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| Opinion |  Top |
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| Editorials |
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Making genomics functional p1
doi:10.1038/nbt0198-1a
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Label this science science-free p1
doi:10.1038/nbt0198-1b
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| Commentary |
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Combinatorial chemistry at the crossroads pp2 - 3
Robert S. Whitehead
doi:10.1038/nbt0198-2
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Microbial natural products: Alive and well in 1998 pp3 - 4
Arnold L. Demain
doi:10.1038/nbt0198-3
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(761K)
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Toward a global filamentous fungus genome sequencing effort p5
Nigel Dunn-Coleman
& Rolf Prade
doi:10.1038/nbt0198-5
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Arrogance on human cloning may pose a threat to biotechnology p6
Russ Hoyle
doi:10.1038/nbt0198-6
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| In Brief | Top |
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| Business and Regulatory News |
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Business & Regulatory News pp7 - 8
doi:10.1038/nbt0198-7
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| Research News |
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Research News p9
doi:10.1038/nbt0198-9
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| This Month in Biotechnology |
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This month in Nature Biotechnology p10
doi:10.1038/nbt0198-10
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(411K)
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| Analysis | Top |
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| Business and Regulatory News |
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US to EU: Please, pass the maize p11
Jeffrey L. Fox
doi:10.1038/nbt0198-11a
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(141K)
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Maize faces new hurdle in EU pp11 - 12
John Hodgson
doi:10.1038/nbt0198-11b
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(328K)
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Either DNA or protein, dummy p12
John Hodgson
doi:10.1038/nbt0198-12a
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(205K)
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Research ministry makes companies a soft option pp12 - 13
Adam Michael
doi:10.1038/nbt0198-12b
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Myriad's lifestyle test targets borderline hypertensives p13
Vicki Glaser
doi:10.1038/nbt0198-13
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Weapons inspections challenge pharma industry p14
Emma Dorey
doi:10.1038/nbt0198-14
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(163K)
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Latent HIV needs second knockout punch p15
Vicki Brower
doi:10.1038/nbt0198-15
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Elanex battles for a piece of the erythropoietin market p16
Ken Chahine
doi:10.1038/nbt0198-16
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Transplant antibodies vie for attention p17
Sylvia Davidson
doi:10.1038/nbt0198-17
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Merger leaves biotechnology partners anxious p18
Debra Robertson
doi:10.1038/nbt0198-18
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(1,035K)
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| Research News |
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Sugaring the pill by design pp19 - 20
Sabine Gaisser
& Peter F. Leadlay
doi:10.1038/nbt0198-19
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Sleeping beauty awakes pp20 - 21
Angela Dawson
& David J. Finnegan
doi:10.1038/nbt0198-20
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(332K)
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Urine as a substitute for milk? pp21 - 22
Harry Meade
& Carol Ziomek
doi:10.1038/nbt0198-21
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(286K)
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A panoramic view of bacterial transcription p23
Jean-Francois Tomb
doi:10.1038/nbt0198-23
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Searching for the ideal partner p24
Fritz Eckstein
doi:10.1038/nbt0198-24
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(156K)
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Getting closer to efficient gene discovery, in silico p25
Lorenzo Segovia
doi:10.1038/nbt0198-25
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| Feature | Top |
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DNA chips: An array of possibilities pp27 - 31
Andrew Marshall
& John Hodgson
doi:10.1038/nbt0198-27
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| Research Reviews | Top |
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DNA variation and the future of human genetics pp33 - 39
Alan J. Schafer
& J. Ross Hawkins
doi:10.1038/nbt0198-33
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(1,267K)
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DNA chips: State-of-the art pp40 - 44
Graham Ramsay
doi:10.1038/nbt0198-40
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(1,565K)
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| Research Articles | Top |
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Bacterial transcript imaging by hybridization of total RNA to oligonucleotide arrays pp45 - 48
Antoine de Saizieu, Ulrich Certa, Janet Warrington, Christopher Gray, Wolfgang Keck
& Jan Mous
doi:10.1038/nbt0198-45
Abstract + references | PDF
(1,241K)
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Multicolor molecular beacons for allele discrimination pp49 - 53
Sanjay Tyagi, Diana P. Bratu
& Fred Russell Kramer
doi:10.1038/nbt0198-49
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(1,544K)
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Accurate sequencing by hybridization for DNA diagnostics and individual genomics pp54 - 58
Snezana Drmanac, David Kita, Ivan Labat, Brian Hauser, Carl Schmidt, John D. Burczak
& Radoje Drmanac
doi:10.1038/nbt0198-54
Abstract + references | PDF
(698K)
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Mapping of RNA accessible sites for antisense experiments with oligonucleotide libraries pp59 - 63
Siew Peng Ho, Yijia Bao, Treena Lesher, Rohit Malhotra, L. Y. Ma, Steve J. Fluharty
& Randall R. Sakai
doi:10.1038/nbt0198-59
Abstract + references | PDF
(1,477K)
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Theoretical design of antisense RNA structures substantially improves annealing kinetics and efficacy in human cells pp64 - 68
Volker Patzel
& Georg Sczakiel
doi:10.1038/nbt0198-64
Abstract + references | PDF
(659K)
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Production of the antitumor drug epirubicin (4'-epidoxorubicin) and its precursor by a genetically engineered strain of Streptomyces peucetius pp69 - 74
Krishnamurthy Madduri, Jonathan Kennedy, Giovanni Rivola, Augusto Inventi-Solari, Silvia Filippini, Giovanna Zanuso, Anna Luisa Colombo, Keith M. Gewain, James L. Occi, Douglas J. MacNeil
& C.Richard Hutchinson
doi:10.1038/nbt0198-69
Abstract + references | PDF
(887K)
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The bladder as a bioreactor: Urothelium production and secretion of growth hormone into urine pp75 - 79
David E. Kerr, Fengxia Liang, Kenneth R. Bondioli, Haiping Zhao, Gert Kreibich, Robert J. Wall
& Tung-Tien Sun
doi:10.1038/nbt0198-75
Abstract + references | PDF
(1,011K)
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DNA vector chemistry: The covalent attachment of signal peptides to plasmid DNA pp80 - 85
Magdolna G. Sebestyén, James J. Ludtke, Michael C. Bassik, Guofeng Zhang, Vladimir Budker, Eugeny A. Lukhtanov, James E. Hagstrom
& Jon A. Wolff
doi:10.1038/nbt0198-80
Abstract + references | PDF
(1,893K)
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| Resources | Top |
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| Patents |
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The written-description requirement in UC v. Lilly pp87 - 88
Howard W. Levine
doi:10.1038/nbt0198-87
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(274K)
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Patent applications in automation and robotics p89
doi:10.1038/nbt0198-89
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(369K)
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| In the Laboratory |
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Methods for extracting and amplifying genomic DNA isolated from frozen serum pp91 - 94
Shannon C. Dixon, József Horti, Yi Guo, Eddie Reed
& William D. Figg
doi:10.1038/nbt0198-91
References | PDF
(1,058K)
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| New Products |
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Separating the microfuges pp96 - 97
Adam Michael
& John Hodgson
doi:10.1038/nbt0198-96
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(445K)
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| WWW Guide |
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Biotechnology education for school-age students p98
Dean Madden
doi:10.1038/nbt0198-98
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(338K)
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| People |
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People p99
doi:10.1038/nbt0198-99
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(459K)
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| Industry Trends |
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Lead validation platforms pp100 - 101
Aris Persidis
doi:10.1038/nbt0198-100
References | PDF
(459K)
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| Quiz |
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The Nature Biotechnology 1998 New Year quiz p102
doi:10.1038/nbt0198-102
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(1,529K)
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