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Biocatalytic plastics as active and stable materials for biotransformations

Nature Biotechnology volume 15, pages 789–793 (1997)Cite this article

Abstract

Enzyme-containing polymeric materials have been developed that have high activity and stability in both aqueous and organic media. These biocatalytic plastics, containing α-chymotrypsin and subtilisin Carlsberg, can contain up to 50% (w/w) total protein in plastic materials such as poly(methyl methacrylate, styrane, vinyl acetate, and ethyl vinyl ether). The activation achieved in organic solvents by incorporating proteases in plastic matrices allows for the efficient synthesis of peptides, and sugar and nucleoside esters. The marriage of enzyme technology with polymer chemistry opens up an array of unique applications for plastic enzymes, including active and stable biocatalysts in paints, coatings, resins, foams, and beads, as well as membranes, fibers, and tubings.

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Authors and Affiliations

  1. Department of Chemical and Biochemical Engineering, and Center for Biocatalysis and Bioprocessing, University of Iowa, Iowa City, IA, 52242

    Ping Wang, Maria V. Sergeeva, Lilian Lim & Jonathan S. Dordick

Authors
  1. Ping Wang
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  2. Maria V. Sergeeva
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  3. Lilian Lim
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  4. Jonathan S. Dordick
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Correspondence to Jonathan S. Dordick.

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Wang, P., Sergeeva, M., Lim, L. et al. Biocatalytic plastics as active and stable materials for biotransformations. Nat Biotechnol 15, 789–793 (1997). https://doi.org/10.1038/nbt0897-789

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