Supplements

Neurodegeneration

Vol. 443, No. 7113 pp767-803

The prevalence of neurodegenerative disorders such as Alzheimer�s disease and Parkinson�s disease is increasing, but effective treatments are lacking. Researchers have revealed many parallels among this diverse group of disorders, including protein aggregation and mitochondrial dysfunction. It is hoped that greater understanding of these processes and their role in disease will lead to new treatments.

In this supplement

• Editorial
• Reviews

Editorial

Neurodegeneration

Marie-Th�r�se Heemels

doi:10.1038/443767a

Full Text | PDF (132KB)

Reviews

A network dysfunction perspective on neurodegenerative diseases Free access

Jorge J. Palop, Jeannie Chin and Lennart Mucke

doi:10.1038/nature05289

Abstract |Full Text | PDF (468KB)

A century-old debate on protein aggregation and neurodegeneration enters the clinic

Peter T. Lansbury and Hilal A. Lashuel

doi:10.1038/nature05290

Abstract | Full Text | PDF (367KB)

The roles of intracellular protein-degradation pathways in neurodegeneration

David C. Rubinsztein

doi:10.1038/nature05291

Abstract | Full Text | PDF (485KB)

Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases

Michael T. Lin and M. Flint Beal

doi:10.1038/nature05292

Abstract | Full Text | PDF (581KB)

Cell death in the nervous system

Dale E. Bredesen, Rammohan V. Rao and Patrick Mehlen

doi:10.1038/nature05293

Abstract | Full Text | PDF(519KB)

Prions and their partners in crime

Byron Caughey and Gerald S. Baron

doi:10.1038/nature05294

Abstract | Full Text | PDF (3,287KB)