4 March 2004
Chromosome instability
An abnormal chromosome number (aneuploidy) has long been recognized as a characteristic of cancer cells. However, the mechanisms responsible for chromosome instability giving rise to aneuploidy have remained elusive. Now a mutation associated with chromosome instability has been identified in 12% of human colorectal cancers, and in their precursor lesions. The mutation is in the CDC4 protein, thought to be involved in regulating the cell cycle.
Inactivation of hCDC4 can cause chromosomal
instability
HARITH RAJAGOPALAN, PRASAD V. JALLEPALLI, CARLO RAGO,
VICTOR E. VELCULESCU, KENNETH W. KINZLER, BERT VOGELSTEIN & CHRISTOPH
LENGAUER
Nature 428, 77–81 (2004); doi:10.1038/nature02313
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