<?xml version="1.0" encoding="UTF-8"?>
<job>
  <id type="integer">119794</id>
  <reference-id></reference-id>
  <requisition-number>PD-4663</requisition-number>
  <source>Naturejobs.com - Ecommerce</source>
  <company-url>http://www.niehs.nih.gov/</company-url>
  <employer-url>http://www.niehs.nih.gov/</employer-url>
  <application-email>williamsrs@niehs.nih.gov</application-email>
  <application-url>http://www.training.nih.gov/apps/publicForms/postdoctoral/forms/adIndex.aspx?strSearch</application-url>
  <employer-name>National Institutes of Health (NIH)</employer-name>
  <company-name>National Institutes of Health (NIH)</company-name>
  <description>
    <![CDATA[Two postdoctoral positions are available in the Genome Stability Structural Biology group (Williams Laboratory) of the National Institute of Environmental Health Sciences (NIEHS/NIH), Research Triangle Park, North Carolina. Related research projects will investigate structural and functional aspects of DNA repair and maintenance of genome integrity using X-ray crystallography, small angle X-ray scattering (SAXS) and biochemical methods, with collaborative in vivo analysis of targeted systems. 

The Williams group is in the Laboratory (i.e., department) of Structural Biology (LSB) in the Division of Intramural Research, with investigators renowned for their contributions to the area of genome stability, protein-DNA, and protein-RNA structural biology and biochemistry. The exceptional training environment within the LSB is coupled to the strong NIEHS/NIH infrastructure, and offers a highly supportive and interactive scientific environment with many diverse areas of expertise. The group has a fully equipped molecular biology and protein chemistry laboratory and access to superb in house X-ray crystallographic data collection and crystallization robotics equipment. NIEHS is located in an especially attractive part of North Carolina that is central to prominent research institutions, and within driving distance of the beautiful North Carolina coast to the East and the Appalachian mountains to the West. 

Applicants must possess a doctoral level degree. While candidates with less than five years of relevant postdoctoral research experience are eligible, recent graduates are encouraged to apply. Experienced applicants with skills in molecular biology, protein chemistry, and/or backgrounds in protein structure are preferred. Motivated individuals looking to expand their skill set to include crystallographic methods are also encouraged to apply. Starting postdoctoral salary is $46,800, plus medical benefits. 

For additional information please see http://www.niehs.nih.gov/ and http://www.niehs.nih.gov/research/atniehs/labs/lsb/sfr/xray.cfm. 

To apply please visit:
http://www.training.nih.gov/apps/publicForms/postdoctoral/forms/adIndex.aspx?strSearch


Job Number: PD-4663

Or:

Send CV and names of 3 references to: 

R. Scott Williams 
Laboratory of Structural Biology 
NIH/NIEHS, Maildrop F3-03 
111 TW Alexander Dr 
RTP, NC 27709 
williamsrs@niehs.nih.gov 

Relevant publications:
Williams, R.S., Dodson, G.E., Limbo, O., Yamada, Y., Williams, J.S., Guenther, G., Classen, S., Glover, J.N.M., Iwasaki, H., Russell, P., and Tainer, J.A. Nbs1 is an Extended Flexible Arm Binding to Ctp1 and Mre11-Rad50 to Coordinate dsDNA Break Processing. Cell. 139(1): 87-99 (2009)
Williams, R.S., Moncalian, G., Williams, J.S., Yamada, Y, Limbo, O., Shin, D.S., Groocock, L.M., Cahill., D., Hitomi, C., Guenther, G., Moiani, D., Carney, J.P., Russell, P., and Tainer, J.A. Mre11 Dimers Coordinate DNA End Bridging and Nuclease Processing in DNA Double Strand Break Repair. Cell 135 (1): 97-109 (2008)
Williams, R.S., and Tainer, J.A. A Nanomachine for Making Ends Meet: MRN is a Flexing Scaffold for the Repair of DNA Double Strand Breaks. Molecular Cell 19 (6) 724-726 (2005).
Bernstein, N., Williams, R.S., Rakovszky, M., Cui, D., Green, R., Karimi-Busheri, F., Mani, R., Galicia, S., Koch C.A., Cass, C., Durocher, D., Weinfeld, M., and Glover, J.N. The Molecular architecture of the mammalian DNA repair enzyme, polynucleotide kinase. Molecular Cell 17(5): 657-670 (2005)
Glover, J.N.M., Williams, R.S., and Lee, MS. BRCT repeat-phosphoprotein interactions: tangled up in two. Trends in Biochemical Sciences 29(11) 579-585 (2004)
Williams, R.S., Lee, MS., Hau., D.D. and Glover, J.N.M. Structural basis of phospho-peptide recognition by the BRCA1 BRCT domain. Nature Structural and Molecular Biology. 11(6):519-525 (2004)
Williams, R.S., Green, R., and Glover, J.N.M. Crystal structure of the BRCT repeat region from the breast cancer-associated protein BRCA1. Nature Structural Biology 8(10): 838-843 (2001).

The National Institute of Environmental Health Sciences (NIEHS) is located in Research Triangle Park, North Carolina. 

_The NIH is dedicated to building a diverse community in its training and employment programs._]]>
  </description>
  <location>111 TW Alexander Dr.,Research Triangle Park, NC, 27709</location>
  <title>Structural Biology of DNA Repair and Genome Maintenance </title>
  <created-on type="datetime">Fri, 06 Nov 2009 11:44:18 -0500</created-on>
  <expires-on type="datetime">Tue, 05 Jan 2010 00:00:00 -0500</expires-on>
  <url>http://www.nature.com/naturejobs/science/jobs/119794-Structural-Biology-of-DNA-Repair-and-Genome-Maintenance</url>
  <packages>
  </packages>
</job>
