Focus

Nature Biotechnology 15th Anniversary

Focus issue:
March 2011 Volume 29, No 3

Nature Biotechnology is 15! We have brought together a collection of commentaries, features and profiles from thought-leaders in the sector that touch upon the issues that are likely to be important in the coming years.

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Editorial

Nature Biotechnology 15th Anniversary

Realigning interests p171

doi:10.1038/nbt.1829

Fifteen years after Nature Biotechnology was launched, the old paradigms in life science commercialization are no longer tenable. It's time to realign the interests of companies, patients and payors so that innovation is prioritized.

Abstract | Full Text | PDF (134 KB)

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News

Profiles

Nature Biotechnology 15th Anniversary

Gary Pisano p183

doi:10.1038/nbt.1817

The author of the landmark book Science Business: the Promise, the Reality and the Future of Biotech discusses key challenges in life science commercialization.

Abstract | Full Text | PDF (128 KB)

Nature Biotechnology 15th Anniversary

Stelios Papadopoulos p184

doi:10.1038/nbt.1826

A longtime investor, company founder, investment banker and industry observer discusses the factors shaping biotech financing.

Abstract | Full Text | PDF (121 KB)

Nature Biotechnology 15th Anniversary

Paul Keckley p185

doi:10.1038/nbt.1827

The executive director of the Deloitte Center for Healthcare Solutions discusses how the changing policy and reimbursement environment is likely to affect the biotech and pharmaceutical sectors.

Abstract | Full Text | PDF (109 KB)

Nature Biotechnology 15th Anniversary

Merv Turner p186

doi:10.1038/nbt.1811

An industry veteran talks about the challenges facing a world-leading pharmaceutical corporation.

Abstract | Full Text | PDF (113 KB)

Nature Biotechnology 15th Anniversary

Anthony Coyle p187

doi:10.1038/nbt.1821

The man spearheading Pfizer's Centers for Therapeutic Innovation (CTI) initiative outlines how his company hopes to spur academia collaborations.

Abstract | Full Text | PDF (107 KB)

Nature Biotechnology 15th Anniversary

Elias Zerhouni p188

doi:10.1038/nbt.1825

The former National Institutes of Health (NIH) director lays out the numerous challenges facing the translation of academic discoveries.

Abstract | Full Text | PDF (106 KB)

Nature Biotechnology 15th Anniversary

Edison Liu p189

doi:10.1038/nbt.1824

The executive director of the Genome Institute of Singapore surveys the changing global landscape of healthcare provisioning.

Abstract | Full Text | PDF (123 KB)

Nature Biotechnology 15th Anniversary

Greg Winter p190

doi:10.1038/nbt.1815

The inventor of humanized monoclonal antibodies and cofounder of Cambridge Antibody Technology, Greg Winter, muses on the future of antibody therapeutics and UK life science innovation.

Abstract | Full Text | PDF (123 KB)

Nature Biotechnology 15th Anniversary

Lee Hood p191

doi:10.1038/nbt.1809

Lee Hood outlines his vision of personalized medicine for the next 10 years.

Abstract | Full Text | PDF (111 KB)

Nature Biotechnology 15th Anniversary

Robert Weinberg p192

doi:10.1038/nbt.1814

A decade after publishing the seminal “The hallmarks of cancer” paper in Cell with Doug Hanahan, Robert Weinberg reflects on where we stand in the fight against cancer.

Abstract | Full Text | PDF (179 KB)

Nature Biotechnology 15th Anniversary

Arnold Demain p193

doi:10.1038/nbt.1810

A trailblazer in the field of antibiotics reflects on natural product discovery in the genomic age.

Abstract | Full Text | PDF (127 KB)

Nature Biotechnology 15th Anniversary

Irv Weissman p194

doi:10.1038/nbt.1816

An authority on hematopoiesis talks about the difficulties encountered in commercializing stem cell therapies.

Abstract | Full Text | PDF (111 KB)

Nature Biotechnology 15th Anniversary

Barbara Mazur p195

doi:10.1038/nbt.1812

A research leader at a major agrochemical company comments on the application of biotechnologies in commercial crop science.

Abstract | Full Text | PDF (126 KB)

Nature Biotechnology 15th Anniversary

Lee Lynd p196

doi:10.1038/nbt.1813

Reflecting on progress in the bioenergy sector, Lee Lynd considers the prospects of producing liquid biofuels on a scale sufficient to impact energy challenges.

Abstract | Full Text | PDF (124 KB)

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Opinion and Comment

Commentary

Nature Biotechnology 15th Anniversary

Biomedical technology and the clinic of the future p215

doi:10.1038/nbt.1796

Technology pioneers trade views with a clinician and an entrepreneur on the likely impact of large-scale systems technology in healthcare.

Abstract | Full Text | PDF (98 KB)

Nature Biotechnology 15th Anniversary

POINT: Are we prepared for the future doctor visit? pp215 - 218

Stephen H Friend & Trey Ideker

doi:10.1038/nbt.1794

Full Text | PDF (502 KB)

Nature Biotechnology 15th Anniversary

COUNTERPOINT: Do not opine before it's time pp218 - 219

Isaac S Kohane & David M Margulies

doi:10.1038/nbt.1797

Full Text | PDF (134 KB)

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Feature

Nature Biotechnology 15th Anniversary

Five more years of Nature Biotechnology research pp221 - 227

Monya Baker & Laura DeFrancesco

doi:10.1038/nbt.1798

Authors of the past five years' most highly cited research articles discuss their work and new directions in their respective areas.

Abstract | Full Text | PDF (939 KB)

Patents

Nature Biotechnology 15th Anniversary

Unsettled expectations: how recent patent decisions affect biotech pp229 - 230

Brenda M Simon & Christopher T Scott

doi:10.1038/nbt.1795

A look back shows that broad patents are a thing of the past and biotech inventors face heightened requirements for patentability.

Abstract | Full Text | PDF (126 KB)

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Computational Biology

Profile

Nature Biotechnology 15th Anniversary

David Haussler p243

doi:10.1038/nbt.1808

Human genome pioneer David Haussler talks about the evolving role of annotated data repositories.

Abstract | Full Text | PDF (154 KB)

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Research

Perspective

Nature Biotechnology 15th Anniversary

Beyond natural antibodies: the power of in vitro display technologies pp245 - 254

Andrew R M Bradbury, Sachdev Sidhu, Stefan Dübel & John McCafferty

doi:10.1038/nbt.1791

Abstract | Full Text | PDF (1,140 KB)

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