<?xml version="1.0" encoding="UTF-8"?>
<job>
  <id type="integer">119810</id>
  <reference-id></reference-id>
  <requisition-number></requisition-number>
  <source>Naturejobs.com - Ecommerce</source>
  <company-url>https://careers.buckinstitute.org</company-url>
  <employer-url>https://careers.buckinstitute.org</employer-url>
  <application-email></application-email>
  <application-url>http://careers.buckinstitute.org</application-url>
  <employer-name>Buck Institute for Age Research</employer-name>
  <company-name>Buck Institute for Age Research</company-name>
  <description>
    <![CDATA[POSTDOCTORAL FELLOW – Kapahi Laboratory

http://www.buckinstitute.org/TheScience/KapahiLab/default.asp

POSITION SUMMARY: 
The focus of the Kapahi Laboratory is to identify and characterize the genetic pathways that mediate effects on lifespan and metabolism. This is being achieved by using an interdisciplinary approach combining genetic, biochemical and genomic techniques in invertebrate model systems Caenorhabditis elegans and Drosophila melanogaster and human cells. In particular the lab is following their discovery that the TOR pathway and modulation of mRNA translation modulates lifespan and metabolism. We are currently combining polysomal profiling and microarrays to investigate translationally regulated genes relevant for longevity. The broader significance of this research is to help uncover the role of nutrition in the etiology of age-related human diseases like diabetes, obesity, cancer and neurodegeneration. Candidates with interest and experience with D. melanogaster, C. elegans, disease models, mRNA translational regulation and deep sequencing approaches are encouraged to apply. Additional details regarding this NIH-supported project can be found by email Pkapahi@buckinstitute.org
Receive training in specific area(s) of research with the aim of progressing towards an independent career. The appointment is up to a usual maximum of three to four years, each year contingent upon satisfactory progress, as evaluated by the supervisor/mentor. 
Selected publications

1. Zid BM, Rogers AN, Katewa SD, Vargas MA, Kolipinski MC, Lu TA, Benzer S, Kapahi P. 4E-BP modulates lifespan and mitochondrial translation upon dietary restriction in Drosophila. Cell. 2009 Oct 2;139(1):149-60. 
2. Kaeberlein M, Kapahi P. Aging is RSKy business. Science 2009. 326(5949)55-6
3. Chen, D; Thomas E L; Kapahi P. HIF-1 Modulates Dietary Restriction-mediated Lifespan Extension via IRE-1 in C. elegans. PLOS Genetics; 2009 5(5):e1000486.
4. Pan KZ, Palter JE, Rogers AN, Olsen A, Chen D, Lithgow GJ, Kapahi P. Inhibition of mRNA translation extends lifespan in C. elegans. Aging Cell. 2007. 6: 111–119.
5. Chen D, Pan KZ, Palter JE, Kapahi P. Longevity determined by developmental arrest genes in Caenorhabditis elegans. Aging Cell, 2007, 6: 525-533. 
6. Kapahi P, Zid BM, Harper T, Koslover D, Sapin V, & Benzer S. Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathway. Curr Biol. 2004 14(10):885-90

The Buck Institute is the only independent institute in the U.S. devoted solely to research on aging and age-related diseases such as Alzheimer’s, Parkinson’s, cancer, arthritis, diabetes, and stroke. Our mission is to increase the healthspan, the healthy years of life. Awarded a federal grant to establish interdisciplinary research in a new field called Geroscience, Buck scientists work in a unique, collaborative environment that allows scientists to initiate studies quickly and respond to new opportunities in fields such as stem cell research and regenerative medicine. The Buck has an excellent postdoctoral training program and our scientists represent a variety of complementary fields, including genetics, epigenetics, biochemistry, molecular biology, bioenergetics, age-associated disease; and technological disciplines such as genomics, proteomics, protein interaction networks and bio-informatics.

The Buck Institute, which was designed by world famous architect I.M. Pei, is located in Novato, California, 25 miles north of the Golden Gate Bridge.

TO APPLY: Please go to the Buck Institute careers page at https://careers.buckinstitute.org and apply online. You can also go to www.buckinstitute.org and click onto “Jobs.”

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  </description>
  <location>Novato, CA </location>
  <title>Postdoctoral Fellow - Kapahi Laboratory</title>
  <created-on type="datetime">Fri, 06 Nov 2009 12:54:54 -0500</created-on>
  <expires-on type="datetime">Tue, 05 Jan 2010 00:00:00 -0500</expires-on>
  <url>http://www.nature.com/naturejobs/science/jobs/119810-Postdoctoral-Fellow-Kapahi-Laboratory</url>
  <packages>
  </packages>
</job>
