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Jeck and Sharpless review recent advances in sequencing, bioinformatics and biochemical analyses that have uncovered numerous circular RNA transcripts in mammalian cells.
Georgiou and colleagues discuss rapidly evolving methods for high-throughput sequencing of the antibody repertoire, and how the resulting data may be applied to answer basic and translational research questions.
Davis and Newell explain how cytometry, and single-cell and sequencing methodologies can be used to characterize human T-cell responses in health and disease.