3 February 2005
Essence of E. coli
Proteomic analysis of native protein–protein interactions in E. coli combined with protein mass spectrometry has revealed an interaction network consisting of the proteins essential to bacterial life. The network is highly conserved, providing insight into core bacterial processes, the nature of evolutionary constraints, and suitable new antimicrobial drug targets.
Interaction network containing conserved and essential protein complexes in Escherichia coli
GARETH BUTLAND, JOS� MANUEL PEREGR�N-ALVAREZ, JOYCE LI, WEHONG YANG, XIAOCHUN YANG, VERONICA CANADIEN, ANDREI STAROSTINE, DAWN RICHARDS, BRYAN BEATTIE, NEVAN KROGAN, MICHAEL DAVEY, JOHN PARKINSON , JACK GREENBLATT & ANDREW EMILI
Nature 433, 531–537 (2005); doi:10.1038/nature03239
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