Environmental experience can lead to long-lasting changes in the brain and behavior, which may be mediated in part by epigenetic mechanisms, such as histone modification. This one-day meeting will draw on Houston's research community along with leading experts from other universities. Speakers will address the role of epigenetics in memory, drug addiction, maternal care and stress reactivity, the effects of endocrine disruption and human disorders such as Rett and Angelman syndromes.