 |
| Opinion |  Top |
|
 |
|
| Editorials |
|
|
|
FDA drug approvals: No worse is simply not good enough p403
doi:10.1038/nbt0496-403a
PDF
(146K)
|
|
|
|
Xenotransplantation and the "yuk" factor pp403 - 404
doi:10.1038/nbt0496-403b
PDF
(268K)
|
|
|
|
Ex Novartis ad astra p404
doi:10.1038/nbt0496-404
PDF
(141K)
|
|
 |
|
| Correspondence |
|
|
|
Risk assessment made (too) simple? p406
Lars Landbo
& Thomas R. Mikkelsen
doi:10.1038/nbt0496-406a
PDF
(336K)
|
|
|
|
| Commentary |
|
|
|
Parascientific education for PhDs pp406 - 408
Aris Persidis, Wendell E. Dunn III
& Ian C. MacMillan
doi:10.1038/nbt0496-406b
References | PDF
(478K)
|
|
| In Brief | Top |
|
|
|
| Business and Regulatory News |
|
|
|
Business & Regulatory News pp410 - 413
doi:10.1038/nbt0496-410
PDF
(792K)
|
|
|
|
| Research News |
|
|
|
Research News p414
doi:10.1038/nbt0496-414
PDF
(296K)
|
|
| Analysis | Top |
|
|
|
| Business and Regulatory News |
|
|
|
And then there was one: The Basel merger p418
Mike Ward
doi:10.1038/nbt0496-418
PDF
(182K)
|
|
|
|
Drug giants target China's medical molecular biology p419
Sylvia Davidson
doi:10.1038/nbt0496-419a
PDF
(142K)
|
|
|
|
Orphan drugs: European biotechnology waits for EC act pp419 - 420
Sylvia Davidson
doi:10.1038/nbt0496-419b
PDF
(426K)
|
|
|
|
Stents and biology combination for restenosis p422
Vicki Brower
doi:10.1038/nbt0496-422a
PDF
(364K)
|
|
|
|
Early-stage restinosis therapeutics move ahead pp422 - 424
Vicki Brower
doi:10.1038/nbt0496-422b
PDF
(640K)
|
|
|
|
Xenotransplantation: Proceed with caution pp424 - 426
Barbara Nasto
doi:10.1038/nbt0496-424
PDF
(429K)
|
|
|
|
Gene therapy patent challenge: Round one p426
Emma Johnson
doi:10.1038/nbt0496-426
PDF
(159K)
|
|
|
|
Two more HIV protease inhibitors approved p427
Jeffrey L. Fox
doi:10.1038/nbt0496-427
PDF
(202K)
|
|
|
|
Beyond protease inhibitors p428
Jeffrey L. Fox
doi:10.1038/nbt0496-428a
PDF
(155K)
|
|
|
|
Diabetes treatments near and far p428
James Kling
doi:10.1038/nbt0496-428b
PDF
(155K)
|
|
|
|
| Research News |
|
|
|
Turning yeast sequence into protein function p429
Gunnar von Heijne
doi:10.1038/nbt0496-429a
PDF
(120K)
|
|
|
|
In vivo veritas: Live phage display panning pp429 - 431
Anna M. Wu
doi:10.1038/nbt0496-429b
References | PDF
(422K)
|
|
|
|
Visualizing virus fitness gains pp431 - 432
John J. Holland
doi:10.1038/nbt0496-431
References | PDF
(251K)
|
|
|
|
Is random mutation more rational? pp432 - 436
Peter Halling
doi:10.1038/nbt0496-432
References | PDF
(255K)
|
|
|
|
Unexpected pathways to protein stabilization p436
Jonathan King
doi:10.1038/nbt0496-436
References | PDF
(134K)
|
|
|
|
Slow release devices: STD protection at last? pp437 - 438
Robert P. Lanza
& William L. Chick
doi:10.1038/nbt0496-437
References | PDF
(420K)
|
|
|
|
Tissue-specific gene therapy p438
Mima Predich
doi:10.1038/nbt0496-438
PDF
(200K)
|
|
| Features | Top |
|
|
|
Industry and the university pp441 - 442
Edgar Haber
doi:10.1038/nbt0496-441
Abstract + references | PDF
(326K)
|
|
|
|
Genetic engineering to enhance microbial interference and related therapeutic applications pp444 - 447
Henry Chang
doi:10.1038/nbt0496-444
Abstract + references | PDF
(816K)
|
|
| Research Review | Top |
|
|
|
Electrospray ionization and matrix assisted laser desorption/ionization mass spectrometry: Powerful analytical tools in recombinant protein chemistry pp449 - 457
Jens S. Andersen, Birte Svensson
& Peter Roepstorff
doi:10.1038/nbt0496-449
Abstract + references | PDF
(1,219K)
|
|
| Research Articles | Top |
|
|
|
Directed evolution of a para-nitrobenzyl esterase for aqueous-organic solvents pp458 - 467
Jeffrey C. Moore
& Frances H. Arnold
doi:10.1038/nbt0496-458
Abstract + references | PDF
(1,171K)
|
|
|
|
Controlled release of antibodies for long-term topical passive immunoprotection of female mice against genital herpes pp468 - 471
Jill K. Sherwood, Larry Zeitlin, Kevin J. Whaley, Richard A. Cone
& Mark Saltzman
doi:10.1038/nbt0496-468
Abstract + references | PDF
(501K)
|
|
|
|
Synthetic CD4 exocyclic peptides antagonize CD4 holoreceptor binding and T cell activation pp472 - 475
Xin Zhang, Dominique Piatier-Tonneau, Charles Auffray, Ramachandran Murali, Ajit Mahapatra, Fuqing Zhang, Curtis C. Maier, H. Saragovi
& Mark I. Greene
doi:10.1038/nbt0496-472
Abstract + references | PDF
(609K)
|
|
|
|
Effect of disulfide bonds on the structure, function, and stability of the trypsin/tPA inhibitor from Erythrina caffra: Site-directed mutagenesis, expression, and physiochemical characterization pp476 - 480
Karla Lehle, Ulrich Kohnert, Anne Stern, Fritz Popp
& Rainer Jaenicke
doi:10.1038/nbt0496-476
Abstract + references | PDF
(531K)
|
|
|
|
A fusion protein designed for noncovalent immobilization: stability, enzymatic activity, and use in an enzyme reactor pp481 - 484
Günter Stempfer, Bärbel Höll-Neugebauer, Erhard Kopetzki
& Rainer Rudolph
doi:10.1038/nbt0496-481
Abstract + references | PDF
(445K)
|
|
|
|
Radioactive labeling of recombinant antibody fragments by phosphorylation using human casein kinase II and [ -32P]-ATP pp485 - 490
Dario Neri, Heike Petrul, Greg Winter, Yvonne Light, Richard Marais, Keith E. Britton
& Andrew M. Creighton
doi:10.1038/nbt0496-485
Abstract + references | PDF
(800K)
|
|
|
|
Detection of evolving viruses pp491 - 493
Yih Lee
& John Yin
doi:10.1038/nbt0496-491
Abstract + references | PDF
(381K)
|
|
|
|
Transgenic rice plants harboring an introduced potato proteinase inhibitor II gene are insect resistant pp494 - 498
Xiaolan Duan, Xiaogang Li, Qingzhong Xue, Mahmoud Abo-EI-Saad, Deping Xu
& Ray Wu
doi:10.1038/nbt0496-494
Abstract + references | PDF
(703K)
|
|
|
|
Efficient control of gene expression by single step integration of the tetracycline system in transgenic mice pp499 - 503
Nathalie Schultze, Yvonne Burki, Yolande Lang, Ulrich Certa
& Horst Bluethmann
doi:10.1038/nbt0496-499
Abstract + references | PDF
(582K)
|
|
|
|
Affinity—based screening of combinatorial libraries using automated, serial-column chromatography pp504 - 507
David M. Evans, Kevin P. Williams, Brian McGuinness, George Tarr, Fred Regnier, Noubar Afeyan
& Satish Jindal
doi:10.1038/nbt0496-504
Abstract + references | PDF
(409K)
|
|
| Resources | Top |
|
|
|
| Patents and drug development |
|
|
|
Experimental use and the orphan drug act: A biotechnology conundrum pp511 - 512
Paul J. Koivuniemi
doi:10.1038/nbt0496-511
References | PDF
(386K)
|
|
|
|
| In the Laboratory |
|
|
|
High throughput screening on a low budget pp513 - 515
Michelle A. J. Palmer
doi:10.1038/nbt0496-513
Abstract | PDF
(492K)
|
|
|
|
| People |
|
|
|
People p516
doi:10.1038/nbt0496-516
PDF
(146K)
|
|
|
|
| WWW Guide |
|
|
|
Thermocycling on the Web: A user's guide p517
Richard Peters
& Robert Sikorski
doi:10.1038/nbt0496-517
PDF
(241K)
|
|
|
|
| New Products |
|
|
|
New Products p518
doi:10.1038/nbt0496-518
PDF
(193K)
|
|
|
Top |
|
|
