Browse Articles

  • Letter |

    Primary macrophages engineered to express chimeric antigen receptors have anti-tumor activity in humanized mice.

    • Michael Klichinsky
    • , Marco Ruella
    • , Olga Shestova
    • , Xueqing Maggie Lu
    • , Andrew Best
    • , Martha Zeeman
    • , Maggie Schmierer
    • , Konrad Gabrusiewicz
    • , Nicholas R. Anderson
    • , Nicholas E. Petty
    • , Katherine D. Cummins
    • , Feng Shen
    • , Xinhe Shan
    • , Kimberly Veliz
    • , Kristin Blouch
    • , Yumi Yashiro-Ohtani
    • , Saad S. Kenderian
    • , Miriam Y. Kim
    • , Roddy S. O’Connor
    • , Stephen R. Wallace
    • , Miroslaw S. Kozlowski
    • , Dylan M. Marchione
    • , Maksim Shestov
    • , Benjamin A. Garcia
    • , Carl H. June
    •  & Saar Gill
  • News Feature |

    Companies are doing their best to accelerate experimental drugs and vaccines for COVID-19 through the pipeline. Each faces its own set of challenges, but all agree on the need for a radical rethink of the clinical development process for pandemics.

    • John Hodgson
  • Publisher Correction
    | Open Access

    • Christian Lieven
    • , Moritz E. Beber
    • , Brett G. Olivier
    • , Frank T. Bergmann
    • , Meric Ataman
    • , Parizad Babaei
    • , Jennifer A. Bartell
    • , Lars M. Blank
    • , Siddharth Chauhan
    • , Kevin Correia
    • , Christian Diener
    • , Andreas Dräger
    • , Birgitta E. Ebert
    • , Janaka N. Edirisinghe
    • , José P. Faria
    • , Adam M. Feist
    • , Georgios Fengos
    • , Ronan M. T. Fleming
    • , Beatriz García-Jiménez
    • , Vassily Hatzimanikatis
    • , Wout van Helvoirt
    • , Christopher S. Henry
    • , Henning Hermjakob
    • , Markus J. Herrgård
    • , Ali Kaafarani
    • , Hyun Uk Kim
    • , Zachary King
    • , Steffen Klamt
    • , Edda Klipp
    • , Jasper J. Koehorst
    • , Matthias König
    • , Meiyappan Lakshmanan
    • , Dong-Yup Lee
    • , Sang Yup Lee
    • , Sunjae Lee
    • , Nathan E. Lewis
    • , Filipe Liu
    • , Hongwu Ma
    • , Daniel Machado
    • , Radhakrishnan Mahadevan
    • , Paulo Maia
    • , Adil Mardinoglu
    • , Gregory L. Medlock
    • , Jonathan M. Monk
    • , Jens Nielsen
    • , Lars Keld Nielsen
    • , Juan Nogales
    • , Intawat Nookaew
    • , Bernhard O. Palsson
    • , Jason A. Papin
    • , Kiran R. Patil
    • , Mark Poolman
    • , Nathan D. Price
    • , Osbaldo Resendis-Antonio
    • , Anne Richelle
    • , Isabel Rocha
    • , Benjamín J. Sánchez
    • , Peter J. Schaap
    • , Rahuman S. Malik Sheriff
    • , Saeed Shoaie
    • , Nikolaus Sonnenschein
    • , Bas Teusink
    • , Paulo Vilaça
    • , Jon Olav Vik
    • , Judith A. H. Wodke
    • , Joana C. Xavier
    • , Qianqian Yuan
    • , Maksim Zakhartsev
    •  & Cheng Zhang
  • News Feature |

    Long neglected compared with the gut microbiome, skin microbes are beginning to yield their secrets in health and disease, spurring a new cadre of biotech startups.

    • Charlie Schmidt
  • Brief Communication |

    Prime editors are optimized for use in plants.

    • Qiupeng Lin
    • , Yuan Zong
    • , Chenxiao Xue
    • , Shengxing Wang
    • , Shuai Jin
    • , Zixu Zhu
    • , Yanpeng Wang
    • , Andrew V. Anzalone
    • , Aditya Raguram
    • , Jordan L. Doman
    • , David R. Liu
    •  & Caixia Gao
  • Article |

    A continuously evolved adenine base editor is compatible with various Cas proteins and mediates efficient A•T-to-G•C base conversions at a wide variety of PAM sites.

    • Michelle F. Richter
    • , Kevin T. Zhao
    • , Elliot Eton
    • , Audrone Lapinaite
    • , Gregory A. Newby
    • , Benjamin W. Thuronyi
    • , Christopher Wilson
    • , Luke W. Koblan
    • , Jing Zeng
    • , Daniel E. Bauer
    • , Jennifer A. Doudna
    •  & David R. Liu
  • Article |

    T cell receptors are identified in large-scale screening of T cell repertoires cloned from primary human T cells.

    • Matthew J. Spindler
    • , Ayla L. Nelson
    • , Ellen K. Wagner
    • , Natasha Oppermans
    • , John S. Bridgeman
    • , James M. Heather
    • , Adam S. Adler
    • , Michael A. Asensio
    • , Robert C. Edgar
    • , Yoong Wearn Lim
    • , Everett H. Meyer
    • , Robert E. Hawkins
    • , Mark Cobbold
    •  & David S. Johnson
  • Brief Communication |

    Gene-edited waxy corn lines have higher yields in field trials than hybrids produced by traditional trait introgression.

    • Huirong Gao
    • , Mark J. Gadlage
    • , H. Renee Lafitte
    • , Brian Lenderts
    • , Meizhu Yang
    • , Megan Schroder
    • , Jeffry Farrell
    • , Kay Snopek
    • , Dave Peterson
    • , Lanie Feigenbutz
    • , Spencer Jones
    • , Grace St Clair
    • , Melissa Rahe
    • , Nathalie Sanyour-Doyel
    • , Chenna Peng
    • , Lijuan Wang
    • , Joshua K. Young
    • , Mary Beatty
    • , Brian Dahlke
    • , Jan Hazebroek
    • , Thomas W. Greene
    • , A. Mark Cigan
    • , N. Doane Chilcoat
    •  & R. Bob Meeley
  • Editorial |

    In the post-Brexit era, Britain must rapidly harmonize national and European law, secure unfettered access to global talent and address funding shortfalls to ensure continued leadership in the life sciences.

  • Article |

    PIC-seq characterizes cellular crosstalk by sorting and sequencing physically interacting cells.

    • Amir Giladi
    • , Merav Cohen
    • , Chiara Medaglia
    • , Yael Baran
    • , Baoguo Li
    • , Mor Zada
    • , Pierre Bost
    • , Ronnie Blecher-Gonen
    • , Tomer-Meir Salame
    • , Johannes U. Mayer
    • , Eyal David
    • , Franca Ronchese
    • , Amos Tanay
    •  & Ido Amit
  • Patents |

    Recent patents related to methods of transcranial magnetic and electrostimulation.

  • People |

    Recent moves of note in and around the biotech and pharma industries.

  • Building a Business |

    Some practical advice on how to protect research that you are seeking to commercialize.

    • Sadhana Chitale
    • , Colm Lawler
    •  & Scott Macfarlane
  • Article |

    The protein complexes associated with specific chromatin marks in living cells are identified using engineered binding proteins.

    • Rodrigo Villaseñor
    • , Ramon Pfaendler
    • , Christina Ambrosi
    • , Stefan Butz
    • , Sara Giuliani
    • , Elana Bryan
    • , Thomas W. Sheahan
    • , Annika L. Gable
    • , Nina Schmolka
    • , Massimiliano Manzo
    • , Joël Wirz
    • , Christian Feller
    • , Christian von Mering
    • , Ruedi Aebersold
    • , Philipp Voigt
    •  & Tuncay Baubec
  • Correspondence
    | Open Access

    • Christian Lieven
    • , Moritz E. Beber
    • , Brett G. Olivier
    • , Frank T. Bergmann
    • , Meric Ataman
    • , Parizad Babaei
    • , Jennifer A. Bartell
    • , Lars M. Blank
    • , Siddharth Chauhan
    • , Kevin Correia
    • , Christian Diener
    • , Andreas Dräger
    • , Birgitta E. Ebert
    • , Janaka N. Edirisinghe
    • , José P. Faria
    • , Adam M. Feist
    • , Georgios Fengos
    • , Ronan M. T. Fleming
    • , Beatriz García-Jiménez
    • , Vassily Hatzimanikatis
    • , Wout van Helvoirt
    • , Christopher S. Henry
    • , Henning Hermjakob
    • , Markus J. Herrgård
    • , Ali Kaafarani
    • , Hyun Uk Kim
    • , Zachary King
    • , Steffen Klamt
    • , Edda Klipp
    • , Jasper J. Koehorst
    • , Matthias König
    • , Meiyappan Lakshmanan
    • , Dong-Yup Lee
    • , Sang Yup Lee
    • , Sunjae Lee
    • , Nathan E. Lewis
    • , Filipe Liu
    • , Hongwu Ma
    • , Daniel Machado
    • , Radhakrishnan Mahadevan
    • , Paulo Maia
    • , Adil Mardinoglu
    • , Gregory L. Medlock
    • , Jonathan M. Monk
    • , Jens Nielsen
    • , Lars Keld Nielsen
    • , Juan Nogales
    • , Intawat Nookaew
    • , Bernhard O. Palsson
    • , Jason A. Papin
    • , Kiran R. Patil
    • , Mark Poolman
    • , Nathan D. Price
    • , Osbaldo Resendis-Antonio
    • , Anne Richelle
    • , Isabel Rocha
    • , Benjamín J. Sánchez
    • , Peter J. Schaap
    • , Rahuman S. Malik Sheriff
    • , Saeed Shoaie
    • , Nikolaus Sonnenschein
    • , Bas Teusink
    • , Paulo Vilaça
    • , Jon Olav Vik
    • , Judith A. H. Wodke
    • , Joana C. Xavier
    • , Qianqian Yuan
    • , Maksim Zakhartsev
    •  & Cheng Zhang
  • Letter |

    Pig embryos with a human endothelium are generated through blastocyst complementation using human induced pluripotent stem cells.

    • Satyabrata Das
    • , Naoko Koyano-Nakagawa
    • , Ohad Gafni
    • , Geunho Maeng
    • , Bhairab N. Singh
    • , Tara Rasmussen
    • , Xiaoyan Pan
    • , Kyung-Dal Choi
    • , Daniel Mickelson
    • , Wuming Gong
    • , Pruthvi Pota
    • , Cyprian V. Weaver
    • , Stefan Kren
    • , Jacob H. Hanna
    • , Demetris Yannopoulos
    • , Mary G. Garry
    •  & Daniel J. Garry
  • Article |

    Nematode bacterial symbionts were evolved in vitro to resist insect-sequestered plant toxins to improve the insect-killing efficacy of their nematode host.

    • Ricardo A. R. Machado
    • , Lisa Thönen
    • , Carla C. M. Arce
    • , Vanitha Theepan
    • , Fausto Prada
    • , Daniel Wüthrich
    • , Christelle A. M. Robert
    • , Evangelia Vogiatzaki
    • , Yi-Ming Shi
    • , Olivier P. Schaeren
    • , Matheus Notter
    • , Rémy Bruggmann
    • , Siegfried Hapfelmeier
    • , Helge B. Bode
    •  & Matthias Erb
  • Retraction |

    • Luc Baeyens
    • , Marie Lemper
    • , Gunter Leuckx
    • , Sofie De Groef
    • , Paola Bonfanti
    • , Geert Stangé
    • , Ruth Shemer
    • , Christoffer Nord
    • , David W. Scheel
    • , Fong C. Pan
    • , Ulf Ahlgren
    • , Guoqiang Gu
    • , Doris A. Stoffers
    • , Yuval Dor
    • , Jorge Ferrer
    • , Gerard Gradwohl
    • , Christopher V. E. Wright
    • , Mark Van de Casteele
    • , Michael S. German
    • , Luc Bouwens
    •  & Harry Heimberg
  • News Feature |

    Lymphatics in the central nervous system are attracting both controversy and drug hunters in search of therapeutic targets for a host of diseases.

    • Elie Dolgin
  • News & Views |

    Machine learning provides a functional score for ~120,000 human phosphorylation sites.

    • Giulia Franciosa
    • , Ana Martinez-Val
    •  & Jesper V. Olsen
  • Publisher Correction
    | Open Access

    • Sergei Yakneen
    • , Sebastian M. Waszak
    • , Sergei Yakneen
    • , Brice Aminou
    • , Javier Bartolome
    • , Keith A. Boroevich
    • , Rich Boyce
    • , Angela N. Brooks
    • , Alex Buchanan
    • , Ivo Buchhalter
    • , Adam P. Butler
    • , Niall J. Byrne
    • , Andy Cafferkey
    • , Peter J. Campbell
    • , Zhaohong Chen
    • , Sunghoon Cho
    • , Wan Choi
    • , Peter Clapham
    • , Brandi N. Davis-Dusenbery
    • , Francisco M. De La Vega
    • , Jonas Demeulemeester
    • , Michelle T. Dow
    • , Lewis Jonathan Dursi
    • , Juergen Eils
    • , Roland Eils
    • , Kyle Ellrott
    • , Claudiu Farcas
    • , Francesco Favero
    • , Nodirjon Fayzullaev
    • , Vincent Ferretti
    • , Paul Flicek
    • , Nuno A. Fonseca
    • , Josep Ll. Gelpi
    • , Gad Getz
    • , Bob Gibson
    • , Robert L. Grossman
    • , Olivier Harismendy
    • , Allison P. Heath
    • , Michael C. Heinold
    • , Julian M. Hess
    • , Oliver Hofmann
    • , Jongwhi H. Hong
    • , Thomas J. Hudson
    • , Barbara Hutter
    • , Carolyn M. Hutter
    • , Daniel Hübschmann
    • , Seiya Imoto
    • , Sinisa Ivkovic
    • , Seung-Hyup Jeon
    • , Wei Jiao
    • , Jongsun Jung
    • , Rolf Kabbe
    • , Andre Kahles
    • , Jules N. A. Kerssemakers
    • , Hyung-Lae Kim
    • , Hyunghwan Kim
    • , Jihoon Kim
    • , Youngwook Kim
    • , Kortine Kleinheinz
    • , Michael Koscher
    • , Antonios Koures
    • , Milena Kovacevic
    • , Chris Lawerenz
    • , Ignaty Leshchiner
    • , Jia Liu
    • , Dimitri Livitz
    • , George L. Mihaiescu
    • , Sanja Mijalkovic
    • , Ana Mijalkovic Lazic
    • , Satoru Miyano
    • , Naoki Miyoshi
    • , Hardeep K. Nahal-Bose
    • , Hidewaki Nakagawa
    • , Mia Nastic
    • , Steven J. Newhouse
    • , Jonathan Nicholson
    • , Brian D. O’Connor
    • , David Ocana
    • , Kazuhiro Ohi
    • , Lucila Ohno-Machado
    • , Larsson Omberg
    • , B. F Francis Ouellette
    • , Nagarajan Paramasivam
    • , Marc D. Perry
    • , Todd D. Pihl
    • , Manuel Prinz
    • , Montserrat Puiggròs
    • , Petar Radovic
    • , Keiran M. Raine
    • , Esther Rheinbay
    • , Mara Rosenberg
    • , Romina Royo
    • , Gunnar Rätsch
    • , Gordon Saksena
    • , Matthias Schlesner
    • , Solomon I. Shorser
    • , Charles Short
    • , Heidi J. Sofia
    • , Jonathan Spring
    • , Lincoln D. Stein
    • , Adam J. Struck
    • , Grace Tiao
    • , Nebojsa Tijanic
    • , David Torrents
    • , Peter Van Loo
    • , Miguel Vazquez
    • , David Vicente
    • , Jeremiah A. Wala
    • , Zhining Wang
    • , Sebastian M. Waszak
    • , Joachim Weischenfeldt
    • , Johannes Werner
    • , Ashley Williams
    • , Youngchoon Woo
    • , Adam J. Wright
    • , Qian Xiang
    • , Liming Yang
    • , Denis Yuen
    • , Christina K. Yung
    • , Junjun Zhang
    • , Jan O. Korbel
    • , Michael Gertz
    •  & Jan O. Korbel