Supplements
Cancer
In this supplement
Cancer is driven by multiple genetic and epigenetic changes. This collection highlights recent studies that catalogue these alterations and shed light on the mechanisms by which cancer genes function. These papers feature important advances in the understanding of the complex biological processes underlying tumorigenesis and metastasis, and demonstrate how these insights might translate into clinical applications.
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Editorial
Editorial
Insights into the development of cancer - Free access
Barbara Marte
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Cancer collection
Article
Efficient tumour formation by single human melanoma cells - Free access
Elsa Quintana et al.
Nature 456, 593—598 (4 December 2008) doi:10.1038/nature07567
Abstract | Full Text | PDF | Supplementary Information
Letter
Epigenetic silencing of tumour suppressor gene p15 by its antisense RNA - Free access
Wenqiang Yu et al.
Nature 451, 202—206 (10 January 2008) doi:10.1038/nature06468
Abstract | Full Text | PDF | Supplementary Information
Letter
Metabolomic profiles delineate potential role for sarcosine in prostate cancer progression - Free access
Arun Sreekumar et al.
Nature 457, 910—914 (12 February 2009) doi:10.1038/nature07762
Abstract | Full Text | PDF | Supplementary Information
Letter
Regulation of ERBB2 by oestrogen receptor—PAX2 determines response to tamoxifen - Free access
Antoni Hurtado et al.
Nature 456, 663—666 (4 December 2008) doi:10.1038/nature07483
Abstract | Full Text | PDF | Supplementary Information
Letter
Carcinoma-produced factors activate myeloid cells through TLR2 to stimulate metastasis - Free access
Sunhwa Kim et al.
Nature 457, 102—106 (1 January 2009) doi:10.1038/nature07623
Abstract | Full Text | PDF | Supplementary Information
Article
Comprehensive genomic characterization defines human glioblastoma genes and core pathways - Free access
The Cancer Genome Atlas Research Network
Nature 455, 1061—1068 (23 October 2008) doi:10.1038/nature07385
Abstract | Full Text | PDF | Supplementary Information
Article
DNA sequencing of a cytogenetically normal acute myeloid leukaemia genome - Free access
Timothy J. Ley et al.
Nature 456, 66—72 (6 November 2008) doi:10.1038/nature07485
Abstract | Full Text | PDF | Supplementary Information
Article
Somatic mutations affect key pathways in lung adenocarcinoma - Free access
Li Ding et al.
Nature 455, 1069—1075 (23 October 2008) doi:10.1038/nature07423
Abstract | Full Text | PDF | Supplementary Information
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Other cancer research
News and Views
Fresh target for cancer therapy
Raymond J. Deshaies
Nature 458, 709—710 (9 April 2009) doi:10.1038/458709a
News and Views
When restriction is good
Anne Brunet
Nature 458, 713—714 (9 April 2009) doi:10.1038/458713a
Review
The cancer genome
Michael R. Stratton, Peter J. Campbell & P. Andrew Futreal
Nature 458, 719—724 (9 April 2009) doi:10.1038/nature07943
Article
Tumours with PI3K activation are resistant to dietary restriction
Nada Y. Kalaany & David M. Sabatini
Nature 458, 725—731 (9 April 2009) doi:10.1038/nature07782
Abstract | Full Text | PDF | Supplementary Information
Article
An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer
Teresa A. Soucy et al.
Nature 458, 732—736 (9 April 2009) doi:10.1038/nature07884
Abstract | Full Text | PDF | Supplementary Information
Letter
c-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism
Ping Gao et al.
Nature 458, 762—765 (9 April 2009) doi:10.1038/nature07823
Abstract | Full Text | PDF | Supplementary Information
Letter
Hedgehog signalling is essential for maintenance of cancer stem cells in myeloid leukaemia
Chen Zhao et al.
Nature 458, 776—779 (9 April 2009) doi:10.1038/nature07737
Abstract | Full Text | PDF | Supplementary Information
Letter
Association of reactive oxygen species levels and radioresistance in cancer stem cells
Maximilian Diehn et al.
Nature 458, 780—783 (9 April 2009) doi:10.1038/nature07733
Abstract | Full Text | PDF | Supplementary Information
Letter
Genetic architecture of mouse skin inflammation and tumour susceptibility
David A. Quigley et al.
Nature 458, 505—508 (26 March 2009) doi:10.1038/nature07683
Abstract | Full Text | PDF | Supplementary Information
Letter
Transcriptome sequencing to detect gene fusions in cancer
Christopher A. Maher et al.
Nature 458, 97—101 (5 March 2009) doi:10.1038/nature07638
Abstract | Full Text | PDF | Supplementary Information
Letter
Crypt stem cells as the cells-of-origin of intestinal cancer
Nick Barker et al.
Nature 457, 608—611 (29 January 2009) doi:10.1038/nature07602
Abstract | Full Text | PDF | Supplementary Information
Letter
Prominin 1 marks intestinal stem cells that are susceptible to neoplastic transformation
Liqin Zhu et al.
Nature 457, 603—607 (29 January 2009) doi:10.1038/nature07589
Abstract | Full Text | PDF | Supplementary Information
Letter
Frequent somatic mutations of GNAQ in uveal melanoma and blue naevi
Catherine D. Van Raamsdonk et al.
Nature 457, 599—602 (29 January 2009) doi:10.1038/nature07586
Abstract | Full Text | PDF | Supplementary Information
Letter
Frequent in-frame somatic deletions activate gp130 in inflammatory hepatocellular tumours
Sandra Rebouissou et al.
Nature 457, 200—204 (8 January 2009) doi:10.1038/nature07475
Abstract | Full Text | PDF | Supplementary Information
Article
Cell-cycle restriction limits DNA damage and maintains self-renewal of leukaemia stem cells
Andrea Viale et al.
Nature 457, 51—56 (1 January 2009) doi:10.1038/nature07618
Abstract | Full Text | PDF | Supplementary Information
Letter
Suppression of Myc oncogenic activity by ribosomal protein haploinsufficiency
Maria Barna et al.
Nature 456, 971—975 (18 December 2008) doi:10.1038/nature07449
Abstract | Full Text | PDF | Supplementary Information
Letter
Deletion of vascular endothelial growth factor in myeloid cells accelerates tumorigenesis
Christian Stockmann et al.
Nature 456, 814—818 (11 December 2008) doi:10.1038/nature07445
Abstract | Full Text | PDF | Supplementary Information
Letter
A role for VEGF as a negative regulator of pericyte function and vessel maturation
Joshua I. Greenberg et al.
Nature 456, 809—813 (11 December 2008) doi:10.1038/nature07424
Abstract | Full Text | PDF | Supplementary Information
Article
Glycogen synthase kinase 3 in MLL leukaemia maintenance and targeted therapy
Zhong Wang et al.
Nature 455, 1205—1209 (30 October 2008) doi:10.1038/nature07284
Abstract | Full Text | PDF | Supplementary Information
Letter
p53 and Pten control neural and glioma stem/progenitor cell renewal and differentiation
Hongwu Zheng et al.
Nature 455, 1129—1133 (23 October 2008) doi:10.1038/nature07443
Abstract | Full Text | PDF | Supplementary Information
Letter
Activating mutations in ALK provide a therapeutic target in neuroblastoma
Rani E. George et al.
Nature 455, 975—978 (16 October 2008) doi:10.1038/nature07397
Abstract | Full Text | PDF | Supplementary Information
Letter
Oncogenic mutations of ALK kinase in neuroblastoma
Yuyan Chen et al.
Nature 455, 971—974 (16 October 2008) doi:10.1038/nature07399
Abstract | Full Text | PDF | Supplementary Information
Letter
Somatic and germline activating mutations of the ALK kinase receptor in neuroblastoma
Isabelle Janoueix-Lerosey et al.
Nature 455, 967—970 (16 October 2008) doi:10.1038/nature07398
Abstract | Full Text | PDF | Supplementary Information
Article
Identification of ALK as a major familial neuroblastoma predisposition gene
Yaël P. Mossé et al.
Nature 455, 930—935 (16 October 2008) doi:10.1038/nature07261
Letter
The deubiquitinylation and localization of PTEN are regulated by a HAUSP�PML network
Min Sup Song et al.
Nature 455, 813—817 (9 October 2008) doi:10.1038/nature07290
Abstract | Full Text | PDF | Supplementary Information
Letter
Modelling Myc inhibition as a cancer therapy
Laura Soucek et al.
Nature 455, 679—683 (2 October 2008) doi:10.1038/nature07260
Abstract | Full Text | PDF | Supplementary Information
Letter
E2F1 represses β-catenin transcription and is antagonized by both pRB and CDK8
Erick J. Morris et al.
Nature 455, 552—556 (25 September 2008) doi:10.1038/nature07310
Abstract | Full Text | PDF | Supplementary Information
Letter
CDK8 is a colorectal cancer oncogene that regulates β-catenin activity
Ron Firestein et al.
Nature 455, 547—551 (25 September 2008) doi:10.1038/nature07179
Abstract | Full Text | PDF | Supplementary Information
Letter
A paracrine requirement for hedgehog signalling in cancer
Robert L. Yauch et al.
Nature 455, 406—410 (18 September 2008) doi:10.1038/nature07275
Abstract | Full Text | PDF | Supplementary Information
Letter
Essential roles of PI(3)K�p110β in cell growth, metabolism and tumorigenesis
Shidong Jia et al.
Nature 454, 776—779 (7 August 2008) doi:10.1038/nature07091
Abstract | Full Text | PDF | Supplementary Information
Letter
Blocking VEGFR-3 suppresses angiogenic sprouting and vascular network formation
Tuomas Tammela et al.
Nature 454, 656—660 (31 July 2008) doi:10.1038/nature07083
Abstract | Full Text | PDF | Supplementary Information
Letter
IRF4 addiction in multiple myeloma
Arthur L. Shaffer et al.
Nature 454, 226—231 (10 July 2008) doi:10.1038/nature07064
Abstract | Full Text | PDF | Supplementary Information
Letter
Synergistic response to oncogenic mutations defines gene class critical to cancer phenotype
Helene R. McMurray et al.
Nature 453, 1112—1116 (19 June 2008) doi:10.1038/nature06973
Abstract | Full Text | PDF | Supplementary Information
Article
PML targeting eradicates quiescent leukaemia-initiating cells
Keisuke Ito et al.
Nature 453, 1072—1078 (19 June 2008) doi:10.1038/nature07016
Abstract | Full Text | PDF | Supplementary Information
Letter
Multi-genetic events collaboratively contribute to Pten-null leukaemia stem-cell formation
Wei Guo et al.
Nature 453, 529—533 (22 May 2008) doi:10.1038/nature06933
Abstract | Full Text | PDF | Supplementary Information
Letter
Vascular normalization in Rgs5-deficient tumours promotes immune destruction
Juliana Hamzah et al.
Nature 453, 410—414 (15 May 2008) doi:10.1038/nature06868
Abstract | Full Text | PDF | Supplementary Information
Letter
BCR�ABL1 lymphoblastic leukaemia is characterized by the deletion of Ikaros
Charles G. Mullighan et al.
Nature 453, 110—114 (1 May 2008) doi:10.1038/nature06866
Abstract | Full Text | PDF | Supplementary Information
Letter
Cutaneous cancer stem cell maintenance is dependent on β-catenin signalling
Ilaria Malanchi et al.
Nature 452, 650—653 (3 April 2008) doi:10.1038/nature06835
Abstract | Full Text | PDF | Supplementary Information
Letter
Tumour maintenance is mediated by eNOS
Kian-Huat Lim, Brooke B. Ancrile, David F. Kashatus & Christopher M. Counter
Nature 452, 646—649 (3 April 2008) doi:10.1038/nature06778
Abstract | Full Text | PDF | Supplementary Information
Letter
A variant associated with nicotine dependence, lung cancer and peripheral arterial disease
Thorgeir E. Thorgeirsson et al.
Nature 452, 638—642 (3 April 2008) doi:10.1038/nature06846
Abstract | Full Text | PDF | Supplementary Information
Letter
A susceptibility locus for lung cancer maps to nicotinic acetylcholine receptor subunit genes on 15q25
Rayjean J. Hung et al.
Nature 452, 633—637 (3 April 2008) doi:10.1038/nature06885
Abstract | Full Text | PDF | Supplementary Information
Letter
The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth
Heather R. Christofk et al.
Nature 452, 230—233 (13 March 2008) doi:10.1038/nature06734
Abstract | Full Text | PDF | Supplementary Information
Article
SATB1 reprogrammes gene expression to promote breast tumour growth and metastasis
Hye-Jung Han, Jose Russo, Yoshinori Kohwi & Terumi Kohwi-Shigematsu
Nature 452, 187—193 (13 March 2008) doi:10.1038/nature06781
Abstract | Full Text | PDF | Supplementary Information
Letter
Secondary mutations as a mechanism of cisplatin resistance in BRCA2-mutated cancers
Wataru Sakai et al.
Nature 451, 1116—1120 (28 February 2008) doi:10.1038/nature06633
Abstract | Full Text | PDF | Supplementary Information
Letter
Resistance to therapy caused by intragenic deletion in BRCA2
Stacey L. Edwards et al.
Nature 451, 1111—1115 (28 February 2008) doi:10.1038/nature06548
Abstract | Full Text | PDF | Supplementary Information
Letter
HIF-independent regulation of VEGF and angiogenesis by the transcriptional coactivator PGC-1α
Zoltan Arany et al.
Nature 451, 1008—1012 (21 February 2008) doi:10.1038/nature06613
Abstract | Full Text | PDF | Supplementary Information
Letter
Identification of cells initiating human melanomas
Tobias Schatton et al.
Nature 451, 345—349 (17 January 2008) doi:10.1038/nature06489
Abstract | Full Text | PDF | Supplementary Information
Letter
Identification of RPS14 as a 5q- syndrome gene by RNA interference screen
Benjamin L. Ebert et al.
Nature 451, 335—339 (17 January 2008) doi:10.1038/nature06494
Abstract | Full Text | PDF | Supplementary Information
Article
Endogenous human microRNAs that suppress breast cancer metastasis
Sohail F. Tavazoie et al.
Nature 451, 147—152 (10 January 2008) doi:10.1038/nature06487
Abstract | Full Text | PDF | Supplementary Information
Letter
NUMB controls p53 tumour suppressor activity
Ivan N. Colaluca et al.
Nature 451, 76—80 (3 January 2008) doi:10.1038/nature06412
Abstract | Full Text | PDF | Supplementary Information
Letter
Trisomy represses ApcMin-mediated tumours in mouse models of Down's syndrome
Thomas E. Sussan, Annan Yang, Fu Li, Michael C. Ostrowski & Roger H. Reeves
Nature 451, 73—75 (3 January 2008) doi:10.1038/nature06446
Abstract | Full Text | PDF | Supplementary Information
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Links
- Nature Reviews Cancer
- cancer@nature.com
- Cancer genomics collection
- Cancer stem cells Nature web focus
- Molecular cancer diagnostics Nature Insight
- Signalling in cancer Nature Insight
- Nanotechnology in Cancer Nature Collection
