Latest Research

  • Letter |

    Laboratory experiments with the brine shrimp Artemia salina illustrate the potential for turbulence generated by the diurnal vertical migrations of aggregations of centimetre-scale zooplankton to affect the physical and biogeochemical structure of oceanic water columns.

    • Isabel A. Houghton
    • , Jeffrey R. Koseff
    • , Stephen G. Monismith
    •  & John O. Dabiri
  • Letter |

    A way of integrating photonics with silicon nanoelectronics is described, using polycrystalline silicon on glass islands alongside transistors on bulk silicon complementary metal–oxide–semiconductor chips.

    • Amir H. Atabaki
    • , Sajjad Moazeni
    • , Fabio Pavanello
    • , Hayk Gevorgyan
    • , Jelena Notaros
    • , Luca Alloatti
    • , Mark T. Wade
    • , Chen Sun
    • , Seth A. Kruger
    • , Huaiyu Meng
    • , Kenaish Al Qubaisi
    • , Imbert Wang
    • , Bohan Zhang
    • , Anatol Khilo
    • , Christopher V. Baiocco
    • , Miloš A. Popović
    • , Vladimir M. Stojanović
    •  & Rajeev J. Ram
  • Article |

    Laser spectroscopy is used to investigate the hyperfine structure and determine the fundamental nuclear properties of the isomer 229mTh, the strongest candidate for the realization of a nuclear clock.

    • Johannes Thielking
    • , Maxim V. Okhapkin
    • , Przemysław Głowacki
    • , David M. Meier
    • , Lars von der Wense
    • , Benedict Seiferle
    • , Christoph E. Düllmann
    • , Peter G. Thirolf
    •  & Ekkehard Peik
  • Letter |

    Binding of an ES cell-specific transcription factor pre-marks cell-type-restricted enhancers in ES cells, and this premarking is required for the robustness of enhancer activation in differentiated cells.

    • Hong Sook Kim
    • , Yuliang Tan
    • , Wubin Ma
    • , Daria Merkurjev
    • , Eugin Destici
    • , Qi Ma
    • , Tom Suter
    • , Kenneth Ohgi
    • , Meyer Friedman
    • , Dorota Skowronska-Krawczyk
    •  & Michael G. Rosenfeld
  • Letter |

    Observations of NGC 6240 show two differently driven outflows of different gases with a combined outflow rate comparable to the star formation rate, suggesting possible negative feedback on star formation.

    • F. Müller-Sánchez
    • , R. Nevin
    • , J. M. Comerford
    • , R. I. Davies
    • , G. C. Privon
    •  & E. Treister
  • Letter |

    A high-resolution X-ray structure and molecular dynamics simulations of the N-methyl-d-aspartate receptor in complexes with channel-blocking ligands reveals the molecular basis of the ligand binding and channel block.

    • Xianqiang Song
    • , Morten Ø. Jensen
    • , Vishwanath Jogini
    • , Richard A. Stein
    • , Chia-Hsueh Lee
    • , Hassane S. Mchaourab
    • , David E. Shaw
    •  & Eric Gouaux
  • Article |

    Epithelial-to-mesenchymal transition in tumour cells occurs through distinct intermediate states, associated with different metastatic potential, cellular properties, gene expression, and chromatin landscape

    • Ievgenia Pastushenko
    • , Audrey Brisebarre
    • , Alejandro Sifrim
    • , Marco Fioramonti
    • , Tatiana Revenco
    • , Soufiane Boumahdi
    • , Alexandra Van Keymeulen
    • , Daniel Brown
    • , Virginie Moers
    • , Sophie Lemaire
    • , Sarah De Clercq
    • , Esmeralda Minguijón
    • , Cédric Balsat
    • , Youri Sokolow
    • , Christine Dubois
    • , Florian De Cock
    • , Samuel Scozzaro
    • , Federico Sopena
    • , Angel Lanas
    • , Nicky D’Haene
    • , Isabelle Salmon
    • , Jean-Christophe Marine
    • , Thierry Voet
    • , Panagiota A. Sotiropoulou
    •  & Cédric Blanpain
  • Letter |

    The immunoregulatory metabolite itaconate and its dimethyl derivative induce electrophilic stress and react with glutathione to induce both Nrf2-dependent and Nrf2-independent responses, resulting in AF3-mediated inhibition of the inflammation-related protein IκBζ.

    • Monika Bambouskova
    • , Laurent Gorvel
    • , Vicky Lampropoulou
    • , Alexey Sergushichev
    • , Ekaterina Loginicheva
    • , Kendall Johnson
    • , Daniel Korenfeld
    • , Mary Elizabeth Mathyer
    • , Hyeryun Kim
    • , Li-Hao Huang
    • , Dustin Duncan
    • , Howard Bregman
    • , Abdurrahman Keskin
    • , Andrea Santeford
    • , Rajendra S. Apte
    • , Raghav Sehgal
    • , Britney Johnson
    • , Gaya K. Amarasinghe
    • , Miguel P. Soares
    • , Takashi Satoh
    • , Shizuo Akira
    • , Tsonwin Hai
    • , Cristina de Guzman Strong
    • , Karine Auclair
    • , Thomas P. Roddy
    • , Scott A. Biller
    • , Marko Jovanovic
    • , Eynav Klechevsky
    • , Kelly M. Stewart
    • , Gwendalyn J. Randolph
    •  & Maxim N. Artyomov
  • Article |

    A new version of the phylogenetic bootstrap method enables assessment of the robustness of phylogenies that are based on large datasets of hundreds or thousands of taxa.

    • F. Lemoine
    • , J.-B. Domelevo Entfellner
    • , E. Wilkinson
    • , D. Correia
    • , M. Dávila Felipe
    • , T. De Oliveira
    •  & O. Gascuel
  • Article |

    SAMHD1 has an essential role in the replication stress response and prevents inflammation by activating the MRE11 nuclease to degrade nascent DNA strands at stalled replication forks, thus enabling replication.

    • Flavie Coquel
    • , Maria-Joao Silva
    • , Hervé Técher
    • , Karina Zadorozhny
    • , Sushma Sharma
    • , Jadwiga Nieminuszczy
    • , Clément Mettling
    • , Elodie Dardillac
    • , Antoine Barthe
    • , Anne-Lyne Schmitz
    • , Alexy Promonet
    • , Alexandra Cribier
    • , Amélie Sarrazin
    • , Wojciech Niedzwiedz
    • , Bernard Lopez
    • , Vincenzo Costanzo
    • , Lumir Krejci
    • , Andrei Chabes
    • , Monsef Benkirane
    • , Yea-Lih Lin
    •  & Philippe Pasero
  • Letter |

    Molten-salt-assisted chemical vapour deposition is used to synthesize a wide variety of two-dimensional transition-metal chalcogenides.

    • Jiadong Zhou
    • , Junhao Lin
    • , Xiangwei Huang
    • , Yao Zhou
    • , Yu Chen
    • , Juan Xia
    • , Hong Wang
    • , Yu Xie
    • , Huimei Yu
    • , Jincheng Lei
    • , Di Wu
    • , Fucai Liu
    • , Qundong Fu
    • , Qingsheng Zeng
    • , Chuang-Han Hsu
    • , Changli Yang
    • , Li Lu
    • , Ting Yu
    • , Zexiang Shen
    • , Hsin Lin
    • , Boris I. Yakobson
    • , Qian Liu
    • , Kazu Suenaga
    • , Guangtong Liu
    •  & Zheng Liu
  • Letter |

    Chirality can be ‘encoded’ into gold nanoparticles by introducing chiral amino acids or peptides during the growth process, leading to the formation of helicoid morphologies.

    • Hye-Eun Lee
    • , Hyo-Yong Ahn
    • , Jungho Mun
    • , Yoon Young Lee
    • , Minkyung Kim
    • , Nam Heon Cho
    • , Kiseok Chang
    • , Wook Sung Kim
    • , Junsuk Rho
    •  & Ki Tae Nam
  • Letter |

    Acute heat stress from the extended marine heatwave of 2016 is a potent driver of the transformation of coral assemblages, which affects even the most remote and well-protected reefs of the Great Barrier Reef.

    • Terry P. Hughes
    • , James T. Kerry
    • , Andrew H. Baird
    • , Sean R. Connolly
    • , Andreas Dietzel
    • , C. Mark Eakin
    • , Scott F. Heron
    • , Andrew S. Hoey
    • , Mia O. Hoogenboom
    • , Gang Liu
    • , Michael J. McWilliam
    • , Rachel J. Pears
    • , Morgan S. Pratchett
    • , William J. Skirving
    • , Jessica S. Stella
    •  & Gergely Torda
  • Article |

    Normothermic machine perfusion of the liver improved early graft function, demonstrated by reduced peak serum aspartate transaminase levels and early allograft dysfunction rates, and improved organ utilization and preservation times, although no differences were seen in graft or patient survival.

    • David Nasralla
    • , Constantin C. Coussios
    • , Hynek Mergental
    • , M. Zeeshan Akhtar
    • , Andrew J. Butler
    • , Carlo D. L. Ceresa
    • , Virginia Chiocchia
    • , Susan J. Dutton
    • , Juan Carlos García-Valdecasas
    • , Nigel Heaton
    • , Charles Imber
    • , Wayel Jassem
    • , Ina Jochmans
    • , John Karani
    • , Simon R. Knight
    • , Peri Kocabayoglu
    • , Massimo Malagò
    • , Darius Mirza
    • , Peter J. Morris
    • , Arvind Pallan
    • , Andreas Paul
    • , Mihai Pavel
    • , M. Thamara P. R. Perera
    • , Jacques Pirenne
    • , Reena Ravikumar
    • , Leslie Russell
    • , Sara Upponi
    • , Chris J. E. Watson
    • , Annemarie Weissenbacher
    • , Rutger J. Ploeg
    •  & Peter J. Friend
  • Letter |

    Crystal structures of the neuropeptide Y1 receptor in complex with two distinct antagonists combined with NMR, molecular docking and mutagenesis studies inform a proposed model for receptor–agonist binding.

    • Zhenlin Yang
    • , Shuo Han
    • , Max Keller
    • , Anette Kaiser
    • , Brian J. Bender
    • , Mathias Bosse
    • , Kerstin Burkert
    • , Lisa M. Kögler
    • , David Wifling
    • , Guenther Bernhardt
    • , Nicole Plank
    • , Timo Littmann
    • , Peter Schmidt
    • , Cuiying Yi
    • , Beibei Li
    • , Sheng Ye
    • , Rongguang Zhang
    • , Bo Xu
    • , Dan Larhammar
    • , Raymond C. Stevens
    • , Daniel Huster
    • , Jens Meiler
    • , Qiang Zhao
    • , Annette G. Beck-Sickinger
    • , Armin Buschauer
    •  & Beili Wu
  • Letter |

    An aluminium compound is synthesized in which the aluminium is formally anionic; reactions with various substrates suggest that this compound acts as the nucleophilic partner in both metal–carbon and metal–metal bond-forming reactions.

    • Jamie Hicks
    • , Petra Vasko
    • , Jose M. Goicoechea
    •  & Simon Aldridge
  • Letter |

    Loss of the ribosome-rescue factor Pelo in a subset of mouse epidermal stem cells results in hyperproliferation and altered differentiation of these cells.

    • Kifayathullah Liakath-Ali
    • , Eric W. Mills
    • , Inês Sequeira
    • , Beate M. Lichtenberger
    • , Angela Oliveira Pisco
    • , Kalle H. Sipilä
    • , Ajay Mishra
    • , Harunori Yoshikawa
    • , Colin Chih-Chien Wu
    • , Tony Ly
    • , Angus I. Lamond
    • , Ibrahim M. Adham
    • , Rachel Green
    •  & Fiona M. Watt
  • Letter |

    Ostracod species (small, bivalved crustaceans) with high sexual dimorphism, and therefore high male investment, had markedly higher extinction rates than low-investment species, indicating that sexual selection can be a substantial risk factor for extinction.

    • Maria João Fernandes Martins
    • , T. Markham Puckett
    • , Rowan Lockwood
    • , John P. Swaddle
    •  & Gene Hunt
  • Letter |

    In a ferret model, the microcephaly-associated gene Aspm regulates cortical expansion by controlling the transition of ventricular radial glial cells to more differentiated cell types.

    • Matthew B. Johnson
    • , Xingshen Sun
    • , Andrew Kodani
    • , Rebeca Borges-Monroy
    • , Kelly M. Girskis
    • , Steven C. Ryu
    • , Peter P. Wang
    • , Komal Patel
    • , Dilenny M. Gonzalez
    • , Yu Mi Woo
    • , Ziying Yan
    • , Bo Liang
    • , Richard S. Smith
    • , Manavi Chatterjee
    • , Daniel Coman
    • , Xenophon Papademetris
    • , Lawrence H. Staib
    • , Fahmeed Hyder
    • , Joseph B. Mandeville
    • , P. Ellen Grant
    • , Kiho Im
    • , Hojoong Kwak
    • , John F. Engelhardt
    • , Christopher A. Walsh
    •  & Byoung-Il Bae
  • Article |

    Peripheral stimuli can induce acute immune training and tolerance in the brain and lead to long-lasting epigenetic reprogramming of microglia; these changes alter pathology in mouse models of stroke and Alzheimer’s pathology .

    • Ann-Christin Wendeln
    • , Karoline Degenhardt
    • , Lalit Kaurani
    • , Michael Gertig
    • , Thomas Ulas
    • , Gaurav Jain
    • , Jessica Wagner
    • , Lisa M. Häsler
    • , Katleen Wild
    • , Angelos Skodras
    • , Thomas Blank
    • , Ori Staszewski
    • , Moumita Datta
    • , Tonatiuh Pena Centeno
    • , Vincenzo Capece
    • , Md. Rezaul Islam
    • , Cemil Kerimoglu
    • , Matthias Staufenbiel
    • , Joachim L. Schultze
    • , Marc Beyer
    • , Marco Prinz
    • , Mathias Jucker
    • , André Fischer
    •  & Jonas J. Neher
  • Letter |

    1,024 random bits that are uniformly distributed to within 10−12 and unpredictable assuming the impossibility of superluminal communication are generated and certified using a loophole-free Bell test.

    • Peter Bierhorst
    • , Emanuel Knill
    • , Scott Glancy
    • , Yanbao Zhang
    • , Alan Mink
    • , Stephen Jordan
    • , Andrea Rommal
    • , Yi-Kai Liu
    • , Bradley Christensen
    • , Sae Woo Nam
    • , Martin J. Stevens
    •  & Lynden K. Shalm
  • Article | | open

    Whole-genome sequencing of 1,011 natural isolates of the yeast Saccharomyces cerevisiae reveals its evolutionary history, including a single out-of-China origin and multiple domestication events, and provides a framework for genotype–phenotype studies in this model organism.

    • Jackson Peter
    • , Matteo De Chiara
    • , Anne Friedrich
    • , Jia-Xing Yue
    • , David Pflieger
    • , Anders Bergström
    • , Anastasie Sigwalt
    • , Benjamin Barre
    • , Kelle Freel
    • , Agnès Llored
    • , Corinne Cruaud
    • , Karine Labadie
    • , Jean-Marc Aury
    • , Benjamin Istace
    • , Kevin Lebrigand
    • , Pascal Barbry
    • , Stefan Engelen
    • , Arnaud Lemainque
    • , Patrick Wincker
    • , Gianni Liti
    •  & Joseph Schacherer
  • Letter |

    Palaeoclimate records show that the Atlantic meridional overturning circulation weakened substantially at the end of the Little Ice Age, probably in response to enhanced freshwater fluxes from the Arctic and Nordic seas.

    • David J. R. Thornalley
    • , Delia W. Oppo
    • , Pablo Ortega
    • , Jon I. Robson
    • , Chris M. Brierley
    • , Renee Davis
    • , Ian R. Hall
    • , Paola Moffa-Sanchez
    • , Neil L. Rose
    • , Peter T. Spooner
    • , Igor Yashayaev
    •  & Lloyd D. Keigwin
  • Letter |

    Non-lysine ubiquitination activity of the E3 ubiquitin ligase MYCBP2 is identified by activity-based profiling; biochemical and structural analysis of MYCBP2 suggests the basis for its mechanism and specificity.

    • Kuan-Chuan Pao
    • , Nicola T. Wood
    • , Axel Knebel
    • , Karim Rafie
    • , Mathew Stanley
    • , Peter D. Mabbitt
    • , Ramasubramanian Sundaramoorthy
    • , Kay Hofmann
    • , Daan M. F. van Aalten
    •  & Satpal Virdee