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Volume 425 Issue 6953, 4 September 2003

Editorial

  • The world's leading space agency is suffering not only from managerial dysfunction, but also from a failure to address strategic issues. NASA and its stakeholders need to face up to the challenges ahead.

    Editorial

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News

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News in Brief

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Correction

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News Feature

  • Disease therapies based on a technique for gene silencing called RNA interference are racing towards the clinic. Erika Check investigates molecular medicine's next big thing.

    • Erika Check
    News Feature
  • Were the last dinosaurs wiped out when interplanetary debris hit what is now the coast of Mexico? A drilling project that promised answers has been plagued by squabbles over access to samples. Rex Dalton reports.

    • Rex Dalton
    News Feature
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Correspondence

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Books & Arts

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Concepts

  • Elucidation of all of the mechanisms that regulate developmental potential will allow us to discover the true limits of cell differentiation.

    • Neil D. Theise
    • Ian Wilmut
    Concepts
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News & Views

  • A study of 33 ancient skulls excavated from Mexico invites us to reconsider our view of the ancestry of the early Americans. Unlike most other early American remains, the skulls resemble those from south Asian populations.

    • Tom D. Dillehay
    News & Views
  • A new model could explain why Earth's upper mantle is depleted of many trace elements. At a certain depth, minerals might release water, creating a molten filter that traps trace elements in the mantle beneath.

    • Albrecht W. Hofmann
    News & Views
  • Cells are packed with large molecules. The ramifications of this 'crowding' for a wide range of intracellular processes are only now becoming more generally understood.

    • R. John Ellis
    • Allen P. Minton
    News & Views
  • Entanglement is a quantum phenomenon usually associated with the microscopic world. Now it is clear that its effects are also relevant on macroscopic scales, such as in the magnetic properties of some solids.

    • Vlatko Vedral
    News & Views
  • Mutations in model organisms are grist to the geneticists' mill: they help in assigning function to genes. Chromosome engineering in mice makes it easier to pinpoint the location of randomly induced mutations.

    • Janet Rossant
    News & Views
  • A new reconstruction of temperatures in the Atlantic Ocean during the last ice age, 21,000 years ago, is the latest act in providing climate modellers with details of the past to help predict the future.

    • Alan C. Mix
    News & Views
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Brief Communication

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Hypothesis

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Letter

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Corrigendum

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Erratum

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Corrigendum

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Prospects

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Regions

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