Latest Research

  • Letter |

    A synthetic gene circuit implementing an integral feedback topology is shown to achieve robust perfect adaptation in living cells--mathematical analysis proves this topology is necessary for adaptation in networks with noisy dynamics.

    • Stephanie K. Aoki
    • , Gabriele Lillacci
    • , Ankit Gupta
    • , Armin Baumschlager
    • , David Schweingruber
    •  & Mustafa Khammash
  • Letter |

    Perfect transmission of electrons through a finite potential barrier between a normal metal and a topological superconducting state is demonstrated, as evidenced by an exact doubling of conductance in point contact measurements.

    • Seunghun Lee
    • , Valentin Stanev
    • , Xiaohang Zhang
    • , Drew Stasak
    • , Jack Flowers
    • , Joshua S. Higgins
    • , Sheng Dai
    • , Thomas Blum
    • , Xiaoqing Pan
    • , Victor M. Yakovenko
    • , Johnpierre Paglione
    • , Richard L. Greene
    • , Victor Galitski
    •  & Ichiro Takeuchi
  • Letter |

    Bayesian hierarchical regression analysis of a global database of bird introduction events reveals the environmental, climatic and biotic factors that are the primary determinants of the successful establishment of populations of alien species.

    • David W. Redding
    • , Alex L. Pigot
    • , Ellie E. Dyer
    • , Çağan H. Şekercioğlu
    • , Salit Kark
    •  & Tim M. Blackburn
  • Letter |

    An intestine-critical region on human chromosome 16, and its regulation of PERCC1, a newly identified gene, is shown to underlie the genetic basis of a severe, inherited form of diarrhoea.

    • Danit Oz-Levi
    • , Tsviya Olender
    • , Ifat Bar-Joseph
    • , Yiwen Zhu
    • , Dina Marek-Yagel
    • , Iros Barozzi
    • , Marco Osterwalder
    • , Anna Alkelai
    • , Elizabeth K. Ruzzo
    • , Yujun Han
    • , Erica S. M. Vos
    • , Haike Reznik-Wolf
    • , Corina Hartman
    • , Raanan Shamir
    • , Batia Weiss
    • , Rivka Shapiro
    • , Ben Pode-Shakked
    • , Pavlo Tatarskyy
    • , Roni Milgrom
    • , Michael Schvimer
    • , Iris Barshack
    • , Denise M. Imai
    • , Devin Coleman-Derr
    • , Diane E. Dickel
    • , Alex S. Nord
    • , Veena Afzal
    • , Kelly Lammerts van Bueren
    • , Ralston M. Barnes
    • , Brian L. Black
    • , Christopher N. Mayhew
    • , Matthew F. Kuhar
    • , Amy Pitstick
    • , Mehmet Tekman
    • , Horia C. Stanescu
    • , James M. Wells
    • , Robert Kleta
    • , Wouter de Laat
    • , David B. Goldstein
    • , Elon Pras
    • , Axel Visel
    • , Doron Lancet
    • , Yair Anikster
    •  & Len A. Pennacchio
  • Letter |

    A bulk photovoltaic effect is observed in devices based on tungsten disulfide, and is enhanced if the devices take the form of polar nanotubes, showing the importance of reducing crystal symmetry to a polar structure in achieving higher efficiencies.

    • Y. J. Zhang
    • , T. Ideue
    • , M. Onga
    • , F. Qin
    • , R. Suzuki
    • , A. Zak
    • , R. Tenne
    • , J. H. Smet
    •  & Y. Iwasa
  • Letter |

    Experiments demonstrate a class of van der Waals nanowires, made from layered crystals of the semiconductor germanium sulfide, in which a tunable interlayer twist evolves naturally during synthesis.

    • Yin Liu
    • , Jie Wang
    • , Sujung Kim
    • , Haoye Sun
    • , Fuyi Yang
    • , Zixuan Fang
    • , Nobumichi Tamura
    • , Ruopeng Zhang
    • , Xiaohui Song
    • , Jianguo Wen
    • , Bo Z. Xu
    • , Michael Wang
    • , Shuren Lin
    • , Qin Yu
    • , Kyle B. Tom
    • , Yang Deng
    • , John Turner
    • , Emory Chan
    • , Dafei Jin
    • , Robert O. Ritchie
    • , Andrew M. Minor
    • , Daryl C. Chrzan
    • , Mary C. Scott
    •  & Jie Yao
  • Letter |

    Genetic analyses of ancestrally diverse populations show evidence of heterogeneity across ancestries and provide insights into clinical implications, highlighting the importance of including ancestrally diverse populations to maximize genetic discovery and reduce health disparities.

    • Genevieve L. Wojcik
    • , Mariaelisa Graff
    • , Katherine K. Nishimura
    • , Ran Tao
    • , Jeffrey Haessler
    • , Christopher R. Gignoux
    • , Heather M. Highland
    • , Yesha M. Patel
    • , Elena P. Sorokin
    • , Christy L. Avery
    • , Gillian M. Belbin
    • , Stephanie A. Bien
    • , Iona Cheng
    • , Sinead Cullina
    • , Chani J. Hodonsky
    • , Yao Hu
    • , Laura M. Huckins
    • , Janina Jeff
    • , Anne E. Justice
    • , Jonathan M. Kocarnik
    • , Unhee Lim
    • , Bridget M. Lin
    • , Yingchang Lu
    • , Sarah C. Nelson
    • , Sung-Shim L. Park
    • , Hannah Poisner
    • , Michael H. Preuss
    • , Melissa A. Richard
    • , Claudia Schurmann
    • , Veronica W. Setiawan
    • , Alexandra Sockell
    • , Karan Vahi
    • , Marie Verbanck
    • , Abhishek Vishnu
    • , Ryan W. Walker
    • , Kristin L. Young
    • , Niha Zubair
    • , Victor Acuña-Alonso
    • , Jose Luis Ambite
    • , Kathleen C. Barnes
    • , Eric Boerwinkle
    • , Erwin P. Bottinger
    • , Carlos D. Bustamante
    • , Christian Caberto
    • , Samuel Canizales-Quinteros
    • , Matthew P. Conomos
    • , Ewa Deelman
    • , Ron Do
    • , Kimberly Doheny
    • , Lindsay Fernández-Rhodes
    • , Myriam Fornage
    • , Benyam Hailu
    • , Gerardo Heiss
    • , Brenna M. Henn
    • , Lucia A. Hindorff
    • , Rebecca D. Jackson
    • , Cecelia A. Laurie
    • , Cathy C. Laurie
    • , Yuqing Li
    • , Dan-Yu Lin
    • , Andres Moreno-Estrada
    • , Girish Nadkarni
    • , Paul J. Norman
    • , Loreall C. Pooler
    • , Alexander P. Reiner
    • , Jane Romm
    • , Chiara Sabatti
    • , Karla Sandoval
    • , Xin Sheng
    • , Eli A. Stahl
    • , Daniel O. Stram
    • , Timothy A. Thornton
    • , Christina L. Wassel
    • , Lynne R. Wilkens
    • , Cheryl A. Winkler
    • , Sachi Yoneyama
    • , Steven Buyske
    • , Christopher A. Haiman
    • , Charles Kooperberg
    • , Loic Le Marchand
    • , Ruth J. F. Loos
    • , Tara C. Matise
    • , Kari E. North
    • , Ulrike Peters
    • , Eimear E. Kenny
    •  & Christopher S. Carlson
  • Article |

    A high-throughput chemical–genetic screening approach for the discovery of targets and chemicals to treat Mycobacterium tuberculosis yields tenfold more hit compounds than conventional whole-cell screening methods.

    • Eachan O. Johnson
    • , Emily LaVerriere
    • , Emma Office
    • , Mary Stanley
    • , Elisabeth Meyer
    • , Tomohiko Kawate
    • , James E. Gomez
    • , Rebecca E. Audette
    • , Nirmalya Bandyopadhyay
    • , Natalia Betancourt
    • , Kayla Delano
    • , Israel Da Silva
    • , Joshua Davis
    • , Christina Gallo
    • , Michelle Gardner
    • , Aaron J. Golas
    • , Kristine M. Guinn
    • , Sofia Kennedy
    • , Rebecca Korn
    • , Jennifer A. McConnell
    • , Caitlin E. Moss
    • , Kenan C. Murphy
    • , Raymond M. Nietupski
    • , Kadamba G. Papavinasasundaram
    • , Jessica T. Pinkham
    • , Paula A. Pino
    • , Megan K. Proulx
    • , Nadine Ruecker
    • , Naomi Song
    • , Matthew Thompson
    • , Carolina Trujillo
    • , Shoko Wakabayashi
    • , Joshua B. Wallach
    • , Christopher Watson
    • , Thomas R. Ioerger
    • , Eric S. Lander
    • , Brian K. Hubbard
    • , Michael H. Serrano-Wu
    • , Sabine Ehrt
    • , Michael Fitzgerald
    • , Eric J. Rubin
    • , Christopher M. Sassetti
    • , Dirk Schnappinger
    •  & Deborah T. Hung
  • Article |

    An energy-dense hydraulic fluid is used to construct a synthetic circulatory system in a lionfish-like soft robot, enabling untethered movement for up to 36 hours.

    • Cameron A. Aubin
    • , Snehashis Choudhury
    • , Rhiannon Jerch
    • , Lynden A. Archer
    • , James H. Pikul
    •  & Robert F. Shepherd
  • Letter |

    Standing-wave optics can be used to control microfibril and cavity formation in polymer films and the resulting porous layered structures can produce tunable structural colour, enabling inkless ‘printing’ of images.

    • Masateru M. Ito
    • , Andrew H. Gibbons
    • , Detao Qin
    • , Daisuke Yamamoto
    • , Handong Jiang
    • , Daisuke Yamaguchi
    • , Koichiro Tanaka
    •  & Easan Sivaniah
  • Letter |

    A machine-learning approach is used to train artificial neural networks to analyse experimental scanning tunnelling microscopy image arrays of quantum materials.

    • Yi Zhang
    • , A. Mesaros
    • , K. Fujita
    • , S. D. Edkins
    • , M. H. Hamidian
    • , K. Ch’ng
    • , H. Eisaki
    • , S. Uchida
    • , J. C. Séamus Davis
    • , Ehsan Khatami
    •  & Eun-Ah Kim
  • Letter |

    Numerical modelling of rotating turbulent convective flows shows that the length scale of convection in planetary cores is set by the flow speed and not by the fluid viscosity.

    • Céline Guervilly
    • , Philippe Cardin
    •  & Nathanaël Schaeffer
  • Letter |

    Genetic, pharmacological and metabolomics experiments reveal that the malate–aspartate shuttle and mitochondrial citrate export support the differentiation of mouse T helper 1 cells, whereas succinate dehydrogenase enforces their terminal effector function.

    • Will Bailis
    • , Justin A. Shyer
    • , Jun Zhao
    • , Juan Carlos Garcia Canaveras
    • , Fatimah J. Al Khazal
    • , Rihao Qu
    • , Holly R. Steach
    • , Piotr Bielecki
    • , Omair Khan
    • , Ruaidhri Jackson
    • , Yuval Kluger
    • , Louis J. Maher III
    • , Joshua Rabinowitz
    • , Joe Craft
    •  & Richard A. Flavell
  • Letter |

    A greater diversity of crops at the national level increases the temporal stability of total national harvest, reflecting markedly lower frequencies of years with sharp harvest losses.

    • Delphine Renard
    •  & David Tilman
  • Letter |

    • Andrew C. Scott
    • , Friederike Dündar
    • , Paul Zumbo
    • , Smita S. Chandran
    • , Christopher A. Klebanoff
    • , Mojdeh Shakiba
    • , Prerak Trivedi
    • , Laura Menocal
    • , Heather Appleby
    • , Steven J. Camara
    • , Dmitriy Zamarin
    • , Tyler Walther
    • , Alexandra C. Snyder
    • , Matthew R. Femia
    • , Elizabeth A. Comen
    • , Hannah Y. Wen
    • , Matthew D. Hellmann
    • , Niroshana Anandasabapathy
    • , Yong Liu
    • , Nasser K. Altorki
    • , Peter Lauer
    • , Olivier Levy
    • , Michael Glickman
    • , Jonathan Kaye
    • , Doron Betel
    • , Mary Philip
    •  & Andrea Schietinger
  • Article |

    Analysis of forest-management studies finds that forest removal is more likely to increase streamflow in areas with greater water storage between the surface and bedrock, and that forest planting is more likely to decrease streamflow in drier climates.

    • Jaivime Evaristo
    •  & Jeffrey J. McDonnell
  • Article |

    • Omar Khan
    • , Josephine R. Giles
    • , Sierra McDonald
    • , Sasikanth Manne
    • , Shin Foong Ngiow
    • , Kunal P. Patel
    • , Michael T. Werner
    • , Alexander C. Huang
    • , Katherine A. Alexander
    • , Jennifer E. Wu
    • , John Attanasio
    • , Patrick Yan
    • , Sangeeth M. George
    • , Bertram Bengsch
    • , Ryan P. Staupe
    • , Greg Donahue
    • , Wei Xu
    • , Ravi K. Amaravadi
    • , Xiaowei Xu
    • , Giorgos C. Karakousis
    • , Tara C. Mitchell
    • , Lynn M. Schuchter
    • , Jonathan Kaye
    • , Shelley L. Berger
    •  & E. John Wherry
  • Article |

    The CRISPR–Cas9-mediated generation of germline-transmissible mutations of SHANK3 in cynomolgus macaques (Macaca fascicularis) forms the basis of a non-human-primate model of autism spectrum disorder and Phelan–McDermid syndrome.

    • Yang Zhou
    • , Jitendra Sharma
    • , Qiong Ke
    • , Rogier Landman
    • , Jingli Yuan
    • , Hong Chen
    • , David S. Hayden
    • , John W. Fisher III
    • , Minqing Jiang
    • , William Menegas
    • , Tomomi Aida
    • , Ting Yan
    • , Ying Zou
    • , Dongdong Xu
    • , Shivangi Parmar
    • , Julia B. Hyman
    • , Adrian Fanucci-Kiss
    • , Olivia Meisner
    • , Dongqing Wang
    • , Yan Huang
    • , Yaqing Li
    • , Yanyang Bai
    • , Wenjing Ji
    • , Xinqiang Lai
    • , Weiqiang Li
    • , Lihua Huang
    • , Zhonghua Lu
    • , Liping Wang
    • , Sheeba A. Anteraper
    • , Mriganka Sur
    • , Huihui Zhou
    • , Andy Peng Xiang
    • , Robert Desimone
    • , Guoping Feng
    •  & Shihua Yang
  • Letter |

    Cryo-electron microscopy structures of the yeast 60S ribosomal subunit in complex with Vms1 provides insights into the roles of proteins in the ribosome-associated quality control pathway.

    • Ting Su
    • , Toshiaki Izawa
    • , Matthias Thoms
    • , Yui Yamashita
    • , Jingdong Cheng
    • , Otto Berninghausen
    • , F. Ulrich Hartl
    • , Toshifumi Inada
    • , Walter Neupert
    •  & Roland Beckmann
  • Letter |

    In a mouse model of herpes simplex 2 virus infection, circulating memory B cells—rather than plasma cells—are shown to be the source of antibody secretion in the vaginal lumen following secondary infection.

    • Ji Eun Oh
    • , Norifumi Iijima
    • , Eric Song
    • , Peiwen Lu
    • , Jonathan Klein
    • , Ruoyi Jiang
    • , Steven H. Kleinstein
    •  & Akiko Iwasaki
  • Analysis |

    Climate has affected organized armed conflict within countries, and intensifying climate change is estimated to increase future risks of conflict, although other drivers are substantially more influential and the mechanisms of climate–conflict linkages remain uncertain.

    • Katharine J. Mach
    • , Caroline M. Kraan
    • , W. Neil Adger
    • , Halvard Buhaug
    • , Marshall Burke
    • , James D. Fearon
    • , Christopher B. Field
    • , Cullen S. Hendrix
    • , Jean-Francois Maystadt
    • , John O’Loughlin
    • , Philip Roessler
    • , Jürgen Scheffran
    • , Kenneth A. Schultz
    •  & Nina von Uexkull
  • Perspective |

    This Perspective discusses the challenges associated with the prediction of chemical synthesis, in particular the reaction conditions required for organic transformations, and the role of machine-learning approaches in the prediction process.

    • Ian W. Davies
  • Letter |

    Comparison of transcriptomes, cell fates and behaviour of three primary cell types from the sponge Amphimedon queenslandica with choanoflagellates and other unicellular holozoans suggests that the first animal cells transitioned between multiple states.

    • Shunsuke Sogabe
    • , William L. Hatleberg
    • , Kevin M. Kocot
    • , Tahsha E. Say
    • , Daniel Stoupin
    • , Kathrein E. Roper
    • , Selene L. Fernandez-Valverde
    • , Sandie M. Degnan
    •  & Bernard M. Degnan
  • Article |

    A cryo-electron microscopy structure of human NLRP3 in complex with the mitotic kinase NEK7 provides insights into the interactions that mediate the activation of the NLRP3 inflammasome.

    • Humayun Sharif
    • , Li Wang
    • , Wei Li Wang
    • , Venkat Giri Magupalli
    • , Liudmila Andreeva
    • , Qi Qiao
    • , Arthur V. Hauenstein
    • , Zhaolong Wu
    • , Gabriel Núñez
    • , Youdong Mao
    •  & Hao Wu
  • Letter |

    A copper oxide high-temperature superconductor magnet generates a direct-current magnetic field of 45.5 tesla—the highest value reported so far—using a design that enables operation at high current densities.

    • Seungyong Hahn
    • , Kwanglok Kim
    • , Kwangmin Kim
    • , Xinbo Hu
    • , Thomas Painter
    • , Iain Dixon
    • , Seokho Kim
    • , Kabindra R. Bhattarai
    • , So Noguchi
    • , Jan Jaroszynski
    •  & David C. Larbalestier
  • Letter |

    By enhancing the spin–orbit coupling in bilayer graphene using the proximity effect in a van der Waals heterostructure, band inversion occurs and an incompressible, gapped phase is produced.

    • J. O. Island
    • , X. Cui
    • , C. Lewandowski
    • , J. Y. Khoo
    • , E. M. Spanton
    • , H. Zhou
    • , D. Rhodes
    • , J. C. Hone
    • , T. Taniguchi
    • , K. Watanabe
    • , L. S. Levitov
    • , M. P. Zaletel
    •  & A. F. Young
  • Letter |

    A mouse blastocyst model reveals how lumenal pressure, cell cortical tension and tissue stiffness act at the tissue scale to regulate embryo size, which in turn influences the division pattern of trophectoderm cells and their fate specification.

    • Chii Jou Chan
    • , Maria Costanzo
    • , Teresa Ruiz-Herrero
    • , Gregor Mönke
    • , Ryan J. Petrie
    • , Martin Bergert
    • , Alba Diz-Muñoz
    • , L. Mahadevan
    •  & Takashi Hiiragi
  • Article |

    Measurements collected during recent polynya events in the Southern Ocean reveal that these sea ice openings formed as a result of weakened stratification and severe storms and were sustained by deep overturning.

    • Ethan C. Campbell
    • , Earle A. Wilson
    • , G. W. Kent Moore
    • , Stephen C. Riser
    • , Casey E. Brayton
    • , Matthew R. Mazloff
    •  & Lynne D. Talley
  • Letter |

    Attractions between heterochromatic regions are essential for phase separation of the active and inactive genome in inverted and conventional nuclei, whereas chromatin–lamina interactions are necessary to build the conventional genomic architecture from these segregated phases.

    • Martin Falk
    • , Yana Feodorova
    • , Natalia Naumova
    • , Maxim Imakaev
    • , Bryan R. Lajoie
    • , Heinrich Leonhardt
    • , Boris Joffe
    • , Job Dekker
    • , Geoffrey Fudenberg
    • , Irina Solovei
    •  & Leonid A. Mirny
  • Letter |

    Synchrotron Mössbauer source spectroscopy is used to reveal that haematite remains magnetic in cold subducting slabs at the depth of the transition zone in the Earth’s mantle, with implications for the locations of magnetic poles during inversions of the Earth’s magnetic field.

    • I. Kupenko
    • , G. Aprilis
    • , D. M. Vasiukov
    • , C. McCammon
    • , S. Chariton
    • , V. Cerantola
    • , I. Kantor
    • , A. I. Chumakov
    • , R. Rüffer
    • , L. Dubrovinsky
    •  & C. Sanchez-Valle
  • Letter |

    Bose–Einstein condensates are transported at hypersonic speeds over a distance of 15 cm in a neutral-atom accelerator ring while preserving their internal coherence.

    • Saurabh Pandey
    • , Hector Mas
    • , Giannis Drougakis
    • , Premjith Thekkeppatt
    • , Vasiliki Bolpasi
    • , Georgios Vasilakis
    • , Konstantinos Poulios
    •  & Wolf von Klitzing
  • Letter |

    Group 3 innate lymphoid cells are recruited to the lung and involved in the immune response to infection with tuberculosis in humans and mice, as a reduction in group 3 innate lymphoid cells in the lung impaired early immune control of Mycobacterium tuberculosis in mice.

    • Amanda Ardain
    • , Racquel Domingo-Gonzalez
    • , Shibali Das
    • , Samuel W. Kazer
    • , Nicole C. Howard
    • , Alveera Singh
    • , Mushtaq Ahmed
    • , Shepherd Nhamoyebonde
    • , Javier Rangel-Moreno
    • , Paul Ogongo
    • , Lan Lu
    • , Duran Ramsuran
    • , Maria de la Luz Garcia-Hernandez
    • , Tyler K. Ulland
    • , Matthew Darby
    • , Eugene Park
    • , Farina Karim
    • , Laura Melocchi
    • , Rajhmun Madansein
    • , Kaylesh Jay Dullabh
    • , Micah Dunlap
    • , Nancy Marin-Agudelo
    • , Takashi Ebihara
    • , Thumbi Ndung’u
    • , Deepak Kaushal
    • , Alexander S. Pym
    • , Jay K. Kolls
    • , Adrie Steyn
    • , Joaquín Zúñiga
    • , William Horsnell
    • , Wayne M. Yokoyama
    • , Alex K. Shalek
    • , Henrik N. Kløverpris
    • , Marco Colonna
    • , Alasdair Leslie
    •  & Shabaana A. Khader
  • Article |

    Whole-ecosystem manipulations of Caribbean islands occupied by brown anoles, involving the addition of competitors (green anoles) and/or top predators (curly-tailed lizards), demonstrate that predator introductions can alter the ecological niches and destabilize the coexistence of competing prey species.

    • Robert M. Pringle
    • , Tyler R. Kartzinel
    • , Todd M. Palmer
    • , Timothy J. Thurman
    • , Kena Fox-Dobbs
    • , Charles C. Y. Xu
    • , Matthew C. Hutchinson
    • , Tyler C. Coverdale
    • , Joshua H. Daskin
    • , Dominic A. Evangelista
    • , Kiyoko M. Gotanda
    • , Naomi A. Man in ’t Veld
    • , Johanna E. Wegener
    • , Jason J. Kolbe
    • , Thomas W. Schoener
    • , David A. Spiller
    • , Jonathan B. Losos
    •  & Rowan D. H. Barrett
  • Letter |

    DNA analysis of ancient individuals and modern populations suggests that the population history of North America can be explained by the admixture of two ancestral lineages—Palaeo-Eskimos and First Peoples.

    • Pavel Flegontov
    • , N. Ezgi Altınışık
    • , Piya Changmai
    • , Nadin Rohland
    • , Swapan Mallick
    • , Nicole Adamski
    • , Deborah A. Bolnick
    • , Nasreen Broomandkhoshbacht
    • , Francesca Candilio
    • , Brendan J. Culleton
    • , Olga Flegontova
    • , T. Max Friesen
    • , Choongwon Jeong
    • , Thomas K. Harper
    • , Denise Keating
    • , Douglas J. Kennett
    • , Alexander M. Kim
    • , Thiseas C. Lamnidis
    • , Ann Marie Lawson
    • , Iñigo Olalde
    • , Jonas Oppenheimer
    • , Ben A. Potter
    • , Jennifer Raff
    • , Robert A. Sattler
    • , Pontus Skoglund
    • , Kristin Stewardson
    • , Edward J. Vajda
    • , Sergey Vasilyev
    • , Elizaveta Veselovskaya
    • , M. Geoffrey Hayes
    • , Dennis H. O’Rourke
    • , Johannes Krause
    • , Ron Pinhasi
    • , David Reich
    •  & Stephan Schiffels