Multiple sclerosis is an inflammatory autoimmune disease targeting the central nervous system, leading to demyelination and axon degeneration and to severe disability as the disease progresses. Multiple sclerosis presents as a clinically heterogeneous disease, which has been problematic for efforts to develop appropriate animal models. Many environmental and genetic factors have been identified that may initiate disease. Various immune and neural cells have been found to play key roles in disease pathogenesis and progression. This Emergence & Convergence mini-symposium will address open questions in multiple sclerosis research, with the goal of identifying future directions that may lead to therapy.

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