Latest Research

  • Letter |

    The functionalization of specific inert C–H bonds avoids the need for functional groups in organic synthesis and here the challenges of this approach are overcome using a dirhodium catalyst that is capable of C–H bond site-selectivity.

    • Kuangbiao Liao
    • , Thomas C. Pickel
    • , Vyacheslav Boyarskikh
    • , John Bacsa
    • , Djamaladdin G. Musaev
    •  & Huw M. L. Davies
  • Letter |

    • Karen J. Meech
    • , Robert Weryk
    • , Marco Micheli
    • , Jan T. Kleyna
    • , Olivier R. Hainaut
    • , Robert Jedicke
    • , Richard J. Wainscoat
    • , Kenneth C. Chambers
    • , Jacqueline V. Keane
    • , Andreea Petric
    • , Larry Denneau
    • , Eugene Magnier
    • , Travis Berger
    • , Mark E. Huber
    • , Heather Flewelling
    • , Chris Waters
    • , Eva Schunova-Lilly
    •  & Serge Chastel
  • Letter |

    Quantitive microbiome profiling reveals that total microbial load is an important determinant of enterotypes and may be a key driver of microbiota alterations in patients with Crohn’s disease.

    • Doris Vandeputte
    • , Gunter Kathagen
    • , Kevin D’hoe
    • , Sara Vieira-Silva
    • , Mireia Valles-Colomer
    • , João Sabino
    • , Jun Wang
    • , Raul Y. Tito
    • , Lindsey De Commer
    • , Youssef Darzi
    • , Séverine Vermeire
    • , Gwen Falony
    •  & Jeroen Raes
  • Letter |

    Modelling results find that the temperature of Pluto’s atmosphere is regulated by haze particles rather than gas molecules, suggesting that Pluto should be brighter than previously thought at mid-infrared wavelengths.

    • Xi Zhang
    • , Darrell F. Strobel
    •  & Hiroshi Imanaka
  • Letter |

    Loss of the PD-1 receptor promotes the development of T cell non-Hodgkin lymphomas by modulating oncogenic signalling pathways, and blocking these pathways reduces tumourigenesis.

    • Tim Wartewig
    • , Zsuzsanna Kurgyis
    • , Selina Keppler
    • , Konstanze Pechloff
    • , Erik Hameister
    • , Rupert Öllinger
    • , Roman Maresch
    • , Thorsten Buch
    • , Katja Steiger
    • , Christof Winter
    • , Roland Rad
    •  & Jürgen Ruland
  • Erratum |

    • Antonia Wallrapp
    • , Samantha J. Riesenfeld
    • , Patrick R. Burkett
    • , Raja-Elie E. Abdulnour
    • , Jackson Nyman
    • , Danielle Dionne
    • , Matan Hofree
    • , Michael S. Cuoco
    • , Christopher Rodman
    • , Daneyal Farouq
    • , Brian J. Haas
    • , Timothy L. Tickle
    • , John J. Trombetta
    • , Pankaj Baral
    • , Christoph S. N. Klose
    • , Tanel Mahlakõiv
    • , David Artis
    • , Orit Rozenblatt-Rosen
    • , Isaac M. Chiu
    • , Bruce D. Levy
    • , Monika S. Kowalczyk
    • , Aviv Regev
    •  & Vijay K. Kuchroo
  • Article |

    A high-resolution structure of the human ribosome determined by cryo-electron microscopy visualizes numerous RNA modifications that are concentrated at functional sites with an extended shell, and suggests the possibility of designing more specific ribosome-targeting drugs.

    • S. Kundhavai Natchiar
    • , Alexander G. Myasnikov
    • , Hanna Kratzat
    • , Isabelle Hazemann
    •  & Bruno P. Klaholz
  • Article |

    An estimate of Earth’s deep-mantle buoyancy is derived from GPS-based measurements of body tide deformation and shown to be dominated by dense material possibly related to subducted oceanic plates or primordial rock.

    • Harriet C. P. Lau
    • , Jerry X. Mitrovica
    • , James L. Davis
    • , Jeroen Tromp
    • , Hsin-Ying Yang
    •  & David Al-Attar
  • Letter | | open

    A combination of advanced sequencing and mapping techniques is used to produce a reference genome of Aegilops tauschii, progenitor of the wheat D genome, providing a valuable resource for comparative genetic studies.

    • Ming-Cheng Luo
    • , Yong Q. Gu
    • , Daniela Puiu
    • , Hao Wang
    • , Sven O. Twardziok
    • , Karin R. Deal
    • , Naxin Huo
    • , Tingting Zhu
    • , Le Wang
    • , Yi Wang
    • , Patrick E. McGuire
    • , Shuyang Liu
    • , Hai Long
    • , Ramesh K. Ramasamy
    • , Juan C. Rodriguez
    • , Sonny L. Van
    • , Luxia Yuan
    • , Zhenzhong Wang
    • , Zhiqiang Xia
    • , Lichan Xiao
    • , Olin D. Anderson
    • , Shuhong Ouyang
    • , Yong Liang
    • , Aleksey V. Zimin
    • , Geo Pertea
    • , Peng Qi
    • , Jeffrey L. Bennetzen
    • , Xiongtao Dai
    • , Matthew W. Dawson
    • , Hans-Georg Müller
    • , Karl Kugler
    • , Lorena Rivarola-Duarte
    • , Manuel Spannagl
    • , Klaus F. X. Mayer
    • , Fu-Hao Lu
    • , Michael W. Bevan
    • , Philippe Leroy
    • , Pingchuan Li
    • , Frank M. You
    • , Qixin Sun
    • , Zhiyong Liu
    • , Eric Lyons
    • , Thomas Wicker
    • , Steven L. Salzberg
    • , Katrien M. Devos
    •  & Jan Dvořák
  • Article |

    High salt intake changed the gut microbiome and increased TH17 cell numbers in mice, and reduced intestinal survival of Lactobacillus species, increased the number of TH17 cells and increased blood pressure in humans.

    • Nicola Wilck
    • , Mariana G. Matus
    • , Sean M. Kearney
    • , Scott W. Olesen
    • , Kristoffer Forslund
    • , Hendrik Bartolomaeus
    • , Stefanie Haase
    • , Anja Mähler
    • , András Balogh
    • , Lajos Markó
    • , Olga Vvedenskaya
    • , Friedrich H. Kleiner
    • , Dmitry Tsvetkov
    • , Lars Klug
    • , Paul I. Costea
    • , Shinichi Sunagawa
    • , Lisa Maier
    • , Natalia Rakova
    • , Valentin Schatz
    • , Patrick Neubert
    • , Christian Frätzer
    • , Alexander Krannich
    • , Maik Gollasch
    • , Diana A. Grohme
    • , Beatriz F. Côrte-Real
    • , Roman G. Gerlach
    • , Marijana Basic
    • , Athanasios Typas
    • , Chuan Wu
    • , Jens M. Titze
    • , Jonathan Jantsch
    • , Michael Boschmann
    • , Ralf Dechend
    • , Markus Kleinewietfeld
    • , Stefan Kempa
    • , Peer Bork
    • , Ralf A. Linker
    • , Eric J. Alm
    •  & Dominik N. Müller
  • Letter |

    Analyses of house-size distributions in the Old and New World showed that wealth disparities increased with the domestication of plants and animals and with increased sociopolitical scale.

    • Timothy A. Kohler
    • , Michael E. Smith
    • , Amy Bogaard
    • , Gary M. Feinman
    • , Christian E. Peterson
    • , Alleen Betzenhauser
    • , Matthew Pailes
    • , Elizabeth C. Stone
    • , Anna Marie Prentiss
    • , Timothy J. Dennehy
    • , Laura J. Ellyson
    • , Linda M. Nicholas
    • , Ronald K. Faulseit
    • , Amy Styring
    • , Jade Whitlam
    • , Mattia Fochesato
    • , Thomas A. Foor
    •  & Samuel Bowles
  • Letter |

    High-resolution X-ray spectra show near-solar abundances of chromium, manganese and nickel with respect to iron in the Perseus cluster, suggesting that the progenitors of type Ia supernovae could be near- and sub-Chandrasekhar-mass white dwarfs.

    • Hitomi Collaboration
    • , Felix Aharonian
    • , Hiroki Akamatsu
    • , Fumie Akimoto
    • , Steven W. Allen
    • , Lorella Angelini
    • , Marc Audard
    • , Hisamitsu Awaki
    • , Magnus Axelsson
    • , Aya Bamba
    • , Marshall W. Bautz
    • , Roger Blandford
    • , Laura W. Brenneman
    • , Gregory V. Brown
    • , Esra Bulbul
    • , Edward M. Cackett
    • , Maria Chernyakova
    • , Meng P. Chiao
    • , Paolo S. Coppi
    • , Elisa Costantini
    • , Jelle de Plaa
    • , Jan-Willem den Herder
    • , Chris Done
    • , Tadayasu Dotani
    • , Ken Ebisawa
    • , Megan E. Eckart
    • , Teruaki Enoto
    • , Yuichiro Ezoe
    • , Andrew C. Fabian
    • , Carlo Ferrigno
    • , Adam R. Foster
    • , Ryuichi Fujimoto
    • , Yasushi Fukazawa
    • , Akihiro Furuzawa
    • , Massimiliano Galeazzi
    • , Luigi C. Gallo
    • , Poshak Gandhi
    • , Margherita Giustini
    • , Andrea Goldwurm
    • , Liyi Gu
    • , Matteo Guainazzi
    • , Yoshito Haba
    • , Kouichi Hagino
    • , Kenji Hamaguchi
    • , Ilana M. Harrus
    • , Isamu Hatsukade
    • , Katsuhiro Hayashi
    • , Takayuki Hayashi
    • , Kiyoshi Hayashida
    • , Junko S. Hiraga
    • , Ann Hornschemeier
    • , Akio Hoshino
    • , John P. Hughes
    • , Yuto Ichinohe
    • , Ryo Iizuka
    • , Hajime Inoue
    • , Yoshiyuki Inoue
    • , Manabu Ishida
    • , Kumi Ishikawa
    • , Yoshitaka Ishisaki
    • , Masachika Iwai
    • , Jelle Kaastra
    • , Tim Kallman
    • , Tsuneyoshi Kamae
    • , Jun Kataoka
    • , Satoru Katsuda
    • , Nobuyuki Kawai
    • , Richard L. Kelley
    • , Caroline A. Kilbourne
    • , Takao Kitaguchi
    • , Shunji Kitamoto
    • , Tetsu Kitayama
    • , Takayoshi Kohmura
    • , Motohide Kokubun
    • , Katsuji Koyama
    • , Shu Koyama
    • , Peter Kretschmar
    • , Hans A. Krimm
    • , Aya Kubota
    • , Hideyo Kunieda
    • , Philippe Laurent
    • , Shiu-Hang Lee
    • , Maurice A. Leutenegger
    • , Olivier Limousine
    • , Michael Loewenstein
    • , Knox S. Long
    • , David Lumb
    • , Greg Madejski
    • , Yoshitomo Maeda
    • , Daniel Maier
    • , Kazuo Makishima
    • , Maxim Markevitch
    • , Hironori Matsumoto
    • , Kyoko Matsushita
    • , Dan McCammon
    • , Brian R. McNamara
    • , Missagh Mehdipour
    • , Eric D. Miller
    • , Jon M. Miller
    • , Shin Mineshige
    • , Kazuhisa Mitsuda
    • , Ikuyuki Mitsuishi
    • , Takuya Miyazawa
    • , Tsunefumi Mizuno
    • , Hideyuki Mori
    • , Koji Mori
    • , Koji Mukai
    • , Hiroshi Murakami
    • , Richard F. Mushotzky
    • , Takao Nakagawa
    • , Hiroshi Nakajima
    • , Takeshi Nakamori
    • , Shinya Nakashima
    • , Kazuhiro Nakazawa
    • , Kumiko K. Nobukawa
    • , Masayoshi Nobukawa
    • , Hirofumi Noda
    • , Hirokazu Odaka
    • , Takaya Ohashi
    • , Masanori Ohno
    • , Takashi Okajima
    • , Naomi Ota
    • , Masanobu Ozaki
    • , Frits Paerels
    • , Stéphane Paltani
    • , Robert Petre
    • , Ciro Pinto
    • , Frederick S. Porter
    • , Katja Pottschmidt
    • , Christopher S. Reynolds
    • , Samar Safi-Harb
    • , Shinya Saito
    • , Kazuhiro Sakai
    • , Toru Sasaki
    • , Goro Sato
    • , Kosuke Sato
    • , Rie Sato
    • , Makoto Sawada
    • , Norbert Schartel
    • , Peter J. Serlemitsos
    • , Hiromi Seta
    • , Megumi Shidatsu
    • , Aurora Simionescu
    • , Randall K. Smith
    • , Yang Soong
    • , Lukasz Stawarz
    • , Yasuharu Sugawara
    • , Satoshi Sugita
    • , Andrew Szymkowiak
    • , Hiroyasu Tajima
    • , Hiromitsu Takahashi
    • , Tadayuki Takahashi
    • , Shin'ichiro Takeda
    • , Yoh Takei
    • , Toru Tamagawa
    • , Takayuki Tamura
    • , Takaaki Tanaka
    • , Yasuo Tanaka
    • , Yasuyuki T. Tanaka
    • , Makoto S. Tashiro
    • , Yuzuru Tawara
    • , Yukikatsu Terada
    • , Yuichi Terashima
    • , Francesco Tombesi
    • , Hiroshi Tomida
    • , Yohko Tsuboi
    • , Masahiro Tsujimoto
    • , Hiroshi Tsunemi
    • , Takeshi Go Tsuru
    • , Hiroyuki Uchida
    • , Hideki Uchiyama
    • , Yasunobu Uchiyama
    • , Shutaro Ueda
    • , Yoshihiro Ueda
    • , Shin'ichiro Uno
    • , C. Megan Urry
    • , Eugenio Ursino
    • , Cor P. de Vries
    • , Shin Watanabe
    • , Norbert Werner
    • , Daniel R. Wik
    • , Dan R. Wilkins
    • , Brian J. Williams
    • , Shinya Yamada
    • , Hiroya Yamaguchi
    • , Kazutaka Yamaoka
    • , Noriko Y. Yamasaki
    • , Makoto Yamauchi
    • , Shigeo Yamauchi
    • , Tahir Yaqoob
    • , Yoichi Yatsu
    • , Daisuke Yonetoku
    • , Irina Zhuravleva
    •  & Abderahmen Zoghbi
  • Letter |

    • Sebastian Schafer
    • , Sivakumar Viswanathan
    • , Anissa A Widjaja
    • , Wei-Wen Lim
    • , Aida Moreno-Moral
    • , Daniel M DeLaughter
    • , Benjamin Ng
    • , Giannino Patone
    • , Kingsley Chow
    • , Ester Khin
    • , Jessie Tan
    • , Sonia P Chothani
    • , Lei Ye
    • , Owen J L Rackham
    • , Nicole S J Ko
    • , Norliza E Sahib
    • , Chee Jian Pua
    • , Nicole T G Zhen
    • , Chen Xie
    • , Mao Wang
    • , Henrike Maatz
    • , Shiqi Lim
    • , Kathrin Saar
    • , Susanne Blachut
    • , Enrico Petretto
    • , Sabine Schmidt
    • , Tracy Putoczki
    • , Nuno Guimarães-Camboa
    • , Hiroko Wakimoto
    • , Sebastiaan van Heesch
    • , Kristmundur Sigmundsson
    • , See L Lim
    • , Jia L Soon
    • , Victor T T Chao
    • , Yeow L Chua
    • , Teing E Tan
    • , Sylvia M Evans
    • , Yee J Loh
    • , Muhammad H Jamal
    • , Kim K Ong
    • , Kim C Chua
    • , Boon-Hean Ong
    • , Mathew J Chakaramakkil
    • , Jonathan G Seidman
    • , Christine E Seidman
    • , Norbert Hubner
    • , Kenny Y K Sin
    •  & Stuart A Cook
  • Letter |

    In European Neolithic populations, the arrival of farmers prompted admixture with local hunter-gatherers over many centuries, resulting in distinct signatures in each region due to a complex series of interactions.

    • Mark Lipson
    • , Anna Szécsényi-Nagy
    • , Swapan Mallick
    • , Annamária Pósa
    • , Balázs Stégmár
    • , Victoria Keerl
    • , Nadin Rohland
    • , Kristin Stewardson
    • , Matthew Ferry
    • , Megan Michel
    • , Jonas Oppenheimer
    • , Nasreen Broomandkhoshbacht
    • , Eadaoin Harney
    • , Susanne Nordenfelt
    • , Bastien Llamas
    • , Balázs Gusztáv Mende
    • , Kitti Köhler
    • , Krisztián Oross
    • , Mária Bondár
    • , Tibor Marton
    • , Anett Osztás
    • , János Jakucs
    • , Tibor Paluch
    • , Ferenc Horváth
    • , Piroska Csengeri
    • , Judit Koós
    • , Katalin Sebők
    • , Alexandra Anders
    • , Pál Raczky
    • , Judit Regenye
    • , Judit P. Barna
    • , Szilvia Fábián
    • , Gábor Serlegi
    • , Zoltán Toldi
    • , Emese Gyöngyvér Nagy
    • , János Dani
    • , Erika Molnár
    • , György Pálfi
    • , László Márk
    • , Béla Melegh
    • , Zsolt Bánfai
    • , László Domboróczki
    • , Javier Fernández-Eraso
    • , José Antonio Mujika-Alustiza
    • , Carmen Alonso Fernández
    • , Javier Jiménez Echevarría
    • , Ruth Bollongino
    • , Jörg Orschiedt
    • , Kerstin Schierhold
    • , Harald Meller
    • , Alan Cooper
    • , Joachim Burger
    • , Eszter Bánffy
    • , Kurt W. Alt
    • , Carles Lalueza-Fox
    • , Wolfgang Haak
    •  & David Reich
  • Article |

    IgA+ B cells expressing programmed death ligand 1 (PD-L1) and interleukin 10 accumulate in the inflamed livers of humans and mice with non-alcoholic fatty liver disease where they promote the progression to hepatocellular carcinoma by limiting the local activation of PD-1-expressing CD8+ T cells.

    • Shabnam Shalapour
    • , Xue-Jia Lin
    • , Ingmar N. Bastian
    • , John Brain
    • , Alastair D. Burt
    • , Alexander A. Aksenov
    • , Alison F. Vrbanac
    • , Weihua Li
    • , Andres Perkins
    • , Takaji Matsutani
    • , Zhenyu Zhong
    • , Debanjan Dhar
    • , Jose A. Navas-Molina
    • , Jun Xu
    • , Rohit Loomba
    • , Michael Downes
    • , Ruth T. Yu
    • , Ronald M. Evans
    • , Pieter C. Dorrestein
    • , Rob Knight
    • , Christopher Benner
    • , Quentin M. Anstee
    •  & Michael Karin
  • Letter |

    A signalling mechanism in human cells for sensing DNA damage induced by alkylation involves ubiquitin-dependent recruitment of the alkylation repair complex ASCC to the vicinity of the damage and co-localization with transcription and splicing factors.

    • Joshua R. Brickner
    • , Jennifer M. Soll
    • , Patrick M. Lombardi
    • , Cathrine B. Vågbø
    • , Miranda C. Mudge
    • , Clement Oyeniran
    • , Renana Rabe
    • , Jessica Jackson
    • , Meagan E. Sullender
    • , Elyse Blazosky
    • , Andrea K. Byrum
    • , Yu Zhao
    • , Mark A. Corbett
    • , Jozef Gécz
    • , Michael Field
    • , Alessandro Vindigni
    • , Geir Slupphaug
    • , Cynthia Wolberger
    •  & Nima Mosammaparast
  • Letter |

    Application of cryo-electron tomography and subtomogram averaging to determine the structure of the Ebola virus nucleocapsid within intact viruses and recombinant nucleocapsid-like assemblies.

    • William Wan
    • , Larissa Kolesnikova
    • , Mairi Clarke
    • , Alexander Koehler
    • , Takeshi Noda
    • , Stephan Becker
    •  & John A. G. Briggs
  • Letter |

    Observations of an event (several energetic eruptions leading to a terminal explosion that is surprisingly hydrogen-rich) with the spectrum of a supernova do not match with other observations of supernovae.

    • Iair Arcavi
    • , D. Andrew Howell
    • , Daniel Kasen
    • , Lars Bildsten
    • , Griffin Hosseinzadeh
    • , Curtis McCully
    • , Zheng Chuen Wong
    • , Sarah Rebekah Katz
    • , Avishay Gal-Yam
    • , Jesper Sollerman
    • , Francesco Taddia
    • , Giorgos Leloudas
    • , Christoffer Fremling
    • , Peter E. Nugent
    • , Assaf Horesh
    • , Kunal Mooley
    • , Clare Rumsey
    • , S. Bradley Cenko
    • , Melissa L. Graham
    • , Daniel A. Perley
    • , Ehud Nakar
    • , Nir J. Shaviv
    • , Omer Bromberg
    • , Ken J. Shen
    • , Eran O. Ofek
    • , Yi Cao
    • , Xiaofeng Wang
    • , Fang Huang
    • , Liming Rui
    • , Tianmeng Zhang
    • , Wenxiong Li
    • , Zhitong Li
    • , Jujia Zhang
    • , Stefano Valenti
    • , David Guevel
    • , Benjamin Shappee
    • , Christopher S. Kochanek
    • , Thomas W.-S. Holoien
    • , Alexei V. Filippenko
    • , Rob Fender
    • , Anders Nyholm
    • , Ofer Yaron
    • , Mansi M. Kasliwal
    • , Mark Sullivan
    • , Nadja Blagorodnova
    • , Richard S. Walters
    • , Ragnhild Lunnan
    • , Danny Khazov
    • , Igor Andreoni
    • , Russ R. Laher
    • , Nick Konidaris
    • , Przemek Wozniak
    •  & Brian Bue
  • Letter |

    Stacking-disordered ice crystallites are shown to have an ice nucleation rate much higher than predicted by classical nucleation theory, which needs to be taken into account in cloud modelling.

    • Laura Lupi
    • , Arpa Hudait
    • , Baron Peters
    • , Michael Grünwald
    • , Ryan Gotchy Mullen
    • , Andrew H. Nguyen
    •  & Valeria Molinero