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Analysis of forest-management studies finds that forest removal is more likely to increase streamflow in areas with greater water storage between the surface and bedrock, and that forest planting is more likely to decrease streamflow in drier climates.
The CRISPR–Cas9-mediated generation of germline-transmissible mutations of SHANK3 in cynomolgus macaques (Macaca fascicularis) forms the basis of a non-human-primate model of autism spectrum disorder and Phelan–McDermid syndrome.
In a mouse model of herpes simplex 2 virus infection, circulating memory B cells—rather than plasma cells—are shown to be the source of antibody secretion in the vaginal lumen following secondary infection.
Climate has affected organized armed conflict within countries, and intensifying climate change is estimated to increase future risks of conflict, although other drivers are substantially more influential and the mechanisms of climate–conflict linkages remain uncertain.
This Perspective discusses the challenges associated with the prediction of chemical synthesis, in particular the reaction conditions required for organic transformations, and the role of machine-learning approaches in the prediction process.
Comparison of transcriptomes, cell fates and behaviour of three primary cell types from the sponge Amphimedon queenslandica with choanoflagellates and other unicellular holozoans suggests that the first animal cells transitioned between multiple states.
A copper oxide high-temperature superconductor magnet generates a direct-current magnetic field of 45.5 tesla—the highest value reported so far—using a design that enables operation at high current densities.
A mouse blastocyst model reveals how lumenal pressure, cell cortical tension and tissue stiffness act at the tissue scale to regulate embryo size, which in turn influences the division pattern of trophectoderm cells and their fate specification.
Measurements collected during recent polynya events in the Southern Ocean reveal that these sea ice openings formed as a result of weakened stratification and severe storms and were sustained by deep overturning.
Attractions between heterochromatic regions are essential for phase separation of the active and inactive genome in inverted and conventional nuclei, whereas chromatin–lamina interactions are necessary to build the conventional genomic architecture from these segregated phases.
Synchrotron Mössbauer source spectroscopy is used to reveal that haematite remains magnetic in cold subducting slabs at the depth of the transition zone in the Earth’s mantle, with implications for the locations of magnetic poles during inversions of the Earth’s magnetic field.
Group 3 innate lymphoid cells are recruited to the lung and involved in the immune response to infection with tuberculosis in humans and mice, as a reduction in group 3 innate lymphoid cells in the lung impaired early immune control of Mycobacterium tuberculosis in mice.
Whole-ecosystem manipulations of Caribbean islands occupied by brown anoles, involving the addition of competitors (green anoles) and/or top predators (curly-tailed lizards), demonstrate that predator introductions can alter the ecological niches and destabilize the coexistence of competing prey species.
DNA analysis of ancient individuals and modern populations suggests that the population history of North America can be explained by the admixture of two ancestral lineages—Palaeo-Eskimos and First Peoples.
Cryo-electron microscopy structure of the human Smoothened protein bound to 24(S),25-epoxycholesterol and a heterotrimeric Gi protein provides insights into the activation of a Frizzled-class G-protein-coupled receptor and Hedgehog signal transduction.
Ultrathin freestanding crystalline films of transition-metal oxide perovskites are fabricated and transferred to various substrates, proving their potential for exploring emergent 2D correlated phases.
Analyses of 34 ancient genomes from northeastern Siberia, dating to between 31,000 and 600 years ago, reveal at least three major migration events in the late Pleistocene population history of the region.
Recombination of excitons to produce molecular light emission is made more efficient by controlling electron spin within the molecule to produce spin-triplet excitons only, without the usual accompanying spin-singlet excitons.
Single-cell RNA-sequencing analysis demonstrates that individual human brain organoids generate the cellular diversity of the cerebral cortex with organoid-to-organoid variability that is comparable to that of individual endogenous brains.
The immunogen RC1 facilitates recognition of the V3-glycan patch on the envelope of HIV-1 and elicits specific serological responses in mice and macaques, making it a possible priming immunogen for sequential vaccination strategies in humans.
The spectrum of Hawking radiation is measured in an analogue black hole composed of rubidium atoms, confirming Hawking’s prediction that Hawking radiation is thermal with a temperature given by the surface gravity.