Browse Articles

  • Feature |

    Investment and funding has continued to flow into biotech, unlike most business sectors. But with healthcare and hospital budgets increasingly under pressure, do belt-tightening and consolidation lie ahead? Melanie Senior investigates, with additional reporting by Riku Lähteenmäki.

    • Melanie Senior
  • Review Article |

    As CRISPR therapies move into clinical testing, David Schaffer and colleagues review a raft of different delivery technologies being road tested to address cargo capacity limitations, maximize potency, minimize off-target effects and avoid immunogenicity.

    • Joost van Haasteren
    • , Jie Li
    • , Olivia J. Scheideler
    • , Niren Murthy
    •  & David V. Schaffer
  • Article |

    Microscopy datasets are processed orders-of-magnitude faster with improved algorithms and deep learning.

    • Min Guo
    • , Yue Li
    • , Yijun Su
    • , Talley Lambert
    • , Damian Dalle Nogare
    • , Mark W. Moyle
    • , Leighton H. Duncan
    • , Richard Ikegami
    • , Anthony Santella
    • , Ivan Rey-Suarez
    • , Daniel Green
    • , Anastasia Beiriger
    • , Jiji Chen
    • , Harshad Vishwasrao
    • , Sundar Ganesan
    • , Victoria Prince
    • , Jennifer C. Waters
    • , Christina M. Annunziata
    • , Markus Hafner
    • , William A. Mohler
    • , Ajay B. Chitnis
    • , Arpita Upadhyaya
    • , Ted B. Usdin
    • , Zhirong Bao
    • , Daniel Colón-Ramos
    • , Patrick La Riviere
    • , Huafeng Liu
    • , Yicong Wu
    •  & Hari Shroff
  • Article |

    Transient p53 inhibition and induced cell-cycle progression increase clonal engraftment and homology-directed repair in hematopoietic stem cells.

    • Samuele Ferrari
    • , Aurelien Jacob
    • , Stefano Beretta
    • , Giulia Unali
    • , Luisa Albano
    • , Valentina Vavassori
    • , Davide Cittaro
    • , Dejan Lazarevic
    • , Chiara Brombin
    • , Federica Cugnata
    • , Anna Kajaste-Rudnitski
    • , Ivan Merelli
    • , Pietro Genovese
    •  & Luigi Naldini
  • Editorial |

    A slew of national COVID-19 exposure apps have failed because of poor public engagement and acceptance. Apps from the workplace may offer a partial solution if privacy can be guaranteed.

  • Article |

    Single-cell analysis of COVID-19 patient samples identifies activated immune pathways that correlate with severe disease.

    • Robert Lorenz Chua
    • , Soeren Lukassen
    • , Saskia Trump
    • , Bianca P. Hennig
    • , Daniel Wendisch
    • , Fabian Pott
    • , Olivia Debnath
    • , Loreen Thürmann
    • , Florian Kurth
    • , Maria Theresa Völker
    • , Julia Kazmierski
    • , Bernd Timmermann
    • , Sven Twardziok
    • , Stefan Schneider
    • , Felix Machleidt
    • , Holger Müller-Redetzky
    • , Melanie Maier
    • , Alexander Krannich
    • , Sein Schmidt
    • , Felix Balzer
    • , Johannes Liebig
    • , Jennifer Loske
    • , Norbert Suttorp
    • , Jürgen Eils
    • , Naveed Ishaque
    • , Uwe Gerd Liebert
    • , Christof von Kalle
    • , Andreas Hocke
    • , Martin Witzenrath
    • , Christine Goffinet
    • , Christian Drosten
    • , Sven Laudi
    • , Irina Lehmann
    • , Christian Conrad
    • , Leif-Erik Sander
    •  & Roland Eils
  • News Feature |

    The University of Washington’s Institute for Protein Design has become a hub to galvanize de novo protein engineering, citizen science and much more since its founding in 2012.

    • Caroline Seydel
  • Correspondence |

    • Jim Aitken
    • , Karen Ambrose
    • , Sam Barrell
    • , Rupert Beale
    • , Ganka Bineva-Todd
    • , Dhruva Biswas
    • , Richard Byrne
    • , Simon Caidan
    • , Peter Cherepanov
    • , Laura Churchward
    • , Graham Clark
    • , Margaret Crawford
    • , Laura Cubitt
    • , Vicky Dearing
    • , Christopher Earl
    • , Amelia Edwards
    • , Chris Ekin
    • , Efthymios Fidanis
    • , Alessandra Gaiba
    • , Steve Gamblin
    • , Sonia Gandhi
    • , Jacki Goldman
    • , Robert Goldstone
    • , Paul R. Grant
    • , Maria Greco
    • , Judith Heaney
    • , Steve Hindmarsh
    • , Catherine F. Houlihan
    • , Michael Howell
    • , Michael Hubank
    • , Deborah Hughes
    • , Rachael Instrell
    • , Deborah Jackson
    • , Mariam Jamal-Hanjani
    • , Ming Jiang
    • , Mark Johnson
    • , Leigh Jones
    • , Nnennaya Kanu
    • , George Kassiotis
    • , Stuart Kirk
    • , Svend Kjaer
    • , Andrew Levett
    • , Lisa Levett
    • , Marcel Levi
    • , Wei-Ting Lu
    • , James I. MacRae
    • , John Matthews
    • , Laura E. McCoy
    • , Catherine Moore
    • , David Moore
    • , Eleni Nastouli
    • , Jerome Nicod
    • , Luke Nightingale
    • , Jessica Olsen
    • , Nicola O’Reilly
    • , Amar Pabari
    • , Venizelos Papayannopoulos
    • , Namita Patel
    • , Nigel Peat
    • , Marc Pollitt
    • , Peter Ratcliffe
    • , Caetano Reis e Sousa
    • , Annachiara Rosa
    • , Rachel Rosenthal
    • , Chloe Roustan
    • , Andrew Rowan
    • , Gee Yen Shin
    • , Daniel M. Snell
    • , Ok-Ryul Song
    • , Moira J. Spyer
    • , Amy Strange
    • , Charles Swanton
    • , James M. A. Turner
    • , Melanie Turner
    • , Andreas Wack
    • , Philip A. Walker
    • , Sophia Ward
    • , Wai Keong Wong
    • , Joshua Wright
    •  & Mary Wu
  • Correspondence |

    • Alexandra M. Amen
    • , Kerrie W. Barry
    • , John M. Boyle
    • , Cara E. Brook
    • , Seunga Choo
    • , L. T. Cornmesser
    • , David J. Dilworth
    • , Jennifer A. Doudna
    • , Alexander J. Ehrenberg
    • , Indro Fedrigo
    • , Skyler E. Friedline
    • , Thomas G. W. Graham
    • , Ralph Green
    • , Jennifer R. Hamilton
    • , Ariana Hirsh
    • , Megan L. Hochstrasser
    • , Dirk Hockemeyer
    • , Netravathi Krishnappa
    • , Azra Lari
    • , Hanqin Li
    • , Enrique Lin-Shiao
    • , Tianlin Lu
    • , Elijah F. Lyons
    • , Kevin G. Mark
    • , Lisa Argento Martell
    • , A. Raquel O. Martins
    • , Shana L. McDevitt
    • , Patrick S. Mitchell
    • , Erica A. Moehle
    • , Christine Naca
    • , Divya Nandakumar
    • , Elizabeth O’Brien
    • , Derek J. Pappas
    • , Kathleen Pestal
    • , Diana L. Quach
    • , Benjamin E. Rubin
    • , Rohan Sachdeva
    • , Elizabeth C. Stahl
    • , Abdullah Muhammad Syed
    • , I-Li Tan
    • , Amy L. Tollner
    • , Connor A. Tsuchida
    • , C. Kimberly Tsui
    • , Timothy K. Turkalo
    • , Fyodor D. Urnov
    • , M. Bryan Warf
    • , Oscar N. Whitney
    •  & Lea B. Witkowsky
  • Article |

    Gut microbiome composition is remodeled using small peptides.

    • Poshen B. Chen
    • , Audrey S. Black
    • , Adam L. Sobel
    • , Yannan Zhao
    • , Purba Mukherjee
    • , Bhuvan Molparia
    • , Nina E. Moore
    • , German R. Aleman Muench
    • , Jiejun Wu
    • , Weixuan Chen
    • , Antonio F. M. Pinto
    • , Bruce E. Maryanoff
    • , Alan Saghatelian
    • , Pejman Soroosh
    • , Ali Torkamani
    • , Luke J. Leman
    •  & M. Reza Ghadiri
  • Brief Communication |

    Mass spectral fragmentations of lipids across 117 lipid subclasses are presented in a lipidome atlas.

    • Hiroshi Tsugawa
    • , Kazutaka Ikeda
    • , Mikiko Takahashi
    • , Aya Satoh
    • , Yoshifumi Mori
    • , Haruki Uchino
    • , Nobuyuki Okahashi
    • , Yutaka Yamada
    • , Ipputa Tada
    • , Paolo Bonini
    • , Yasuhiro Higashi
    • , Yozo Okazaki
    • , Zhiwei Zhou
    • , Zheng-Jiang Zhu
    • , Jeremy Koelmel
    • , Tomas Cajka
    • , Oliver Fiehn
    • , Kazuki Saito
    • , Masanori Arita
    •  & Makoto Arita
  • Resource |

    Detection of structural variants in the human genome is facilitated by a benchmark set of large deletions and insertions.

    • Justin M. Zook
    • , Nancy F. Hansen
    • , Nathan D. Olson
    • , Lesley Chapman
    • , James C. Mullikin
    • , Chunlin Xiao
    • , Stephen Sherry
    • , Sergey Koren
    • , Adam M. Phillippy
    • , Paul C. Boutros
    • , Sayed Mohammad E. Sahraeian
    • , Vincent Huang
    • , Alexandre Rouette
    • , Noah Alexander
    • , Christopher E. Mason
    • , Iman Hajirasouliha
    • , Camir Ricketts
    • , Joyce Lee
    • , Rick Tearle
    • , Ian T. Fiddes
    • , Alvaro Martinez Barrio
    • , Jeremiah Wala
    • , Andrew Carroll
    • , Noushin Ghaffari
    • , Oscar L. Rodriguez
    • , Ali Bashir
    • , Shaun Jackman
    • , John J. Farrell
    • , Aaron M. Wenger
    • , Can Alkan
    • , Arda Soylev
    • , Michael C. Schatz
    • , Shilpa Garg
    • , George Church
    • , Tobias Marschall
    • , Ken Chen
    • , Xian Fan
    • , Adam C. English
    • , Jeffrey A. Rosenfeld
    • , Weichen Zhou
    • , Ryan E. Mills
    • , Jay M. Sage
    • , Jennifer R. Davis
    • , Michael D. Kaiser
    • , John S. Oliver
    • , Anthony P. Catalano
    • , Mark J. P. Chaisson
    • , Noah Spies
    • , Fritz J. Sedlazeck
    •  & Marc Salit
  • Article |

    The genome-wide activity of Cas9 is measured in unprecedented detail.

    • Cicera R. Lazzarotto
    • , Nikolay L. Malinin
    • , Yichao Li
    • , Ruochi Zhang
    • , Yang Yang
    • , GaHyun Lee
    • , Eleanor Cowley
    • , Yanghua He
    • , Xin Lan
    • , Kasey Jividen
    • , Varun Katta
    • , Natalia G. Kolmakova
    • , Christopher T. Petersen
    • , Qian Qi
    • , Evgheni Strelcov
    • , Samantha Maragh
    • , Giedre Krenciute
    • , Jian Ma
    • , Yong Cheng
    •  & Shengdar Q. Tsai
  • Patents |

    Recent patents related to vaccines and methods of treatment of coronaviruses.

  • Career Feature |

    Though academic institutions have contributed enormously to the remarkable growth in the healthcare industry, a key limiting resource for this continued growth is the creation of career opportunities for doctoral graduates.

    • Sinje Gehr
    • , Craig C. Garner
    •  & Karin N. Kleinhans
  • People |

    Recent moves of note in and around the biotech and pharma industries.

  • Author Correction |

    • Tatiana Mitiouchkina
    • , Alexander S. Mishin
    • , Louisa Gonzalez Somermeyer
    • , Nadezhda M. Markina
    • , Tatiana V. Chepurnyh
    • , Elena B. Guglya
    • , Tatiana A. Karataeva
    • , Kseniia A. Palkina
    • , Ekaterina S. Shakhova
    • , Liliia I. Fakhranurova
    • , Sofia V. Chekova
    • , Aleksandra S. Tsarkova
    • , Yaroslav V. Golubev
    • , Vadim V. Negrebetsky
    • , Sergey A. Dolgushin
    • , Pavel V. Shalaev
    • , Dmitry Shlykov
    • , Olesya A. Melnik
    • , Victoria O. Shipunova
    • , Sergey M. Deyev
    • , Andrey I. Bubyrev
    • , Alexander S. Pushin
    • , Vladimir V. Choob
    • , Sergey V. Dolgov
    • , Fyodor A. Kondrashov
    • , Ilia V. Yampolsky
    •  & Karen S. Sarkisyan
  • Editorial |

    Insufficient SARS-CoV-2 testing has left many nations flying blind as they reopen their economies. Without adequate testing, new infections could outrun control measures.

  • Brief Communication |

    Base editors that modify both adenosine and cytosine broaden the potential applications of base editing.

    • Rina C. Sakata
    • , Soh Ishiguro
    • , Hideto Mori
    • , Mamoru Tanaka
    • , Kenji Tatsuno
    • , Hiroki Ueda
    • , Shogo Yamamoto
    • , Motoaki Seki
    • , Nanami Masuyama
    • , Keiji Nishida
    • , Hiroshi Nishimasu
    • , Kazuharu Arakawa
    • , Akihiko Kondo
    • , Osamu Nureki
    • , Masaru Tomita
    • , Hiroyuki Aburatani
    •  & Nozomu Yachie
  • Brief Communication |

    Base editors that modify both adenine and cytosine broaden the potential applications of base editing.

    • Xiaohui Zhang
    • , Biyun Zhu
    • , Liang Chen
    • , Ling Xie
    • , Weishi Yu
    • , Ying Wang
    • , Linxi Li
    • , Shuming Yin
    • , Lei Yang
    • , Handan Hu
    • , Honghui Han
    • , Yongmei Li
    • , Liren Wang
    • , Geng Chen
    • , Xueyun Ma
    • , Hongquan Geng
    • , Wanfeng Huang
    • , Xiufeng Pang
    • , Zuozhen Yang
    • , Yuxuan Wu
    • , Stefan Siwko
    • , Ryo Kurita
    • , Yukio Nakamura
    • , Li Yang
    • , Mingyao Liu
    •  & Dali Li
  • Publisher Correction |

    • Joo Guan Yeo
    • , Martin Wasser
    • , Pavanish Kumar
    • , Lu Pan
    • , Su Li Poh
    • , Fauziah Ally
    • , Thaschawee Arkachaisri
    • , Amanda Jin Mei Lim
    • , Jing Yao Leong
    • , Liyun Lai
    • , Kee Thai Yeo
    • , Elene Seck Choon Lee
    • , Camillus Jian Hui Chua
    • , Anis Larbi
    • , Ma Shwe Zin Nyunt
    • , Tze Pin Ng
    • , Sabrina Chiesa
    • , Marco Gattorno
    • , Alberto Martini
    • , Bhairav Suryakant Paleja
    • , Charles-Antoine Dutertre
    • , Jinmiao Chen
    • , Katherine Nay Yaung
    • , Swee Ping Tang
    • , Sue Kheng Ng
    • , Chee Fu Yung
    • , Angela Yun June Tan
    • , Shu Ying Lee
    • , Florent Ginhoux
    •  & Salvatore Albani
  • Article |

    The location of genetic and epigenetic elements in mammalian nuclei is measured by gradual DNA fragmentation.

    • Gabriele Girelli
    • , Joaquin Custodio
    • , Tomasz Kallas
    • , Federico Agostini
    • , Erik Wernersson
    • , Bastiaan Spanjaard
    • , Ana Mota
    • , Solrun Kolbeinsdottir
    • , Eleni Gelali
    • , Nicola Crosetto
    •  & Magda Bienko
  • Author Correction |

    • Annabelle Gérard
    • , Adam Woolfe
    • , Guillaume Mottet
    • , Marcel Reichen
    • , Carlos Castrillon
    • , Vera Menrath
    • , Sami Ellouze
    • , Adeline Poitou
    • , Raphaël Doineau
    • , Luis Briseno-Roa
    • , Pablo Canales-Herrerias
    • , Pascaline Mary
    • , Gregory Rose
    • , Charina Ortega
    • , Matthieu Delincé
    • , Sosthene Essono
    • , Bin Jia
    • , Bruno Iannascoli
    • , Odile Richard-Le Goff
    • , Roshan Kumar
    • , Samantha N. Stewart
    • , Yannick Pousse
    • , Bingqing Shen
    • , Kevin Grosselin
    • , Baptiste Saudemont
    • , Antoine Sautel-Caillé
    • , Alexei Godina
    • , Scott McNamara
    • , Klaus Eyer
    • , Gaël A. Millot
    • , Jean Baudry
    • , Patrick England
    • , Clément Nizak
    • , Allan Jensen
    • , Andrew D. Griffiths
    • , Pierre Bruhns
    •  & Colin Brenan
  • News Feature |

    Capturing the value back from plastic waste has been the holy grail of recyclers. Biotechnology is taking us closer to a solution.

    • Laura DeFrancesco