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A synthetic gene circuit implementing an integral feedback topology is shown to achieve robust perfect adaptation in living cells--mathematical analysis proves this topology is necessary for adaptation in networks with noisy dynamics.
Perfect transmission of electrons through a finite potential barrier between a normal metal and a topological superconducting state is demonstrated, as evidenced by an exact doubling of conductance in point contact measurements.
Bayesian hierarchical regression analysis of a global database of bird introduction events reveals the environmental, climatic and biotic factors that are the primary determinants of the successful establishment of populations of alien species.
A bulk photovoltaic effect is observed in devices based on tungsten disulfide, and is enhanced if the devices take the form of polar nanotubes, showing the importance of reducing crystal symmetry to a polar structure in achieving higher efficiencies.
Genetic analyses of ancestrally diverse populations show evidence of heterogeneity across ancestries and provide insights into clinical implications, highlighting the importance of including ancestrally diverse populations to maximize genetic discovery and reduce health disparities.
A high-throughput chemical–genetic screening approach for the discovery of targets and chemicals to treat Mycobacterium tuberculosis yields tenfold more hit compounds than conventional whole-cell screening methods.
Standing-wave optics can be used to control microfibril and cavity formation in polymer films and the resulting porous layered structures can produce tunable structural colour, enabling inkless ‘printing’ of images.
Genetic, pharmacological and metabolomics experiments reveal that the malate–aspartate shuttle and mitochondrial citrate export support the differentiation of mouse T helper 1 cells, whereas succinate dehydrogenase enforces their terminal effector function.
Analysis of forest-management studies finds that forest removal is more likely to increase streamflow in areas with greater water storage between the surface and bedrock, and that forest planting is more likely to decrease streamflow in drier climates.
The CRISPR–Cas9-mediated generation of germline-transmissible mutations of SHANK3 in cynomolgus macaques (Macaca fascicularis) forms the basis of a non-human-primate model of autism spectrum disorder and Phelan–McDermid syndrome.
In a mouse model of herpes simplex 2 virus infection, circulating memory B cells—rather than plasma cells—are shown to be the source of antibody secretion in the vaginal lumen following secondary infection.
Climate has affected organized armed conflict within countries, and intensifying climate change is estimated to increase future risks of conflict, although other drivers are substantially more influential and the mechanisms of climate–conflict linkages remain uncertain.
This Perspective discusses the challenges associated with the prediction of chemical synthesis, in particular the reaction conditions required for organic transformations, and the role of machine-learning approaches in the prediction process.
Comparison of transcriptomes, cell fates and behaviour of three primary cell types from the sponge Amphimedon queenslandica with choanoflagellates and other unicellular holozoans suggests that the first animal cells transitioned between multiple states.
A copper oxide high-temperature superconductor magnet generates a direct-current magnetic field of 45.5 tesla—the highest value reported so far—using a design that enables operation at high current densities.
A mouse blastocyst model reveals how lumenal pressure, cell cortical tension and tissue stiffness act at the tissue scale to regulate embryo size, which in turn influences the division pattern of trophectoderm cells and their fate specification.
Measurements collected during recent polynya events in the Southern Ocean reveal that these sea ice openings formed as a result of weakened stratification and severe storms and were sustained by deep overturning.
Attractions between heterochromatic regions are essential for phase separation of the active and inactive genome in inverted and conventional nuclei, whereas chromatin–lamina interactions are necessary to build the conventional genomic architecture from these segregated phases.
Synchrotron Mössbauer source spectroscopy is used to reveal that haematite remains magnetic in cold subducting slabs at the depth of the transition zone in the Earth’s mantle, with implications for the locations of magnetic poles during inversions of the Earth’s magnetic field.
Group 3 innate lymphoid cells are recruited to the lung and involved in the immune response to infection with tuberculosis in humans and mice, as a reduction in group 3 innate lymphoid cells in the lung impaired early immune control of Mycobacterium tuberculosis in mice.
Whole-ecosystem manipulations of Caribbean islands occupied by brown anoles, involving the addition of competitors (green anoles) and/or top predators (curly-tailed lizards), demonstrate that predator introductions can alter the ecological niches and destabilize the coexistence of competing prey species.
DNA analysis of ancient individuals and modern populations suggests that the population history of North America can be explained by the admixture of two ancestral lineages—Palaeo-Eskimos and First Peoples.