Recent studies clearly indicate that epigenetic changes influence immune cell development and function. However, the precise molecular and cellular mechanisms through which chromatin dynamics alter hematopoietic lineage choice, antigen receptor rearrangement and allelic exclusion, and immune responses to pathogens are not yet completely understood.

By bringing together investigators exploring the epigenetic regulation of gene expression and its impact on diverse immunological biological processes, this Emergence & Convergence mini-symposium aims to foster interdisciplinary discussion, and to advance our understanding of the ways in which epigenetic factors exert such broad influence over the immune system.

Attendance for up to 120 delegates is by application only. Successful applicants will be contacted in January and invited to register for the meeting, with instructions for online payment.

Download the conference poster for the meeting.

Epigenetic Dynamics in the Immune System

• Organizers

  • Yves Christen (Fondation IPSEN, France)
  • Laurie Dempsey (Nature Immunology, USA)
  • Arianne Heinrichs (Nature Reviews Molecular Cell Biology, UK)
  • Jacqueline Mervaillie (Fondation IPSEN, France)

• Date

  February 19, 2010

• Venue

  The St. Anthony, San Antonio, TX, USA

Image: Three-dimensional immunofluorescence in situ hybridization revealing localization of Tcrb loci (green), γ-satellite repeats (red) and lamin B1 (blue) in the nucleus of pro-B cells. Staining by Ryan Schlimgen (Duke University, USA) and Karen Reddy (University of Chicago, USA), in the laboratories of Michael Krangel (Duke University, USA) and Harinder Singh (University of Chicago, USA), respectively.

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