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  • Focus |

    Researchers have generated more than 3.5 terabytes of human microbiome genomic information – more than 1,000 times that generated by the Human Genome Project. This Focus highlights progress in microbiome research and how these data might translate into a better understanding of human diseases and rational design of new therapies.

  • Focus |

    Performance gains and falling costs have fueled diverse applications of high-throughput DNA sequencing. This focus issue of Nature Biotechnology summarizes the current status of these technologies as applied to life sciences and medical research. Produced with support from Ion Torrent - by Life Technologies.

  • Focus |

    The present system for commercializing biomedical research remains woefully inefficient and underpowered. This issue of Nature Biotechnologycollects several articles that describe alternatives to current pathways for clinical translation of academic discovery.

  • Focus |

    Increased understanding of the molecular defects associated with malignancies is opening up new opportunities in diagnosis and therapy. This focus issue of Nature Biotechnology highlights a selection of new technologies that promise to facilitate the development of more effective cancer treatments.

  • Focus |

    Sixteen years after the commercialization of crops produced by traditional transgenic technology, a raft of new approaches are opening new opportunities in plant biotechnology. This focus issue of Nature Biotechnologyhighlights these technologies and their impact on plant breeding and their impact on regulatory oversight.

  • Focus |

    Nature Biotechnology is 15! We have brought together a collection of commentaries, features and profiles from thought-leaders in the sector that touch upon the issues that are likely to be important in the coming years.

  • Collection |

    Transcription activator-like (TAL) effector nucleases have emerged as a powerful tool in genome engineering. Several Nature Biotechnology articles on TAL effector nucleases are brought together in this collection produced with support from Cellectis bioresearch.

  • Focus |

    Recent years have seen an explosive increase in our knowledge of such epigenetic mechanisms as chromatin remodeling and DNA methylation in development and disease. This focus issue discusses the current state of the field and how current insights can be translated into practical applications.

  • Focus |

    Articles from Nature Biotechnology and The Pharmacogenomics Journal that explore best practices for developing and validating predictive models based on data from gene expression and genotyping microarrays. These report the second phase of a collaboration between industry, academic and government researchers as part of the MicroArray Quality Control (MAQC) consortium.

  • Focus |

    The first formal results of the Predictive Testing Safety Consortium, a community-wide effort involving over 190 scientists from industry, non-profit institutions and regulators that set out to qualify nephrotoxicity biomarkers in the preclinical and clinical settings.

  • Focus |

    The latest iteration of genetic engineering offers the prospect of the design and construction of new life forms from biological parts, devices and systems. Although still in its infancy, this focus discusses some of the progress in synthetic biology toward practical applications.

  • Focus |

    A series of articles that focuses on the massively parallel sequencing technology that are making progress in the quest for a $1000 human genome sequence.