7 April 2005
Two into 2 will go
The comprehensive annotated sequences of human chromosomes 2 and 4 are published this week. Together, they represent 5% of the estimated size of the human genome; chromosome 2 contains the largest amount of genetically active DNA sequence of any human chromosome. Chromosome 2 is of particular interest in terms of human evolution, as it is the product of head-to-head fusion of two ancestral chromosomes after the separation of the human and chimpanzee lineages.
Generation and annotation of the DNA sequences of human chromosomes 2 and 4
LADEANA W. HILLIER et al.
Nature 434, 724–731 (2005); doi:10.1038/nature03466
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