Supplements

Insight: Lab on a chip

Vol. 442, No. 7101 pp367-418

The ability to perform laboratory operations on small scales using miniaturized (lab-on-a-chip) devices has many benefits. Designing and fabricating such systems is extremely challenging, but physicists and engineers are beginning to construct highly integrated and compact labs on chips with exciting functionality as outlined in this Insight. The collection also highlights recent advances in the application of microfluidic-chip-based technologies such as chemical synthesis, the study of complex cellular processes and medical diagnostics.

In this supplement

• Editorial
• Overview
• Reviews

Editorial

Lab on a chip

Rosamund Daw and Joshua Finkelstein

doi:10.1038/442367a

Full Text | PDF (598KB)

Overview

The origins and the future of microfluidics

George M. Whitesides

doi:10.1038/nature05058

Abstract |Full Text | PDF (598KB)

Reviews

Scaling and the design of miniaturized chemical-analysis systems

Dirk Janasek, Joachim Franzke and Andreas Manz

doi:10.1038/nature05059

Abstract | Full Text | PDF (559KB)

Developing optofluidic technology through the fusion of microfluidics and optics

Demetri Psaltis, Stephen R. Quake and Changhuei Yang

doi:10.1038/nature05060

Abstract | Full Text | PDF (859KB)

Future lab-on-a-chip technologies for interrogating individual molecules

Harold Craighead

doi:10.1038/nature05061

Abstract | Full Text | PDF (759KB)

Control and detection of chemical reactions in microfluidic systems

Andrew J. deMello

doi:10.1038/nature05062

Abstract | Full Text | PDF (1179KB)

Cells on chips

Jamil El-Ali, Peter K. Sorger and Klavs F. Jensen

doi:10.1038/nature05063

Abstract | Full Text | PDF (1459KB)

Microfluidic diagnostic technologies for global public health

Paul Yager, Thayne Edwards, Elain Fu, Kristen Helton, Kjell Nelson, Milton R. Tam and Bernhard H. Weigl

doi:10.1038/nature05064

Abstract | Full Text | PDF (636KB)