2 September 2004
Genomics: Stick to the script
A genome sequence holds all the information needed to make and run an organism. But important to understanding how that organism works is the script that specifies where and when each gene is active. That is the genome's transcriptional regulatory code, the sequences used by DNA-binding regulators to control genome expression. A first draft of that code has now been compiled for the yeast Saccharomyces. The code was derived by combining data on genomic binding locations for transcriptional regulators in yeast cells grown in different conditions, knowledge of genome sequence conservation and prior evidence for regulator–DNA interactions. The resulting regulatory code map goes some way towards showing how the regulatory potential embedded in the genome is used in living cells.
Transcriptional regulatory code of a eukaryotic
genome
CHRISTOPHER T. HARBISON et al.
Nature 431, 99–104 (2004); doi:10.1038/nature02800
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