Latest Research

  • Letter |

    • Andrew C. Scott
    • , Friederike Dündar
    • , Paul Zumbo
    • , Smita S. Chandran
    • , Christopher A. Klebanoff
    • , Mojdeh Shakiba
    • , Prerak Trivedi
    • , Laura Menocal
    • , Heather Appleby
    • , Steven J. Camara
    • , Dmitriy Zamarin
    • , Tyler Walther
    • , Alexandra C. Snyder
    • , Matthew R. Femia
    • , Elizabeth A. Comen
    • , Hannah Y. Wen
    • , Matthew D. Hellmann
    • , Niroshana Anandasabapathy
    • , Yong Liu
    • , Nasser K. Altorki
    • , Peter Lauer
    • , Olivier Levy
    • , Michael Glickman
    • , Jonathan Kaye
    • , Doron Betel
    • , Mary Philip
    •  & Andrea Schietinger
  • Article |

    Analysis of forest-management studies finds that forest removal is more likely to increase streamflow in areas with greater water storage between the surface and bedrock, and that forest planting is more likely to decrease streamflow in drier climates.

    • Jaivime Evaristo
    •  & Jeffrey J. McDonnell
  • Article |

    • Omar Khan
    • , Josephine R. Giles
    • , Sierra McDonald
    • , Sasikanth Manne
    • , Shin Foong Ngiow
    • , Kunal P. Patel
    • , Michael T. Werner
    • , Alexander C. Huang
    • , Katherine A. Alexander
    • , Jennifer E. Wu
    • , John Attanasio
    • , Patrick Yan
    • , Sangeeth M. George
    • , Bertram Bengsch
    • , Ryan P. Staupe
    • , Greg Donahue
    • , Wei Xu
    • , Ravi K. Amaravadi
    • , Xiaowei Xu
    • , Giorgos C. Karakousis
    • , Tara C. Mitchell
    • , Lynn M. Schuchter
    • , Jonathan Kaye
    • , Shelley L. Berger
    •  & E. John Wherry
  • Article |

    The CRISPR–Cas9-mediated generation of germline-transmissible mutations of SHANK3 in cynomolgus macaques (Macaca fascicularis) forms the basis of a non-human-primate model of autism spectrum disorder and Phelan–McDermid syndrome.

    • Yang Zhou
    • , Jitendra Sharma
    • , Qiong Ke
    • , Rogier Landman
    • , Jingli Yuan
    • , Hong Chen
    • , David S. Hayden
    • , John W. Fisher III
    • , Minqing Jiang
    • , William Menegas
    • , Tomomi Aida
    • , Ting Yan
    • , Ying Zou
    • , Dongdong Xu
    • , Shivangi Parmar
    • , Julia B. Hyman
    • , Adrian Fanucci-Kiss
    • , Olivia Meisner
    • , Dongqing Wang
    • , Yan Huang
    • , Yaqing Li
    • , Yanyang Bai
    • , Wenjing Ji
    • , Xinqiang Lai
    • , Weiqiang Li
    • , Lihua Huang
    • , Zhonghua Lu
    • , Liping Wang
    • , Sheeba A. Anteraper
    • , Mriganka Sur
    • , Huihui Zhou
    • , Andy Peng Xiang
    • , Robert Desimone
    • , Guoping Feng
    •  & Shihua Yang
  • Letter |

    Cryo-electron microscopy structures of the yeast 60S ribosomal subunit in complex with Vms1 provides insights into the roles of proteins in the ribosome-associated quality control pathway.

    • Ting Su
    • , Toshiaki Izawa
    • , Matthias Thoms
    • , Yui Yamashita
    • , Jingdong Cheng
    • , Otto Berninghausen
    • , F. Ulrich Hartl
    • , Toshifumi Inada
    • , Walter Neupert
    •  & Roland Beckmann
  • Letter |

    In a mouse model of herpes simplex 2 virus infection, circulating memory B cells—rather than plasma cells—are shown to be the source of antibody secretion in the vaginal lumen following secondary infection.

    • Ji Eun Oh
    • , Norifumi Iijima
    • , Eric Song
    • , Peiwen Lu
    • , Jonathan Klein
    • , Ruoyi Jiang
    • , Steven H. Kleinstein
    •  & Akiko Iwasaki
  • Analysis |

    Climate has affected organized armed conflict within countries, and intensifying climate change is estimated to increase future risks of conflict, although other drivers are substantially more influential and the mechanisms of climate–conflict linkages remain uncertain.

    • Katharine J. Mach
    • , Caroline M. Kraan
    • , W. Neil Adger
    • , Halvard Buhaug
    • , Marshall Burke
    • , James D. Fearon
    • , Christopher B. Field
    • , Cullen S. Hendrix
    • , Jean-Francois Maystadt
    • , John O’Loughlin
    • , Philip Roessler
    • , Jürgen Scheffran
    • , Kenneth A. Schultz
    •  & Nina von Uexkull
  • Perspective |

    This Perspective discusses the challenges associated with the prediction of chemical synthesis, in particular the reaction conditions required for organic transformations, and the role of machine-learning approaches in the prediction process.

    • Ian W. Davies
  • Letter |

    Comparison of transcriptomes, cell fates and behaviour of three primary cell types from the sponge Amphimedon queenslandica with choanoflagellates and other unicellular holozoans suggests that the first animal cells transitioned between multiple states.

    • Shunsuke Sogabe
    • , William L. Hatleberg
    • , Kevin M. Kocot
    • , Tahsha E. Say
    • , Daniel Stoupin
    • , Kathrein E. Roper
    • , Selene L. Fernandez-Valverde
    • , Sandie M. Degnan
    •  & Bernard M. Degnan
  • Article |

    A cryo-electron microscopy structure of human NLRP3 in complex with the mitotic kinase NEK7 provides insights into the interactions that mediate the activation of the NLRP3 inflammasome.

    • Humayun Sharif
    • , Li Wang
    • , Wei Li Wang
    • , Venkat Giri Magupalli
    • , Liudmila Andreeva
    • , Qi Qiao
    • , Arthur V. Hauenstein
    • , Zhaolong Wu
    • , Gabriel Núñez
    • , Youdong Mao
    •  & Hao Wu
  • Letter |

    A copper oxide high-temperature superconductor magnet generates a direct-current magnetic field of 45.5 tesla—the highest value reported so far—using a design that enables operation at high current densities.

    • Seungyong Hahn
    • , Kwanglok Kim
    • , Kwangmin Kim
    • , Xinbo Hu
    • , Thomas Painter
    • , Iain Dixon
    • , Seokho Kim
    • , Kabindra R. Bhattarai
    • , So Noguchi
    • , Jan Jaroszynski
    •  & David C. Larbalestier
  • Letter |

    By enhancing the spin–orbit coupling in bilayer graphene using the proximity effect in a van der Waals heterostructure, band inversion occurs and an incompressible, gapped phase is produced.

    • J. O. Island
    • , X. Cui
    • , C. Lewandowski
    • , J. Y. Khoo
    • , E. M. Spanton
    • , H. Zhou
    • , D. Rhodes
    • , J. C. Hone
    • , T. Taniguchi
    • , K. Watanabe
    • , L. S. Levitov
    • , M. P. Zaletel
    •  & A. F. Young
  • Letter |

    A mouse blastocyst model reveals how lumenal pressure, cell cortical tension and tissue stiffness act at the tissue scale to regulate embryo size, which in turn influences the division pattern of trophectoderm cells and their fate specification.

    • Chii Jou Chan
    • , Maria Costanzo
    • , Teresa Ruiz-Herrero
    • , Gregor Mönke
    • , Ryan J. Petrie
    • , Martin Bergert
    • , Alba Diz-Muñoz
    • , L. Mahadevan
    •  & Takashi Hiiragi
  • Article |

    Measurements collected during recent polynya events in the Southern Ocean reveal that these sea ice openings formed as a result of weakened stratification and severe storms and were sustained by deep overturning.

    • Ethan C. Campbell
    • , Earle A. Wilson
    • , G. W. Kent Moore
    • , Stephen C. Riser
    • , Casey E. Brayton
    • , Matthew R. Mazloff
    •  & Lynne D. Talley
  • Letter |

    Attractions between heterochromatic regions are essential for phase separation of the active and inactive genome in inverted and conventional nuclei, whereas chromatin–lamina interactions are necessary to build the conventional genomic architecture from these segregated phases.

    • Martin Falk
    • , Yana Feodorova
    • , Natalia Naumova
    • , Maxim Imakaev
    • , Bryan R. Lajoie
    • , Heinrich Leonhardt
    • , Boris Joffe
    • , Job Dekker
    • , Geoffrey Fudenberg
    • , Irina Solovei
    •  & Leonid A. Mirny
  • Letter |

    Synchrotron Mössbauer source spectroscopy is used to reveal that haematite remains magnetic in cold subducting slabs at the depth of the transition zone in the Earth’s mantle, with implications for the locations of magnetic poles during inversions of the Earth’s magnetic field.

    • I. Kupenko
    • , G. Aprilis
    • , D. M. Vasiukov
    • , C. McCammon
    • , S. Chariton
    • , V. Cerantola
    • , I. Kantor
    • , A. I. Chumakov
    • , R. Rüffer
    • , L. Dubrovinsky
    •  & C. Sanchez-Valle
  • Letter |

    Bose–Einstein condensates are transported at hypersonic speeds over a distance of 15 cm in a neutral-atom accelerator ring while preserving their internal coherence.

    • Saurabh Pandey
    • , Hector Mas
    • , Giannis Drougakis
    • , Premjith Thekkeppatt
    • , Vasiliki Bolpasi
    • , Georgios Vasilakis
    • , Konstantinos Poulios
    •  & Wolf von Klitzing
  • Letter |

    Group 3 innate lymphoid cells are recruited to the lung and involved in the immune response to infection with tuberculosis in humans and mice, as a reduction in group 3 innate lymphoid cells in the lung impaired early immune control of Mycobacterium tuberculosis in mice.

    • Amanda Ardain
    • , Racquel Domingo-Gonzalez
    • , Shibali Das
    • , Samuel W. Kazer
    • , Nicole C. Howard
    • , Alveera Singh
    • , Mushtaq Ahmed
    • , Shepherd Nhamoyebonde
    • , Javier Rangel-Moreno
    • , Paul Ogongo
    • , Lan Lu
    • , Duran Ramsuran
    • , Maria de la Luz Garcia-Hernandez
    • , Tyler K. Ulland
    • , Matthew Darby
    • , Eugene Park
    • , Farina Karim
    • , Laura Melocchi
    • , Rajhmun Madansein
    • , Kaylesh Jay Dullabh
    • , Micah Dunlap
    • , Nancy Marin-Agudelo
    • , Takashi Ebihara
    • , Thumbi Ndung’u
    • , Deepak Kaushal
    • , Alexander S. Pym
    • , Jay K. Kolls
    • , Adrie Steyn
    • , Joaquín Zúñiga
    • , William Horsnell
    • , Wayne M. Yokoyama
    • , Alex K. Shalek
    • , Henrik N. Kløverpris
    • , Marco Colonna
    • , Alasdair Leslie
    •  & Shabaana A. Khader
  • Article |

    Whole-ecosystem manipulations of Caribbean islands occupied by brown anoles, involving the addition of competitors (green anoles) and/or top predators (curly-tailed lizards), demonstrate that predator introductions can alter the ecological niches and destabilize the coexistence of competing prey species.

    • Robert M. Pringle
    • , Tyler R. Kartzinel
    • , Todd M. Palmer
    • , Timothy J. Thurman
    • , Kena Fox-Dobbs
    • , Charles C. Y. Xu
    • , Matthew C. Hutchinson
    • , Tyler C. Coverdale
    • , Joshua H. Daskin
    • , Dominic A. Evangelista
    • , Kiyoko M. Gotanda
    • , Naomi A. Man in ’t Veld
    • , Johanna E. Wegener
    • , Jason J. Kolbe
    • , Thomas W. Schoener
    • , David A. Spiller
    • , Jonathan B. Losos
    •  & Rowan D. H. Barrett
  • Letter |

    DNA analysis of ancient individuals and modern populations suggests that the population history of North America can be explained by the admixture of two ancestral lineages—Palaeo-Eskimos and First Peoples.

    • Pavel Flegontov
    • , N. Ezgi Altınışık
    • , Piya Changmai
    • , Nadin Rohland
    • , Swapan Mallick
    • , Nicole Adamski
    • , Deborah A. Bolnick
    • , Nasreen Broomandkhoshbacht
    • , Francesca Candilio
    • , Brendan J. Culleton
    • , Olga Flegontova
    • , T. Max Friesen
    • , Choongwon Jeong
    • , Thomas K. Harper
    • , Denise Keating
    • , Douglas J. Kennett
    • , Alexander M. Kim
    • , Thiseas C. Lamnidis
    • , Ann Marie Lawson
    • , Iñigo Olalde
    • , Jonas Oppenheimer
    • , Ben A. Potter
    • , Jennifer Raff
    • , Robert A. Sattler
    • , Pontus Skoglund
    • , Kristin Stewardson
    • , Edward J. Vajda
    • , Sergey Vasilyev
    • , Elizaveta Veselovskaya
    • , M. Geoffrey Hayes
    • , Dennis H. O’Rourke
    • , Johannes Krause
    • , Ron Pinhasi
    • , David Reich
    •  & Stephan Schiffels
  • Letter |

    Cryo-electron microscopy structure of the human Smoothened protein bound to 24(S),25-epoxycholesterol and a heterotrimeric Gi protein provides insights into the activation of a Frizzled-class G-protein-coupled receptor and Hedgehog signal transduction.

    • Xiaofeng Qi
    • , Heng Liu
    • , Bonne Thompson
    • , Jeffrey McDonald
    • , Cheng Zhang
    •  & Xiaochun Li
  • Letter |

    Ultrathin freestanding crystalline films of transition-metal oxide perovskites are fabricated and transferred to various substrates, proving their potential for exploring emergent 2D correlated phases.

    • Dianxiang Ji
    • , Songhua Cai
    • , Tula R. Paudel
    • , Haoying Sun
    • , Chunchen Zhang
    • , Lu Han
    • , Yifan Wei
    • , Yipeng Zang
    • , Min Gu
    • , Yi Zhang
    • , Wenpei Gao
    • , Huaixun Huyan
    • , Wei Guo
    • , Di Wu
    • , Zhengbin Gu
    • , Evgeny Y. Tsymbal
    • , Peng Wang
    • , Yuefeng Nie
    •  & Xiaoqing Pan
  • Letter |

    Proteins designed de novo by players of the online protein-folding game Foldit can be expressed in Escherichia coli and adopt the designed structure in solution.

    • Brian Koepnick
    • , Jeff Flatten
    • , Tamir Husain
    • , Alex Ford
    • , Daniel-Adriano Silva
    • , Matthew J. Bick
    • , Aaron Bauer
    • , Gaohua Liu
    • , Yojiro Ishida
    • , Alexander Boykov
    • , Roger D. Estep
    • , Susan Kleinfelter
    • , Toke Nørgård-Solano
    • , Linda Wei
    • , Foldit Players
    • , Gaetano T. Montelione
    • , Frank DiMaio
    • , Zoran Popović
    • , Firas Khatib
    • , Seth Cooper
    •  & David Baker
  • Letter |

    Emission from the 1.3-millimetre hydrogen recombination line reveals a rotating disk of cool gas 0.004 parsecs in radius around the supermassive black hole at the centre of our Galaxy.

    • Elena M. Murchikova
    • , E. Sterl Phinney
    • , Anna Pancoast
    •  & Roger D. Blandford
  • Article |

    Analyses of 34 ancient genomes from northeastern Siberia, dating to between 31,000 and 600 years ago, reveal at least three major migration events in the late Pleistocene population history of the region.

    • Martin Sikora
    • , Vladimir V. Pitulko
    • , Vitor C. Sousa
    • , Morten E. Allentoft
    • , Lasse Vinner
    • , Simon Rasmussen
    • , Ashot Margaryan
    • , Peter de Barros Damgaard
    • , Constanza de la Fuente
    • , Gabriel Renaud
    • , Melinda A. Yang
    • , Qiaomei Fu
    • , Isabelle Dupanloup
    • , Konstantinos Giampoudakis
    • , David Nogués-Bravo
    • , Carsten Rahbek
    • , Guus Kroonen
    • , Michaël Peyrot
    • , Hugh McColl
    • , Sergey V. Vasilyev
    • , Elizaveta Veselovskaya
    • , Margarita Gerasimova
    • , Elena Y. Pavlova
    • , Vyacheslav G. Chasnyk
    • , Pavel A. Nikolskiy
    • , Andrei V. Gromov
    • , Valeriy I. Khartanovich
    • , Vyacheslav Moiseyev
    • , Pavel S. Grebenyuk
    • , Alexander Yu. Fedorchenko
    • , Alexander I. Lebedintsev
    • , Sergey B. Slobodin
    • , Boris A. Malyarchuk
    • , Rui Martiniano
    • , Morten Meldgaard
    • , Laura Arppe
    • , Jukka U. Palo
    • , Tarja Sundell
    • , Kristiina Mannermaa
    • , Mikko Putkonen
    • , Verner Alexandersen
    • , Charlotte Primeau
    • , Nurbol Baimukhanov
    • , Ripan S. Malhi
    • , Karl-Göran Sjögren
    • , Kristian Kristiansen
    • , Anna Wessman
    • , Antti Sajantila
    • , Marta Mirazon Lahr
    • , Richard Durbin
    • , Rasmus Nielsen
    • , David J. Meltzer
    • , Laurent Excoffier
    •  & Eske Willerslev
  • Letter |

    Recombination of excitons to produce molecular light emission is made more efficient by controlling electron spin within the molecule to produce spin-triplet excitons only, without the usual accompanying spin-singlet excitons.

    • Kensuke Kimura
    • , Kuniyuki Miwa
    • , Hiroshi Imada
    • , Miyabi Imai-Imada
    • , Shota Kawahara
    • , Jun Takeya
    • , Maki Kawai
    • , Michael Galperin
    •  & Yousoo Kim
  • Letter |

    Single-cell RNA-sequencing analysis demonstrates that individual human brain organoids generate the cellular diversity of the cerebral cortex with organoid-to-organoid variability that is comparable to that of individual endogenous brains.

    • Silvia Velasco
    • , Amanda J. Kedaigle
    • , Sean K. Simmons
    • , Allison Nash
    • , Marina Rocha
    • , Giorgia Quadrato
    • , Bruna Paulsen
    • , Lan Nguyen
    • , Xian Adiconis
    • , Aviv Regev
    • , Joshua Z. Levin
    •  & Paola Arlotta
  • Letter |

    Experiment overturns Bohr’s view of quantum jumps, demonstrating that they possess a degree of predictability and when completed are continuous, coherent and even deterministic.

    • Z. K. Minev
    • , S. O. Mundhada
    • , S. Shankar
    • , P. Reinhold
    • , R. Gutiérrez-Jáuregui
    • , R. J. Schoelkopf
    • , M. Mirrahimi
    • , H. J. Carmichael
    •  & M. H. Devoret
  • Author Correction |

    • Joshi M. Ramanjulu
    • , G. Scott Pesiridis
    • , Jingsong Yang
    • , Nestor Concha
    • , Robert Singhaus
    • , Shu-Yun Zhang
    • , Jean-Luc Tran
    • , Patrick Moore
    • , Stephanie Lehmann
    • , H. Christian Eberl
    • , Marcel Muelbaier
    • , Jessica L. Schneck
    • , Jim Clemens
    • , Michael Adam
    • , John Mehlmann
    • , Joseph Romano
    • , Angel Morales
    • , James Kang
    • , Lara Leister
    • , Todd L. Graybill
    • , Adam K. Charnley
    • , Guosen Ye
    • , Neysa Nevins
    • , Kamelia Behnia
    • , Amaya I. Wolf
    • , Viera Kasparcova
    • , Kelvin Nurse
    • , Liping Wang
    • , Ana C. Puhl
    • , Yue Li
    • , Michael Klein
    • , Christopher B. Hopson
    • , Jeffrey Guss
    • , Marcus Bantscheff
    • , Giovanna Bergamini
    • , Michael A. Reilly
    • , Yiqian Lian
    • , Kevin J. Duffy
    • , Jerry Adams
    • , Kevin P. Foley
    • , Peter J. Gough
    • , Robert W. Marquis
    • , James Smothers
    • , Axel Hoos
    •  & John Bertin
  • Letter |

    Distinct subsets of fibroblasts, which differ in their expression of thymus cell antigen 1 (THY1), are responsible for inflammation and tissue damage in mouse models of arthritis.

    • Adam P. Croft
    • , Joana Campos
    • , Kathrin Jansen
    • , Jason D. Turner
    • , Jennifer Marshall
    • , Moustafa Attar
    • , Loriane Savary
    • , Corinna Wehmeyer
    • , Amy J. Naylor
    • , Samuel Kemble
    • , Jenefa Begum
    • , Kerstin Dürholz
    • , Harris Perlman
    • , Francesca Barone
    • , Helen M. McGettrick
    • , Douglas T. Fearon
    • , Kevin Wei
    • , Soumya Raychaudhuri
    • , Ilya Korsunsky
    • , Michael B. Brenner
    • , Mark Coles
    • , Stephen N. Sansom
    • , Andrew Filer
    •  & Christopher D. Buckley
  • Article |

    Cryo-electron microscopy structures reveal that the DNA-repair factor UV-DDB exposes inaccessible nucleosome lesions for binding by inducing a translational shift in the nucleosome position.

    • Syota Matsumoto
    • , Simone Cavadini
    • , Richard D. Bunker
    • , Ralph S. Grand
    • , Alessandro Potenza
    • , Julius Rabl
    • , Junpei Yamamoto
    • , Andreas D. Schenk
    • , Dirk Schübeler
    • , Shigenori Iwai
    • , Kaoru Sugasawa
    • , Hitoshi Kurumizaka
    •  & Nicolas H. Thomä
  • Article |

    The immunogen RC1 facilitates recognition of the V3-glycan patch on the envelope of HIV-1 and elicits specific serological responses in mice and macaques, making it a possible priming immunogen for sequential vaccination strategies in humans.

    • Amelia Escolano
    • , Harry B. Gristick
    • , Morgan E. Abernathy
    • , Julia Merkenschlager
    • , Rajeev Gautam
    • , Thiago Y. Oliveira
    • , Joy Pai
    • , Anthony P. West Jr
    • , Christopher O. Barnes
    • , Alexander A. Cohen
    • , Haoqing Wang
    • , Jovana Golijanin
    • , Daniel Yost
    • , Jennifer R. Keeffe
    • , Zijun Wang
    • , Peng Zhao
    • , Kai-Hui Yao
    • , Jens Bauer
    • , Lilian Nogueira
    • , Han Gao
    • , Alisa V. Voll
    • , David C. Montefiori
    • , Michael S. Seaman
    • , Anna Gazumyan
    • , Murillo Silva
    • , Andrew T. McGuire
    • , Leonidas Stamatatos
    • , Darrell J. Irvine
    • , Lance Wells
    • , Malcolm A. Martin
    • , Pamela J. Bjorkman
    •  & Michel C. Nussenzweig