Increasing evidence suggests that reciprocal signaling pathways regulate the development of various T subsets, in particular T helper and T regulatory cells. Consequences of how these regulatory pathways operate can either exacerbate or ameliorate disease and infection; of paramount importance to outcome are intrinsic (gene programs) and extrinsic factors (cytokines) that determine which subset of T cell develops. Discussions will approach these issues from different angles, linking a broad range of experimental approaches and cellular and molecular mechanisms with chronic inflammation and disease.

This is a closed meeting with a non-traditional, highly interactive, discussion-driven format, in which attendees are chosen by invitation or application. The aim is to stimulate conceptual breakthroughs leading to advancement in the fields of chronic inflammation and control of infection mediated by T lymphocytes.