News & Views in 2015

Cpf1 is one of a growing number of class II CRISPR-Cas effectors that expand both our understanding of bacterial immunity and our genome-editing toolset.

An approach for efficient genome editing in human hematopoietic stem cells could be useful in the treatment of immunological disorders.

Use of sophisticated reductionist and whole-system approaches are providing much-needed technologies to unravel the complex mélange of microbiome functions.

Particles formed by polymeric adjuvants preferentially localize to the lymph node and elicit robust immunity.

Human induced pluripotent stem cells are found to be nearly identical to embryonic stem cells, supporting their suitability for clinical applications.

A well-designed mouse phenotyping study adds to the catalog of mammalian gene function.

Chemical synthesis of specialty and commodity products still reigns supreme but greener, metabolic engineering approaches are gaining ground.

Genome assembly of closely related strains present in very large metagenome data sets is enabled by a de novo pre-assembly algorithm.

T cells are targeted to tumor cells expressing an intracellular antigen using a bispecific antibody.

The EasyPhos pipeline simplifies analysis of phosphorylation-dependent signaling networks at high temporal resolution.

A method to identify interacting regions in a folded RNA is a step toward solving RNA structures from sequencing data.

Applying social network algorithms to mass cytometry data from single cancer cells leads to more accurate predictions of patient outcomes.

Computational modeling of DNA and RNA targets of regulatory proteins is improved by a deep-learning approach.