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Insight: Ion channels

Vol. 440, No. 7083 pp439-489

Ion channels are essential for cellular existence, and mutations and other disruptions have serious, sometimes life-threatening consequences. Until recently, the way these channels operated was something of a mystery. But now high-resolution structural studies are revealing the secrets of these membrane proteins. Although treatments for diseases caused by faulty channels are a long way off, according to this Nature Insight, we are heading in the right direction.

In this supplement

• Editorial
• Reviews

Editorial

Ion channels

Lesley Anson

doi:10.1038/440439a

Full Text | PDF (140KB)

Reviews

From molecule to malady Free access

Frances M. Ashcroft

doi:10.1038/nature04707

Abstract | Full Text | PDF (901KB)

Recent advances in Cys-loop receptor structure and function

Steven M. Sine and Andrew G. Engel

doi:10.1038/nature04708

Abstract | Full Text | PDF (821KB)

Glutamate receptors at atomic resolution

Mark L. Mayer

doi:10.1038/nature04709

Abstract | Full Text | PDF (2077 KB)

hERG potassium channels and cardiac arrhythmia

Michael C. Sanguinetti and Martin Tristani-Firouzi

doi:10.1038/nature04710

Abstract | Full Text | PDF (1584 KB)

KATP channels as molecular sensors of cellular metabolism

Colin G. Nichols

doi:10.1038/nature04711

Abstract | Full Text | PDF (738 KB)

The ABC protein turned chloride channel whose failure causes cystic fibrosis

David C. Gadsby, Paola Vergani and László Csanády

doi:10.1038/nature04712

Abstract | Full Text | PDF (2677 KB)

ClC chloride channels viewed through a transporter lens Free access

Christopher Miller

doi:10.1038/nature04713

Abstract | Full Text | PDF (418 KB)