Supplements
Cancer Genomics
In this supplement
Cancer is driven by multiple genetic and epigenetic changes. In recent years, advanced high-throughput technologies have allowed researchers to survey large numbers of cancer genomes, providing an overview of the landscape of somatic mutations and copy-number alterations in human cancers. It has emerged that human tumours are more heterogeneous and carry alterations in more genes than previously thought. In addition, large-scale association studies have uncovered variations that determine the genetic susceptibility to various types of cancer. This collection highlights some of the recent studies that are shedding light on the mechanisms by which cancer genes function and are informing therapeutic choices.
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Current Research
EDITORIAL
Insights into the cancer genome
Chris Gunter & Barbara Marte
LETTER
Characterizing the cancer genome in lung adenocarcinoma
Barbara A. Weir et al.
Nature 450, 893–898 (06 December 2007) doi:10.1038/nature06358
Abstract | Full Text | PDF | Supplementary Information
LETTER
LKB1 modulates lung cancer differentiation and metastasis
Hongbin Ji et al.
Nature 448, 807–810 (16 August 2007) doi:10.1038/nature06030
Abstract | Full Text | PDF | Supplementary Information
ARTICLE
Identification of the transforming EML4-ALK fusion gene in non-small-cell lung cancer
Manabu Soda et al.
Nature 448, 561–566 (2 August 2007) doi:10.1038/nature05945
Abstract | Full Text | PDF | Supplementary Information
LETTER
Distinct classes of chromosomal rearrangements create oncogenic ETS gene fusions in prostate cancer
Scott A. Tomlins et al.
Nature 448, 595–599 (2 August 2007) doi:10.1038/nature06024
Abstract | Full Text | PDF | Supplementary Information
ARTICLE
A transforming mutation in the pleckstrin homology domain of AKT1 in cancer
John D. Carpten et al.
Nature 448, 439–444 (26 July 2007) doi:10.1038/nature05933
Abstract | Full Text | PDF | Supplementary Information
ARTICLE
Chromosomally unstable mouse tumours have genomic alterations similar to diverse human cancers
Richard S. Maser et al.
Nature 447, 966–971 (21 July 2007) doi:10.1038/nature05886
Abstract | Full Text | PDF | Supplementary Information
ARTICLE
Genome-wide association study identifies novel breast cancer susceptibility loci
Douglas F. Easton et al.
Nature 447, 1087–1093 (28 June 2007) doi:10.1038/nature05887
Abstract | Full Text | PDF | Supplementary Information
ARTICLE
Genome-wide analysis of genetic alterations in acute lymphoblastic leukaemia
Charles G. Mullighan et al.
Nature 446, 758–764 (12 April 2007) doi:10.1038/nature05690
Abstract | Full Text | PDF | Supplementary Information
LETTER
A recurrent mutation in PALB2 in Finnish cancer families
Hannele Erkko et al.
Nature 446, 316–319 (15 March 2007) doi:10.1038/nature05609
Abstract | Full Text | PDF | Supplementary Information
ARTICLE
Patterns of somatic mutation in human cancer genomes
Christopher Greenman et al.
Nature 446, 153–158 (8 March 2007) doi:10.1038/nature05610
Abstract | Full Text | PDF | Supplementary Information
