Latest Research

  • Article |

    High-pressure diamond anvil cell experiments reveal that compression strengthening of nanocrystalline nickel increases as its grain sizes decrease to 3 nanometres, owing to dislocation hardening and suppression of grain boundary plasticity.

    • Xiaoling Zhou
    • , Zongqiang Feng
    • , Linli Zhu
    • , Jianing Xu
    • , Lowell Miyagi
    • , Hongliang Dong
    • , Hongwei Sheng
    • , Yanju Wang
    • , Quan Li
    • , Yanming Ma
    • , Hengzhong Zhang
    • , Jinyuan Yan
    • , Nobumichi Tamura
    • , Martin Kunz
    • , Katie Lutker
    • , Tianlin Huang
    • , Darcy A. Hughes
    • , Xiaoxu Huang
    •  & Bin Chen
  • Article |

    Isotopic evidence from ice cores indicates that preindustrial-era geological methane emissions were lower than previously thought, suggesting that present-day emissions of methane from fossil fuels are underestimated.

    • Benjamin Hmiel
    • , V. V. Petrenko
    • , M. N. Dyonisius
    • , C. Buizert
    • , A. M. Smith
    • , P. F. Place
    • , C. Harth
    • , R. Beaudette
    • , Q. Hua
    • , B. Yang
    • , I. Vimont
    • , S. E. Michel
    • , J. P. Severinghaus
    • , D. Etheridge
    • , T. Bromley
    • , J. Schmitt
    • , X. Faïn
    • , R. F. Weiss
    •  & E. Dlugokencky
  • Article |

    Single-cell RNA sequencing and spatial transcriptomics reveal that the somitogenesis clock is active in mouse gastruloids, which can be induced to generate somites with the correct rostral–caudal patterning.

    • Susanne C. van den Brink
    • , Anna Alemany
    • , Vincent van Batenburg
    • , Naomi Moris
    • , Marloes Blotenburg
    • , Judith Vivié
    • , Peter Baillie-Johnson
    • , Jennifer Nichols
    • , Katharina F. Sonnen
    • , Alfonso Martinez Arias
    •  & Alexander van Oudenaarden
  • Article |

    A closed-loop machine learning methodology of optimizing fast-charging protocols for lithium-ion batteries can identify high-lifetime charging protocols accurately and efficiently, considerably reducing the experimental time compared to simpler approaches.

    • Peter M. Attia
    • , Aditya Grover
    • , Norman Jin
    • , Kristen A. Severson
    • , Todor M. Markov
    • , Yang-Hung Liao
    • , Michael H. Chen
    • , Bryan Cheong
    • , Nicholas Perkins
    • , Zi Yang
    • , Patrick K. Herring
    • , Muratahan Aykol
    • , Stephen J. Harris
    • , Richard D. Braatz
    • , Stefano Ermon
    •  & William C. Chueh
  • Article |

    Tumour-infiltrating group 2 innate lymphoid cells prime CD8+ T cells and amplify the anti-tumour effects of PD-1 blockade in pancreatic ductal adenocarcinoma.

    • John Alec Moral
    • , Joanne Leung
    • , Luis A. Rojas
    • , Jennifer Ruan
    • , Julia Zhao
    • , Zachary Sethna
    • , Anita Ramnarain
    • , Billel Gasmi
    • , Murali Gururajan
    • , David Redmond
    • , Gokce Askan
    • , Umesh Bhanot
    • , Ela Elyada
    • , Youngkyu Park
    • , David A. Tuveson
    • , Mithat Gönen
    • , Steven D. Leach
    • , Jedd D. Wolchok
    • , Ronald P. DeMatteo
    • , Taha Merghoub
    •  & Vinod P. Balachandran
  • Article |

    WDR5 and TBP recruit anaphase-promoting complex to specific transcription start sites in mitosis, initiating a ubiquitin-dependent mechanism that preserves cell identity by linking gene expression and cell division.

    • Eugene Oh
    • , Kevin G. Mark
    • , Annamaria Mocciaro
    • , Edmond R. Watson
    • , J. Rajan Prabu
    • , Denny D. Cha
    • , Martin Kampmann
    • , Nathan Gamarra
    • , Coral Y. Zhou
    •  & Michael Rape
  • Article |

    Using a global molecular phylogenetic dataset of birds on islands, the sensitivity of island-specific rates of colonization, speciation and extinction to island features (area and isolation) is estimated.

    • Luis Valente
    • , Albert B. Phillimore
    • , Martim Melo
    • , Ben H. Warren
    • , Sonya M. Clegg
    • , Katja Havenstein
    • , Ralph Tiedemann
    • , Juan Carlos Illera
    • , Christophe Thébaud
    • , Tina Aschenbach
    •  & Rampal S. Etienne
  • Article |

    Cas1–Cas2 selects precursor prespacers from DNA fragments in a length- and PAM-sequence-dependent manner, and these precursors are trimmed by DnaQ exonucleases to enable integration into the CRISPR locus in the correct orientation.

    • Sungchul Kim
    • , Luuk Loeff
    • , Sabina Colombo
    • , Slobodan Jergic
    • , Stan J. J. Brouns
    •  & Chirlmin Joo
  • Article
    | Open Access

    Precision measurements of the 1S–2P transition in antihydrogen that take into account the standard Zeeman and hyperfine effects confirm the predictions of quantum electrodynamics.

    • M. Ahmadi
    • , B. X. R. Alves
    • , C. J. Baker
    • , W. Bertsche
    • , A. Capra
    • , C. Carruth
    • , C. L. Cesar
    • , M. Charlton
    • , S. Cohen
    • , R. Collister
    • , S. Eriksson
    • , A. Evans
    • , N. Evetts
    • , J. Fajans
    • , T. Friesen
    • , M. C. Fujiwara
    • , D. R. Gill
    • , P. Granum
    • , J. S. Hangst
    • , W. N. Hardy
    • , M. E. Hayden
    • , E. D. Hunter
    • , C. A. Isaac
    • , M. A. Johnson
    • , J. M. Jones
    • , S. A. Jones
    • , S. Jonsell
    • , A. Khramov
    • , P. Knapp
    • , L. Kurchaninov
    • , N. Madsen
    • , D. Maxwell
    • , J. T. K. McKenna
    • , S. Menary
    • , J. M. Michan
    • , T. Momose
    • , J. J. Munich
    • , K. Olchanski
    • , A. Olin
    • , P. Pusa
    • , C. Ø. Rasmussen
    • , F. Robicheaux
    • , R. L. Sacramento
    • , M. Sameed
    • , E. Sarid
    • , D. M. Silveira
    • , C. So
    • , D. M. Starko
    • , G. Stutter
    • , T. D. Tharp
    • , R. I. Thompson
    • , D. P. van der Werf
    •  & J. S. Wurtele
  • Article |

    HPCA1, a member of a previously uncharacterized subfamily of leucine-rich-repeat receptor-like kinases, is the hydrogen-peroxide sensor at the plasma membrane in Arabidopsis.

    • Feihua Wu
    • , Yuan Chi
    • , Zhonghao Jiang
    • , Yuanyuan Xu
    • , Ling Xie
    • , Feifei Huang
    • , Di Wan
    • , Jun Ni
    • , Fang Yuan
    • , Xiaomei Wu
    • , Yanyan Zhang
    • , Li Wang
    • , Rui Ye
    • , Benjamin Byeon
    • , Wenhua Wang
    • , Shu Zhang
    • , Matthew Sima
    • , Suping Chen
    • , Minghua Zhu
    • , Jessica Pei
    • , Douglas M. Johnson
    • , Shan Zhu
    • , Xiaoqiang Cao
    • , Christopher Pei
    • , Zijing Zai
    • , Yihao Liu
    • , Tianyi Liu
    • , Gary B. Swift
    • , Weiguo Zhang
    • , Min Yu
    • , Zhangli Hu
    • , James N. Siedow
    • , Xian Chen
    •  & Zhen-Ming Pei
  • Article |

    The cryo-electron microscopy structure of a phycobilisome from the red alga Porphyridium purpureum reveals how aromatic interactions between the linker proteins and the chromophores drive a unidirectional transfer of energy.

    • Jianfei Ma
    • , Xin You
    • , Shan Sun
    • , Xiaoxiao Wang
    • , Song Qin
    •  & Sen-Fang Sui
  • Article |

    Vγ6+ Vδ1+ γδ T cells control tolerance to cold by activating adipocyte IL-17RC and promoting sympathetic innervation of thermogenic adipose tissue in mice.

    • Bo Hu
    • , Chengcheng Jin
    • , Xing Zeng
    • , Jon M. Resch
    • , Mark P. Jedrychowski
    • , Zongfang Yang
    • , Bhavna N. Desai
    • , Alexander S. Banks
    • , Bradford B. Lowell
    • , Diane Mathis
    •  & Bruce M. Spiegelman
  • Article |

    Structures of the orphan G-protein-coupled receptor GPR52 in ligand-free, G-protein-coupled and ligand-bound states reveal that extracellular loop 2 occupies the orthosteric binding pocket and functions as a built-in agonist to activate the receptor.

    • Xi Lin
    • , Mingyue Li
    • , Niandong Wang
    • , Yiran Wu
    • , Zhipu Luo
    • , Shimeng Guo
    • , Gye-Won Han
    • , Shaobai Li
    • , Yang Yue
    • , Xiaohu Wei
    • , Xin Xie
    • , Yong Chen
    • , Suwen Zhao
    • , Jian Wu
    • , Ming Lei
    •  & Fei Xu
  • Article |

    Direct measurement of the Berry curvature and the quantum metric of photonic modes in a high-finesse planar microcavity is achieved, enabling quantitative prediction of the independently measured anomalous Hall drift.

    • A. Gianfrate
    • , O. Bleu
    • , L. Dominici
    • , V. Ardizzone
    • , M. De Giorgi
    • , D. Ballarini
    • , G. Lerario
    • , K. W. West
    • , L. N. Pfeiffer
    • , D. D. Solnyshkov
    • , D. Sanvitto
    •  & G. Malpuech
  • Article |

    Caveolae in arteriolar endothelial cells—but not those in neighbouring smooth muscle cells—have a key role in neurovascular coupling, an essential function for meeting acute brain energy demand.

    • Brian W. Chow
    • , Vicente Nuñez
    • , Luke Kaplan
    • , Adam J. Granger
    • , Karina Bistrong
    • , Hannah L. Zucker
    • , Payal Kumar
    • , Bernardo L. Sabatini
    •  & Chenghua Gu
  • Article |

    In mixed bacterial populations that colonize nutrient patches, a growth–migration trade-off can lead to spatial exclusion that provides an advantage to populations that become rare, thereby stabilizing the community.

    • Sebastian Gude
    • , Erçağ Pinçe
    • , Katja M. Taute
    • , Anne-Bart Seinen
    • , Thomas S. Shimizu
    •  & Sander J. Tans
  • Article |

    Using lead-absorbing materials to coat the front and back of perovskite solar cells can prevent lead leaching from damaged devices, without affecting the device performance or long-term operation stability.

    • Xun Li
    • , Fei Zhang
    • , Haiying He
    • , Joseph J. Berry
    • , Kai Zhu
    •  & Tao Xu
  • Article |

    A new type of energy-harvesting device, based on protein nanowires from the microbe Geobacter sulforreducens, can generate a sustained power output by producing a moisture gradient across the nanowire film using natural humidity.

    • Xiaomeng Liu
    • , Hongyan Gao
    • , Joy E. Ward
    • , Xiaorong Liu
    • , Bing Yin
    • , Tianda Fu
    • , Jianhan Chen
    • , Derek R. Lovley
    •  & Jun Yao
  • Publisher Correction |

    • Anthony P. Coll
    • , Michael Chen
    • , Pranali Taskar
    • , Debra Rimmington
    • , Satish Patel
    • , John A. Tadross
    • , Irene Cimino
    • , Ming Yang
    • , Paul Welsh
    • , Samuel Virtue
    • , Deborah A. Goldspink
    • , Emily L. Miedzybrodzka
    • , Adam R. Konopka
    • , Raul Ruiz Esponda
    • , Jeffrey T.-J. Huang
    • , Y. C. Loraine Tung
    • , Sergio Rodriguez-Cuenca
    • , Rute A. Tomaz
    • , Heather P. Harding
    • , Audrey Melvin
    • , Giles S. H. Yeo
    • , David Preiss
    • , Antonio Vidal-Puig
    • , Ludovic Vallier
    • , K. Sreekumaran Nair
    • , Nicholas J. Wareham
    • , David Ron
    • , Fiona M. Gribble
    • , Frank Reimann
    • , Naveed Sattar
    • , David B. Savage
    • , Bernard B. Allan
    •  & Stephen O’Rahilly
  • Article |

    Single-cell RNA sequencing of cells from humans with multiple sclerosis and mice with a model of the disease identifies a population of disease-promoting astrocytes in which anti-oxidant and anti-inflammatory proteins are suppressed.

    • Michael A. Wheeler
    • , Iain C. Clark
    • , Emily C. Tjon
    • , Zhaorong Li
    • , Stephanie E. J. Zandee
    • , Charles P. Couturier
    • , Brianna R. Watson
    • , Giulia Scalisi
    • , Sarah Alkwai
    • , Veit Rothhammer
    • , Assaf Rotem
    • , John A. Heyman
    • , Shravan Thaploo
    • , Liliana M. Sanmarco
    • , Jiannis Ragoussis
    • , David A. Weitz
    • , Kevin Petrecca
    • , Jeffrey R. Moffitt
    • , Burkhard Becher
    • , Jack P. Antel
    • , Alexandre Prat
    •  & Francisco J. Quintana
  • Article |

    • Wenjuan Zhang
    • , Airi Tarutani
    • , Kathy L. Newell
    • , Alexey G. Murzin
    • , Tomoyasu Matsubara
    • , Benjamin Falcon
    • , Ruben Vidal
    • , Holly J. Garringer
    • , Yang Shi
    • , Takeshi Ikeuchi
    • , Shigeo Murayama
    • , Bernardino Ghetti
    • , Masato Hasegawa
    • , Michel Goedert
    •  & Sjors H. W. Scheres
  • Article |

    A topological laser based on the valley degree of freedom in a compact photonic crystal can be pumped electrically, bringing topological physics concepts closer to real-life applications.

    • Yongquan Zeng
    • , Udvas Chattopadhyay
    • , Bofeng Zhu
    • , Bo Qiang
    • , Jinghao Li
    • , Yuhao Jin
    • , Lianhe Li
    • , Alexander Giles Davies
    • , Edmund Harold Linfield
    • , Baile Zhang
    • , Yidong Chong
    •  & Qi Jie Wang
  • Review Article |

    The scientific, technical and ethical aspects of using CRISPR technology for therapeutic applications in humans are discussed, highlighting both opportunities and challenges of this technology to treat, cure and prevent genetic disease.

    • Jennifer A. Doudna
  • Article |

    Phenotypic selection analysis is used to estimate the type and strength of selection that acts on more than 15,000 transcripts in rice (Oryza sativa), which provides insight into the adaptive evolutionary role of selection on gene expression.

    • Simon C. Groen
    • , Irina Ćalić
    • , Zoé Joly-Lopez
    • , Adrian E. Platts
    • , Jae Young Choi
    • , Mignon Natividad
    • , Katherine Dorph
    • , William M. Mauck III
    • , Bernadette Bracken
    • , Carlo Leo U. Cabral
    • , Arvind Kumar
    • , Rolando O. Torres
    • , Rahul Satija
    • , Georgina Vergara
    • , Amelia Henry
    • , Steven J. Franks
    •  & Michael D. Purugganan
  • Article |

    An HLA- and gluten-dependent mouse model of coeliac disease with villous atrophy provides evidence for the cooperative role of IL-15 and gluten-specific CD4+ T cells in licensing the full activation of cytotoxic T cells that are necessary for inducing epithelial damage.

    • Valérie Abadie
    • , Sangman M. Kim
    • , Thomas Lejeune
    • , Brad A. Palanski
    • , Jordan D. Ernest
    • , Olivier Tastet
    • , Jordan Voisine
    • , Valentina Discepolo
    • , Eric V. Marietta
    • , Mohamed B. F. Hawash
    • , Cezary Ciszewski
    • , Romain Bouziat
    • , Kaushik Panigrahi
    • , Irina Horwath
    • , Matthew A. Zurenski
    • , Ian Lawrence
    • , Anne Dumaine
    • , Vania Yotova
    • , Jean-Christophe Grenier
    • , Joseph A. Murray
    • , Chaitan Khosla
    • , Luis B. Barreiro
    •  & Bana Jabri
  • Article |

    In mice, the interaction of the innate immune sensor TLR9 with beclin 1 is shown to have a role in glucose metabolism and AMPK activation in skeletal muscle during exercise.

    • Yang Liu
    • , Phong T. Nguyen
    • , Xun Wang
    • , Yuting Zhao
    • , Corbin E. Meacham
    • , Zhongju Zou
    • , Bogdan Bordieanu
    • , Manuel Johanns
    • , Didier Vertommen
    • , Tobias Wijshake
    • , Herman May
    • , Guanghua Xiao
    • , Sanae Shoji-Kawata
    • , Mark H. Rider
    • , Sean J. Morrison
    • , Prashant Mishra
    •  & Beth Levine
  • Article |

    The entanglement of two atomic-ensemble quantum memories via optical fibres, enabled by the use of cavity enhancement and quantum frequency conversion, is demonstrated over dozens of kilometres.

    • Yong Yu
    • , Fei Ma
    • , Xi-Yu Luo
    • , Bo Jing
    • , Peng-Fei Sun
    • , Ren-Zhou Fang
    • , Chao-Wei Yang
    • , Hui Liu
    • , Ming-Yang Zheng
    • , Xiu-Ping Xie
    • , Wei-Jun Zhang
    • , Li-Xing You
    • , Zhen Wang
    • , Teng-Yun Chen
    • , Qiang Zhang
    • , Xiao-Hui Bao
    •  & Jian-Wei Pan
  • Article |

    This analysis of the exchange of air pollution amongst the contiguous United States finds that, on average, around half of the early deaths caused by a state’s air pollution occurs outside that state, with different contributions by different emission sectors and chemical species.

    • Irene C. Dedoussi
    • , Sebastian D. Eastham
    • , Erwan Monier
    •  & Steven R. H. Barrett
  • Article |

    A cryo-electron microscopy structure provides insights into the activation of cullin–RING E3 ligases by NEDD8 and the consequent catalysis of ubiquitylation reactions.

    • Kheewoong Baek
    • , David T. Krist
    • , J. Rajan Prabu
    • , Spencer Hill
    • , Maren Klügel
    • , Lisa-Marie Neumaier
    • , Susanne von Gronau
    • , Gary Kleiger
    •  & Brenda A. Schulman
  • Article |

    The glycopeptide antibiotic-related compounds complestatin and corbomycin function by binding to peptidoglycan and blocking the action of autolysins—peptidoglycan hydrolase enzymes that remodel the cell wall during growth.

    • Elizabeth J. Culp
    • , Nicholas Waglechner
    • , Wenliang Wang
    • , Aline A. Fiebig-Comyn
    • , Yen-Pang Hsu
    • , Kalinka Koteva
    • , David Sychantha
    • , Brian K. Coombes
    • , Michael S. Van Nieuwenhze
    • , Yves V. Brun
    •  & Gerard D. Wright
  • Article |

    Glycolysis in normal epithelial cells responds to microenvironmental mechanics via the modulation of actin bundles that sequester the phosphofructokinase-targeting ubiquitin ligase TRIM21, a process superseded by persistent actin bundles in cancer cells.

    • Jin Suk Park
    • , Christoph J. Burckhardt
    • , Rossana Lazcano
    • , Luisa M. Solis
    • , Tadamoto Isogai
    • , Linqing Li
    • , Christopher S. Chen
    • , Boning Gao
    • , John D. Minna
    • , Robert Bachoo
    • , Ralph J. DeBerardinis
    •  & Gaudenz Danuser
  • Article |

    A structure homologous to the mammalian claustrum exists in reptiles and has a role in generating sharp waves in the brain during slow-wave sleep.

    • Hiroaki Norimoto
    • , Lorenz A. Fenk
    • , Hsing-Hsi Li
    • , Maria Antonietta Tosches
    • , Tatiana Gallego-Flores
    • , David Hain
    • , Sam Reiter
    • , Riho Kobayashi
    • , Angeles Macias
    • , Anja Arends
    • , Michaela Klinkmann
    •  & Gilles Laurent
  • Article |

    The growth of single-crystal Prussian blue analogues and their analysis using X-ray diffuse scattering reveals diverse, non-random vacancy arrangements and information about the micropore-network characteristics of these materials.

    • Arkadiy Simonov
    • , Trees De Baerdemaeker
    • , Hanna L. B. Boström
    • , María Laura Ríos Gómez
    • , Harry J. Gray
    • , Dmitry Chernyshov
    • , Alexey Bosak
    • , Hans-Beat Bürgi
    •  & Andrew L. Goodwin
  • Article
    | Open Access

    Genomic analyses of major clades of huge phages sampled from across Earth’s ecosystems show that they have diverse genetic inventories, including a variety of CRISPR–Cas systems and translation-relevant genes.

    • Basem Al-Shayeb
    • , Rohan Sachdeva
    • , Lin-Xing Chen
    • , Fred Ward
    • , Patrick Munk
    • , Audra Devoto
    • , Cindy J. Castelle
    • , Matthew R. Olm
    • , Keith Bouma-Gregson
    • , Yuki Amano
    • , Christine He
    • , Raphaël Méheust
    • , Brandon Brooks
    • , Alex Thomas
    • , Adi Lavy
    • , Paula Matheus-Carnevali
    • , Christine Sun
    • , Daniela S. A. Goltsman
    • , Mikayla A. Borton
    • , Allison Sharrar
    • , Alexander L. Jaffe
    • , Tara C. Nelson
    • , Rose Kantor
    • , Ray Keren
    • , Katherine R. Lane
    • , Ibrahim F. Farag
    • , Shufei Lei
    • , Kari Finstad
    • , Ronald Amundson
    • , Karthik Anantharaman
    • , Jinglie Zhou
    • , Alexander J. Probst
    • , Mary E. Power
    • , Susannah G. Tringe
    • , Wen-Jun Li
    • , Kelly Wrighton
    • , Sue Harrison
    • , Michael Morowitz
    • , David A. Relman
    • , Jennifer A. Doudna
    • , Anne-Catherine Lehours
    • , Lesley Warren
    • , Jamie H. D. Cate
    • , Joanne M. Santini
    •  & Jillian F. Banfield
  • Article |

    MicroRNAs from head and neck cancer cells, shuttled to sensory neurons by extracellular vesicles, cause a shift to an adrenergic neuronal phenotype that promotes tumour progression.

    • Moran Amit
    • , Hideaki Takahashi
    • , Mihnea Paul Dragomir
    • , Antje Lindemann
    • , Frederico O. Gleber-Netto
    • , Curtis R. Pickering
    • , Simone Anfossi
    • , Abdullah A. Osman
    • , Yu Cai
    • , Rong Wang
    • , Erik Knutsen
    • , Masayoshi Shimizu
    • , Cristina Ivan
    • , Xiayu Rao
    • , Jing Wang
    • , Deborah A. Silverman
    • , Samantha Tam
    • , Mei Zhao
    • , Carlos Caulin
    • , Assaf Zinger
    • , Ennio Tasciotti
    • , Patrick M. Dougherty
    • , Adel El-Naggar
    • , George A. Calin
    •  & Jeffrey N. Myers
  • Article |

    Generation of intense attosecond waveforms with independently controllable amplitude and phase is performed by using a seeded free-electron laser.

    • Praveen Kumar Maroju
    • , Cesare Grazioli
    • , Michele Di Fraia
    • , Matteo Moioli
    • , Dominik Ertel
    • , Hamed Ahmadi
    • , Oksana Plekan
    • , Paola Finetti
    • , Enrico Allaria
    • , Luca Giannessi
    • , Giovanni De Ninno
    • , Carlo Spezzani
    • , Giuseppe Penco
    • , Simone Spampinati
    • , Alexander Demidovich
    • , Miltcho B. Danailov
    • , Roberto Borghes
    • , George Kourousias
    • , Carlos Eduardo Sanches Dos Reis
    • , Fulvio Billé
    • , Alberto A. Lutman
    • , Richard J. Squibb
    • , Raimund Feifel
    • , Paolo Carpeggiani
    • , Maurizio Reduzzi
    • , Tommaso Mazza
    • , Michael Meyer
    • , Samuel Bengtsson
    • , Neven Ibrakovic
    • , Emma Rose Simpson
    • , Johan Mauritsson
    • , Tamás Csizmadia
    • , Mathieu Dumergue
    • , Sergei Kühn
    • , Harshitha Nandiga Gopalakrishna
    • , Daehyun You
    • , Kiyoshi Ueda
    • , Marie Labeye
    • , Jens Egebjerg Bækhøj
    • , Kenneth J. Schafer
    • , Elena V. Gryzlova
    • , Alexei N. Grum-Grzhimailo
    • , Kevin C. Prince
    • , Carlo Callegari
    •  & Giuseppe Sansone
  • Article |

    • Reed M. Stein
    • , Hye Jin Kang
    • , John D. McCorvy
    • , Grant C. Glatfelter
    • , Anthony J. Jones
    • , Tao Che
    • , Samuel Slocum
    • , Xi-Ping Huang
    • , Olena Savych
    • , Yurii S. Moroz
    • , Benjamin Stauch
    • , Linda C. Johansson
    • , Vadim Cherezov
    • , Terry Kenakin
    • , John J. Irwin
    • , Brian K. Shoichet
    • , Bryan L. Roth
    •  & Margarita L. Dubocovich
  • Article
    | Open Access

    Whole-genome sequencing data for 2,778 cancer samples from 2,658 unique donors across 38 cancer types is used to reconstruct the evolutionary history of cancer, revealing that driver mutations can precede diagnosis by several years to decades.

    • Moritz Gerstung
    • , Clemency Jolly
    • , Ignaty Leshchiner
    • , Stefan C. Dentro
    • , Santiago Gonzalez
    • , Daniel Rosebrock
    • , Thomas J. Mitchell
    • , Yulia Rubanova
    • , Pavana Anur
    • , Kaixian Yu
    • , Maxime Tarabichi
    • , Amit Deshwar
    • , Jeff Wintersinger
    • , Kortine Kleinheinz
    • , Ignacio Vázquez-García
    • , Kerstin Haase
    • , Lara Jerman
    • , Subhajit Sengupta
    • , Geoff Macintyre
    • , Salem Malikic
    • , Nilgun Donmez
    • , Dimitri G. Livitz
    • , Marek Cmero
    • , Jonas Demeulemeester
    • , Steven Schumacher
    • , Yu Fan
    • , Xiaotong Yao
    • , Juhee Lee
    • , Matthias Schlesner
    • , Paul C. Boutros
    • , David D. Bowtell
    • , Hongtu Zhu
    • , Gad Getz
    • , Marcin Imielinski
    • , Rameen Beroukhim
    • , S. Cenk Sahinalp
    • , Yuan Ji
    • , Martin Peifer
    • , Florian Markowetz
    • , Ville Mustonen
    • , Ke Yuan
    • , Wenyi Wang
    • , Quaid D. Morris
    • , Stefan C. Dentro
    • , Ignaty Leshchiner
    • , Moritz Gerstung
    • , Clemency Jolly
    • , Kerstin Haase
    • , Maxime Tarabichi
    • , Jeff Wintersinger
    • , Amit G. Deshwar
    • , Kaixian Yu
    • , Santiago Gonzalez
    • , Yulia Rubanova
    • , Geoff Macintyre
    • , David J. Adams
    • , Pavana Anur
    • , Rameen Beroukhim
    • , Paul C. Boutros
    • , David D. Bowtell
    • , Peter J. Campbell
    • , Shaolong Cao
    • , Elizabeth L. Christie
    • , Marek Cmero
    • , Yupeng Cun
    • , Kevin J. Dawson
    • , Jonas Demeulemeester
    • , Nilgun Donmez
    • , Ruben M. Drews
    • , Roland Eils
    • , Yu Fan
    • , Matthew Fittall
    • , Dale W. Garsed
    • , Gad Getz
    • , Gavin Ha
    • , Marcin Imielinski
    • , Lara Jerman
    • , Yuan Ji
    • , Kortine Kleinheinz
    • , Juhee Lee
    • , Henry Lee-Six
    • , Dimitri G. Livitz
    • , Salem Malikic
    • , Florian Markowetz
    • , Inigo Martincorena
    • , Thomas J. Mitchell
    • , Ville Mustonen
    • , Layla Oesper
    • , Martin Peifer
    • , Myron Peto
    • , Benjamin J. Raphael
    • , Daniel Rosebrock
    • , S. Cenk Sahinalp
    • , Adriana Salcedo
    • , Matthias Schlesner
    • , Steven Schumacher
    • , Subhajit Sengupta
    • , Ruian Shi
    • , Seung Jun Shin
    • , Oliver Spiro
    • , Lincoln D. Stein
    • , Ignacio Vázquez-García
    • , Shankar Vembu
    • , David A. Wheeler
    • , Tsun-Po Yang
    • , Xiaotong Yao
    • , Ke Yuan
    • , Hongtu Zhu
    • , Wenyi Wang
    • , Quaid D. Morris
    • , Paul T. Spellman
    • , David C. Wedge
    • , Peter Van Loo
    • , Paul T. Spellman
    • , David C. Wedge
    •  & Peter Van Loo
  • Article
    | Open Access

    The characterization of 4,645 whole-genome and 19,184 exome sequences, covering most types of cancer, identifies 81 single-base substitution, doublet-base substitution and small-insertion-and-deletion mutational signatures, providing a systematic overview of the mutational processes that contribute to cancer development.

    • Ludmil B. Alexandrov
    • , Jaegil Kim
    • , Nicholas J. Haradhvala
    • , Mi Ni Huang
    • , Alvin Wei Tian Ng
    • , Yang Wu
    • , Arnoud Boot
    • , Kyle R. Covington
    • , Dmitry A. Gordenin
    • , Erik N. Bergstrom
    • , S. M. Ashiqul Islam
    • , Nuria Lopez-Bigas
    • , Leszek J. Klimczak
    • , John R. McPherson
    • , Sandro Morganella
    • , Radhakrishnan Sabarinathan
    • , David A. Wheeler
    • , Ville Mustonen
    • , Ludmil B. Alexandrov
    • , Erik N. Bergstrom
    • , Arnoud Boot
    • , Paul Boutros
    • , Kin Chan
    • , Kyle R. Covington
    • , Akihiro Fujimoto
    • , Gad Getz
    • , Dmitry A. Gordenin
    • , Nicholas J. Haradhvala
    • , Mi Ni Huang
    • , S. M. Ashiqul Islam
    • , Marat Kazanov
    • , Jaegil Kim
    • , Leszek J. Klimczak
    • , Nuria Lopez-Bigas
    • , Michael Lawrence
    • , Iñigo Martincorena
    • , John R. McPherson
    • , Sandro Morganella
    • , Ville Mustonen
    • , Hidewaki Nakagawa
    • , Alvin Wei Tian Ng
    • , Paz Polak
    • , Stephenie Prokopec
    • , Steven A. Roberts
    • , Steven G. Rozen
    • , Radhakrishnan Sabarinathan
    • , Natalie Saini
    • , Tatsuhiro Shibata
    • , Yuichi Shiraishi
    • , Michael R. Stratton
    • , Bin Tean Teh
    • , Ignacio Vázquez-García
    • , David A. Wheeler
    • , Yang Wu
    • , Fouad Yousif
    • , Willie Yu
    • , Gad Getz
    • , Steven G. Rozen
    •  & Michael R. Stratton