Senior Physical Properties Scientist - GlaxoSmithKline Locations: Harlow - Essex and Stevenage and Ware - Hertfordshire, Southeast England
GlaxoSmithKline (GSK) R&D is currently recruiting a number of bulk properties and solid-state scientists to join the Physical Properties and Developability department, Pharmaceutical Development, UK.
At GSK, one of the world's leading healthcare businesses, we discover, develop and produce products that help people live longer, do more and feel better.
Job Details:
The Physical Properties and Developability department (PP&D) within Pharmaceutical Development is involved with development of new drugs from early Discovery support, through to development of the drug product (tablet, capsule, etc.), continuing on to post-launch support.
In the Discovery support role, the group is responsible for generating physico-chemical data (solubility, solution and solid stability, salt selection) to help with the rational design and selection of the drug molecule and support for in vitro and toxicological safety testing.
The group is also responsible for producing data to understand the physical properties of the drug molecule throughout all stages of development. Properties of the active pharmaceutical ingredient (API) such as particle size; morphology; morphic form; propensity to pick up moisture/solvents; are typically critical in determining the processing and biological properties of the API.
PP&D also provides a number of in silico tools to predict oral drug absorption, in vivo and to help with formulation design.
The ideal candidates for these roles will bring not only a strong scientific academic track record, but also strong project management skills and prior industrial experience in the field of physical properties / solid state characterisation; utilising techniques such as X-ray powder diffraction (XRPD), Thermal Analysis (DSC, TGA), Particle Size / Specific Surface Area Analysis, Moisture / Vapour sorption and Flow Properties Characterisation amongst others.
All applicants need to be aware that these roles are based at our Harlow, Stevenage or Ware UK R&D sites. Travel between these sites will be required; therefore holding a current valid driving licence will be an advantage.
Basic Qualifications: The key responsibilities for this role will include:
Demonstrable scientific ability to relate the fundamental physical properties of drugs and drug products to the performance when used by patients, and during secondary drug product manufacture BSc or equivalent or PhD in Chemical Engineering, Pharmacy, Chemistry or Physics; Materials, Pharmaceutical Formulation, Bio-medical, Engineering Sciences Experience working in a pharmaceutical research and development environment and an understanding of the drug development process Excellent written and verbal communication, interpersonal and problem solving skills, with the confidence to discuss, explain and defend your work with more experienced colleagues, as well as recording and reporting work in formal documents.
Preferred Qualifications: The following would also be advantageous:
Knowledge and experience of the practical application of the physical sciences relating to finely divided powders, drug substance and formulated drug products and an in-depth knowledge of at least one subject area, including: Crystalline solid state; polymorphism; thermal properties; moisture sorption; particle size analysis; surface area; colloidal dispersion and sub-micron particles; bulk powder flow; mechanical compression and fracture and/or pharmaceutical drug product formulation Working knowledge of the other drug development topics The ability to explain how to inter-relate specific products and their importance in drug product development and use by patients The ability to communicate the understanding gained to an interdisciplinary team and lead investigations to clearly establish the importance of the physical properties for each product being developed The ability to develop, validate and implement analytical methods to measure the physical characteristics of the drug and drug product. This requires extensive knowledge and understanding of analytical chemistry, GMP, safety, quality and regulatory systems, which support product development.
More experienced applicants will also require:
Excellent project management skills Ability to prioritise workload and effectively manage resources The ability to influence colleagues and managers.
This role may include supervision of one or more scientists within the PP&D department.
To Apply:
At GSK we provide a supportive working environment, and a range of development challenges and opportunities. We also offer competitive benefits and compensation packages designed to attract and to retain the very best.
For confidential consideration and efficient processing, please apply online at:
Please only apply by clicking on this link or by cutting and pasting it into your web browser
Alternatively, if you reside in the U.K. and are unable to apply electronically, call 44 (0) 208 047 4777. If you reside in the U.S. and are unable to apply electronically, call 1 888 825 5249.
Thank you for taking the time and effort to apply for this role. Please note that we will only contact you again if you are invited to interview All data processed in accordance with the provisions of the Data Protection Act.
For a full listing of current opportunities, please visit our website at http://www.gsk.com GSK is an equal opportunities employer and is proud to promote an open culture, encouraging people to be themselves and giving their ideas a chance to flourish. To enable GSK to meet its commitment as a two ticks employer please let us know if you have a disability.
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Harlow - Essex and Stevenage and Ware - Hertfordshire, United KingdomSenior Physical Properties ScientistTue, 10 Jul 2007 07:09:40 -0400Mon, 08 Oct 2007 00:00:00 -0400http://www.nature.com/naturejobs/science/jobs/14039-Senior-Physical-Properties-Scientist