Supplements

Neuropsychiatric disease

Vol. 455, No. 7215 pp 889–923

Neuropsychiatric Disease cover

In this supplement

Neuropsychiatric diseases, such as schizophrenia, depression and autism, are a huge burden on society, impairing the health of those affected, as well as their ability to learn and to work. After half a century of concerted effort, researchers are now making progress towards defining the biological basis of these diseases. Technological advances in the areas of genomics and large-scale studies, as well as the development of new animal models, are improving our understanding of these diseases and are offering the prospect of fundamentally different options for treatment.

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Editorial

Neuropsychiatric disease

I-han Chou & Tanguy Chouard

doi:10.1038/455889a


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Introduction

A glimmer of light for neuropsychiatric disorders

Steven E. Hyman

doi:10.1038/nature07454


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Reviews

The molecular neurobiology of depression

Vaishnav Krishnan & Eric J. Nestler

doi:10.1038/nature07455


Neuroligins and neurexins link synaptic function to cognitive disease

Thomas C. Südhof

doi:10.1038/nature07456


Failure of neuronal homeostasis results in common neuropsychiatric phenotypes

Melissa B. Ramocki & Huda Y. Zoghbi

doi:10.1038/nature07457


Copy-number variations associated with neuropsychiatric conditions

Edwin H. Cook Jr & Stephen W. Scherer

doi:10.1038/nature07458