Browse Articles

  • Patents |

    Recent patents related to new antimicrobial materials and methods of imparting antimicrobial activity to an article or product.

  • Feature |

    European biotech companies continued to raise unprecedented amounts of capital last year. Can they survive what are likely to be leaner times ahead?

    • Melanie Senior
  • People |

    Recent moves of note in and around the biotech and pharma industries.

  • Analysis |

    A multicenter study compares 13 commonly used single-cell RNA-seq protocols.

    • Elisabetta Mereu
    • , Atefeh Lafzi
    • , Catia Moutinho
    • , Christoph Ziegenhain
    • , Davis J. McCarthy
    • , Adrián Álvarez-Varela
    • , Eduard Batlle
    • , Sagar
    • , Dominic Grün
    • , Julia K. Lau
    • , Stéphane C. Boutet
    • , Chad Sanada
    • , Aik Ooi
    • , Robert C. Jones
    • , Kelly Kaihara
    • , Chris Brampton
    • , Yasha Talaga
    • , Yohei Sasagawa
    • , Kaori Tanaka
    • , Tetsutaro Hayashi
    • , Caroline Braeuning
    • , Cornelius Fischer
    • , Sascha Sauer
    • , Timo Trefzer
    • , Christian Conrad
    • , Xian Adiconis
    • , Lan T. Nguyen
    • , Aviv Regev
    • , Joshua Z. Levin
    • , Swati Parekh
    • , Aleksandar Janjic
    • , Lucas E. Wange
    • , Johannes W. Bagnoli
    • , Wolfgang Enard
    • , Marta Gut
    • , Rickard Sandberg
    • , Itoshi Nikaido
    • , Ivo Gut
    • , Oliver Stegle
    •  & Holger Heyn
  • Analysis |

    Seven methods for single-cell RNA sequencing are benchmarked on cell lines, primary cells and mouse cortex.

    • Jiarui Ding
    • , Xian Adiconis
    • , Sean K. Simmons
    • , Monika S. Kowalczyk
    • , Cynthia C. Hession
    • , Nemanja D. Marjanovic
    • , Travis K. Hughes
    • , Marc H. Wadsworth
    • , Tyler Burks
    • , Lan T. Nguyen
    • , John Y. H. Kwon
    • , Boaz Barak
    • , William Ge
    • , Amanda J. Kedaigle
    • , Shaina Carroll
    • , Shuqiang Li
    • , Nir Hacohen
    • , Orit Rozenblatt-Rosen
    • , Alex K. Shalek
    • , Alexandra-Chloé Villani
    • , Aviv Regev
    •  & Joshua Z. Levin
  • Article |

    Mosquitoes are nearly eradicated in three suburbs of California using accurately sorted sterile male mosquitoes.

    • Jacob E. Crawford
    • , David W. Clarke
    • , Victor Criswell
    • , Mark Desnoyer
    • , Devon Cornel
    • , Brittany Deegan
    • , Kyle Gong
    • , Kaycie C. Hopkins
    • , Paul Howell
    • , Justin S. Hyde
    • , Josh Livni
    • , Charlie Behling
    • , Renzo Benza
    • , Willa Chen
    • , Karen L. Dobson
    • , Craig Eldershaw
    • , Daniel Greeley
    • , Yi Han
    • , Bridgette Hughes
    • , Evdoxia Kakani
    • , Joe Karbowski
    • , Angus Kitchell
    • , Erika Lee
    • , Teresa Lin
    • , Jianyi Liu
    • , Martin Lozano
    • , Warren MacDonald
    • , James W. Mains
    • , Matty Metlitz
    • , Sara N. Mitchell
    • , David Moore
    • , Johanna R. Ohm
    • , Kathleen Parkes
    • , Alexandra Porshnikoff
    • , Chris Robuck
    • , Martin Sheridan
    • , Robert Sobecki
    • , Peter Smith
    • , Jessica Stevenson
    • , Jordan Sullivan
    • , Brian Wasson
    • , Allison M. Weakley
    • , Mark Wilhelm
    • , Joshua Won
    • , Ari Yasunaga
    • , William C. Chan
    • , Jodi Holeman
    • , Nigel Snoad
    • , Linus Upson
    • , Tiantian Zha
    • , Stephen L. Dobson
    • , F. Steven Mulligan
    • , Peter Massaro
    •  & Bradley J. White
  • Editorial |

    In the onslaught of the COVID-19 pandemic, the open sharing of materials, information and data is gaining increasing importance in biotech.

  • Comment |

    The stepwise application of biotechnology will be instrumental to addressing four key challenges of Martian settlement.

    • Shannon N. Nangle
    • , Mikhail Y. Wolfson
    • , Lucas Hartsough
    • , Natalie J. Ma
    • , Christopher E. Mason
    • , Massimo Merighi
    • , Vinitra Nathan
    • , Pamela A. Silver
    • , Mark Simon
    • , Jacob Swett
    • , David B. Thompson
    •  & Marika Ziesack
  • Letter |

    Millions of primary IgG-secreting cells from mouse and human are characterized for activity and antibody sequence at the single-cell level.

    • Annabelle Gérard
    • , Adam Woolfe
    • , Guillaume Mottet
    • , Marcel Reichen
    • , Carlos Castrillon
    • , Vera Menrath
    • , Sami Ellouze
    • , Adeline Poitou
    • , Raphaël Doineau
    • , Luis Briseno-Roa
    • , Pablo Canales-Herrerias
    • , Pascaline Mary
    • , Gregory Rose
    • , Charina Ortega
    • , Matthieu Delincé
    • , Sosthene Essono
    • , Bin Jia
    • , Bruno Iannascoli
    • , Odile Richard-Le Goff
    • , Roshan Kumar
    • , Samantha N. Stewart
    • , Yannick Pousse
    • , Bingqing Shen
    • , Kevin Grosselin
    • , Baptiste Saudemont
    • , Antoine Sautel-Caillé
    • , Alexei Godina
    • , Scott McNamara
    • , Klaus Eyer
    • , Gaël A. Millot
    • , Jean Baudry
    • , Patrick England
    • , Clément Nizak
    • , Allan Jensen
    • , Andrew D. Griffiths
    • , Pierre Bruhns
    •  & Colin Brenan
  • Letter |

    Single-cell CRISPR screens are readily multiplexed and scaled with an improved version of Perturb-seq.

    • Joseph M. Replogle
    • , Thomas M. Norman
    • , Albert Xu
    • , Jeffrey A. Hussmann
    • , Jin Chen
    • , J. Zachery Cogan
    • , Elliott J. Meer
    • , Jessica M. Terry
    • , Daniel P. Riordan
    • , Niranjan Srinivas
    • , Ian T. Fiddes
    • , Joseph G. Arthur
    • , Luigi J. Alvarado
    • , Katherine A. Pfeiffer
    • , Tarjei S. Mikkelsen
    • , Jonathan S. Weissman
    •  & Britt Adamson
  • Letter |

    Primary macrophages engineered to express chimeric antigen receptors have anti-tumor activity in humanized mice.

    • Michael Klichinsky
    • , Marco Ruella
    • , Olga Shestova
    • , Xueqing Maggie Lu
    • , Andrew Best
    • , Martha Zeeman
    • , Maggie Schmierer
    • , Konrad Gabrusiewicz
    • , Nicholas R. Anderson
    • , Nicholas E. Petty
    • , Katherine D. Cummins
    • , Feng Shen
    • , Xinhe Shan
    • , Kimberly Veliz
    • , Kristin Blouch
    • , Yumi Yashiro-Ohtani
    • , Saad S. Kenderian
    • , Miriam Y. Kim
    • , Roddy S. O’Connor
    • , Stephen R. Wallace
    • , Miroslaw S. Kozlowski
    • , Dylan M. Marchione
    • , Maksim Shestov
    • , Benjamin A. Garcia
    • , Carl H. June
    •  & Saar Gill
  • News Feature |

    Companies are doing their best to accelerate experimental drugs and vaccines for COVID-19 through the pipeline. Each faces its own set of challenges, but all agree on the need for a radical rethink of the clinical development process for pandemics.

    • John Hodgson
  • Publisher Correction
    | Open Access

    • Christian Lieven
    • , Moritz E. Beber
    • , Brett G. Olivier
    • , Frank T. Bergmann
    • , Meric Ataman
    • , Parizad Babaei
    • , Jennifer A. Bartell
    • , Lars M. Blank
    • , Siddharth Chauhan
    • , Kevin Correia
    • , Christian Diener
    • , Andreas Dräger
    • , Birgitta E. Ebert
    • , Janaka N. Edirisinghe
    • , José P. Faria
    • , Adam M. Feist
    • , Georgios Fengos
    • , Ronan M. T. Fleming
    • , Beatriz García-Jiménez
    • , Vassily Hatzimanikatis
    • , Wout van Helvoirt
    • , Christopher S. Henry
    • , Henning Hermjakob
    • , Markus J. Herrgård
    • , Ali Kaafarani
    • , Hyun Uk Kim
    • , Zachary King
    • , Steffen Klamt
    • , Edda Klipp
    • , Jasper J. Koehorst
    • , Matthias König
    • , Meiyappan Lakshmanan
    • , Dong-Yup Lee
    • , Sang Yup Lee
    • , Sunjae Lee
    • , Nathan E. Lewis
    • , Filipe Liu
    • , Hongwu Ma
    • , Daniel Machado
    • , Radhakrishnan Mahadevan
    • , Paulo Maia
    • , Adil Mardinoglu
    • , Gregory L. Medlock
    • , Jonathan M. Monk
    • , Jens Nielsen
    • , Lars Keld Nielsen
    • , Juan Nogales
    • , Intawat Nookaew
    • , Bernhard O. Palsson
    • , Jason A. Papin
    • , Kiran R. Patil
    • , Mark Poolman
    • , Nathan D. Price
    • , Osbaldo Resendis-Antonio
    • , Anne Richelle
    • , Isabel Rocha
    • , Benjamín J. Sánchez
    • , Peter J. Schaap
    • , Rahuman S. Malik Sheriff
    • , Saeed Shoaie
    • , Nikolaus Sonnenschein
    • , Bas Teusink
    • , Paulo Vilaça
    • , Jon Olav Vik
    • , Judith A. H. Wodke
    • , Joana C. Xavier
    • , Qianqian Yuan
    • , Maksim Zakhartsev
    •  & Cheng Zhang
  • News Feature |

    Long neglected compared with the gut microbiome, skin microbes are beginning to yield their secrets in health and disease, spurring a new cadre of biotech startups.

    • Charlie Schmidt
  • Brief Communication |

    Prime editors are optimized for use in plants.

    • Qiupeng Lin
    • , Yuan Zong
    • , Chenxiao Xue
    • , Shengxing Wang
    • , Shuai Jin
    • , Zixu Zhu
    • , Yanpeng Wang
    • , Andrew V. Anzalone
    • , Aditya Raguram
    • , Jordan L. Doman
    • , David R. Liu
    •  & Caixia Gao
  • Article |

    A continuously evolved adenine base editor is compatible with various Cas proteins and mediates efficient A•T-to-G•C base conversions at a wide variety of PAM sites.

    • Michelle F. Richter
    • , Kevin T. Zhao
    • , Elliot Eton
    • , Audrone Lapinaite
    • , Gregory A. Newby
    • , Benjamin W. Thuronyi
    • , Christopher Wilson
    • , Luke W. Koblan
    • , Jing Zeng
    • , Daniel E. Bauer
    • , Jennifer A. Doudna
    •  & David R. Liu
  • Article |

    T cell receptors are identified in large-scale screening of T cell repertoires cloned from primary human T cells.

    • Matthew J. Spindler
    • , Ayla L. Nelson
    • , Ellen K. Wagner
    • , Natasha Oppermans
    • , John S. Bridgeman
    • , James M. Heather
    • , Adam S. Adler
    • , Michael A. Asensio
    • , Robert C. Edgar
    • , Yoong Wearn Lim
    • , Everett H. Meyer
    • , Robert E. Hawkins
    • , Mark Cobbold
    •  & David S. Johnson
  • Brief Communication |

    Gene-edited waxy corn lines have higher yields in field trials than hybrids produced by traditional trait introgression.

    • Huirong Gao
    • , Mark J. Gadlage
    • , H. Renee Lafitte
    • , Brian Lenderts
    • , Meizhu Yang
    • , Megan Schroder
    • , Jeffry Farrell
    • , Kay Snopek
    • , Dave Peterson
    • , Lanie Feigenbutz
    • , Spencer Jones
    • , Grace St Clair
    • , Melissa Rahe
    • , Nathalie Sanyour-Doyel
    • , Chenna Peng
    • , Lijuan Wang
    • , Joshua K. Young
    • , Mary Beatty
    • , Brian Dahlke
    • , Jan Hazebroek
    • , Thomas W. Greene
    • , A. Mark Cigan
    • , N. Doane Chilcoat
    •  & R. Bob Meeley
  • Editorial |

    In the post-Brexit era, Britain must rapidly harmonize national and European law, secure unfettered access to global talent and address funding shortfalls to ensure continued leadership in the life sciences.

  • Article |

    PIC-seq characterizes cellular crosstalk by sorting and sequencing physically interacting cells.

    • Amir Giladi
    • , Merav Cohen
    • , Chiara Medaglia
    • , Yael Baran
    • , Baoguo Li
    • , Mor Zada
    • , Pierre Bost
    • , Ronnie Blecher-Gonen
    • , Tomer-Meir Salame
    • , Johannes U. Mayer
    • , Eyal David
    • , Franca Ronchese
    • , Amos Tanay
    •  & Ido Amit
  • Patents |

    Recent patents related to methods of transcranial magnetic and electrostimulation.

  • People |

    Recent moves of note in and around the biotech and pharma industries.

  • Building a Business |

    Some practical advice on how to protect research that you are seeking to commercialize.

    • Sadhana Chitale
    • , Colm Lawler
    •  & Scott Macfarlane