Latest Research

  • Author Correction |

    • Serena Nik-Zainal
    • , Helen Davies
    • , Johan Staaf
    • , Manasa Ramakrishna
    • , Dominik Glodzik
    • , Xueqing Zou
    • , Inigo Martincorena
    • , Ludmil B. Alexandrov
    • , Sancha Martin
    • , David C. Wedge
    • , Peter Van Loo
    • , Young Seok Ju
    • , Marcel Smid
    • , Arie B. Brinkman
    • , Sandro Morganella
    • , Miriam R. Aure
    • , Ole Christian Lingjærde
    • , Anita Langerød
    • , Markus Ringnér
    • , Sung-Min Ahn
    • , Sandrine Boyault
    • , Jane E. Brock
    • , Annegien Broeks
    • , Adam Butler
    • , Christine Desmedt
    • , Luc Dirix
    • , Serge Dronov
    • , Aquila Fatima
    • , John A. Foekens
    • , Moritz Gerstung
    • , Gerrit K. J. Hooijer
    • , Se Jin Jang
    • , David R. Jones
    • , Hyung-Yong Kim
    • , Tari A. King
    • , Savitri Krishnamurthy
    • , Hee Jin Lee
    • , Jeong-Yeon Lee
    • , Yilong Li
    • , Stuart McLaren
    • , Andrew Menzies
    • , Ville Mustonen
    • , Sarah O’Meara
    • , Iris Pauporté
    • , Xavier Pivot
    • , Colin A. Purdie
    • , Keiran Raine
    • , Kamna Ramakrishnan
    • , F. Germán Rodríguez-González
    • , Gilles Romieu
    • , Anieta M. Sieuwerts
    • , Peter T. Simpson
    • , Rebecca Shepherd
    • , Lucy Stebbings
    • , Olafur A. Stefansson
    • , Jon Teague
    • , Stefania Tommasi
    • , Isabelle Treilleux
    • , Gert G. Van den Eynden
    • , Peter Vermeulen
    • , Anne Vincent-Salomon
    • , Lucy Yates
    • , Carlos Caldas
    • , Laura van’t Veer
    • , Andrew Tutt
    • , Stian Knappskog
    • , Benita Kiat Tee Tan
    • , Jos Jonkers
    • , Åke Borg
    • , Naoto T. Ueno
    • , Christos Sotiriou
    • , Alain Viari
    • , P. Andrew Futreal
    • , Peter J. Campbell
    • , Paul N. Span
    • , Steven Van Laere
    • , Sunil R. Lakhani
    • , Jorunn E. Eyfjord
    • , Alastair M. Thompson
    • , Ewan Birney
    • , Hendrik G. Stunnenberg
    • , Marc J. van de Vijver
    • , John W. M. Martens
    • , Anne-Lise Børresen-Dale
    • , Andrea L. Richardson
    • , Gu Kong
    • , Gilles Thomas
    •  & Michael R. Stratton
  • Letter |

    Organoids derived from human stem cells recapitulate the structure and functions of human blood vessels, and can be used to model and identify regulators of diabetic vasculopathy.

    • Reiner A. Wimmer
    • , Alexandra Leopoldi
    • , Martin Aichinger
    • , Nikolaus Wick
    • , Brigitte Hantusch
    • , Maria Novatchkova
    • , Jasmin Taubenschmid
    • , Monika Hämmerle
    • , Christopher Esk
    • , Joshua A. Bagley
    • , Dominik Lindenhofer
    • , Guibin Chen
    • , Manfred Boehm
    • , Chukwuma A. Agu
    • , Fengtang Yang
    • , Beiyuan Fu
    • , Johannes Zuber
    • , Juergen A. Knoblich
    • , Dontscho Kerjaschki
    •  & Josef M. Penninger
  • Letter |

    Cell-labelling experiments are used to demonstrate that the hindgut in the chick embryo is formed by cells moving through the stationary caudal intestinal portal as a result of a contractile force gradient directed by fibroblast growth factor signalling.

    • Nandan L. Nerurkar
    • , ChangHee Lee
    • , L. Mahadevan
    •  & Clifford J. Tabin
  • Article |

    Inspired by the enhanced mechanical strength of microstructured metals, damage-tolerant architected materials are developed in which the internal structure is granular, with different regions having different lattice orientations.

    • Minh-Son Pham
    • , Chen Liu
    • , Iain Todd
    •  & Jedsada Lertthanasarn
  • Letter |

    A magnetic contribution to the spin Hall effect is observed in the non-collinear antiferromagnet Mn3Sn, which is attributed to momentum-dependent spin splitting produced by non-collinear magnetic order.

    • Motoi Kimata
    • , Hua Chen
    • , Kouta Kondou
    • , Satoshi Sugimoto
    • , Prasanta K. Muduli
    • , Muhammad Ikhlas
    • , Yasutomo Omori
    • , Takahiro Tomita
    • , Allan. H. MacDonald
    • , Satoru Nakatsuji
    •  & Yoshichika Otani
  • Article |

    Transcriptomic and genetic analyses of a deletion set of all known introns in genes of the budding yeast Saccharomyces cerevisiae indicate that introns promote resistance to starvation.

    • Julie Parenteau
    • , Laurine Maignon
    • , Mélodie Berthoumieux
    • , Mathieu Catala
    • , Vanessa Gagnon
    •  & Sherif Abou Elela
  • Letter |

    Distinct but partially overlapping subsets of neurons in the orbitofrontal cortex of mice respond to feeding and/or social stimuli and, when optogenetically stimulated at single-cell resolution, specifically regulate reward-seeking behaviours.

    • Joshua H. Jennings
    • , Christina K. Kim
    • , James H. Marshel
    • , Misha Raffiee
    • , Li Ye
    • , Sean Quirin
    • , Sally Pak
    • , Charu Ramakrishnan
    •  & Karl Deisseroth
  • Letter |

    Quantitative explorations using biomechanics and robotics of the gait of Orobates, a stem amniote, indicate that the development of relatively erect, power-saving and balanced locomotion preceded the diversification of crown amniotes

    • John A. Nyakatura
    • , Kamilo Melo
    • , Tomislav Horvat
    • , Kostas Karakasiliotis
    • , Vivian R. Allen
    • , Amir Andikfar
    • , Emanuel Andrada
    • , Patrick Arnold
    • , Jonas Lauströer
    • , John R. Hutchinson
    • , Martin S. Fischer
    •  & Auke J. Ijspeert
  • Letter |

    Increased glutamine metabolism caused by unregulated HIF-1α signalling in mouse chondrocytes results in increased post-translational modification of collagen and skeletal dysplasia, demonstrating that strict regulation of HIF-1α signalling in chondrocytes is essential for normal bone growth.

    • Steve Stegen
    • , Kjell Laperre
    • , Guy Eelen
    • , Gianmarco Rinaldi
    • , Peter Fraisl
    • , Sophie Torrekens
    • , Riet Van Looveren
    • , Shauni Loopmans
    • , Geert Bultynck
    • , Stefan Vinckier
    • , Filip Meersman
    • , Patrick H. Maxwell
    • , Jyoti Rai
    • , MaryAnn Weis
    • , David R. Eyre
    • , Bart Ghesquière
    • , Sarah-Maria Fendt
    • , Peter Carmeliet
    •  & Geert Carmeliet
  • Letter |

    A kiwellin protein in maize is found to inhibit the activity of the secreted enzyme chorismate mutase from a maize-infecting pathogenic fungus, suggesting a role for kiwellins in plant immunity.

    • Xiaowei Han
    • , Florian Altegoer
    • , Wieland Steinchen
    • , Lynn Binnebesel
    • , Jan Schuhmacher
    • , Timo Glatter
    • , Pietro I. Giammarinaro
    • , Armin Djamei
    • , Stefan A. Rensing
    • , Stefanie Reissmann
    • , Regine Kahmann
    •  & Gert Bange
  • Article |

    A set of 34 excised introns in Saccharomyces cerevisiae, characterized by having a short distance between the lariat branch point and the 3′ splice site, have a biological function within the TOR growth-signalling network.

    • Jeffrey T. Morgan
    • , Gerald R. Fink
    •  & David P. Bartel
  • Letter |

    Photoredox transformations are achieved with infrared light by using triplet fusion upconversion that converts infrared into visible light, enabling the use of photoredox chemistry on larger scales and through barriers that are impenetrable by visible light.

    • Benjamin D. Ravetz
    • , Andrew B. Pun
    • , Emily M. Churchill
    • , Daniel N. Congreve
    • , Tomislav Rovis
    •  & Luis M. Campos
  • Letter |

    Multi-epoch observations of a supernova associated with a γ-ray burst reveal spectral features at extremely high expansion velocities within the first day after the burst, indicative of a choked jet.

    • L. Izzo
    • , A. de Ugarte Postigo
    • , K. Maeda
    • , C. C. Thöne
    • , D. A. Kann
    • , M. Della Valle
    • , A. Sagues Carracedo
    • , M. J. Michałowski
    • , P. Schady
    • , S. Schmidl
    • , J. Selsing
    • , R. L. C. Starling
    • , A. Suzuki
    • , K. Bensch
    • , J. Bolmer
    • , S. Campana
    • , Z. Cano
    • , S. Covino
    • , J. P. U. Fynbo
    • , D. H. Hartmann
    • , K. E. Heintz
    • , J. Hjorth
    • , J. Japelj
    • , K. Kamiński
    • , L. Kaper
    • , C. Kouveliotou
    • , M. Krużyński
    • , T. Kwiatkowski
    • , G. Leloudas
    • , A. J. Levan
    • , D. B. Malesani
    • , T. Michałowski
    • , S. Piranomonte
    • , G. Pugliese
    • , A. Rossi
    • , R. Sánchez-Ramírez
    • , S. Schulze
    • , D. Steeghs
    • , N. R. Tanvir
    • , K. Ulaczyk
    • , S. D. Vergani
    •  & K. Wiersema
  • Author Correction |

    • Belén Fadrique
    • , Selene Báez
    • , Álvaro Duque
    • , Agustina Malizia
    • , Cecilia Blundo
    • , Julieta Carilla
    • , Oriana Osinaga-Acosta
    • , Lucio Malizia
    • , Miles Silman
    • , William Farfán-Ríos
    • , Yadvinder Malhi
    • , Kenneth R. Young
    • , Cuesta C. Francisco
    • , Jurgen Homeier
    • , Manuel Peralvo
    • , Esteban Pinto
    • , Oswaldo Jadan
    • , Nikolay Aguirre
    • , Zhofre Aguirre
    •  & Kenneth J. Feeley
  • Letter |

    Imaging steady-state negative capacitance in SrTiO3/PbTiO3 superlattices with atomic resolution provides solid microscale support for this phenomenon.

    • Ajay K. Yadav
    • , Kayla X. Nguyen
    • , Zijian Hong
    • , Pablo García-Fernández
    • , Pablo Aguado-Puente
    • , Christopher T. Nelson
    • , Sujit Das
    • , Bhagawati Prasad
    • , Daewoong Kwon
    • , Suraj Cheema
    • , Asif I. Khan
    • , Chenming Hu
    • , Jorge Íñiguez
    • , Javier Junquera
    • , Long-Qing Chen
    • , David A. Muller
    • , Ramamoorthy Ramesh
    •  & Sayeef Salahuddin
  • Letter |

    A ferroelectric thin film that behaves as a single domain is found to exhibit both negative capacitance and the predicted double-well polarization–energy relationship.

    • Michael Hoffmann
    • , Franz P. G. Fengler
    • , Melanie Herzig
    • , Terence Mittmann
    • , Benjamin Max
    • , Uwe Schroeder
    • , Raluca Negrea
    • , Pintilie Lucian
    • , Stefan Slesazeck
    •  & Thomas Mikolajick
  • Letter |

    A three-dimensional photonic topological insulator is presented, made of split-ring resonators with strong magneto-electric coupling, which has an extremely wide topological bandgap, forbidding light propagation.

    • Yihao Yang
    • , Zhen Gao
    • , Haoran Xue
    • , Li Zhang
    • , Mengjia He
    • , Zhaoju Yang
    • , Ranjan Singh
    • , Yidong Chong
    • , Baile Zhang
    •  & Hongsheng Chen
  • Letter |

    • M. Amiri
    • , K. Bandura
    • , M. Bhardwaj
    • , P. Boubel
    • , M. M. Boyce
    • , P. J. Boyle
    • , C. Brar
    • , M. Burhanpurkar
    • , T. Cassanelli
    • , P. Chawla
    • , J. F. Cliche
    • , D. Cubranic
    • , M. Deng
    • , N. Denman
    • , M. Dobbs
    • , M. Fandino
    • , E. Fonseca
    • , B. M. Gaensler
    • , A. J. Gilbert
    • , A. Gill
    • , U. Giri
    • , D. C. Good
    • , M. Halpern
    • , D. S. Hanna
    • , A. S. Hill
    • , G. Hinshaw
    • , C. Höfer
    • , A. Josephy
    • , V. M. Kaspi
    • , T. L. Landecker
    • , D. A. Lang
    • , H.-H. Lin
    • , K. W. Masui
    • , R. Mckinven
    • , J. Mena-Parra
    • , M. Merryfield
    • , D. Michilli
    • , N. Milutinovic
    • , C. Moatti
    • , A. Naidu
    • , L. B. Newburgh
    • , C. Ng
    • , C. Patel
    • , U.-L. Pen
    • , T. Pinsonneault-Marotte
    • , Z. Pleunis
    • , M. Rafiei-Ravandi
    • , M. Rahman
    • , S. M. Ransom
    • , A. Renard
    • , P. Scholz
    • , J. R. Shaw
    • , S. R. Siegel
    • , K. M. Smith
    • , I. H. Stairs
    • , S. P. Tendulkar
    • , I. Tretyakov
    • , K. Vanderlinde
    •  & P. Yadav
  • Letter |

    Photometry and parallax data from the Gaia satellite provide direct observational evidence of a theoretically predicted pile-up in the cooling sequence of white dwarfs, which is associated with core crystallization.

    • Pier-Emmanuel Tremblay
    • , Gilles Fontaine
    • , Nicola Pietro Gentile Fusillo
    • , Bart H. Dunlap
    • , Boris T. Gänsicke
    • , Mark A. Hollands
    • , J. J. Hermes
    • , Thomas R. Marsh
    • , Elena Cukanovaite
    •  & Tim Cunningham
  • Letter |

    Radial growth in the roots of Arabidopsis, which is mediated by gene expression activated by the mobile PEAR1 and PEAR2 transcription factors, is initiated around protophloem-sieve-element cell files of procambial tissue.

    • Shunsuke Miyashima
    • , Pawel Roszak
    • , Iris Sevilem
    • , Koichi Toyokura
    • , Bernhard Blob
    • , Jung-ok Heo
    • , Nathan Mellor
    • , Hanna Help-Rinta-Rahko
    • , Sofia Otero
    • , Wouter Smet
    • , Mark Boekschoten
    • , Guido Hooiveld
    • , Kayo Hashimoto
    • , Ondřej Smetana
    • , Riccardo Siligato
    • , Eva-Sophie Wallner
    • , Ari Pekka Mähönen
    • , Yuki Kondo
    • , Charles W. Melnyk
    • , Thomas Greb
    • , Keiji Nakajima
    • , Rosangela Sozzani
    • , Anthony Bishopp
    • , Bert De Rybel
    •  & Ykä Helariutta
  • Letter |

    Specific ablation of mitochondrial complex III subunits in Treg cells in mice results in inflammatory disease, altered Treg gene expression and defective Treg function, indicating a key functional role for mitochondrial complex III in Treg cells.

    • Samuel E. Weinberg
    • , Benjamin D. Singer
    • , Elizabeth M. Steinert
    • , Carlos A. Martinez
    • , Manan M. Mehta
    • , Inmaculada Martínez-Reyes
    • , Peng Gao
    • , Kathryn A. Helmin
    • , Hiam Abdala-Valencia
    • , Laura A. Sena
    • , Paul T. Schumacker
    • , Laurence A. Turka
    •  & Navdeep S. Chandel
  • Letter |

    In the roots of Arabidopsis thaliana, cells with xylem identity and high levels of auxin signalling function as organizer cells that direct neighbouring vascular cambial cells to act as stem cells.

    • Ondřej Smetana
    • , Riikka Mäkilä
    • , Munan Lyu
    • , Ali Amiryousefi
    • , Filomeno Sánchez Rodríguez
    • , Miin-Feng Wu
    • , Anna Solé-Gil
    • , Marina Leal Gavarrón
    • , Riccardo Siligato
    • , Shunsuke Miyashima
    • , Pawel Roszak
    • , Tiina Blomster
    • , Jason W. Reed
    • , Suvi Broholm
    •  & Ari Pekka Mähönen
  • Letter |

    A frequently recurring nova is surrounded by an enormous cavity in space, produced as the nova’s ejecta ‘sweeps up’ the interstellar medium around the star after each eruption.

    • M. J. Darnley
    • , R. Hounsell
    • , T. J. O’Brien
    • , M. Henze
    • , P. Rodríguez-Gil
    • , A. W. Shafter
    • , M. M. Shara
    • , N. M. H. Vaytet
    • , M. F. Bode
    • , R. Ciardullo
    • , B. D. Davis
    • , R. Galera-Rosillo
    • , D. J. Harman
    • , E. J. Harvey
    • , M. W. Healy
    • , J.-U. Ness
    • , V. A. R. M. Ribeiro
    •  & S. C. Williams
  • Letter |

    A new metal–organic framework has several conformational degrees of freedom that can be modified by the external chemical environment to change the structure and trigger the uptake of a guest molecule.

    • Alexandros P. Katsoulidis
    • , Dmytro Antypov
    • , George F. S. Whitehead
    • , Elliot J. Carrington
    • , Dave J. Adams
    • , Neil G. Berry
    • , George R. Darling
    • , Matthew S. Dyer
    •  & Matthew J. Rosseinsky
  • Letter |

    X-ray observations of the evolution of a black-hole transient suggest a shrinkage of its corona, rather than a change in the inner edge of the accretion disk.

    • E. Kara
    • , J. F. Steiner
    • , A. C. Fabian
    • , E. M. Cackett
    • , P. Uttley
    • , R. A. Remillard
    • , K. C. Gendreau
    • , Z. Arzoumanian
    • , D. Altamirano
    • , S. Eikenberry
    • , T. Enoto
    • , J. Homan
    • , J. Neilsen
    •  & A. L. Stevens
  • Article |

    A hyper-stable de novo protein mimic of interleukin-2 computationally designed to not interact with a regulatory T-cell specific receptor subunit has improved therapeutic activity in mouse models of melanoma and colon cancer.

    • Daniel-Adriano Silva
    • , Shawn Yu
    • , Umut Y. Ulge
    • , Jamie B. Spangler
    • , Kevin M. Jude
    • , Carlos Labão-Almeida
    • , Lestat R. Ali
    • , Alfredo Quijano-Rubio
    • , Mikel Ruterbusch
    • , Isabel Leung
    • , Tamara Biary
    • , Stephanie J. Crowley
    • , Enrique Marcos
    • , Carl D. Walkey
    • , Brian D. Weitzner
    • , Fátima Pardo-Avila
    • , Javier Castellanos
    • , Lauren Carter
    • , Lance Stewart
    • , Stanley R. Riddell
    • , Marion Pepper
    • , Gonçalo J. L. Bernardes
    • , Michael Dougan
    • , K. Christopher Garcia
    •  & David Baker
  • Letter |

    • M. Amiri
    • , K. Bandura
    • , M. Bhardwaj
    • , P. Boubel
    • , M. M. Boyce
    • , P. J. Boyle
    • , C. Brar
    • , M. Burhanpurkar
    • , P. Chawla
    • , J. F. Cliche
    • , D. Cubranic
    • , M. Deng
    • , N. Denman
    • , M. Dobbs
    • , M. Fandino
    • , E. Fonseca
    • , B. M. Gaensler
    • , A. J. Gilbert
    • , U. Giri
    • , D. C. Good
    • , M. Halpern
    • , D. Hanna
    • , A. S. Hill
    • , G. Hinshaw
    • , C. Höfer
    • , A. Josephy
    • , V. M. Kaspi
    • , T. L. Landecker
    • , D. A. Lang
    • , K. W. Masui
    • , R. Mckinven
    • , J. Mena-Parra
    • , M. Merryfield
    • , N. Milutinovic
    • , C. Moatti
    • , A. Naidu
    • , L. B. Newburgh
    • , C. Ng
    • , C. Patel
    • , U. Pen
    • , T. Pinsonneault-Marotte
    • , Z. Pleunis
    • , M. Rafiei-Ravandi
    • , S. M. Ransom
    • , A. Renard
    • , P. Scholz
    • , J. R. Shaw
    • , S. R. Siegel
    • , K. M. Smith
    • , I. H. Stairs
    • , S. P. Tendulkar
    • , I. Tretyakov
    • , K. Vanderlinde
    •  & P. Yadav
  • Letter |

    Cryo-electron microscopy structures of feline calicivirus and its cellular receptor show that twelve copies of the minor capsid protein VP2 form a portal-like assembly arranged about a pore in the capsid shell.

    • Michaela J. Conley
    • , Marion McElwee
    • , Liyana Azmi
    • , Mads Gabrielsen
    • , Olwyn Byron
    • , Ian G. Goodfellow
    •  & David Bhella
  • Letter |

    The thermal neutron capture cross-section of 88Zr is measured to be 861,000 ± 69,000 barns, the second-largest neutron capture cross-section ever measured.

    • Jennifer A. Shusterman
    • , Nicholas D. Scielzo
    • , Keenan J. Thomas
    • , Eric B. Norman
    • , Suzanne E. Lapi
    • , C. Shaun Loveless
    • , Nickie J. Peters
    • , J. David Robertson
    • , Dawn A. Shaughnessy
    •  & Anton P. Tonchev
  • Letter |

    Wind from the most massive star in the Trapezium cluster in Orion has carved out a large and expanding cavity around the cluster, bounded by a thin, 2,600-solar-mass shell.

    • C. Pabst
    • , R. Higgins
    • , J. R. Goicoechea
    • , D. Teyssier
    • , O. Berne
    • , E. Chambers
    • , M. Wolfire
    • , S. T. Suri
    • , R. Guesten
    • , J. Stutzki
    • , U. U. Graf
    • , C. Risacher
    •  & A. G. G. M. Tielens
  • Letter |

    Allele-specific single-cell RNA sequencing provides insights into transcription kinetics, with data indicating that core promoter sequences affect burst size, whereas enhancers mainly affect burst frequency.

    • Anton J. M. Larsson
    • , Per Johnsson
    • , Michael Hagemann-Jensen
    • , Leonard Hartmanis
    • , Omid R. Faridani
    • , Björn Reinius
    • , Åsa Segerstolpe
    • , Chloe M. Rivera
    • , Bing Ren
    •  & Rickard Sandberg
  • Letter |

    In a mouse model of ischaemic stroke, regulatory T cells infiltrate the injured brain in response to the chemokines CCL1 and CCL20 and suppress excessive astrogliosis via the production of amphiregulin.

    • Minako Ito
    • , Kyoko Komai
    • , Setsuko Mise-Omata
    • , Mana Iizuka-Koga
    • , Yoshiko Noguchi
    • , Taisuke Kondo
    • , Ryota Sakai
    • , Kazuhiko Matsuo
    • , Takashi Nakayama
    • , Osamu Yoshie
    • , Hiroko Nakatsukasa
    • , Shunsuke Chikuma
    • , Takashi Shichita
    •  & Akihiko Yoshimura
  • Article |

    In physiologically normal epithelia, age-related expansion of clones that carry mutations in NOTCH1 and other driver genes is accelerated by risk factors for developing oesophageal squamous cell carcinoma, such as alcohol consumption or smoking.

    • Akira Yokoyama
    • , Nobuyuki Kakiuchi
    • , Tetsuichi Yoshizato
    • , Yasuhito Nannya
    • , Hiromichi Suzuki
    • , Yasuhide Takeuchi
    • , Yusuke Shiozawa
    • , Yusuke Sato
    • , Kosuke Aoki
    • , Soo Ki Kim
    • , Yoichi Fujii
    • , Kenichi Yoshida
    • , Keisuke Kataoka
    • , Masahiro M. Nakagawa
    • , Yoshikage Inoue
    • , Tomonori Hirano
    • , Yuichi Shiraishi
    • , Kenichi Chiba
    • , Hiroko Tanaka
    • , Masashi Sanada
    • , Yoshitaka Nishikawa
    • , Yusuke Amanuma
    • , Shinya Ohashi
    • , Ikuo Aoyama
    • , Takahiro Horimatsu
    • , Shin’ichi Miyamoto
    • , Shigeru Tsunoda
    • , Yoshiharu Sakai
    • , Maiko Narahara
    • , J. B. Brown
    • , Yoshitaka Sato
    • , Genta Sawada
    • , Koshi Mimori
    • , Sachiko Minamiguchi
    • , Hironori Haga
    • , Hiroshi Seno
    • , Satoru Miyano
    • , Hideki Makishima
    • , Manabu Muto
    •  & Seishi Ogawa
  • Letter |

    Femtosecond time-resolved X-ray diffraction reveals that in the ultrafast demagnitization of ferromagnetic iron, about 80% of the angular momentum lost from the spins is transferred to the lattice on a sub-picosecond timescale.

    • C. Dornes
    • , Y. Acremann
    • , M. Savoini
    • , M. Kubli
    • , M. J. Neugebauer
    • , E. Abreu
    • , L. Huber
    • , G. Lantz
    • , C. A. F. Vaz
    • , H. Lemke
    • , E. M. Bothschafter
    • , M. Porer
    • , V. Esposito
    • , L. Rettig
    • , M. Buzzi
    • , A. Alberca
    • , Y. W. Windsor
    • , P. Beaud
    • , U. Staub
    • , Diling Zhu
    • , Sanghoon Song
    • , J. M. Glownia
    •  & S. L. Johnson
  • Letter |

    Isolates of the Vibrio cholerae O1 serotype Ogawa from Yemen are from a single sublineage of the seventh pandemic El Tor (7PET) lineage and are susceptible to several commonly used antibiotics as well as to polymyxins.

    • François-Xavier Weill
    • , Daryl Domman
    • , Elisabeth Njamkepo
    • , Abdullrahman A. Almesbahi
    • , Mona Naji
    • , Samar Saeed Nasher
    • , Ankur Rakesh
    • , Abdullah M. Assiri
    • , Naresh Chand Sharma
    • , Samuel Kariuki
    • , Mohammad Reza Pourshafie
    • , Jean Rauzier
    • , Abdinasir Abubakar
    • , Jane Y. Carter
    • , Joseph F. Wamala
    • , Caroline Seguin
    • , Christiane Bouchier
    • , Thérèse Malliavin
    • , Bita Bakhshi
    • , Hayder H. N. Abulmaali
    • , Dhirendra Kumar
    • , Samuel M. Njoroge
    • , Mamunur Rahman Malik
    • , John Kiiru
    • , Francisco J. Luquero
    • , Andrew S. Azman
    • , Thandavarayan Ramamurthy
    • , Nicholas R. Thomson
    •  & Marie-Laure Quilici
  • Letter |

    Subglacially produced methane of microbial origin is flushed to the ice margin of the Greenland ice sheet by meltwater, contributing to a previously unaccounted for methane flux to the atmosphere.

    • Guillaume Lamarche-Gagnon
    • , Jemma L. Wadham
    • , Barbara Sherwood Lollar
    • , Sandra Arndt
    • , Peer Fietzek
    • , Alexander D. Beaton
    • , Andrew J. Tedstone
    • , Jon Telling
    • , Elizabeth A. Bagshaw
    • , Jon R. Hawkings
    • , Tyler J. Kohler
    • , Jakub D. Zarsky
    • , Matthew C. Mowlem
    • , Alexandre M. Anesio
    •  & Marek Stibal
  • Article |

    Cryo-electron microscopy structures are reported in which the full-length human α1β3γ2L GABAA receptor in lipid nanodiscs is bound to the channel-blocker picrotoxin, the competitive antagonist bicuculline, the agonist GABA, and the benzodiazepines alprazolam and diazepam.

    • Simonas Masiulis
    • , Rooma Desai
    • , Tomasz Uchański
    • , Itziar Serna Martin
    • , Duncan Laverty
    • , Dimple Karia
    • , Tomas Malinauskas
    • , Jasenko Zivanov
    • , Els Pardon
    • , Abhay Kotecha
    • , Jan Steyaert
    • , Keith W. Miller
    •  & A. Radu Aricescu
  • Letter |

    Terahertz light pulses induce transitions between a topological and a trivial phase in the Weyl semimetal WTe2 through an interlayer shear strain.

    • Edbert J. Sie
    • , Clara M. Nyby
    • , C. D. Pemmaraju
    • , Su Ji Park
    • , Xiaozhe Shen
    • , Jie Yang
    • , Matthias C. Hoffmann
    • , B. K. Ofori-Okai
    • , Renkai Li
    • , Alexander H. Reid
    • , Stephen Weathersby
    • , Ehren Mannebach
    • , Nathan Finney
    • , Daniel Rhodes
    • , Daniel Chenet
    • , Abhinandan Antony
    • , Luis Balicas
    • , James Hone
    • , Thomas P. Devereaux
    • , Tony F. Heinz
    • , Xijie Wang
    •  & Aaron M. Lindenberg
  • Letter |

    A closed-loop implantable bioelectronic device that can modulate peripheral neuronal activity is used to improve bladder function in a rat model of cystitis.

    • Aaron D. Mickle
    • , Sang Min Won
    • , Kyung Nim Noh
    • , Jangyeol Yoon
    • , Kathleen W. Meacham
    • , Yeguang Xue
    • , Lisa A. McIlvried
    • , Bryan A. Copits
    • , Vijay K. Samineni
    • , Kaitlyn E. Crawford
    • , Do Hoon Kim
    • , Paulome Srivastava
    • , Bong Hoon Kim
    • , Seunghwan Min
    • , Young Shiuan
    • , Yeojeong Yun
    • , Maria A. Payne
    • , Jianpeng Zhang
    • , Hokyung Jang
    • , Yuhang Li
    • , H. Henry Lai
    • , Yonggang Huang
    • , Sung-Il Park
    • , Robert W. Gereau IV
    •  & John A. Rogers
  • Letter |

    A high-resolution cryo-electron microscopy structure is reported for the full-length human α1β3γ2L GABAA receptor, functionally reconstituted in lipid nanodiscs.

    • Duncan Laverty
    • , Rooma Desai
    • , Tomasz Uchański
    • , Simonas Masiulis
    • , Wojciech J. Stec
    • , Tomas Malinauskas
    • , Jasenko Zivanov
    • , Els Pardon
    • , Jan Steyaert
    • , Keith W. Miller
    •  & A. Radu Aricescu
  • Letter |

    A transplantable mouse model of persistent cutaneous melanoma shows that immune-mediated tumour suppression can result in a state of melanoma–immune equilibrium, and that tissue-resident memory T cells are essential drivers of this equilibrium state.

    • Simone L. Park
    • , Anthony Buzzai
    • , Jai Rautela
    • , Jyh Liang Hor
    • , Katharina Hochheiser
    • , Maike Effern
    • , Nathan McBain
    • , Teagan Wagner
    • , Jarem Edwards
    • , Robyn McConville
    • , James S. Wilmott
    • , Richard A. Scolyer
    • , Thomas Tüting
    • , Umaimainthan Palendria
    • , David Gyorki
    • , Scott N. Mueller
    • , Nicholas D. Huntington
    • , Sammy Bedoui
    • , Michael Hölzel
    • , Laura K. Mackay
    • , Jason Waithman
    •  & Thomas Gebhardt