Nature Biotechnology - CURRENT ISSUE : July 2009 - Vol 27 No 7
LATEST HIGHLIGHTS
Advance Online Publication
The safety of induced pluripotent stem (iPS) cells seems to depend on how they were generated. Miura et al. examine the effects of the c-Myc transgene, tissue of origin and selection method on the tumor-forming propensity of iPS-cell derivatives.
Current Issue
Safer stem-cell therapies
Commentary by Carpenter et al.Bringing therapies based on pluripotent stem cells from the lab to the clinic will require thorough testing for safety. Carpenter and colleagues discuss the issues that should be addressed to minimize the risks to patients.
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Current Issue
Selective drug combinations
Article by Lehár et al.Although combinations of drugs are often more potent than single agents, they are also believed to induce worse side effects. By screening >94,000 drug pairs in vitro, Lehár et al. show that synergistic combinations tend to be more selective than single drugs and are therefore unlikely to cause synergistic side effects.
Current Issue
Single-molecule transcriptomics
Article by Lipson et al.Lipson et al. profile the yeast transcriptome using single-molecule sequencing. This approach avoids the inherent biases of the digestion, ligation and amplification steps in alternative methods based on microarrays or other sequencing technologies.
Impact Factor
The 2007 impact factor for Nature Biotechnology is 22.8, according to the ISI Journal Citation Reports. This places Nature Biotechnology first among primary research journals in the field of biotechnology.
Special Section
Now that ~1,000 microbial genomes have been sequenced, Kyrpides reflects on the past decade of microbial genomics and proposes solutions to remaining challenges in the field.
