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Humans 2.0

'Humans 2.0' looks at how increasingly powerful genetic technologies are moving us closer to be able to read and manipulate human genomes not only in somatic cells, but also in germ cells and zygotes.

Latest Research

  • Article |

    Efficient Cas9 genome editing in vivo is achieved without viral vectors using chemically modified single-guide RNAs.

    • Hao Yin
    • , Chun-Qing Song
    • , Sneha Suresh
    • , Qiongqiong Wu
    • , Stephen Walsh
    • , Luke Hyunsik Rhym
    • , Esther Mintzer
    • , Mehmet Fatih Bolukbasi
    • , Lihua Julie Zhu
    • , Kevin Kauffman
    • , Haiwei Mou
    • , Alicia Oberholzer
    • , Junmei Ding
    • , Suet-Yan Kwan
    • , Roman L Bogorad
    • , Timofei Zatsepin
    • , Victor Koteliansky
    • , Scot A Wolfe
    • , Wen Xue
    • , Robert Langer
    •  & Daniel G Anderson
  • Perspective |

    Recent developments in bioengineering promise the possibility of new diagnostic and treatment strategies, novel industrial processes, and innovative approaches to thorny problems in fields such as nutrition, agriculture, and biomanufacturing. As modern genetics has matured and developed technologies of increasing power, debates over risk assessments and proper applications of the technology, and over who should have decision-making power over such issues, have become more prominent. Recently, some scientists have advocated that ethicists “step out of the way,” whereas others have called for greater ethical scrutiny, or even for moratoria on some lines of research. As a community, however, we must together determine the proper application of these powerful biological tools. This paper, a consensus statement of a group of interdisciplinary delegates drawn from the top biotech-producing countries of the world, offers a set of ethical principles to contribute to the ethical conversation about human cellular biotechnological research moving forward.

    • Paul Root Wolpe
    • , Karen S Rommelfanger
    •  & the Drafting and Reviewing Delegates of the BEINGS Working Groups

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