<?xml version="1.0" encoding="UTF-8"?>
<job>
  <id type="integer">118769</id>
  <reference-id></reference-id>
  <requisition-number></requisition-number>
  <source>Naturejobs.com - Ecommerce</source>
  <company-url>http://www.umc.edu/</company-url>
  <employer-url>http://www.umc.edu/</employer-url>
  <application-email>gtzivion@ci.umsmed.edu</application-email>
  <application-url></application-url>
  <employer-name>University of Mississippi Medical Center, Cancer Institute</employer-name>
  <company-name>University of Mississippi Medical Center, Cancer Institute</company-name>
  <description>
    <![CDATA[Two postdoctoral positions are available immediately at Dr Guri Tzivion’s lab at the University of Mississippi Medical Center’s Cancer Institute. Dr. Tzivion’s research group studies regulation of cancer and longevity by intracellular signaling pathways involving the Ras-Raf-MAPK, PI3K-AKT-FOXO and nicotinamide-Sirtuin pathways and the 14-3-3 proteins. The lab recently moved from the Karmanos Cancer Institute, Wayne State University in Detroit to a newly established Cancer Institute at the University of Mississippi Medical Center at Jackson, MS. The lab is equipped with state-of-the-art equipment and employs the latest molecular, biochemical and cell biology technologies as well as transgenic mouse models. The medical center and the institute provide access to numerous top-of the line core facilities. 

Candidates may choose from three major projects:
1.	The role of Raf in carcinogenesis and its regulation by Ras and Growth Factors 
2.	Regulation of intracellular signaling and transformation by 14-3-3 proteins
3.	Role of AKT-FoxO and nicotinamide-Sirtuin pathways in lifespan control and cancer

These projects will employ the latest biochemical and molecular biology techniques mass spectrometry and generation and study of transgenic mice. There are many opportunities for collaborations with other faculty members whose work includes various aspects of growth and stress signaling, apoptosis and tumorigenesis. The institute aims to maintain a highly collaborative and friendly working atmosphere and highly competitive research programs.

Candidates with Ph.D. or in final stages of receiving their Ph.D., and trained in advanced molecular or biochemical techniques will get preference, although highly capable candidates from other disciplines also will be considered. Experience with mice handling or transgenic mice work is also an advantage. Highly competitive salary and health benefits will be provided.

The city of Jackson offers the advantages of a metropolitan city combined with a highly developed suburban area with excellent schools at low living costs. 

Dr. Tzivion received his Ph.D. in immunology from the Hebrew University, Jerusalem, Israel and obtained his post-doctoral training at Joseph Avruch's lab at the Department of Molecular Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA.

Interested candidates should send a cover letter stating their qualifications, experience, research interests and carrier development goals together with an updated C.V. to Dr. Guri Tzivion e-mail: gtzivion@ci.umsmed.edu.

Selected relevant publications: 
1.	Balan V et al. Lifespan extension and neuronal cell protection by Drosophila nicotinamidase. JBC 283, 27810-19, 2008.
2.	Balan V et al. Identification of novel in vivo Raf-1 phosphorylation sites mediating positive feedback Raf-1 regulation by ERK. Mol Biol Cell 17, 1141-53, 2006.
3.	Zhu J et al. Identification of Raf-1 S471 as a novel phosphorylation site critical for Raf-1 and B-Raf kinase activities and for MEK binding. Mol Biol Cell 16, 4733-44, 2005.
4.	Shen YH et al. Significance of 14-3-3 Self-Dimerization for Phosphorylation-Dependent Target Binding. Mol Biol Cell 14, 4721-33, 2003.
5.	Cahill CM et al. PI-3 kinase signaling inhibits DAF-16 DNA binding and function via 14-3-3-dependent and 14-3-3-independent pathways. JBC 276, 13402-10, 2001.
6.	Tzivion G, Luo ZJ and Avruch J. A dimeric 14-3-3 protein is an essential cofactor for Raf kinase activity. Nature 394, 88-92, 1998.
7.	Luo ZJ & Tzivion G et al. Oligomerization activates c-Raf-1 through a Ras-dependent mechanism. Nature 383, 181-185, 1996.]]>
  </description>
  <location>Jackson, MS</location>
  <title>Two Postdoctoral Positions, Tzivion Lab</title>
  <created-on type="datetime">Thu, 29 Oct 2009 12:02:25 -0400</created-on>
  <expires-on type="datetime">Mon, 28 Dec 2009 00:00:00 -0500</expires-on>
  <url>http://www.nature.com/naturejobs/science/jobs/118769-Two-Postdoctoral-Positions-Tzivion-Lab</url>
  <packages>
  </packages>
</job>
