Latest Research

  • Article |

    A method for systematically exploring interactions between the nucleosome and transcription factors identifies five major interaction patterns.

    • Fangjie Zhu
    • , Lucas Farnung
    • , Eevi Kaasinen
    • , Biswajyoti Sahu
    • , Yimeng Yin
    • , Bei Wei
    • , Svetlana O. Dodonova
    • , Kazuhiro R. Nitta
    • , Ekaterina Morgunova
    • , Minna Taipale
    • , Patrick Cramer
    •  & Jussi Taipale
  • Letter |

    A periosteal stem cell specialized in intramembranous bone formation has been identified and was found to be essential for normal bone development and fracture healing.

    • Shawon Debnath
    • , Alisha R. Yallowitz
    • , Jason McCormick
    • , Sarfaraz Lalani
    • , Tuo Zhang
    • , Ren Xu
    • , Na Li
    • , Yifang Liu
    • , Yeon Suk Yang
    • , Mark Eiseman
    • , Jae-Hyuck Shim
    • , Meera Hameed
    • , John H. Healey
    • , Mathias P. Bostrom
    • , Dan Avi Landau
    •  & Matthew B. Greenblatt
  • Letter |

    Chip-scale lithium niobate electro-optic modulators that rapidly convert electrical to optical signals and use CMOS-compatible voltages could prove useful in optical communication networks, microwave photonic systems and photonic computation.

    • Cheng Wang
    • , Mian Zhang
    • , Xi Chen
    • , Maxime Bertrand
    • , Amirhassan Shams-Ansari
    • , Sethumadhavan Chandrasekhar
    • , Peter Winzer
    •  & Marko Lončar
  • Brief Communications Arising |

    • Lynn N. Bertagnolli
    • , Jennifer A. White
    • , Francesco R. Simonetti
    • , Subul A. Beg
    • , Jun Lai
    • , Costin Tomescu
    • , Alexandra J. Murray
    • , Annukka A. R. Antar
    • , Hao Zhang
    • , Joseph B. Margolick
    • , Rebecca Hoh
    • , Stephen G. Deeks
    • , Pablo Tebas
    • , Luis J. Montaner
    • , Robert F. Siliciano
    • , Gregory M. Laird
    •  & Janet D. Siliciano
  • Letter |

    A reinforcement learning approach allows a suitably equipped glider to navigate thermal plumes autonomously in an open field.

    • Gautam Reddy
    • , Jerome Wong-Ng
    • , Antonio Celani
    • , Terrence J. Sejnowski
    •  & Massimo Vergassola
  • Letter |

    The diversity in the hydraulic traits of trees mediates ecosystem resilience to drought and will probably have an important role in future ecosystem–atmosphere feedback effects.

    • William R. L. Anderegg
    • , Alexandra G. Konings
    • , Anna T. Trugman
    • , Kailiang Yu
    • , David R. Bowling
    • , Robert Gabbitas
    • , Daniel S. Karp
    • , Stephen Pacala
    • , John S. Sperry
    • , Benjamin N. Sulman
    •  & Nicole Zenes
  • Article |

    The detection of hypocretin-specific autoreactive CD4+ and CD8+ T cells in patients with narcolepsy reveals the autoimmune aetiology of this disorder.

    • Daniela Latorre
    • , Ulf Kallweit
    • , Eric Armentani
    • , Mathilde Foglierini
    • , Federico Mele
    • , Antonino Cassotta
    • , Sandra Jovic
    • , David Jarrossay
    • , Johannes Mathis
    • , Francesco Zellini
    • , Burkhard Becher
    • , Antonio Lanzavecchia
    • , Ramin Khatami
    • , Mauro Manconi
    • , Mehdi Tafti
    • , Claudio L. Bassetti
    •  & Federica Sallusto
  • Article |

    A high-resolution cryo-electron microscopy structure of a complete Tc holotoxin complex reveals the precise mechanism of Tc toxin assembly, gate opening and release of the cytotoxic enzyme into the translocation channel.

    • Christos Gatsogiannis
    • , Felipe Merino
    • , Daniel Roderer
    • , David Balchin
    • , Evelyn Schubert
    • , Anne Kuhlee
    • , Manajit Hayer-Hartl
    •  & Stefan Raunser
  • Brief Communications Arising |

    • Christa E. Osuna
    • , So-Yon Lim
    • , Jessica L. Kublin
    • , Richard Apps
    • , Elsa Chen
    • , Talia M. Mota
    • , Szu-Han Huang
    • , Yanqin Ren
    • , Nathaniel D. Bachtel
    • , Athe M. Tsibris
    • , Margaret E. Ackerman
    • , R. Brad Jones
    • , Douglas F. Nixon
    •  & James B. Whitney
  • Letter |

    The absolute timing of the photoelectric effect has proved difficult to measure, but the delay between photon arrival at a tungsten surface and ejection of photoelectrons has now been determined.

    • M. Ossiander
    • , J. Riemensberger
    • , S. Neppl
    • , M. Mittermair
    • , M. Schäffer
    • , A. Duensing
    • , M. S. Wagner
    • , R. Heider
    • , M. Wurzer
    • , M. Gerl
    • , M. Schnitzenbaumer
    • , J. V. Barth
    • , F. Libisch
    • , C. Lemell
    • , J. Burgdörfer
    • , P. Feulner
    •  & R. Kienberger
  • Letter |

    • Yang Liu
    • , Qi Zhao
    • , Ming-Han Li
    • , Jian-Yu Guan
    • , Yanbao Zhang
    • , Bing Bai
    • , Weijun Zhang
    • , Wen-Zhao Liu
    • , Cheng Wu
    • , Xiao Yuan
    • , Hao Li
    • , W. J. Munro
    • , Zhen Wang
    • , Lixing You
    • , Jun Zhang
    • , Xiongfeng Ma
    • , Jingyun Fan
    • , Qiang Zhang
    •  & Jian-Wei Pan
  • Letter |

    An analysis of the motions of six million stars in the Milky Way disk reveals substructures such as snail shells and ridges, indicating that our Galaxy has been recently perturbed.

    • T. Antoja
    • , A. Helmi
    • , M. Romero-Gómez
    • , D. Katz
    • , C. Babusiaux
    • , R. Drimmel
    • , D. W. Evans
    • , F. Figueras
    • , E. Poggio
    • , C. Reylé
    • , A. C. Robin
    • , G. Seabroke
    •  & C. Soubiran
  • Letter |

    The mitotic spindle prevents normal nuclear envelope assembly on missegregated chromosomes, leading to spontaneous envelope disruption of micronuclei and subsequent genome instability.

    • Shiwei Liu
    • , Mijung Kwon
    • , Mark Mannino
    • , Nachen Yang
    • , Fioranna Renda
    • , Alexey Khodjakov
    •  & David Pellman
  • Letter |

    Studies of an Antarctic marine sediment core suggest that the East Antarctic Ice Sheet retreated in the vicinity of the Wilkes Subglacial Basin during extended warm periods of the late Pleistocene, when temperatures were similar to those predicted to occur within this century.

    • David J. Wilson
    • , Rachel A. Bertram
    • , Emma F. Needham
    • , Tina van de Flierdt
    • , Kevin J. Welsh
    • , Robert M. McKay
    • , Anannya Mazumder
    • , Christina R. Riesselman
    • , Francisco J. Jimenez-Espejo
    •  & Carlota Escutia
  • Letter |

    METTL3, the enzyme responsible for m6A modification, influences translation by interacting with eIF3h to mediate looping between the regions near the stop codon and 5′ cap of mRNA.

    • Junho Choe
    • , Shuibin Lin
    • , Wencai Zhang
    • , Qi Liu
    • , Longfei Wang
    • , Julia Ramirez-Moya
    • , Peng Du
    • , Wantae Kim
    • , Shaojun Tang
    • , Piotr Sliz
    • , Pilar Santisteban
    • , Rani E. George
    • , William G. Richards
    • , Kwok-Kin Wong
    • , Nicolas Locker
    • , Frank J. Slack
    •  & Richard I. Gregory
  • Brief Communications Arising |

    • Benjamin Descours
    • , Gael Petitjean
    •  & Monsef Benkirane
  • Review Article |

    By analysing particle production in high-energy nuclear collisions, the phase boundary of strongly interacting matter is located and the phase structure of quantum chromodynamics is elucidated, implying quark–hadron duality.

    • Anton Andronic
    • , Peter Braun-Munzinger
    • , Krzysztof Redlich
    •  & Johanna Stachel
  • Letter |

    Biomechanical analyses of mammaliaform and cynodont fossils demonstrate that miniaturization drove the evolutionary transformation of the mammalian jaw, which preceded the optimization of bite force-to-joint load in the mandible

    • Stephan Lautenschlager
    • , Pamela G. Gill
    • , Zhe-Xi Luo
    • , Michael J. Fagan
    •  & Emily J. Rayfield
  • Letter |

    The retromer complex (the vacuolar protein sorting heterotrimer Vps26–Vps29–Vps35) has been resolved in association with membranes and the sorting nexin protein Vps5 using cryo-electron tomography.

    • Oleksiy Kovtun
    • , Natalya Leneva
    • , Yury S. Bykov
    • , Nicholas Ariotti
    • , Rohan D. Teasdale
    • , Miroslava Schaffer
    • , Benjamin D. Engel
    • , David. J. Owen
    • , John A. G. Briggs
    •  & Brett M. Collins
  • Letter |

    Time-asymmetric light transmission over the entire optical communications band is achieved using a silicon photonic structure with photonic modes that dynamically encircle an exceptional point in the optical domain.

    • Jae Woong Yoon
    • , Youngsun Choi
    • , Choloong Hahn
    • , Gunpyo Kim
    • , Seok Ho Song
    • , Ki-Yeon Yang
    • , Jeong Yub Lee
    • , Yongsung Kim
    • , Chang Seung Lee
    • , Jai Kwang Shin
    • , Hong-Seok Lee
    •  & Pierre Berini
  • Letter |

    During starvation, glyceraldehyde 3-phosphate dehydrogenase (GAPDH) targets GTPase-activating proteins to inhibit multiple intracellular transport pathways, thereby promoting energy homeostasis.

    • Jia-Shu Yang
    • , Jia-Wei Hsu
    • , Seung-Yeol Park
    • , Jian Li
    • , William M. Oldham
    • , Galina V. Beznoussenko
    • , Alexander A. Mironov
    • , Joseph Loscalzo
    •  & Victor W. Hsu
  • Letter |

    A silcrete flake with a 73,000-year-old cross-hatched ochre drawing, from Blombos Cave, South Africa, demonstrates that early Homo sapiens used a range of media and techniques to produce graphic representations.

    • Christopher S. Henshilwood
    • , Francesco d’Errico
    • , Karen L. van Niekerk
    • , Laure Dayet
    • , Alain Queffelec
    •  & Luca Pollarolo
  • Article |

    The tumour microenvironment determines which type of liver cancer develops, with transformed hepatocytes giving rise to intrahepatic cholangiocarcinoma or hepatocellular carcinoma depending or whether they are surrounded by cells undergoing necroptosis or apoptosis.

    • Marco Seehawer
    • , Florian Heinzmann
    • , Luana D’Artista
    • , Jule Harbig
    • , Pierre-François Roux
    • , Lisa Hoenicke
    • , Hien Dang
    • , Sabrina Klotz
    • , Lucas Robinson
    • , Grégory Doré
    • , Nir Rozenblum
    • , Tae-Won Kang
    • , Rishabh Chawla
    • , Thorsten Buch
    • , Mihael Vucur
    • , Mareike Roth
    • , Johannes Zuber
    • , Tom Luedde
    • , Bence Sipos
    • , Thomas Longerich
    • , Mathias Heikenwälder
    • , Xin Wei Wang
    • , Oliver Bischof
    •  & Lars Zender
  • Letter |

    The topological magnet Fe3Sn2 exhibits a giant nematic energy shift of a many-body electronic state, demonstrating anisotropic spin–orbit tunability.

    • Jia-Xin Yin
    • , Songtian S. Zhang
    • , Hang Li
    • , Kun Jiang
    • , Guoqing Chang
    • , Bingjing Zhang
    • , Biao Lian
    • , Cheng Xiang
    • , Ilya Belopolski
    • , Hao Zheng
    • , Tyler A. Cochran
    • , Su-Yang Xu
    • , Guang Bian
    • , Kai Liu
    • , Tay-Rong Chang
    • , Hsin Lin
    • , Zhong-Yi Lu
    • , Ziqiang Wang
    • , Shuang Jia
    • , Wenhong Wang
    •  & M. Zahid Hasan
  • Letter |

    A strategy developed to define off-target effects of gene-editing nucleases in whole organisms is validated and leveraged to show that CRISPR–Cas9 nucleases can be used effectively in vivo without inducing detectable off-target mutations.

    • Pinar Akcakaya
    • , Maggie L. Bobbin
    • , Jimmy A. Guo
    • , Jose Malagon-Lopez
    • , Kendell Clement
    • , Sara P. Garcia
    • , Mick D. Fellows
    • , Michelle J. Porritt
    • , Mike A. Firth
    • , Alba Carreras
    • , Tania Baccega
    • , Frank Seeliger
    • , Mikael Bjursell
    • , Shengdar Q. Tsai
    • , Nhu T. Nguyen
    • , Roberto Nitsch
    • , Lorenz M. Mayr
    • , Luca Pinello
    • , Mohammad Bohlooly-Y
    • , Martin J. Aryee
    • , Marcello Maresca
    •  & J. Keith Joung
  • Letter |

    A global modelling approach shows that in response to rises in global sea level, gains of up to 60% in coastal wetland areas are possible, if appropriate coastal management solutions are developed to help support wetland resilience.

    • Mark Schuerch
    • , Tom Spencer
    • , Stijn Temmerman
    • , Matthew L. Kirwan
    • , Claudia Wolff
    • , Daniel Lincke
    • , Chris J. McOwen
    • , Mark D. Pickering
    • , Ruth Reef
    • , Athanasios T. Vafeidis
    • , Jochen Hinkel
    • , Robert J. Nicholls
    •  & Sally Brown
  • Letter |

    Somatosensory corticospinal neurons facilitate touch sensitivity and touch-evoked neuropathic pain in mice.

    • Yuanyuan Liu
    • , Alban Latremoliere
    • , Xinjian Li
    • , Zicong Zhang
    • , Mengying Chen
    • , Xuhua Wang
    • , Chao Fang
    • , Junjie Zhu
    • , Chloe Alexandre
    • , Zhongyang Gao
    • , Bo Chen
    • , Xin Ding
    • , Jin-Yong Zhou
    • , Yiming Zhang
    • , Chinfei Chen
    • , Kuan Hong Wang
    • , Clifford J. Woolf
    •  & Zhigang He
  • Article |

    Chemical optimization of arylomycins results in an inhibitor of bacterial type I signal peptidase that shows activity both against multidrug-resistant clinical isolates of Gram-negative bacteria in vitro and in several in vivo infection models.

    • Peter A. Smith
    • , Michael F. T. Koehler
    • , Hany S. Girgis
    • , Donghong Yan
    • , Yongsheng Chen
    • , Yuan Chen
    • , James J. Crawford
    • , Matthew R. Durk
    • , Robert I. Higuchi
    • , Jing Kang
    • , Jeremy Murray
    • , Prasuna Paraselli
    • , Summer Park
    • , Wilson Phung
    • , John G. Quinn
    • , Tucker C. Roberts
    • , Lionel Rougé
    • , Jacob B. Schwarz
    • , Elizabeth Skippington
    • , John Wai
    • , Min Xu
    • , Zhiyong Yu
    • , Hua Zhang
    • , Man-Wah Tan
    •  & Christopher E. Heise
  • Letter |

    Tunable spin transport over long distances is demonstrated through the antiferromagnetic insulator haematite, paving the way to the development of spin-logic devices based on antiferromagnetic insulators.

    • R. Lebrun
    • , A. Ross
    • , S. A. Bender
    • , A. Qaiumzadeh
    • , L. Baldrati
    • , J. Cramer
    • , A. Brataas
    • , R. A. Duine
    •  & M. Kläui
  • Article |

    Germline BRCA1 loss-of-function variants are associated with predisposition to early-onset breast and ovarian cancer; here the authors use CRISPR/Cas9 genome editing to functionally assess thousands of BRCA1 variants in order to facilitate the clinical interpretation of these variants.

    • Gregory M. Findlay
    • , Riza M. Daza
    • , Beth Martin
    • , Melissa D. Zhang
    • , Anh P. Leith
    • , Molly Gasperini
    • , Joseph D. Janizek
    • , Xingfan Huang
    • , Lea M. Starita
    •  & Jay Shendure
  • Letter |

    The Gram-positive Listeria monocytogenes pathogen possesses a distinctive extracellular electron transfer mechanism, which is probably present in numerous ecologically diverse species of the Firmcutes phylum.

    • Samuel H. Light
    • , Lin Su
    • , Rafael Rivera-Lugo
    • , Jose A. Cornejo
    • , Alexander Louie
    • , Anthony T. Iavarone
    • , Caroline M. Ajo-Franklin
    •  & Daniel A. Portnoy
  • Article |

    The elucidation of general principles for designing β-barrels enables the de novo creation of fluorescent proteins.

    • Jiayi Dou
    • , Anastassia A. Vorobieva
    • , William Sheffler
    • , Lindsey A. Doyle
    • , Hahnbeom Park
    • , Matthew J. Bick
    • , Binchen Mao
    • , Glenna W. Foight
    • , Min Yen Lee
    • , Lauren A. Gagnon
    • , Lauren Carter
    • , Banumathi Sankaran
    • , Sergey Ovchinnikov
    • , Enrique Marcos
    • , Po-Ssu Huang
    • , Joshua C. Vaughan
    • , Barry L. Stoddard
    •  & David Baker
  • Letter |

    Training of mice to associate a particular sound frequency with locomotion results in selective suppression of cortical responses to that frequency during movement, consistent with a motor-dependent form of auditory cortical plasticity.

    • David M. Schneider
    • , Janani Sundararajan
    •  & Richard Mooney
  • Article |

    A large-scale genomics study shows that the cell of origin and founding mutations determine disease subtype and lead to the expression of multiple haematopoietic lineage-defining antigens in mixed phenotype acute leukaemia.

    • Thomas B. Alexander
    • , Zhaohui Gu
    • , Ilaria Iacobucci
    • , Kirsten Dickerson
    • , John K. Choi
    • , Beisi Xu
    • , Debbie Payne-Turner
    • , Hiroki Yoshihara
    • , Mignon L. Loh
    • , John Horan
    • , Barbara Buldini
    • , Giuseppe Basso
    • , Sarah Elitzur
    • , Valerie de Haas
    • , C. Michel Zwaan
    • , Allen Yeoh
    • , Dirk Reinhardt
    • , Daisuke Tomizawa
    • , Nobutaka Kiyokawa
    • , Tim Lammens
    • , Barbara De Moerloose
    • , Daniel Catchpoole
    • , Hiroki Hori
    • , Anthony Moorman
    • , Andrew S. Moore
    • , Ondrej Hrusak
    • , Soheil Meshinchi
    • , Etan Orgel
    • , Meenakshi Devidas
    • , Michael Borowitz
    • , Brent Wood
    • , Nyla A. Heerema
    • , Andrew Carrol
    • , Yung-Li Yang
    • , Malcolm A. Smith
    • , Tanja M. Davidsen
    • , Leandro C. Hermida
    • , Patee Gesuwan
    • , Marco A. Marra
    • , Yussanne Ma
    • , Andrew J. Mungall
    • , Richard A. Moore
    • , Steven J. M. Jones
    • , Marcus Valentine
    • , Laura J. Janke
    • , Jeffrey E. Rubnitz
    • , Ching-Hon Pui
    • , Liang Ding
    • , Yu Liu
    • , Jinghui Zhang
    • , Kim E. Nichols
    • , James R. Downing
    • , Xueyuan Cao
    • , Lei Shi
    • , Stanley Pounds
    • , Scott Newman
    • , Deqing Pei
    • , Jaime M. Guidry Auvil
    • , Daniela S. Gerhard
    • , Stephen P. Hunger
    • , Hiroto Inaba
    •  & Charles G. Mullighan
  • Letter |

    Observations of a hot flow anomaly accelerating solar-wind ions suggest a mechanism for such acceleration—a Fermi acceleration trap caused by Earth’s bow shock interacting with the solar wind.

    • D. L. Turner
    • , L. B. Wilson III
    • , T. Z. Liu
    • , I. J. Cohen
    • , S. J. Schwartz
    • , A. Osmane
    • , J. F. Fennell
    • , J. H. Clemmons
    • , J. B. Blake
    • , J. Westlake
    • , B. H. Mauk
    • , A. N. Jaynes
    • , T. Leonard
    • , D. N. Baker
    • , R. J. Strangeway
    • , C. T. Russell
    • , D. J. Gershman
    • , L. Avanov
    • , B. L. Giles
    • , R. B. Torbert
    • , J. Broll
    • , R. G. Gomez
    • , S. A. Fuselier
    •  & J. L. Burch