Latest Research

  • Article |

    The cryo-electron microscopy structure of the human adenosine A1 receptor in complex with adenosine and heterotrimeric Gi2 protein provides molecular insights into receptor and G-protein selectivity.

    • Christopher J. Draper-Joyce
    • , Maryam Khoshouei
    • , David M. Thal
    • , Yi-Lynn Liang
    • , Anh T. N. Nguyen
    • , Sebastian G. B. Furness
    • , Hariprasad Venugopal
    • , Jo-Anne Baltos
    • , Jürgen M. Plitzko
    • , Radostin Danev
    • , Wolfgang Baumeister
    • , Lauren T. May
    • , Denise Wootten
    • , Patrick M. Sexton
    • , Alisa Glukhova
    •  & Arthur Christopoulos
  • Letter |

    Enzymes that catalyse modifications of wobble uridine 34 tRNA are essential for the survival of melanoma cells that rely on HIF1α-dependent metabolism through codon-dependent regulation of the translation of HIF1A mRNA.

    • Francesca Rapino
    • , Sylvain Delaunay
    • , Florian Rambow
    • , Zhaoli Zhou
    • , Lars Tharun
    • , Pascal De Tullio
    • , Olga Sin
    • , Kateryna Shostak
    • , Sebastian Schmitz
    • , Jolanda Piepers
    • , Bart Ghesquière
    • , Latifa Karim
    • , Benoit Charloteaux
    • , Diane Jamart
    • , Alexandra Florin
    • , Charles Lambert
    • , Andrée Rorive
    • , Guy Jerusalem
    • , Eleonora Leucci
    • , Michael Dewaele
    • , Marc Vooijs
    • , Sebastian A. Leidel
    • , Michel Georges
    • , Marianne Voz
    • , Bernard Peers
    • , Reinhard Büttner
    • , Jean-Christophe Marine
    • , Alain Chariot
    •  & Pierre Close
  • Letter |

    The electrointercalation of lithium into van der Waals heterostructures of graphene, hexagonal boron nitride and molybdenum dichalcogenides is studied at the level of individual atomic interfaces.

    • D. Kwabena Bediako
    • , Mehdi Rezaee
    • , Hyobin Yoo
    • , Daniel T. Larson
    • , S. Y. Frank Zhao
    • , Takashi Taniguchi
    • , Kenji Watanabe
    • , Tina L. Brower-Thomas
    • , Efthimios Kaxiras
    •  & Philip Kim
  • Letter |

    The high-resolution structure of the serotonin 5-HT1B receptor in complex with the agonist donitriptan and a Go heterotrimer highlights features that may underly the specificity of receptor–G-protein coupling and kinetics of signalling.

    • Javier García-Nafría
    • , Rony Nehmé
    • , Patricia C. Edwards
    •  & Christopher G. Tate
  • Article |

    Polymerization of actin in the cell nucleus, promoted by the ARP2/3 complex, drives the clustering of double-strand DNA breaks into nuclear compartments where they can undergo homology-directed repair.

    • Benjamin R. Schrank
    • , Tomas Aparicio
    • , Yinyin Li
    • , Wakam Chang
    • , Brian T. Chait
    • , Gregg G. Gundersen
    • , Max E. Gottesman
    •  & Jean Gautier
  • Letter |

    An analysis based on functional metagenomics reveals a previously unknown group of microbial light-sensory rhodopsins that are widespread among a diverse range of microorganisms.

    • Alina Pushkarev
    • , Keiichi Inoue
    • , Shirley Larom
    • , José Flores-Uribe
    • , Manish Singh
    • , Masae Konno
    • , Sahoko Tomida
    • , Shota Ito
    • , Ryoko Nakamura
    • , Satoshi P. Tsunoda
    • , Alon Philosof
    • , Itai Sharon
    • , Natalya Yutin
    • , Eugene V. Koonin
    • , Hideki Kandori
    •  & Oded Béjà
  • Letter |

     In the midbrain defensive circuit, the decision to escape is computed by an unreliable synaptic connection that thresholds threat information integrated in the medial superior colliculus, and controls activation of dorsal periaqueductal grey neurons.

    • Dominic A. Evans
    • , A. Vanessa Stempel
    • , Ruben Vale
    • , Sabine Ruehle
    • , Yaara Lefler
    •  & Tiago Branco
  • Letter |

    Specular scattering of atoms of helium gas flowing through atomically flat, two-dimensional channels results in frictionless gas flow, which is much faster than expected assuming purely diffusive scattering.

    • A. Keerthi
    • , A. K. Geim
    • , A. Janardanan
    • , A. P. Rooney
    • , A. Esfandiar
    • , S. Hu
    • , S. A. Dar
    • , I. V. Grigorieva
    • , S. J. Haigh
    • , F. C. Wang
    •  & B. Radha
  • Letter |

    Pancreatic ductal adenocarcinoma in mice induces loss of adipose tissue through altered function of the exocrine pancreas, and supplementing pancreatic enzymes attenuates the wasting of peripheral tissues induced by pancreatic cancer.

    • Laura V. Danai
    • , Ana Babic
    • , Michael H. Rosenthal
    • , Emily A. Dennstedt
    • , Alexander Muir
    • , Evan C. Lien
    • , Jared R. Mayers
    • , Karen Tai
    • , Allison N. Lau
    • , Paul Jones-Sali
    • , Carla M. Prado
    • , Gloria M. Petersen
    • , Naoki Takahashi
    • , Motokazu Sugimoto
    • , Jen Jen Yeh
    • , Nicole Lopez
    • , Nabeel Bardeesy
    • , Carlos Fernandez-del Castillo
    • , Andrew S. Liss
    • , Albert C. Koong
    • , Justin Bui
    • , Chen Yuan
    • , Marisa W. Welch
    • , Lauren K. Brais
    • , Matthew H. Kulke
    • , Courtney Dennis
    • , Clary B. Clish
    • , Brian M. Wolpin
    •  & Matthew G. Vander Heiden
  • Article |

    Relocalization of heterochromatic double-strand breaks to the nuclear periphery in Drosophila cells occurs via directed motions driven by nuclear actin filaments and myosins activated by the Smc5/6 complex.

    • Christopher P. Caridi
    • , Carla D’Agostino
    • , Taehyun Ryu
    • , Grzegorz Zapotoczny
    • , Laetitia Delabaere
    • , Xiao Li
    • , Varandt Y. Khodaverdian
    • , Nuno Amaral
    • , Emily Lin
    • , Alesandra R. Rau
    •  & Irene Chiolo
  • Letter |

    Viperin inhibits the replication of various viruses by catalysing the conversion of CTP to ddhCTP, which is a unique nucleotide that functions as replication-chain terminator of RNA-dependent RNA polymerases.

    • Anthony S. Gizzi
    • , Tyler L. Grove
    • , Jamie J. Arnold
    • , Joyce Jose
    • , Rohit K. Jangra
    • , Scott J. Garforth
    • , Quan Du
    • , Sean M. Cahill
    • , Natalya G. Dulyaninova
    • , James D. Love
    • , Kartik Chandran
    • , Anne R. Bresnick
    • , Craig E. Cameron
    •  & Steven C. Almo
  • Letter |

    Single-cell transcriptomics reveals that, in mice and humans, a population of cells in the stromal vascular fraction of adipose tissue regulates adipogenesis by suppressing adipocyte formation in a paracrine manner.

    • Petra C. Schwalie
    • , Hua Dong
    • , Magda Zachara
    • , Julie Russeil
    • , Daniel Alpern
    • , Nassila Akchiche
    • , Christian Caprara
    • , Wenfei Sun
    • , Kai-Uwe Schlaudraff
    • , Gianni Soldati
    • , Christian Wolfrum
    •  & Bart Deplancke
  • Letter |

    Observations of two absorbers of highly ionized oxygen in the X-ray spectrum of a quasar account for the missing baryons in the Universe.

    • F. Nicastro
    • , J. Kaastra
    • , Y. Krongold
    • , S. Borgani
    • , E. Branchini
    • , R. Cen
    • , M. Dadina
    • , C. W. Danforth
    • , M. Elvis
    • , F. Fiore
    • , A. Gupta
    • , S. Mathur
    • , D. Mayya
    • , F. Paerels
    • , L. Piro
    • , D. Rosa-Gonzalez
    • , J. Schaye
    • , J. M. Shull
    • , J. Torres-Zafra
    • , N. Wijers
    •  & L. Zappacosta
  • Letter |

    • James D. Phelan
    • , Ryan M. Young
    • , Daniel E. Webster
    • , Sandrine Roulland
    • , George W. Wright
    • , Monica Kasbekar
    • , Arthur L. Shaffer III
    • , Michele Ceribelli
    • , James Q. Wang
    • , Roland Schmitz
    • , Masao Nakagawa
    • , Emmanuel Bachy
    • , Da Wei Huang
    • , Yanlong Ji
    • , Lu Chen
    • , Yandan Yang
    • , Hong Zhao
    • , Xin Yu
    • , Weihong Xu
    • , Maryknoll M. Palisoc
    • , Racquel R. Valadez
    • , Theresa Davies-Hill
    • , Wyndham H. Wilson
    • , Wing C. Chan
    • , Elaine S. Jaffe
    • , Randy D. Gascoyne
    • , Elias Campo
    • , Andreas Rosenwald
    • , German Ott
    • , Jan Delabie
    • , Lisa M. Rimsza
    • , Fausto J. Rodriguez
    • , Fayez Estephan
    • , Matthias Holdhoff
    • , Michael J. Kruhlak
    • , Stephen M. Hewitt
    • , Craig J. Thomas
    • , Stefania Pittaluga
    • , Thomas Oellerich
    •  & Louis M. Staudt