae Agarie, Mika Nomura, Hiroshi Fukayama, Hiroko Tsuchida, Kazuko Ono, Sakiko Hirose, Seiichi Toki, Mitsue Miyao
& Makoto Matsuoka
doi:10.1038/5256
Abstract | Full text | PDF
(252K)
See also: Analysis by Edwards |
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| Errata |
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Transposition of the Drosophila element mariner into the
chicken germ line p81
doi:10.1038/5262
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(69K)
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| Resources | Top |
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| Patents |
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Biotechnology patent applications in Europe pp83 - 85
Marie Angele de Looze
& Shyama V. Ramani
doi:10.1038/5263
Abstract | Full text | PDF
(71K)
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Recent patent applications in nitric oxide research p86
doi:10.1038/5268
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(41K)
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| In the Laboratory |
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Dynamic allele-specific hybridization pp87 - 88
W. Mathias Howell, Magnus Jobs, Ulf Gyllensten
& Anthony J. Brookes
doi:10.1038/5270
Abstract | Full text | PDF
(89K)
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| Internet |
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Biosafety and regulation p89
Michael Francisco
doi:10.1038/5274
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(225K)
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| Quiz |
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The Nature Biotechnology 1999 New Year quiz p90
John Hodgson, Andrew Marshall
& Emma Dorey
doi:10.1038/5277
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(128K)
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| People |
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People p91
doi:10.1038/5279
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(95K)
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| New Products |
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New products p92
doi:10.1038/5282
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(113K)
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| Industry Trends |
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Cancer multidrug resistance pp94 - 95
Aris Persidis
doi:10.1038/5289
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(68K)
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