Latest Research

  • Letter |

    The interphase centrosome protein AKNA is necessary and sufficient for the organization of centrosomal microtubules, mediates delamination in the formation of the subventricular zone and regulates exit from this zone.

    • Germán Camargo Ortega
    • , Sven Falk
    • , Pia A. Johansson
    • , Elise Peyre
    • , Loïc Broix
    • , Sanjeeb Kumar Sahu
    • , William Hirst
    • , Thomas Schlichthaerle
    • , Camino De Juan Romero
    • , Kalina Draganova
    • , Stanislav Vinopal
    • , Kaviya Chinnappa
    • , Anna Gavranovic
    • , Tugay Karakaya
    • , Thomas Steininger
    • , Juliane Merl-Pham
    • , Regina Feederle
    • , Wei Shao
    • , Song-Hai Shi
    • , Stefanie M. Hauck
    • , Ralf Jungmann
    • , Frank Bradke
    • , Victor Borrell
    • , Arie Geerlof
    • , Simone Reber
    • , Vijay K. Tiwari
    • , Wieland B. Huttner
    • , Michaela Wilsch-Bräuninger
    • , Laurent Nguyen
    •  & Magdalena Götz
  • Retraction |

    • Heba Samaha
    • , Antonella Pignata
    • , Kristen Fousek
    • , Jun Ren
    • , Fong W. Lam
    • , Fabio Stossi
    • , Julien Dubrulle
    • , Vita S. Salsman
    • , Shanmugarajan Krishnan
    • , Sung-Ha Hong
    • , Matthew L. Baker
    • , Ankita Shree
    • , Ahmed Z. Gad
    • , Thomas Shum
    • , Dai Fukumura
    • , Tiara T. Byrd
    • , Malini Mukherjee
    • , Sean P. Marrelli
    • , Jordan S. Orange
    • , Sujith K. Joseph
    • , Poul H. Sorensen
    • , Michael D. Taylor
    • , Meenakshi Hegde
    • , Maksim Mamonkin
    • , Rakesh K. Jain
    • , Shahenda El-Naggar
    •  & Nabil Ahmed
  • Author Correction |

    • Axel Timmermann
    • , Soon-Il An
    • , Jong-Seong Kug
    • , Fei-Fei Jin
    • , Wenju Cai
    • , Antonietta Capotondi
    • , Kim M. Cobb
    • , Matthieu Lengaigne
    • , Michael J. McPhaden
    • , Malte F. Stuecker
    • , Karl Stein
    • , Andrew T. Wittenberg
    • , Kyung-Sook Yun
    • , Tobias Bayr
    • , Han-Ching Chen
    • , Yoshimitsu Chikamoto
    • , Boris Dewitte
    • , Dietmar Dommenget
    • , Pamela Grothe
    • , Eric Guilyardi
    • , Yoo-Geun Ham
    • , Michiya Hayashi
    • , Sarah Ineson
    • , Daehyun Kang
    • , Sunyong Kim
    • , WonMoo Kim
    • , June-Yi Lee
    • , Tim Li
    • , Jing-Jia Luo
    • , Shayne McGregor
    • , Yann Planton
    • , Scott Power
    • , Harun Rashid
    • , Hong-Li Ren
    • , Agus Santoso
    • , Ken Takahashi
    • , Alexander Todd
    • , Guomin Wang
    • , Guojian Wang
    • , Ruihuang Xie
    • , Woo-Hyun Yang
    • , Sang-Wook Yeh
    • , Jinho Yoon
    • , Elke Zeller
    •  & Xuebin Zhang
  • Article |

    A bacterial family of cGAS/DncV-like nucleotidyltransferases synthesizes a diverse range of cyclic dinucleotide and trinucleotide compounds that are likely to modulate the interaction of both pathogens and commensal microbiota with their animal and plant hosts.

    • Aaron T. Whiteley
    • , James B. Eaglesham
    • , Carina C. de Oliveira Mann
    • , Benjamin R. Morehouse
    • , Brianna Lowey
    • , Eric A. Nieminen
    • , Olga Danilchanka
    • , David S. King
    • , Amy S. Y. Lee
    • , John J. Mekalanos
    •  & Philip J. Kranzusch
  • Letter |

    Simultaneous high-precision measurements of the EMC effect and short-range correlated abundances for several nuclei reveal a universal modification of the structure of nucleons in short-range correlated neutron–proton pairs.

    • B. Schmookler
    • , M. Duer
    • , A. Schmidt
    • , O. Hen
    • , S. Gilad
    • , E. Piasetzky
    • , M. Strikman
    • , L. B. Weinstein
    • , S. Adhikari
    • , M. Amaryan
    • , A. Ashkenazi
    • , H. Avakian
    • , J. Ball
    • , I. Balossino
    • , L. Barion
    • , M. Bashkanov
    • , M. Battaglieri
    • , A. Beck
    • , I. Bedlinskiy
    • , A. S. Biselli
    • , S. Boiarinov
    • , W. J. Briscoe
    • , W. K. Brooks
    • , V. D. Burkert
    • , D. S. Carman
    • , A. Celentano
    • , G. Charles
    • , T. Chetry
    • , G. Ciullo
    • , E. Cohen
    • , P. L. Cole
    • , V. Crede
    • , R. Cruz-Torres
    • , A. D’Angelo
    • , N. Dashyan
    • , E. De Sanctis
    • , R. De Vita
    • , A. Deur
    • , S. Diehl
    • , C. Djalali
    • , R. Dupre
    • , H. Egiyan
    • , L. El Fassi
    • , L. Elouadrhiri
    • , P. Eugenio
    • , G. Fedotov
    • , R. Fersch
    • , A. Filippi
    • , T. A. Forest
    • , G. Gavalian
    • , G. P. Gilfoyle
    • , F. X. Girod
    • , E. Golovatch
    • , R. W. Gothe
    • , K. A. Griffioen
    • , M. Guidal
    • , L. Guo
    • , K. Hafidi
    • , H. Hakobyan
    • , C. Hanretty
    • , N. Harrison
    • , F. Hauenstein
    • , T. B. Hayward
    • , K. Hicks
    • , D. Higinbotham
    • , M. Holtrop
    • , C. E. Hyde
    • , Y. Ilieva
    • , D. G. Ireland
    • , B. S. Ishkhanov
    • , E. L. Isupov
    • , H.-S. Jo
    • , S. Johnston
    • , K. Joo
    • , S. Joosten
    • , M. L. Kabir
    • , D. Keller
    • , G. Khachatryan
    • , M. Khachatryan
    • , M. Khandaker
    • , A. Kim
    • , W. Kim
    • , A. Klein
    • , F. J. Klein
    • , I. Korover
    • , V. Kubarovsky
    • , S. E. Kuhn
    • , S. V. Kuleshov
    • , L. Lanza
    • , G. Laskaris
    • , P. Lenisa
    • , K. Livingston
    • , I. J. D. MacGregor
    • , N. Markov
    • , B. McKinnon
    • , S. Mey-Tal Beck
    • , T. Mineeva
    • , M. Mirazita
    • , V. Mokeev
    • , R. A. Montgomery
    • , C. Munoz Camacho
    • , B. Mustapha
    • , S. Niccolai
    • , M. Osipenko
    • , A. I. Ostrovidov
    • , M. Paolone
    • , R. Paremuzyan
    • , K. Park
    • , E. Pasyuk
    • , M. Patsyuk
    • , O. Pogorelko
    • , J. W. Price
    • , Y. Prok
    • , D. Protopopescu
    • , M. Ripani
    • , D. Riser
    • , A. Rizzo
    • , G. Rosner
    • , P. Rossi
    • , F. Sabatié
    • , C. Salgado
    • , R. A. Schumacher
    • , E. P. Segarra
    • , Y. G. Sharabian
    • , I. U. Skorodumina
    • , D. Sokhan
    • , N. Sparveris
    • , S. Stepanyan
    • , S. Strauch
    • , M. Taiuti
    • , J. A. Tan
    • , M. Ungaro
    • , H. Voskanyan
    • , E. Voutier
    • , D. P. Watts
    • , X. Wei
    • , M. Wood
    • , N. Zachariou
    • , J. Zhang
    • , Z. W. Zhao
    •  & X. Zheng
  • Letter |

    Hubble Space Telescope observations of the seventh inner moon of Neptune, Hippocamp, show that it is smaller than the other six, orbits near Proteus and probably originates from a fragment of Proteus.

    • M. R. Showalter
    • , I. de Pater
    • , J. J. Lissauer
    •  & R. S. French
  • Article |

    In a rat model of multiple sclerosis, β-synuclein-specific T cells induce inflammation and pathological changes in the grey matter of the central nervous system; these cells were also found in higher numbers in patients with multiple sclerosis, particularly those with a chronic progressive course.

    • Dmitri Lodygin
    • , Moritz Hermann
    • , Nils Schweingruber
    • , Cassandra Flügel-Koch
    • , Takashi Watanabe
    • , Corinna Schlosser
    • , Arianna Merlini
    • , Henrike Körner
    • , Hsin-Fang Chang
    • , Henrike J. Fischer
    • , Holger M. Reichardt
    • , Marta Zagrebelsky
    • , Brit Mollenhauer
    • , Sebastian Kügler
    • , Dirk Fitzner
    • , Jens Frahm
    • , Christine Stadelmann
    • , Michael Haberl
    • , Francesca Odoardi
    •  & Alexander Flügel
  • Article |

    Single-cell profiling is used to create a molecular-level atlas of cell differentiation trajectories during gastrulation and early organogenesis in the mouse.

    • Blanca Pijuan-Sala
    • , Jonathan A. Griffiths
    • , Carolina Guibentif
    • , Tom W. Hiscock
    • , Wajid Jawaid
    • , Fernando J. Calero-Nieto
    • , Carla Mulas
    • , Ximena Ibarra-Soria
    • , Richard C. V. Tyser
    • , Debbie Lee Lian Ho
    • , Wolf Reik
    • , Shankar Srinivas
    • , Benjamin D. Simons
    • , Jennifer Nichols
    • , John C. Marioni
    •  & Berthold Göttgens
  • Article |

    Data from single-cell combinatorial-indexing RNA-sequencing analysis of 2 million cells from mouse embryos between embryonic days 9.5 and 13.5 are compiled in a cell atlas of mouse organogenesis, which provides a global view of developmental processes occurring during this critical period.

    • Junyue Cao
    • , Malte Spielmann
    • , Xiaojie Qiu
    • , Xingfan Huang
    • , Daniel M. Ibrahim
    • , Andrew J. Hill
    • , Fan Zhang
    • , Stefan Mundlos
    • , Lena Christiansen
    • , Frank J. Steemers
    • , Cole Trapnell
    •  & Jay Shendure
  • Letter |

    Genomic instability, caused by MCM mutations, results in embryonic lethality that disproportionally affects female mouse embryos and is rescued by testosterone or ibuprofen treatment, both of which ameliorate inflammatory effects.

    • Adrian J. McNairn
    • , Chen-Hua Chuang
    • , Jordana C. Bloom
    • , Marsha D. Wallace
    •  & John C. Schimenti
  • Letter |

    The DR isotype of the human leukocyte antigen of the MHC class II—or its homologues in bats, pigs, mice and chickens—is an essential cell entry determinant for bat influenza A viruses.

    • Umut Karakus
    • , Thiprampai Thamamongood
    • , Kevin Ciminski
    • , Wei Ran
    • , Sira C. Günther
    • , Marie O. Pohl
    • , Davide Eletto
    • , Csaba Jeney
    • , Donata Hoffmann
    • , Sven Reiche
    • , Jan Schinköthe
    • , Reiner Ulrich
    • , Julius Wiener
    • , Michael G. B. Hayes
    • , Max W. Chang
    • , Annika Hunziker
    • , Emilio Yángüez
    • , Teresa Aydillo
    • , Florian Krammer
    • , Josua Oderbolz
    • , Matthias Meier
    • , Annette Oxenius
    • , Anne Halenius
    • , Gert Zimmer
    • , Christopher Benner
    • , Benjamin G. Hale
    • , Adolfo García-Sastre
    • , Martin Beer
    • , Martin Schwemmle
    •  & Silke Stertz
  • Letter |

    A spatially oscillating two-dimensional waveguide array is used to realize a photonic topological insulator in synthetic dimensions with modal-space edge states, unidirectionality and robust topological protection.

    • Eran Lustig
    • , Steffen Weimann
    • , Yonatan Plotnik
    • , Yaakov Lumer
    • , Miguel A. Bandres
    • , Alexander Szameit
    •  & Mordechai Segev
  • Letter |

    A strategy using droplet-based and barcode-linked sequencing captures multiplex chromatin interactions at single-molecule precision, and here provides topological insight into chromatin structures and transcription in Drosophila.

    • Meizhen Zheng
    • , Simon Zhongyuan Tian
    • , Daniel Capurso
    • , Minji Kim
    • , Rahul Maurya
    • , Byoungkoo Lee
    • , Emaly Piecuch
    • , Liang Gong
    • , Jacqueline Jufen Zhu
    • , Zhihui Li
    • , Chee Hong Wong
    • , Chew Yee Ngan
    • , Ping Wang
    • , Xiaoan Ruan
    • , Chia-Lin Wei
    •  & Yijun Ruan
  • Letter |

    The pattern of electrical resistivity in an unconventional superconductor at high magnetic fields and low temperatures across the nematic quantum critical point reveals two classic signatures of quantum criticality.

    • S. Licciardello
    • , J. Buhot
    • , J. Lu
    • , J. Ayres
    • , S. Kasahara
    • , Y. Matsuda
    • , T. Shibauchi
    •  & N. E. Hussey
  • Letter |

    Many clonotypes in human B cell repertoires are shared, including between adult and umbilical cord blood repertoires, which indicates that this similarity is not driven only by exposure to common antigens.

    • Cinque Soto
    • , Robin G. Bombardi
    • , Andre Branchizio
    • , Nurgun Kose
    • , Pranathi Matta
    • , Alexander M. Sevy
    • , Robert S. Sinkovits
    • , Pavlo Gilchuk
    • , Jessica A. Finn
    •  & James E. Crowe Jr
  • Letter |

    Analyses of the output produced by large versus small teams of researchers and innovators demonstrate that their work differs systematically in the extent to which it disrupts or develops existing science and technology.

    • Lingfei Wu
    • , Dashun Wang
    •  & James A. Evans
  • Perspective |

    Complex Earth system challenges can be addressed by incorporating spatial and temporal context into machine learning, especially via deep learning, and further by combining with physical models into hybrid models.

    • Markus Reichstein
    • , Gustau Camps-Valls
    • , Bjorn Stevens
    • , Martin Jung
    • , Joachim Denzler
    • , Nuno Carvalhais
    •  &  Prabhat
  • Letter |

    The ancestral tribosphenic therian chewing stroke is conserved in Monodelphis domestica, and couples tooth-row eversion and inversion in jaw opening and closing, respectively, with a rotational grinding stroke.

    • Bhart-Anjan S. Bhullar
    • , Armita R. Manafzadeh
    • , Juri A. Miyamae
    • , Eva A. Hoffman
    • , Elizabeth L. Brainerd
    • , Catherine Musinsky
    •  & Alfred W. Crompton
  • Letter |

    The ‘negative luminescence’ of a reverse-biased photodiode is harnessed to draw thermal energy from a nearby solid object, thereby realizing photonic cooling without the use of coherent laser radiation.

    • Linxiao Zhu
    • , Anthony Fiorino
    • , Dakotah Thompson
    • , Rohith Mittapally
    • , Edgar Meyhofer
    •  & Pramod Reddy
  • Letter |

    Analyses at single-cell resolution show that diverse subtypes of microglia exist during development and homeostasis of the central nervous system, and identify specific subsets of microglia associated with demyelination and neurodegenerative disease in mice and humans.

    • Takahiro Masuda
    • , Roman Sankowski
    • , Ori Staszewski
    • , Chotima Böttcher
    • , Lukas Amann
    • , Christian Scheiwe
    • , Stefan Nessler
    • , Patrik Kunz
    • , Geert van Loo
    • , Volker Arnd Coenen
    • , Peter Christoph Reinacher
    • , Anna Michel
    • , Ulrich Sure
    • , Ralf Gold
    • , Josef Priller
    • , Christine Stadelmann
    •  & Marco Prinz
  • Article |

    Bilateral sensory stimulation, which is used to treat post-traumatic stress disorder in humans, alleviates fear memory in mice through a circuit involving the superior colliculus and the medial thalamus.

    • Jinhee Baek
    • , Sukchan Lee
    • , Taesup Cho
    • , Seong-Wook Kim
    • , Minsoo Kim
    • , Yongwoo Yoon
    • , Ko Keun Kim
    • , Junweon Byun
    • , Sang Jeong Kim
    • , Jaeseung Jeong
    •  & Hee-Sup Shin
  • Letter |

    Singlet molecular oxygen, produced by indoleamine 2,3-dioxygenase 1 activity, gives rise to a signalling molecule that regulates arterial relaxation under inflammatory conditions.

    • Christopher P. Stanley
    • , Ghassan J. Maghzal
    • , Anita Ayer
    • , Jihan Talib
    • , Andrew M. Giltrap
    • , Sudhir Shengule
    • , Kathryn Wolhuter
    • , Yutang Wang
    • , Preet Chadha
    • , Cacang Suarna
    • , Oleksandra Prysyazhna
    • , Jenna Scotcher
    • , Louise L. Dunn
    • , Fernanda M. Prado
    • , Nghi Nguyen
    • , Jephthah O. Odiba
    • , Jonathan B. Baell
    • , Johannes-Peter Stasch
    • , Yorihiro Yamamoto
    • , Paolo Di Mascio
    • , Philip Eaton
    • , Richard J. Payne
    •  & Roland Stocker
  • Article |

    Islet non-β-cells from non-diabetic and diabetic human donors are modified via the transcription factors PDX1 and MAFA to produce and secrete insulin in response to glucose.

    • Kenichiro Furuyama
    • , Simona Chera
    • , Léon van Gurp
    • , Daniel Oropeza
    • , Luiza Ghila
    • , Nicolas Damond
    • , Heidrun Vethe
    • , Joao A. Paulo
    • , Antoinette M. Joosten
    • , Thierry Berney
    • , Domenico Bosco
    • , Craig Dorrell
    • , Markus Grompe
    • , Helge Ræder
    • , Bart O. Roep
    • , Fabrizio Thorel
    •  & Pedro L. Herrera
  • Letter |

    The authors find that loss of squalene monooxygenase expression alters the lipid metabolism of cancer cells, which confers protection from ferroptotic cell death and thus promotes tumour growth.

    • Javier Garcia-Bermudez
    • , Lou Baudrier
    • , Erol Can Bayraktar
    • , Yihui Shen
    • , Konnor La
    • , Rohiverth Guarecuco
    • , Burcu Yucel
    • , Danilo Fiore
    • , Bernardo Tavora
    • , Elizaveta Freinkman
    • , Sze Ham Chan
    • , Caroline Lewis
    • , Wei Min
    • , Giorgio Inghirami
    • , David M. Sabatini
    •  & Kıvanç Birsoy
  • Letter |

    Measurements of the specific heat of two cuprate materials at low temperature in magnetic fields large enough to suppress superconductivity and over a wide doping range reveal that the pseudogap phase of cuprates ends at a quantum critical point.

    • B. Michon
    • , C. Girod
    • , S. Badoux
    • , J. Kačmarčík
    • , Q. Ma
    • , M. Dragomir
    • , H. A. Dabkowska
    • , B. D. Gaulin
    • , J.-S. Zhou
    • , S. Pyon
    • , T. Takayama
    • , H. Takagi
    • , S. Verret
    • , N. Doiron-Leyraud
    • , C. Marcenat
    • , L. Taillefer
    •  & T. Klein
  • Article |

    Convergent estimates of nitrogen fixation from an inverse biogeochemical and a prognostic ocean model show that biological carbon export in the ocean is higher than expected and that stabilizing nitrogen-cycle feedbacks are weaker than we thought.

    • Wei-Lei Wang
    • , J. Keith Moore
    • , Adam C. Martiny
    •  & François W. Primeau
  • Letter |

    The fragmentation of sleep in Apoe−/− mice induces monocytosis and accelerated atherosclerosis due to a reduction in hypocretin that otherwise restricts bone marrow CSF1 availability.

    • Cameron S. McAlpine
    • , Máté G. Kiss
    • , Sara Rattik
    • , Shun He
    • , Anne Vassalli
    • , Colin Valet
    • , Atsushi Anzai
    • , Christopher T. Chan
    • , John E. Mindur
    • , Florian Kahles
    • , Wolfram C. Poller
    • , Vanessa Frodermann
    • , Ashley M. Fenn
    • , Annemijn F. Gregory
    • , Lennard Halle
    • , Yoshiko Iwamoto
    • , Friedrich F. Hoyer
    • , Christoph J. Binder
    • , Peter Libby
    • , Mehdi Tafti
    • , Thomas E. Scammell
    • , Matthias Nahrendorf
    •  & Filip K. Swirski
  • Publisher Correction |

    • François-Xavier Weill
    • , Daryl Domman
    • , Elisabeth Njamkepo
    • , Abdullrahman A. Almesbahi
    • , Mona Naji
    • , Samar Saeed Nasher
    • , Ankur Rakesh
    • , Abdullah M. Assiri
    • , Naresh Chand Sharma
    • , Samuel Kariuki
    • , Mohammad Reza Pourshafie
    • , Jean Rauzier
    • , Abdinasir Abubakar
    • , Jane Y. Carter
    • , Joseph F. Wamala
    • , Caroline Seguin
    • , Christiane Bouchier
    • , Thérèse Malliavin
    • , Bita Bakhshi
    • , Hayder H. N. Abulmaali
    • , Dhirendra Kumar
    • , Samuel M. Njoroge
    • , Mamunur Rahman Malik
    • , John Kiiru
    • , Francisco J. Luquero
    • , Andrew S. Azman
    • , Thandavarayan Ramamurthy
    • , Nicholas R. Thomson
    •  & Marie-Laure Quilici
  • Author Correction |

    • David M. Hyman
    • , Sarina A. Piha-Paul
    • , Helen Won
    • , Jordi Rodon
    • , Cristina Saura
    • , Geoffrey I. Shapiro
    • , Dejan Juric
    • , David I. Quinn
    • , Victor Moreno
    • , Bernard Doger
    • , Ingrid A. Mayer
    • , Valentina Boni
    • , Emiliano Calvo
    • , Sherene Loi
    • , Albert C. Lockhart
    • , Joseph P. Erinjeri
    • , Maurizio Scaltriti
    • , Gary A. Ulaner
    • , Juber Patel
    • , Jiabin Tang
    • , Hannah Beer
    • , S. Duygu Selcuklu
    • , Aphrothiti J. Hanrahan
    • , Nancy Bouvier
    • , Myra Melcer
    • , Rajmohan Murali
    • , Alison M. Schram
    • , Lillian M. Smyth
    • , Komal Jhaveri
    • , Bob T. Li
    • , Alexander Drilon
    • , James J. Harding
    • , Gopa Iyer
    • , Barry S. Taylor
    • , Michael F. Berger
    • , Richard E. Cutler Jr
    • , Feng Xu
    • , Anna Butturini
    • , Lisa D. Eli
    • , Grace Mann
    • , Cynthia Farrell
    • , Alshad S. Lalani
    • , Richard P. Bryce
    • , Carlos L. Arteaga
    • , Funda Meric-Bernstam
    • , José Baselga
    •  & David B. Solit
  • Letter |

    Evidence from hippocampal place cells shows that path-integration gain, previously thought to be a constant factor in the computation of location, is flexible and can be rapidly fine-tuned.

    • Ravikrishnan P. Jayakumar
    • , Manu S. Madhav
    • , Francesco Savelli
    • , Hugh T. Blair
    • , Noah J. Cowan
    •  & James J. Knierim
  • Author Correction |

    • Simone L. Park
    • , Anthony Buzzai
    • , Jai Rautela
    • , Jyh Liang Hor
    • , Katharina Hochheiser
    • , Maike Effern
    • , Nathan McBain
    • , Teagan Wagner
    • , Jarem Edwards
    • , Robyn McConville
    • , James S. Wilmott
    • , Richard A. Scolyer
    • , Thomas Tüting
    • , Umaimainthan Palendira
    • , David Gyorki
    • , Scott N. Mueller
    • , Nicholas D. Huntington
    • , Sammy Bedoui
    • , Michael Hölzel
    • , Laura K. Mackay
    • , Jason Waithman
    •  & Thomas Gebhardt
  • Letter |

    Angle-resolved photoemission spectroscopy is used to characterize the surface states of bismuth iodide, providing experimental evidence of a weak topological insulator state that had previously been only theoretically predicted.

    • Ryo Noguchi
    • , T. Takahashi
    • , K. Kuroda
    • , M. Ochi
    • , T. Shirasawa
    • , M. Sakano
    • , C. Bareille
    • , M. Nakayama
    • , M. D. Watson
    • , K. Yaji
    • , A. Harasawa
    • , H. Iwasawa
    • , P. Dudin
    • , T. K. Kim
    • , M. Hoesch
    • , V. Kandyba
    • , A. Giampietri
    • , A. Barinov
    • , S. Shin
    • , R. Arita
    • , T. Sasagawa
    •  & Takeshi Kondo
  • Article | | open

    The known species repertoire of the collective human gut microbiota is substantially expanded with the discovery of 1,952 uncultured bacterial species that greatly improve classification of understudied African and South American samples.

    • Alexandre Almeida
    • , Alex L. Mitchell
    • , Miguel Boland
    • , Samuel C. Forster
    • , Gregory B. Gloor
    • , Aleksandra Tarkowska
    • , Trevor D. Lawley
    •  & Robert D. Finn
  • Publisher Correction |

    • Norbert Hilf
    • , Sabrina Kuttruff-Coqui
    • , Katrin Frenzel
    • , Valesca Bukur
    • , Stefan Stevanović
    • , Cecile Gouttefangeas
    • , Michael Platten
    • , Ghazaleh Tabatabai
    • , Valerie Dutoit
    • , Sjoerd H. van der Burg
    • , Per thor Straten
    • , Francisco Martinez-Ricarte
    • , Berta Ponsati
    • , Hideho Okada
    • , Ulrik Lassen
    • , Arie Admon
    • , Christian H. Ottensmeier
    • , Alexander Ulges
    • , Sebastian Kreiter
    • , Andreas von Deimling
    • , Marco Skardelly
    • , Denis Migliorini
    • , Judith R. Kroep
    • , Manja Idorn
    • , Jordi Rodon
    • , Jordi Piro
    • , Hans S. Poulsen
    • , Bracha Shraibman
    • , Katy McCann
    • , Regina Mendrzyk
    • , Martin Lower
    • , Monika Stieglbauer
    • , Cedrik M. Britten
    • , David Capper
    • , Marij J. P. Welters
    • , Juan Sahuquillo
    • , Katharina Kiesel
    • , Evelyna Derhovanessian
    • , Elisa Rusch
    • , Lukas Bunse
    • , Colette Song
    • , Sandra Heesch
    • , Claudia Wagner
    • , Alexandra Kemmer-Bruck
    • , Jorg Ludwig
    • , John C. Castle
    • , Oliver Schoor
    • , Arbel D. Tadmor
    • , Edward Green
    • , Jens Fritsche
    • , Miriam Meyer
    • , Nina Pawlowski
    • , Sonja Dorner
    • , Franziska Hoffgaard
    • , Bernhard Rossler
    • , Dominik Maurer
    • , Toni Weinschenk
    • , Carsten Reinhardt
    • , Christoph Huber
    • , Hans-Georg Rammensee
    • , Harpreet Singh-Jasuja
    • , Ugur Sahin
    • , Pierre-Yves Dietrich
    •  & Wolfgang Wick
  • Article |

    Increased meltwater from the Greenland and Antarctic ice sheets will slow the Atlantic overturning circulation and warm the subsurface ocean around Antarctica, further increasing Antarctic ice loss.

    • Nicholas R. Golledge
    • , Elizabeth D. Keller
    • , Natalya Gomez
    • , Kaitlin A. Naughten
    • , Jorge Bernales
    • , Luke D. Trusel
    •  & Tamsin L. Edwards
  • Letter |

    The authors show that circulating tumour cells can be found in association with neutrophils, an interaction which supports their proliferation and their ability to seed metastasis.

    • Barbara Maria Szczerba
    • , Francesc Castro-Giner
    • , Marcus Vetter
    • , Ilona Krol
    • , Sofia Gkountela
    • , Julia Landin
    • , Manuel C. Scheidmann
    • , Cinzia Donato
    • , Ramona Scherrer
    • , Jochen Singer
    • , Christian Beisel
    • , Christian Kurzeder
    • , Viola Heinzelmann-Schwarz
    • , Christoph Rochlitz
    • , Walter Paul Weber
    • , Niko Beerenwinkel
    •  & Nicola Aceto
  • Letter |

    Scanning tunnelling microscopy shows that 1D channels between quantum Hall states with different valley polarization are metallic or insulating depending on constraints imposed on electron–electron interaction by valley flavour.

    • Mallika T. Randeria
    • , Kartiek Agarwal
    • , Benjamin E. Feldman
    • , Hao Ding
    • , Huiwen Ji
    • , R. J. Cava
    • , S. L. Sondhi
    • , Siddharth A. Parameswaran
    •  & Ali Yazdani
  • Article |

    By better quantifying uncertainties for marine ice-cliff instability, future Antarctic ice loss is predicted to be much lower than previously estimated.

    • Tamsin L. Edwards
    • , Mark A. Brandon
    • , Gael Durand
    • , Neil R. Edwards
    • , Nicholas R. Golledge
    • , Philip B. Holden
    • , Isabel J. Nias
    • , Antony J. Payne
    • , Catherine Ritz
    •  & Andreas Wernecke
  • Letter |

    In experimentally induced osteoarthritis, chondrocytes show increased uptake and metabolism of cholesterol, implicating the CH25H–CYP7B1–RORα axis in the pathogenesis of osteoarthritis.

    • Wan-Su Choi
    • , Gyuseok Lee
    • , Won-Hyun Song
    • , Jeong-Tae Koh
    • , Jiye Yang
    • , Ji-Sun Kwak
    • , Hyo-Eun Kim
    • , Seul Ki Kim
    • , Young-Ok Son
    • , Hojung Nam
    • , Iljung Jin
    • , Zee-Yong Park
    • , Jiyeon Kim
    • , In Young Park
    • , Jeong-Im Hong
    • , Hyun Ah Kim
    • , Churl-Hong Chun
    • , Je-Hwang Ryu
    •  & Jang-Soo Chun
  • Article |

    During cellular senescence in human and mouse cells, L1 transposons become transcriptionally derepressed and trigger a type-1 interferon response, which contributes to age-associated inflammation and age-related phenotypes.

    • Marco De Cecco
    • , Takahiro Ito
    • , Anna P. Petrashen
    • , Amy E. Elias
    • , Nicholas J. Skvir
    • , Steven W. Criscione
    • , Alberto Caligiana
    • , Greta Brocculi
    • , Emily M. Adney
    • , Jef D. Boeke
    • , Oanh Le
    • , Christian Beauséjour
    • , Jayakrishna Ambati
    • , Kameshwari Ambati
    • , Matthew Simon
    • , Andrei Seluanov
    • , Vera Gorbunova
    • , P. Eline Slagboom
    • , Stephen L. Helfand
    • , Nicola Neretti
    •  & John M. Sedivy