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| Opinion |  Top |
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| Editorials |
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The FDA: A dromedary tale p1
doi:10.1038/nbt0197-1a
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(171K)
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Transgenic bagels and neurotic genes p1
doi:10.1038/nbt0197-1b
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(171K)
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| Commentary |
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Food & Drug Administration: Commissioner Kessler's agbio legancy p2
Russ Hoyle
doi:10.1038/nbt0197-2
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(174K)
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Bioinformatics: What lies beyond bioinformatics? pp3 - 4
Bernhard O. Palsson
doi:10.1038/nbt0197-3
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(348K)
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| In Brief | Top |
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| Business and Regulatory News |
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Business & Regulatory News pp5 - 7
doi:10.1038/nbt0197-5
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| Analysis | Top |
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| Business and Regulatory News |
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Kessler's departure from FDA gets mixed response p9
Jeffrey L. Fox
doi:10.1038/nbt0197-9
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(193K)
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Lawyers, physicians seek genomics rules p10
Vicki Brower
doi:10.1038/nbt0197-10a
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(153K)
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Amgen, Genentech gear up for patent challenge pp10 - 11
James Kling
doi:10.1038/nbt0197-10b
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(297K)
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NIHRAC: Disguised retirement or vigorous future? pp11 - 12
Jeffrey L. Fox
doi:10.1038/nbt0197-11
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(398K)
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Boehringer networks to get ahead in gene therapy pp12 - 13
Emma Johnson
doi:10.1038/nbt0197-12
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(408K)
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Myriad pulls IPO from inhospitable market p14
Vicki Glaser
doi:10.1038/nbt0197-14a
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(158K)
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Experts attempt to redefine principles for treating HIV pp14 - 15
Jeffrey L. Fox
doi:10.1038/nbt0197-14b
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(188K)
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Gene centers sweep prizes in German Bioregio competition p15
Christopher Redhead
doi:10.1038/nbt0197-15
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(262K)
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| Research News |
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Safe gene vectors made simpler p17
Manal A. Morsy
& C. Thomas Caskey
doi:10.1038/nbt0197-17a
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(131K)
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E. coli moves into the plastic age pp17 - 18
Sang Yup Lee
doi:10.1038/nbt0197-17b
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(256K)
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Antitumor immunotoxin secretion by T cells: ABSolutely FABulous? pp18 - 19
David J.P. Fitzgerald
doi:10.1038/nbt0197-18
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(303K)
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Amyloid hypothesis of Alzheimer's rides high—for now pp19 - 20
Robert S. Schehr
doi:10.1038/nbt0197-19
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(295K)
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Energetic pursuit of leptin function pp20 - 21
Jeffrey S. Flier
& Joel K. Elmquist
doi:10.1038/nbt0197-20
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(339K)
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| Feature | Top |
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The empire strikes back pp23 - 26
Vicki Brower
doi:10.1038/nbt0197-23
Abstract | PDF
(1,067K)
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| In Brief | Top |
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Nature Biotechnology Research p27
doi:10.1038/nbt0197-27
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(247K)
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| Research Review | Top |
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Display of heterologous proteins on the surface of microorganisms: From the screening of combinatorial libraries to live recombinant vaccines pp29 - 34
George Georgiou, Christos Stathopoulos, Patrick S. Daugherty, Amiya R. Nayak, Brent L. Iverson
& Roy Curtiss III
doi:10.1038/nbt0197-29
Abstract + references | PDF
(790K)
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| Research Articles | Top |
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Bioactive murine and human interleukin-12 fusion proteins which retain antitumor activity in vivo pp35 - 40
Graham J. Lieschke, Prakash K. Rao, Maurice K. Gately
& Richard C. Mulligan
doi:10.1038/nbt0197-35
Abstract + references | PDF
(817K)
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Isolation of a nuclease-resistant decoy RNA that can protect human acetylcholine receptors from myasthenic antibodies pp41 - 45
Seong-Wook Lee
& Bruce A. Sullenger
doi:10.1038/nbt0197-41
Abstract + references | PDF
(700K)
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A new class of antigen-specific killer cells pp46 - 51
An-Gang Yang
& Si.-Yi Chen
doi:10.1038/nbt0197-46
Abstract + references | PDF
(709K)
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Adenovirus dodecahedron, a new vector for human gene transfer pp52 - 56
Pascal Fender, Rob W.H. Ruigrok, Evelyne Gout, Sebastien Buffet
& Jadwiga Chroboczek
doi:10.1038/nbt0197-52
Abstract + references | PDF
(816K)
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Nerve growth factor somatic mosaicism produced by herpes virus-directed expression of ere recombinase
pp57 - 62
Andrew I. Brooks, Bhaskar Muhkerjee, Nariman Panahian, Deborah Cory-Slechta
& Howard J. Federoff
doi:10.1038/nbt0197-57
Abstract + references | PDF
(1,206K)
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PHA synthase activity controls the
molecular weight and polydispersity
of polyhydroxybutyrate in vivo pp63 - 67
Sang Jun Sim, Kristi D. Snell, Scott A. Hogan, JoAnne Stubbe, Chokyun Rha
& Anthony J. Sinskey
doi:10.1038/nbt0197-63
Abstract + references | PDF
(562K)
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Potent 2'-amino-, and 2'-fluoro-2'-
deoxyribonucleotide RNA inhibitors of keratinocyte growth factor pp68 - 73
Nikos C. Pagratis, Carol Bell, Ying-Fon Chang, Susan Jennings, Tim Fitzwater, Derek Jellinek
& Chinh Dang
doi:10.1038/nbt0197-68
Abstract + references | PDF
(713K)
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Efficient epitope mapping by bacteriophage  surface display pp74 - 78
Ichiro Kuwabara, Hiroko Maruyama, Y. Gi Mikawa, Riaz I. Zuberi, Fu-Tong Liu
& Ichi N. Maruyama
doi:10.1038/nbt0197-74
Abstract + references | PDF
(823K)
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Functional antibody production using cell-free translation: Effects of protein disulfide isomerase and chaperones pp79 - 84
Lyubov A. Ryabova, Dominique Desplancq, Alexander S. Spirin
& Andreas Plückthun
doi:10.1038/nbt0197-79
Abstract + references | PDF
(924K)
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| Resources | Top |
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| Patents |
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Beyond the letter of the law: The US Federal Circuit interprets §271 (g)(1) pp86 - 87
Rocky Tsao
& Elizabeth Anne Hurley
doi:10.1038/nbt0197-86
Abstract + references | PDF
(309K)
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Clinical Trials: Investing in risk management pp88 - 89
Philip W. Fiscus
doi:10.1038/nbt0197-88
Abstract | PDF
(505K)
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| WWW Guide |
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Protein databases on the WWW p90
Richard Peters
& Robert S. Sikorski
doi:10.1038/nbt0197-90
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(250K)
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| People |
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People p92
doi:10.1038/nbt0197-92
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(152K)
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| New Products |
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New Products p94
doi:10.1038/nbt0197-94
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(151K)
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