Meeting program

Diseases of Transcription

Scientific sessions

Session I. Basics Of Transcription
Session II. Transcriptional Basis of Metabolic Disease
Session III. Transcriptional Diseases of Development
Session IV. Immune-deficiency Diseases Involving Transcription
Session V. Transcriptional Cancer Therapeutics

Thursday, January 11
Time	Detailed Information
	Registration Reception
6:45pm	OPENING REMARKS Sydney Brenner
7:00pm	KEYNOTE ADDRESS James Darnell

Friday, January 12
Time	Detailed Information
9:00am - 12:30pm	Scientific Session I. Basics Of Transcription Joanne Chory, Chair RNA Polymerase II: Structure & Regulation Roger Kornberg The Human INO80 Chromatin Remodeling Complex: An Essential Coregulator For YY1-Activated Transcription Joan Conaway Seeing Through Transcription Guillermo Calero Coffee Break 30 Minutes Beyond the Double Helix: Writing and Reading the ‘Histone Code’ David Allis Chromatin Signatures of Promoters and Enhancers in the Human Genome Nathaniel D. Heintzman Viral Proteins and Bioreductive Alkylating Agents Meet Chromatin Karolin Luger
2:00pm - 5:30pm	Scientific Session II. Transcriptional Basis of Metabolic Disease Nuclear Receptors: Transcriptional Physiology and Disease Ronald M. Evans, Chair PGC1 Coactivators and the Genomic Control of Energy Homeostasis Bruce Spiegelman Regulation of Metabolism by Transcriptional Corepressor RIP140 Evangelos Kiskinis Coffee Break 30 Minutes SIRT1 Controls PGC-1alpha Activity and Energy Homeostasis Johan Auwerx EMSY Breast Cancer Gene Controls Expression of p53 Isoforms Tony Kouzarides, Chair Transcriptional Pathways in the Treatment of Bone Disease Shigeki Kato
7:00pm	Speaker Dinner

Saturday, January 13
Time	Detailed Information
9:00am - 12:30pm	Scientific Session III. Transcriptional Diseases of Development Transcriptional Pathways in Cardiovascular Development and Disease Eric Olson, Chair Genetic and Molecular Mechanisms Causing Hypertrophic Cardiomyopathy Jon Seidman Coffee Break 30 Minutes Transcriptional Control of Bone Formation and its Therapeutic Implication Gerard Karsenty The Logic of NFAT Signaling in Development and Disease Gerald Crabtree Isolation of a Human Embryonic Stem Cell Coactivator Complex Robert Tjian
2:00pm - 5:30pm	Scientific Session IV. Immune-deficiency Diseases Involving Transcription Inflammation and Immunity Intersect at XBP-1 Laurie Glimcher, Chair A Genetic Dissection of Immunity to Infection in natura Jean Laurent Casanova Active repression of CD4 Expression in Immature Thymocytes is Mediated by the Interaction of Runx1 with P-TEFb via Chromatin Looping Huimin Jiang Coffee Break 30 Minutes Out FOXing T-cells Alexander Rudensky Using Microarrays to Build a Small-Moleucule Toolkit for Studying Transcriptional Regulation Angela N. Koehler MHC Class II Deficiency (“Bare Lymphocyte Syndrome”) : A Genetic Disease of Transcriptional Regulation Bernard Mach
6:00pm	Gala dinner Salk Institute

Sunday, January 14
Time	Detailed Information
9:00am - 12:30pm	Scientific Session V. Transcriptional Cancer Therapeutics EMSY Breast Cancer Gene Controls Expression of p53 Isoforms Tony Kouzarides, Chair HDACs as a Therapeutic Target Victoria Richon Recovery of Dystropic Muscles in Mice Treated with Deacetylase Inhibitors Pier Lorenzo Puri Tumor suppressor BRCA1 ubiquitylates histone H2A and regulates heterochromatin integrity Gerald Pao Coffee Break 30 Minutes PML-RAR-A Model to Cure Leukemia Pier Giuseppe Pellici p53– Single Nucleotides in the P53 Pathway can Influence the Frequency and the Age of Onset of Cancers in Humans Arnold Levine