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Du et al. describe a bead-based method for high-throughput detection of phosphorylated tyrosine kinases and use it to profile 130 human cancer lines. They show that the tyrosine kinase SRC is frequently activated in glioblastoma cells and that a SRC inhibitor blocks the growth of glioblastoma tumors.
Foust et al. describe a viral vector that crosses the blood-brain barrier, providing a non-invasive method for delivering therapeutic genes to the central nervous system. A single intravascular injection of AAV9 results in widespread transduction of astrocytes in adult mice and of astrocytes and neurons in neonatal mice.
The physical properties that determine the propensity of a protein to form a well-ordered crystal suitable for structure determination are poorly understood. An analysis of large-scale crystallization results generated by a structural genomics consortium highlights the importance of low-entropy surface features capable of mediating protein-protein interactions.
Foudi et al. report a method for monitoring the turnover of hematopoietic stem cells that has several advantages over BrdU labeling. Using drug-inducible expression of a histone 2B–GFP fusion protein, which permits a more sensitive analysis of division history, the authors detect hematopoietic stem cells that cycle at a very slow rate.