Latest Research

  • Article |

    Analysis of more than 1,500 microbial genomes sheds light on the processing of carbon released as permafrost thaws.

    • Ben J. Woodcroft
    • , Caitlin M. Singleton
    • , Joel A. Boyd
    • , Paul N. Evans
    • , Joanne B. Emerson
    • , Ahmed A. F. Zayed
    • , Robert D. Hoelzle
    • , Timothy O. Lamberton
    • , Carmody K. McCalley
    • , Suzanne B. Hodgkins
    • , Rachel M. Wilson
    • , Samuel O. Purvine
    • , Carrie D. Nicora
    • , Changsheng Li
    • , Steve Frolking
    • , Jeffrey P. Chanton
    • , Patrick M. Crill
    • , Scott R. Saleska
    • , Virginia I. Rich
    •  & Gene W. Tyson
  • Publisher Correction |

    • Xuchu Que
    • , Ming-Yow Hung
    • , Calvin Yeang
    • , Ayelet Gonen
    • , Thomas A. Prohaska
    • , Xiaoli Sun
    • , Cody Diehl
    • , Antti Määttä
    • , Dalia E. Gaddis
    • , Karen Bowden
    • , Jennifer Pattison
    • , Jeffrey G. MacDonald
    • , Seppo Ylä-Herttuala
    • , Pamela L. Mellon
    • , Catherine C. Hedrick
    • , Klaus Ley
    • , Yury I. Miller
    • , Christopher K. Glass
    • , Kirk L. Peterson
    • , Christoph J. Binder
    • , Sotirios Tsimikas
    •  & Joseph L. Witztum
  • Letter |

    DNA origami is used as a template to produce complex geometric shapes of nanoscale silica hybrid materials.

    • Xiaoguo Liu
    • , Fei Zhang
    • , Xinxin Jing
    • , Muchen Pan
    • , Pi Liu
    • , Wei Li
    • , Bowen Zhu
    • , Jiang Li
    • , Hong Chen
    • , Lihua Wang
    • , Jianping Lin
    • , Yan Liu
    • , Dongyuan Zhao
    • , Hao Yan
    •  & Chunhai Fan
  • Letter |

    Sediment-core and modelling analyses suggest that, during distinct cold periods known as Heinrich Stadials, changes in ocean circulation in the North Atlantic triggered discharge of freshwater from the Cordilleran Ice Sheet into the North Pacific.

    • E. Maier
    • , X. Zhang
    • , A. Abelmann
    • , R. Gersonde
    • , S. Mulitza
    • , M. Werner
    • , M. Méheust
    • , J. Ren
    • , B. Chapligin
    • , H. Meyer
    • , R. Stein
    • , R. Tiedemann
    •  & G. Lohmann
  • Letter |

    Histidine metabolism influences the sensitivity of cancer cells to methotrexate, with mice bearing leukaemia xenografts showing increased response to the drug upon histidine supplementation.

    • Naama Kanarek
    • , Heather R. Keys
    • , Jason R. Cantor
    • , Caroline A. Lewis
    • , Sze Ham Chan
    • , Tenzin Kunchok
    • , Monther Abu-Remaileh
    • , Elizaveta Freinkman
    • , Lawrence D. Schweitzer
    •  & David M. Sabatini
  • Letter |

    Half-integer quantization of the thermal Hall effect in a Kitaev spin liquid reveals chiral currents of charge-neutral Majorana fermions around the edges of the sample, produced by strong electronic correlations.

    • Y. Kasahara
    • , T. Ohnishi
    • , Y. Mizukami
    • , O. Tanaka
    • , Sixiao Ma
    • , K. Sugii
    • , N. Kurita
    • , H. Tanaka
    • , J. Nasu
    • , Y. Motome
    • , T. Shibauchi
    •  & Y. Matsuda
  • Letter |

    An Early Pleistocene artefact assemblage from the Chinese Loess Plateau implies that hominins had left Africa by at least 2.1 million years ago, and occupied the Loess Plateau repeatedly for a long time.

    • Zhaoyu Zhu
    • , Robin Dennell
    • , Weiwen Huang
    • , Yi Wu
    • , Shifan Qiu
    • , Shixia Yang
    • , Zhiguo Rao
    • , Yamei Hou
    • , Jiubing Xie
    • , Jiangwei Han
    •  & Tingping Ouyang
  • Article |

    X-ray and cryo-electron microscopy structures of fungal mitochondrial calcium uniporter proteins reveal a tetrameric architecture and shed light on the function of the channel.

    • Chao Fan
    • , Minrui Fan
    • , Benjamin J. Orlando
    • , Nathan M. Fastman
    • , Jinru Zhang
    • , Yan Xu
    • , Melissa G. Chambers
    • , Xiaofang Xu
    • , Kay Perry
    • , Maofu Liao
    •  & Liang Feng
  • Letter |

    Productivity of coral reefs is enhanced near islands with no invasive rats, as populations of seabirds, which transfer nitrogen from deeper areas of ocean to the nearshore waters via their guano, are much larger than on rat-infested islands.

    • Nicholas A. J. Graham
    • , Shaun K. Wilson
    • , Peter Carr
    • , Andrew S. Hoey
    • , Simon Jennings
    •  & M. Aaron MacNeil
  • Letter |

    A non-viral strategy to introduce large DNA sequences into T cells enables the correction of a pathogenic mutation that causes autoimmunity, and the replacement of an endogenous T-cell receptor with an engineered receptor that can recognize cancer antigens.

    • Theodore L. Roth
    • , Cristina Puig-Saus
    • , Ruby Yu
    • , Eric Shifrut
    • , Julia Carnevale
    • , P. Jonathan Li
    • , Joseph Hiatt
    • , Justin Saco
    • , Paige Krystofinski
    • , Han Li
    • , Victoria Tobin
    • , David N. Nguyen
    • , Michael R. Lee
    • , Amy L. Putnam
    • , Andrea L. Ferris
    • , Jeff W. Chen
    • , Jean-Nicolas Schickel
    • , Laurence Pellerin
    • , David Carmody
    • , Gorka Alkorta-Aranburu
    • , Daniela del Gaudio
    • , Hiroyuki Matsumoto
    • , Montse Morell
    • , Ying Mao
    • , Min Cho
    • , Rolen M. Quadros
    • , Channabasavaiah B. Gurumurthy
    • , Baz Smith
    • , Michael Haugwitz
    • , Stephen H. Hughes
    • , Jonathan S. Weissman
    • , Kathrin Schumann
    • , Jonathan H. Esensten
    • , Andrew P. May
    • , Alan Ashworth
    • , Gary M. Kupfer
    • , Siri Atma W. Greeley
    • , Rosa Bacchetta
    • , Eric Meffre
    • , Maria Grazia Roncarolo
    • , Neil Romberg
    • , Kevan C. Herold
    • , Antoni Ribas
    • , Manuel D. Leonetti
    •  & Alexander Marson
  • Article |

    A cryo-electron microscopy structure of fungal mitochondrial calcium uniporter shows that the channel is tetrameric and sheds light on channel assembly and function.

    • Nam X. Nguyen
    • , Jean-Paul Armache
    • , Changkeun Lee
    • , Yi Yang
    • , Weizhong Zeng
    • , Vamsi K. Mootha
    • , Yifan Cheng
    • , Xiao-chen Bai
    •  & Youxing Jiang
  • Letter |

    The career trajectories of around 30,000 artists, film directors and scientists show that individuals in each domain have ‘hot streaks’ during which their works have increased impact, despite showing no increase in productivity.

    • Lu Liu
    • , Yang Wang
    • , Roberta Sinatra
    • , C. Lee Giles
    • , Chaoming Song
    •  & Dashun Wang
  • Article |

    A female Drosophila melanogaster pheromone is recognized by males from both the same and a closely related species through conserved peripheral sensory neurons; the signal is then differentially propagated to promote conspecific and suppress interspecies courtship.

    • Laura F. Seeholzer
    • , Max Seppo
    • , David L. Stern
    •  & Vanessa Ruta
  • Article |

    Analysis of genotyping data for more than 150,000 individuals from the UK Biobank using long-range phase information sheds light on mechanisms of clonal haematopoiesis.

    • Po-Ru Loh
    • , Giulio Genovese
    • , Robert E. Handsaker
    • , Hilary K. Finucane
    • , Yakir A. Reshef
    • , Pier Francesco Palamara
    • , Brenda M. Birmann
    • , Michael E. Talkowski
    • , Samuel F. Bakhoum
    • , Steven A. McCarroll
    •  & Alkes L. Price
  • Perspective |

    China has addressed widespread rural poverty and environmental degradation head-on via unprecedented investment in sixteen large-scale sustainability programmes.

    • Brett A. Bryan
    • , Lei Gao
    • , Yanqiong Ye
    • , Xiufeng Sun
    • , Jeffery D. Connor
    • , Neville D. Crossman
    • , Mark Stafford-Smith
    • , Jianguo Wu
    • , Chunyang He
    • , Deyong Yu
    • , Zhifeng Liu
    • , Ang Li
    • , Qingxu Huang
    • , Hai Ren
    • , Xiangzheng Deng
    • , Hua Zheng
    • , Jianming Niu
    • , Guodong Han
    •  & Xiangyang Hou
  • Letter |

    Mass spectrometry-based assays are used to reveal specificity and structural determinants of lipid binding to class A G-protein-coupled receptors, and the effects of specific lipids on receptor coupling to G proteins.

    • Hsin-Yung Yen
    • , Kin Kuan Hoi
    • , Idlir Liko
    • , George Hedger
    • , Michael R. Horrell
    • , Wanling Song
    • , Di Wu
    • , Philipp Heine
    • , Tony Warne
    • , Yang Lee
    • , Byron Carpenter
    • , Andreas Plückthun
    • , Christopher G. Tate
    • , Mark S. P. Sansom
    •  & Carol V. Robinson
  • Letter |

    The rapid water transport through graphene oxide membranes can be switched off by introducing localized electric fields within the membranes that ionize surrounding water molecules and thus block transport.

    • K.-G. Zhou
    • , K. S. Vasu
    • , C. T. Cherian
    • , M. Neek-Amal
    • , J. C. Zhang
    • , H. Ghorbanfekr-Kalashami
    • , K. Huang
    • , O. P. Marshall
    • , V. G. Kravets
    • , J. Abraham
    • , Y. Su
    • , A. N. Grigorenko
    • , A. Pratt
    • , A. K. Geim
    • , F. M. Peeters
    • , K. S. Novoselov
    •  & R. R. Nair
  • Letter |

    This study of whole-soil carbon dynamics finds that, of the atmospheric carbon that is incorporated into the topmost metre of soil over 50 years, just 19 per cent reaches the subsoil, in a manner that depends on land use and aridity.

    • Jérôme Balesdent
    • , Isabelle Basile-Doelsch
    • , Joël Chadoeuf
    • , Sophie Cornu
    • , Delphine Derrien
    • , Zuzana Fekiacova
    •  & Christine Hatté