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Research Review
Nature Biotechnology  16, 919 - 924 (1998)
doi:10.1038/nbt1098-919

Peptide modulators of protein−protein interactions in intracellular signaling

Miriam C. Souroujon1, 2 & Daria Mochly-Rosen1, *

  1Department of Molecular Pharmacology, Stanford University, School of Medicine, Stanford, CA 94305-5332

  2The Open University of Israel, Tel Aviv 61392, Israel

  *Corresponding author (e-mail: mochly@stanford.edu).

Signal transduction cascades involve multiple enzymes and are orchestrated by selective protein−protein interactions that are essential for the progression of intracellular signaling events. Modulators of these protein−protein interactions have been used to dissect the role of individual components of each signaling cascade. We describe several methods that have been developed for the identification of pep-tides that inhibit the interaction between signaling proteins and hence selectively modulate their functions. Such peptide modulators provide important tools for basic research and have great potential as leads for the development of new classes of therapeutic drugs.

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