Latest Research

  • Letter |

    Archived vials of cadaveric human growth hormone contain substantial levels of amyloid-β (Aβ) peptides and can seed Aβ plaques in susceptible mice, suggesting that this material could have transmitted Aβ pathology to humans.

    • Silvia A. Purro
    • , Mark A. Farrow
    • , Jacqueline Linehan
    • , Tamsin Nazari
    • , David X. Thomas
    • , Zhicheng Chen
    • , David Mengel
    • , Takashi Saito
    • , Takaomi Saido
    • , Peter Rudge
    • , Sebastian Brandner
    • , Dominic M. Walsh
    •  & John Collinge
  • Letter |

    Direct observation of incommensurate spin correlations in doped and spin-imbalanced Hubbard chains confirms two fundamental predictions for Luttinger liquids and shows that such correlations are suppressed by interchain coupling.

    • Guillaume Salomon
    • , Joannis Koepsell
    • , Jayadev Vijayan
    • , Timon A. Hilker
    • , Jacopo Nespolo
    • , Lode Pollet
    • , Immanuel Bloch
    •  & Christian Gross
  • Letter |

    Misexpression of the sperm-cell-expressed transcription factor BABY BOOM1 in the rice egg cell induces embryo development without fertilization, establishing the feasibility of asexual reproduction in crops and potentially enabling the clonal propagation of hybrids through seeds.

    • Imtiyaz Khanday
    • , Debra Skinner
    • , Bing Yang
    • , Raphael Mercier
    •  & Venkatesan Sundaresan
  • Article |

    Despite inter-model differences in predicting the details of the eastern Pacific El Niño, a robust increase in the corresponding sea surface temperature variability under greenhouse warming is found across models.

    • Wenju Cai
    • , Guojian Wang
    • , Boris Dewitte
    • , Lixin Wu
    • , Agus Santoso
    • , Ken Takahashi
    • , Yun Yang
    • , Aude Carréric
    •  & Michael J. McPhaden
  • Letter |

    A subnanometre-resolution cryo-electron microscopy structure of the Rh5–CyRPA–Ripr complex of Plasmodium falciparum provides insights into how this ligand interacts with the receptor basigin in erythrocyte hosts.

    • Wilson Wong
    • , Rick Huang
    • , Sebastien Menant
    • , Chuan Hong
    • , Jarrod J. Sandow
    • , Richard W. Birkinshaw
    • , Julie Healer
    • , Anthony N. Hodder
    • , Usheer Kanjee
    • , Christopher J. Tonkin
    • , Denise Heckmann
    • , Vladislav Soroka
    • , Teit Max Moscote Søgaard
    • , Thomas Jørgensen
    • , Manoj T. Duraisingh
    • , Peter E. Czabotar
    • , Willem A. de Jongh
    • , Wai-Hong Tham
    • , Andrew I. Webb
    • , Zhiheng Yu
    •  & Alan F. Cowman
  • Letter |

    A fully connected quantum network is demonstrated in which one source of entangled photons distributes quantum states to four users, with the potential for many more users to be added.

    • Sören Wengerowsky
    • , Siddarth Koduru Joshi
    • , Fabian Steinlechner
    • , Hannes Hübel
    •  & Rupert Ursin
  • Article |

    Cryo-electron microscopy structures of connexin channels composed of connexin 46 and connexin 50 in an open-state reveal features that govern permselectivity and the location of mutated residues linked to herediatry cataracts.

    • Janette B. Myers
    • , Bassam G. Haddad
    • , Susan E. O’Neill
    • , Dror S. Chorev
    • , Craig C. Yoshioka
    • , Carol V. Robinson
    • , Daniel M. Zuckerman
    •  & Steve L. Reichow
  • Letter |

    Evaluation of the efficiency of land-use changes and their effect on global carbon storage shows that several land-use and consumption choices relevant to climate policy have greater implications than previously thought.

    • Timothy D. Searchinger
    • , Stefan Wirsenius
    • , Tim Beringer
    •  & Patrice Dumas
  • Article |

    The cryo-electron microscopy structure of the gp120 component of the HIV-1 envelope glycoprotein, in complex with the primary receptor CD4 and coreceptor CCR5, provides insight into the cell-entry mechanism of HIV-1.

    • Md Munan Shaik
    • , Hanqin Peng
    • , Jianming Lu
    • , Sophia Rits-Volloch
    • , Chen Xu
    • , Maofu Liao
    •  & Bing Chen
  • Letter |

    Atrial natriuretic peptide, an anti-inflammatory protein, can protect against cytokine release syndrome induced by therapeutic agents such as tumour-targeting bacteria and CAR-T cells by blocking catecholamine synthesis by macrophages.

    • Verena Staedtke
    • , Ren-Yuan Bai
    • , Kibem Kim
    • , Martin Darvas
    • , Marco L. Davila
    • , Gregory J. Riggins
    • , Paul B. Rothman
    • , Nickolas Papadopoulos
    • , Kenneth W. Kinzler
    • , Bert Vogelstein
    •  & Shibin Zhou
  • Letter |

    In mouse macrophages, a range of short and non-ATG-initiated open reading frames that can generate proteins are identified, one of which is shown to be essential for host immunity to enteric mucosal infection and inflammation.

    • Ruaidhrí Jackson
    • , Lina Kroehling
    • , Alexandra Khitun
    • , Will Bailis
    • , Abigail Jarret
    • , Autumn G. York
    • , Omair M. Khan
    • , J. Richard Brewer
    • , Mathias H. Skadow
    • , Coco Duizer
    • , Christian C. D. Harman
    • , Lelina Chang
    • , Piotr Bielecki
    • , Angel G. Solis
    • , Holly R. Steach
    • , Sarah Slavoff
    •  & Richard A. Flavell
  • Letter |

    A method for encoding the non-canonical amino acid 2,3-diaminopropionate into proteins allows key acyl intermediates in the biosynthesis of valinomycin to be trapped, providing insight into the oligomerization and cyclization reactions involved.

    • Nicolas Huguenin-Dezot
    • , Diego A. Alonzo
    • , Graham W. Heberlig
    • , Mohan Mahesh
    • , Duy P. Nguyen
    • , Mark H. Dornan
    • , Christopher N. Boddy
    • , T. Martin Schmeing
    •  & Jason W. Chin
  • Letter |

    • Alex W. Wilkinson
    • , Jonathan Diep
    • , Shaobo Dai
    • , Shuo Liu
    • , Yaw Shin Ooi
    • , Dan Song
    • , Tie-Mei Li
    • , John R. Horton
    • , Xing Zhang
    • , Chao Liu
    • , Darshan V. Trivedi
    • , Katherine M. Ruppel
    • , José G. Vilches-Moure
    • , Kerriann M. Casey
    • , Justin Mak
    • , Tina Cowan
    • , Joshua E. Elias
    • , Claude M. Nagamine
    • , James A. Spudich
    • , Xiaodong Cheng
    • , Jan E. Carette
    •  & Or Gozani
  • Letter |

    An electrically controlled phase transition from topological insulator to conventional insulator in ultrathin films of the topological Dirac semimetal, Na3Bi.

    • James L. Collins
    • , Anton Tadich
    • , Weikang Wu
    • , Lidia C. Gomes
    • , Joao N. B. Rodrigues
    • , Chang Liu
    • , Jack Hellerstedt
    • , Hyejin Ryu
    • , Shujie Tang
    • , Sung-Kwan Mo
    • , Shaffique Adam
    • , Shengyuan A. Yang
    • , Michael S. Fuhrer
    •  & Mark T. Edmonds
  • Author Correction |

    • Hezhe Lu
    • , Shujing Liu
    • , Gao Zhang
    • , Bin Wu
    • , Yueyao Zhu
    • , Dennie T. Frederick
    • , Yi Hu
    • , Wenqun Zhong
    • , Sergio Randell
    • , Norah Sadek
    • , Wei Zhang
    • , Gang Chen
    • , Chaoran Cheng
    • , Jingwen Zeng
    • , Lawrence W. Wu
    • , Jie Zhang
    • , Xiaoming Liu
    • , Wei Xu
    • , Clemens Krepler
    • , Katrin Sproesser
    • , Min Xiao
    • , Benchun Miao
    • , Jianglan Liu
    • , Claire D. Song
    • , Jephrey Y. Liu
    • , Giorgos C. Karakousis
    • , Lynn M. Schuchter
    • , Yiling Lu
    • , Gordon Mills
    • , Yusheng Cong
    • , Jonathan Chernoff
    • , Jun Guo
    • , Genevieve M. Boland
    • , Ryan J. Sullivan
    • , Zhi Wei
    • , Jeffrey Field
    • , Ravi K. Amaravadi
    • , Keith T. Flaherty
    • , Meenhard Herlyn
    • , Xiaowei Xu
    •  & Wei Guo
  • Letter |

    α1,3-galactosyltransferase-knockout pig hearts that express human CD46 and human thrombomodulin require non-ischaemic preservation with continuous perfusion and post-transplantation growth control to ensure long-term orthotopic function of the xenograft in baboons.

    • Matthias Längin
    • , Tanja Mayr
    • , Bruno Reichart
    • , Sebastian Michel
    • , Stefan Buchholz
    • , Sonja Guethoff
    • , Alexey Dashkevich
    • , Andrea Baehr
    • , Stefanie Egerer
    • , Andreas Bauer
    • , Maks Mihalj
    • , Alessandro Panelli
    • , Lara Issl
    • , Jiawei Ying
    • , Ann Kathrin Fresch
    • , Ines Buttgereit
    • , Maren Mokelke
    • , Julia Radan
    • , Fabian Werner
    • , Isabelle Lutzmann
    • , Stig Steen
    • , Trygve Sjöberg
    • , Audrius Paskevicius
    • , Liao Qiuming
    • , Riccardo Sfriso
    • , Robert Rieben
    • , Maik Dahlhoff
    • , Barbara Kessler
    • , Elisabeth Kemter
    • , Katharina Klett
    • , Rabea Hinkel
    • , Christian Kupatt
    • , Almuth Falkenau
    • , Simone Reu
    • , Reinhard Ellgass
    • , Rudolf Herzog
    • , Uli Binder
    • , Günter Wich
    • , Arne Skerra
    • , David Ayares
    • , Alexander Kind
    • , Uwe Schönmann
    • , Franz-Josef Kaup
    • , Christian Hagl
    • , Eckhard Wolf
    • , Nikolai Klymiuk
    • , Paolo Brenner
    •  & Jan-Michael Abicht
  • Brief Communications Arising |

    • J. B. Berger
    • , H. N. G. Wadley
    •  & R. M. McMeeking
  • Article |

    Combinatorial tagging of single cells using expressed DNA barcodes, delivered by a lentiviral vector, is used to track individual cells and reconstruct their lineages and trajectories during cell fate reprogramming.

    • Brent A. Biddy
    • , Wenjun Kong
    • , Kenji Kamimoto
    • , Chuner Guo
    • , Sarah E. Waye
    • , Tao Sun
    •  & Samantha A. Morris
  • Letter |

    Satellite observations reveal over 200 ammonia hotspots associated with agricultural and industrial point sources, which emit much larger quantities of ammonia to the atmosphere than previously thought.

    • Martin Van Damme
    • , Lieven Clarisse
    • , Simon Whitburn
    • , Juliette Hadji-Lazaro
    • , Daniel Hurtmans
    • , Cathy Clerbaux
    •  & Pierre-François Coheur
  • Article |

    The presence of blubber and distribution of melanophores in a countershading pattern in an Early Jurassic ichthyosaur demonstrate that the evolutionary convergence of these reptiles with extant marine amniotes extends to the cellular and molecular levels.

    • Johan Lindgren
    • , Peter Sjövall
    • , Volker Thiel
    • , Wenxia Zheng
    • , Shosuke Ito
    • , Kazumasa Wakamatsu
    • , Rolf Hauff
    • , Benjamin P. Kear
    • , Anders Engdahl
    • , Carl Alwmark
    • , Mats E. Eriksson
    • , Martin Jarenmark
    • , Sven Sachs
    • , Per E. Ahlberg
    • , Federica Marone
    • , Takeo Kuriyama
    • , Ola Gustafsson
    • , Per Malmberg
    • , Aurélien Thomen
    • , Irene Rodríguez-Meizoso
    • , Per Uvdal
    • , Makoto Ojika
    •  & Mary H. Schweitzer
  • Letter |

    Orthogonal ribosomes are engineered in which the two subunits are stapled together in a way that limits association with endogenous subunits in cells, enabling the evolution of new functionality in the orthogonal ribosome.

    • Wolfgang H. Schmied
    • , Zakir Tnimov
    • , Chayasith Uttamapinant
    • , Christopher D. Rae
    • , Stephen D. Fried
    •  & Jason W. Chin
  • Letter |

    Ice-core-derived melt records reveal that atmospheric warming has recently intensified Greenland ice-sheet surface melt and runoff to levels that are exceptional over at least the last 350 years.

    • Luke D. Trusel
    • , Sarah B. Das
    • , Matthew B. Osman
    • , Matthew J. Evans
    • , Ben E. Smith
    • , Xavier Fettweis
    • , Joseph R. McConnell
    • , Brice P. Y. Noël
    •  & Michiel R. van den Broeke
  • Letter |

    The identification of a complex haematopoietic system in a colonial tunicate sheds light on the evolution of the mammalian blood system.

    • Benyamin Rosental
    • , Mark Kowarsky
    • , Jun Seita
    • , Daniel M. Corey
    • , Katherine J. Ishizuka
    • , Karla J. Palmeri
    • , Shih-Yu Chen
    • , Rahul Sinha
    • , Jennifer Okamoto
    • , Gary Mantalas
    • , Lucia Manni
    • , Tal Raveh
    • , D. Nathaniel Clarke
    • , Jonathan M. Tsai
    • , Aaron M. Newman
    • , Norma F. Neff
    • , Garry P. Nolan
    • , Stephen R. Quake
    • , Irving L. Weissman
    •  & Ayelet Voskoboynik
  • Letter |

    Early results from the COSINE-100 experiment—designed to test a much-debated claim of the detection of a dark-matter signal—show no indications of dark matter, providing evidence against the previous claim.

    • Govinda Adhikari
    • , Pushparaj Adhikari
    • , Estella Barbosa de Souza
    • , Nelson Carlin
    • , Seonho Choi
    • , Mitra Djamal
    • , Anthony C. Ezeribe
    • , Chang Hyon Ha
    • , Insik Hahn
    • , Antonia J. F. Hubbard
    • , Eunju Jeon
    • , Jay Hyun Jo
    • , Hanwool Joo
    • , Woon Gu Kang
    • , Woosik Kang
    • , Matthew Kauer
    • , Bonghee Kim
    • , Hongjoo Kim
    • , Hyounggyu Kim
    • , Kyungwon Kim
    • , Nam Young Kim
    • , Sun Kee Kim
    • , Yeongduk Kim
    • , Yong-Hamb Kim
    • , Young Ju Ko
    • , Vitaly A. Kudryavtsev
    • , Hyun Su Lee
    • , Jaison Lee
    • , Jooyoung Lee
    • , Moo Hyun Lee
    • , Douglas S. Leonard
    • , Warren A. Lynch
    • , Reina H. Maruyama
    • , Frederic Mouton
    • , Stephen L. Olsen
    • , Byungju Park
    • , Hyang Kyu Park
    • , Hyeonseo Park
    • , Jungsic Park
    • , Kangsoon Park
    • , Walter C. Pettus
    • , Hafizh Prihtiadi
    • , Sejin Ra
    • , Carsten Rott
    • , Andrew Scarff
    • , Keon Ah Shin
    • , Neil J. C. Spooner
    • , William G. Thompson
    • , Liang Yang
    •  & Seok Hyun Yong
  • Letter |

    Streptomyces secondary metabolites provide a chemical defence against phage predation.

    • Sarah Kronheim
    • , Martin Daniel-Ivad
    • , Zhuang Duan
    • , Sungwon Hwang
    • , Andrew I. Wong
    • , Ian Mantel
    • , Justin R. Nodwell
    •  & Karen L. Maxwell
  • Article |

    Pyramidal neurons in the hippocampal CA2 region in mice promote social aggression via a disinhibitory circuit involving the lateral septum and ventromedial hypothalamus.

    • Felix Leroy
    • , Jung Park
    • , Arun Asok
    • , David H. Brann
    • , Torcato Meira
    • , Lara M. Boyle
    • , Eric W. Buss
    • , Eric R. Kandel
    •  & Steven A. Siegelbaum
  • Article |

    A scalable spintronic device operating via spin–orbit transduction and magnetoelectric switching and using advanced quantum materials shows non-volatility and improved performance and energy efficiency compared with CMOS devices.

    • Sasikanth Manipatruni
    • , Dmitri E. Nikonov
    • , Chia-Ching Lin
    • , Tanay A. Gosavi
    • , Huichu Liu
    • , Bhagwati Prasad
    • , Yen-Lin Huang
    • , Everton Bonturim
    • , Ramamoorthy Ramesh
    •  & Ian A. Young
  • Letter |

    A refractive lens and a refractive prism for extreme-ultraviolet radiation have been developed that use the deflection of the radiation in an inhomogeneous jet of atoms.

    • L. Drescher
    • , O. Kornilov
    • , T. Witting
    • , G. Reitsma
    • , N. Monserud
    • , A. Rouzée
    • , J. Mikosch
    • , M. J. J. Vrakking
    •  & B. Schütte
  • Letter |

    PD-1 undergoes internalization, FBXO38-mediated ubiquitination and proteasome degradation in activated T cells, and inhibition of this pathway dampens anti-tumour immunity of T cells.

    • Xiangbo Meng
    • , Xiwei Liu
    • , Xingdong Guo
    • , Shutan Jiang
    • , Tingting Chen
    • , Zhiqiang Hu
    • , Haifeng Liu
    • , Yibing Bai
    • , Manman Xue
    • , Ronggui Hu
    • , Shao-cong Sun
    • , Xiaolong Liu
    • , Penghui Zhou
    • , Xiaowu Huang
    • , Lai Wei
    • , Wei Yang
    •  & Chenqi Xu
  • Letter |

    Stella, a factor essential for female fertility, protects the oocyte methylome in mice by suppressing de novo DNA methylation mediated by the DNA methyltransferase DNMT1.

    • Yingfeng Li
    • , Zhuqiang Zhang
    • , Jiayu Chen
    • , Wenqiang Liu
    • , Weiyi Lai
    • , Baodong Liu
    • , Xiang Li
    • , Liping Liu
    • , Shaohua Xu
    • , Qiang Dong
    • , Mingzhu Wang
    • , Xiaoya Duan
    • , Jiajun Tan
    • , Yong Zheng
    • , Pumin Zhang
    • , Guoping Fan
    • , Jiemin Wong
    • , Guo-Liang Xu
    • , Zhigao Wang
    • , Hailin Wang
    • , Shaorong Gao
    •  & Bing Zhu
  • Letter |

    Improved techniques allow the measurement of a frequency difference with an uncertainty of the order of 10–19 between two independent atomic optical lattice clocks, suggesting that they may be able to improve state-of-the-art geodetic techniques.

    • W. F. McGrew
    • , X. Zhang
    • , R. J. Fasano
    • , S. A. Schäffer
    • , K. Beloy
    • , D. Nicolodi
    • , R. C. Brown
    • , N. Hinkley
    • , G. Milani
    • , M. Schioppo
    • , T. H. Yoon
    •  & A. D. Ludlow
  • Letter |

    A modelling framework is presented to determine the optimal layout and physical properties of networks in which the nodes and links have physical sizes and intersections between components is prohibited.

    • Nima Dehmamy
    • , Soodabeh Milanlouei
    •  & Albert-László Barabási
  • Letter |

    Single-cell analysis reveals that interactions with the extracellular matrix via integrin α5 and mechanotransducer YAP1 determine whether pancreatic progenitors develop along the duct or endocrine lineages.

    • Anant Mamidi
    • , Christy Prawiro
    • , Philip A. Seymour
    • , Kristian Honnens de Lichtenberg
    • , Abigail Jackson
    • , Palle Serup
    •  & Henrik Semb
  • Letter |

    High-angular-resolution observations of the quasar 3C 273 reveal that it has a relatively small but thick disk, viewed nearly face-on, in which material is orbiting the central supermassive black hole.

    • E. Sturm
    • , J. Dexter
    • , O. Pfuhl
    • , M. R. Stock
    • , R. I. Davies
    • , D. Lutz
    • , Y. Clénet
    • , A. Eckart
    • , F. Eisenhauer
    • , R. Genzel
    • , D. Gratadour
    • , S. F. Hönig
    • , M. Kishimoto
    • , S. Lacour
    • , F. Millour
    • , H. Netzer
    • , G. Perrin
    • , B. M. Peterson
    • , P. O. Petrucci
    • , D. Rouan
    • , I. Waisberg
    • , J. Woillez
    • , A. Amorim
    • , W. Brandner
    • , N. M. Förster Schreiber
    • , P. J. V. Garcia
    • , S. Gillessen
    • , T. Ott
    • , T. Paumard
    • , K. Perraut
    • , S. Scheithauer
    • , C. Straubmeier
    • , L. J. Tacconi
    •  & F. Widmann
  • Letter |

    In mammalian cells, NP220 is a key protein that recruits the HUSH complex, SETDB1 and the histone deacetylases HDAC1 and HDAC4 to silence unintegrated retroviral DNA.

    • Yiping Zhu
    • , Gary Z. Wang
    • , Oya Cingöz
    •  & Stephen P. Goff