Meeting Program - The Genomics of Common Diseases
The conference will begin on Wednesday, September 23, 2009 with registration at 13.00. The conference will conclude after lunch on Saturday, September 26, 2009.
Meeting Program
| Wednesday, September 23 | ||
|---|---|---|
| Introduction | ||
| 13:00 | Registration - Conference Centre Foyer | |
| 15:00 | Welcome and Introductions | |
|
Where to with GWAS? Chairs: David Altshuler and Peter Donnelly |
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| 15:15 |
Genetics of Type 2 Diabetes David Altshuler Broad Institute of MIT and Harvard, USA |
|
| 15:40 |
Where to with GWAS: from an epidemiologist's perspective Wen Hong Linda Kao Johns Hopkins Bloomberg School of Public Health, USA |
|
| 16:05 |
From GWAS to the hemoglobin switch Stuart Orkin Children's Hospital & Dana Farber Cancer Institute, USA |
|
| 16:30 |
Identification of common polygenic variation from over 135 loci highlights the complex genetic architecture underlying adult height Karol Estrada Erasmus MC, Netherlands |
|
| 16:45 |
Physiological characterization of novel genetic loci implicated in glucose metabolism in humans Erik Ingelsson Karolinska Institutet, Sweden |
|
| 17:00 | Afternoon Tea | |
| 17:30 |
Keynote lecture Chair: David Altshuler Going from susceptibility loci to phenotypes and disease precursors John Todd University of Cambridge, UK |
|
| 18:15 | Drinks reception | |
| 19:30 | Dinner | |
| 21:00 | Close of day | |
| Thursday, September 24 | ||
|---|---|---|
|
Whole genome and targetted resequencing Chairs: Debbie Nickerson and Peter Campbell |
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| 9:00 |
Next-generation Mendelian genetics by exome resequencing Debbie Nickerson University of Washington, USA |
|
| 9:25 |
Targeted enrichment and sequencing of coding exons in cancer Peter Campbell Wellcome Trust Sanger Institute, UK |
|
| 9:50 |
Progress on the 1000 Genomes Project Richard Durbin Wellcome Trust Sanger Institute, UK |
|
| 10:15 |
Loss-of-function mutations in healthy human genomes: implications for clinical genome sequencing Daniel MacArthur Wellcome Trust Sanger Institute, UK |
|
| 10:30 |
High-throughput targeted resequencing of human genomic disease loci using solution sequence capture Rebecca Selzer Roche NimbleGen, Inc. USA |
|
| 10:45 | Morning coffee | |
|
Technologies Chairs: Andre Marziali and Richard Gibbs |
||
| 11:15 |
Electrophoretic nucleic acid concentration with application to sequence enrichment Andre Marziali University of British Columbia, USA |
|
| 11:40 |
Affordable human genome sequencing for large-scale studies of genetic diseases Radoje Drmanac Complete Genomics, Inc. USA |
|
| 12:05 |
Population sequencing of genomic intervals to identify variants underlying complex traits Kelly Frazer University of California San Diego, USA |
|
| 12:30 |
Discovery and analysis of single-nucleotide polymorphisms and short insertion and deletions in low-pass (pilot 1) and deep coverage (pilot 2) whole-genome and hybrid capture (pilot 3) next-generation sequencing in the 1000 genomes project Mark DePristo Broad Institute of MIT and Harvard, USA |
|
| 12:45 |
Single-tube amplification for targeted resequencing of thoUSAnds of target fragments Olle Ericsson Olink Genomics, Sweden |
|
| 13:00 | Lunch | |
|
Cancer genomics Chairs: Lynda Chin and Nazneen Rahman |
||
| 14:00 |
Genome-wide association studies for cancer Gilles Thomas Foundation Jean Dausset, France |
|
| 14:25 |
Lessons from genome-wide association studies of lung cancer Paul Brennan International Agency for Research on Cancer, France |
|
| 14:50 |
Epigenetic predisposition to cancer - lessons from Wilms Nazneen Rahman Institute of Cancer Research, UK |
|
| 15:15 |
Functionalizing the cancer genome Lynda Chin Dana Farber Cancer Institute, USA |
|
| 15:40 | Poster session 1 with afternoon tea | |
| 17:15 |
Keynote lecture Chair: Leena Peltonen Evolution of the cancer genome Michael Stratton Wellcome Trust Sanger Institute, UK |
|
| 18:00 | Drinks reception - Pimms out on the lawn | |
| 19:00 | Conference dinner | |
| 22:00 | Close of day | |
| Friday, September 25 | ||
|---|---|---|
| 7:30 | Breakfast | |
|
Structural variation Chairs: Matthew Hurles and James Lupski |
||
| 9:00 |
Genomic disorders are common diseases: studying copy-number variation (CNV) to understand human development and disease James Lupski Baylor College of Medicine, USA |
|
| 9:25 |
Common copy number variation in the human genome: mechanism, selection and disease Matthew Hurles Wellcome Trust Sanger Institute, UK |
|
| 9:50 |
CNV-targeted genome-wide association study of 16,000 cases of eight common diseases and 3,000 shared controls Chris Holmes University of Oxford, UK |
|
| 10:15 |
Human genome structural variation in common disease Steve McCarroll Broad Institute of MIT and Harvard, UK |
|
| 10:40 |
Structural genomic variation in Asian populations Charles Lee Harvard Medical School, USA |
|
| 11:05 | Morning coffee | |
|
Population and statistical genetics Chairs: Gil McVean and Gonçalo Abecasis |
||
| 11:30 |
"Reverse genomics" approach implies the role of large CNVs in cognitive deficits and Psychiatric disorders in a population cohort Olli Pietiläinen Wellcome Trust Sanger Institute, UK |
|
| 11:45 |
Turnover of primate recombination hotspots is driven by rapid evolution of zinc fingers within a chromatin-modifying gene Gil McVean Oxford University, UK |
|
| 12:10 |
Sequencing 1,000s of Genomes Gonçalo Abecasis University of Michigan,USA |
|
| 12:35 |
Full genome phasing - getting there and going from there Augustine Kong Decode Genetics, Iceland |
|
| 13:00 |
Recent genome selection in humans and malaria parasites Dominic Kwiatkowski Wellcome Trust Sanger Institute, UK |
|
| 13:25 |
Meta-analysis of >100,000 individuals identifies 63 new loci associated with serum lipid concentrations Tanya Teslovich University of Michigan, USA |
|
| 13:40 | Lunch | |
|
Cell and animal models Chairs: Anton Burns and Karen Steel |
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| 14:40 |
New genes involved in deafness from large-scale mouse screens Karen Steel Wellcome Trust Sanger Institute, UK |
|
| 15:05 |
Insertional mutagenesis: a potent oncogenomic tool to unravel the genetics of cancer Anton Berns Netherlands Cancer Institute, Netherlands |
|
| 15:30 |
Genetic architecture of oligogenic disease Nicholas Katsanis Johns Hopkins University School of Medicine, USA |
|
| 15:55 |
Genetic basis of complex traits in mice Jonathan Flint University of Oxford, UK |
|
| 16:20 |
QTL gene identification in rat crescentic glomerulonephritis: implications for human autoimmune disease Jacques Behmoaras Imperial College, London, UK |
|
| 16:35 | Poster session 2 with afternoon tea | |
| 18:00 |
Keynote lecture Chair: Myles Axton Systems genetics of complex traits in Drosophila Trudy MacKay North Carolina State University, USA |
|
| 18:45 | Cheese and wine reception | |
| 19:30 | Dinner | |
| 21:00 | Close of day | |
| Saturday, September 26 | ||
|---|---|---|
| 7:30 | Breakfast | |
|
Translational genetics Chairs: Mary Relling and Tim Aitman |
||
| 9:00 |
Genomic medicine in the UK Tim Aitman UK |
|
| 9:15 |
Pharmacogenomics of childhood acute lymphoblastic leUKemia Mary Relling St Jude Children's Research Hospital, USA |
|
| 9:40 |
Breast cancer genes in clinical practice Diana Eccles University of Southampton, UK |
|
| 10:05 |
Genetic etiology of Inflammatory Bowel Disease - a paradigmatic approach to chronic inflammatory disorders? Stefan Schreiber Christian-Albrechts University, Germany |
|
| 10:30 |
Genetic variants altering individual plasma lipid components and risk for myocardial infarction Sekar Kathiresan Massachusetts General Hospital, USA |
|
| 10:45 |
PNPLA3 variants confer risk of liver but not metabolic disease Elizabeth Speliotes Massachusetts General Hospital, USA |
|
| 11:00 | Morning coffee | |
|
Regulation and epigenetics Chairs: Doug Higgs and Manel Esteller |
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| 11:30 |
Unexpected effects of sequence variation on gene expression Doug Higgs Molecular Haematology Unit, UK |
|
| 11:55 |
Epigenetics in health and disease Manel Esteller Cancer Epigenetics & Biology Programme (PEBC), Spain |
|
| 12:20 |
Links between aging, age-related disease and development Eline Slagboom Leiden University Medicine Centre, Netherlands |
|
| 12:45 |
DNA-methylation; alterations, mechanisms and implications in human disease Tomas Ekstrom Karolinska Institute, Sweeden |
|
| 13:10 |
The FTO obesity and type 2 diabetes susceptibility haplotype is associated with higher levels of DNA methylation Christopher Bell University College London, UK |
|
| 13:25 | Lunch | |
| Close of conference | ||
