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Nature Insight: Glycochemistry & Glycobiology

Vol. 446, No. 7139 pp 999-1051

The importance of carbohydrates in biological processes has long been underappreciated. Armed with new tools for synthesizing, modifying and studying oligosaccharides and glycoconjugates, our understanding of these biomolecules is rapidly improving. This knowledge is also yielding promising candidates for carbohydrate-based diagnostics, drugs and vaccines.

In this supplement

• Editorial
• Reviews

Editorial

Glycochemistry & Glycobiology

Joshua Finkelstein

doi:10.1038/446999a

Full Text | PDF (104KB)

Reviews

Chemical glycosylation in the synthesis of glycoconjugate antitumour vaccines

Danica P. Galoni & David Y. Gin

doi:10.1038/nature05813

Abstract | Full Text | PDF (460KB)

Unusual sugar biosynthesis and natural product glycodiversification

Christopher J. Thibodeaux, Charles E. Melan�on & Hung-wen Liu

doi:10.1038/nature05814

Abstract | Full Text | PDF (704KB)

Cycling of O-linked β-N-acetylglucosamine on nucleocytoplasmic proteins

Gerald W. Hart, Michael P. Housley & Chad Slawson

doi:10.1038/nature05815

Abstract | Full Text | PDF (566KB)

Glycan-based interactions involving vertebrate sialic-acid-recognizing proteins

Ajit Varki

doi:10.1038/nature05816

Abstract | Full Text | PDF (781KB)

Heparan sulphate proteoglycans fine-tune mammalian physiology

Joseph R. Bishop, Manuela Schuksz & Jeffrey D. Esko

doi:10.1038/nature05817

Abstract | Full Text | PDF (3,116KB)

Exploiting the defensive sugars of HIV-1 for drug and vaccine design

Christopher N. Scanlan, John Offer, Nicole Zitzmann & Raymond A. Dwek

doi:10.1038/nature05818

Abstract | Full Text | PDF (1,800KB)

Synthesis and medical applications of oligosaccharides

Peter H. Seeberger & Daniel B. Werz

doi:10.1038/nature05819

Abstract | Full Text | PDF (277KB)